全文获取类型
收费全文 | 2717篇 |
免费 | 155篇 |
国内免费 | 42篇 |
专业分类
耳鼻咽喉 | 42篇 |
儿科学 | 5篇 |
妇产科学 | 11篇 |
基础医学 | 55篇 |
口腔科学 | 3篇 |
临床医学 | 82篇 |
内科学 | 100篇 |
皮肤病学 | 3篇 |
神经病学 | 595篇 |
特种医学 | 194篇 |
外科学 | 349篇 |
综合类 | 201篇 |
预防医学 | 52篇 |
眼科学 | 8篇 |
药学 | 49篇 |
中国医学 | 5篇 |
肿瘤学 | 1160篇 |
出版年
2023年 | 33篇 |
2022年 | 67篇 |
2021年 | 110篇 |
2020年 | 113篇 |
2019年 | 87篇 |
2018年 | 90篇 |
2017年 | 86篇 |
2016年 | 72篇 |
2015年 | 92篇 |
2014年 | 205篇 |
2013年 | 159篇 |
2012年 | 151篇 |
2011年 | 168篇 |
2010年 | 128篇 |
2009年 | 169篇 |
2008年 | 132篇 |
2007年 | 131篇 |
2006年 | 124篇 |
2005年 | 108篇 |
2004年 | 93篇 |
2003年 | 79篇 |
2002年 | 81篇 |
2001年 | 69篇 |
2000年 | 72篇 |
1999年 | 58篇 |
1998年 | 59篇 |
1997年 | 44篇 |
1996年 | 35篇 |
1995年 | 20篇 |
1994年 | 15篇 |
1993年 | 15篇 |
1992年 | 10篇 |
1991年 | 10篇 |
1990年 | 5篇 |
1989年 | 4篇 |
1987年 | 2篇 |
1986年 | 5篇 |
1984年 | 4篇 |
1983年 | 1篇 |
1982年 | 3篇 |
1980年 | 4篇 |
1973年 | 1篇 |
排序方式: 共有2914条查询结果,搜索用时 18 毫秒
1.
Place et modalités de l’irradiation postopératoire dans la prise en charge des métastases cérébrales
《Cancer radiothérapie》2020,24(6-7):477-481
Metastases are the most common brain tumors. After surgery, stereotactic radiotherapy (SRT) of the resection cavity is the standard of care. Data from two randomized trials indicate that SRT to the surgical bed is an effective treatment in reducing local failure as compared with observation, while reducing the risk of cognitive deterioration and maintaining quality of life as compared with whole brain radiation therapy. Local control appears higher after hypofractionated SRT compared to single-fraction SRT. Several questions such as target volumes, the optimal regimen in particular for large tumor bed, strategies to reduce the risk of lepto-meningeal recurrence, and the treatment sequence still need to be answered. 相似文献
2.
3.
4.
Purpose
Chest wall pain is an uncommon but bothersome late complication following lung stereotactic body radiation therapy. Despite numerous studies investigating predictors of chest wall pain, no clear consensus has been established for a chest wall constraint. The aim of our study was to investigate factors related to chest wall pain in a homogeneous group of patients treated at our institution.Patients and methods
All 122 patients were treated with the same stereotactic body radiation therapy regimen of 48 Gy in three fractions, seen for at least 6 months of follow-up, and planned with heterogeneity correction. Chest wall pain was scored according to the Common Terminology Criteria for Adverse Events classification v3.0. Patient (age, sex, diabetes, osteoporosis), tumour (planning target volume, volume of the overlapping region between planning target volume and chest wall) and chest wall dosimetric parameters (volumes receiving at least 30, 40, and 50 Gy, the minimal doses received by the highest irradiated 1, 2, and 5 cm3, and maximum dose) were collected. The correlation between chest wall pain (grade 2 or higher) and the different parameters was evaluated using univariate and multivariate logistic regression.Results
Median follow-up was 18 months (range: 6–56 months). Twelve patients out of 122 developed chest wall pain of any grade (seven with grade 1, three with grade 2 and two with grade 3 pain). In univariate analysis, only the volume receiving 30 Gy or more (P = 0.034) and the volume of the overlapping region between the planning target volume and chest wall (P = 0.038) significantly predicted chest wall pain, but these variables were later proved non-significant in multivariate regression.Conclusion
Our analysis could not find any correlation between the studied parameters and chest wall pain. Considering our present study and the wide range of differing results from the literature, a reasonable conclusion is that a constraint for chest wall pain is yet to be defined. 相似文献5.
6.
Stereotactic body radiotherapy (SBRT) has become an important radiotherapy technology. In recent years, with the continuous improvement of the mechanical properties of the linear accelerator (LINAC), LINAC-based SBRT is gradually emerging. In this article, the history, technological progress, radiation physics, clinical application of LINAC-based SBRT were elaborated, aiming to promote the development of LINAC-based SBRT. 相似文献
7.
目的观察老年非小细胞肺癌立体定向放疗疗效,并探讨其预后因子。方法128例老年非小细胞肺癌患者行常规放疗结合立体定向放疗,定期随访。结果全组患者1年生存率65.72%,单因素分析表明肿瘤体积、肿瘤剂量、卡氏评分影响近期结果,多因素分析仅肿瘤体积和肿瘤剂量为近期疗效预后因子,与生存期有关的预后因素为近期疗效、肿瘤剂量、临床分期。结论立体定向放疗可延长生存时间,对Ⅲ期患者,肿瘤剂量提高至72Gy是安全的。 相似文献
8.
Summary A simple technique of stereotactic craniotomy and intraoperative lesion localisation that uses the Brown-Robert-Wells (BRW) stereotactic frame is presented. The method optimises craniotomy placement and facilitates localisation of small intracerebral lesions. Using the system, 16 patients have had resection of intracranial neoplasms from deep and/or eloquent areas of the brain with no neurological morbidity. 相似文献
9.
自1988年1月至1996年1月采用CT引导立体定向技术对300例颅咽管瘤进行了385次瘤内置入放射性核素的治疗。其中男180例,女120例,年龄3~74岁,平均30.5岁。全部病例均有视路受损症状。CT或MRI检查显示:囊性肿瘤175例,实体性肿瘤40例,实体与囊腔并存85例,无,手术死亡及严重并发症。结果:术后250例随访6个月至8年,平均4年:肿瘤消失180例(72%);肿瘤显著缩小(>80%)30例(12%);肿瘤缩小50%左右20例(8%);肿瘤增大(主要为实体性)16例(6.4%);死亡4例(1.6%)。所使用的P-32和Y-90是纯Beta射线源,因其穿透能力短易于运送与保存、保护、对使用囊壁的治疗量为200Gy(20000rd)为好,可杀死瘤细胞而对周围组织无损害。提示立体定向瘤内放射性核素行间质内照射是治疗颅咽管瘤的一种有效方法。 相似文献
10.
星形胶质细胞瘤伽玛刀治疗的疗效与影响因素 总被引:6,自引:0,他引:6
目的分析星形胶质细胞瘤伽玛刀(γ-刀)治疗的疗效与影响因素.方法回顾性分析48例星形胶质细胞瘤病人的γ-刀治疗结果.以性别、有无普通放疗经过、有无化疗经过、边缘剂量、病灶的平均直径、病变的病理等级、影像学上有无相对较清楚的边界为治疗结果影响因素,判定标准以病灶缩小为有效,采用logistic回归模型,确定多因素条件下治疗结果的影响因素.结果有效32例(66.7%),logistic回归模型分析表明:病理等级和病灶平均直径为与肿瘤控制有关的影响因素.结论γ-刀对星形胶质细胞瘤的治疗有一定的意义. 相似文献