连续性静脉—静脉血液滤过治疗心肾综合征的疗效分析

随着人口老龄化进程加速,心力衰竭发病人数逐年增加,同时,随着对慢性肾脏疾病认识的深入,终末期肾病乃至轻度、中度肾功能不全的发病率均显著升高。引起动脉粥样硬化的糖尿病、脂代谢异常、高血压和高尿酸血症,已经成为心衰和慢性肾脏疾病的共同病因。     

家庭病房治疗心房颤动30例

1临床资料1.1一般情况30例患者中,年龄在60-88岁,男性20例,女性10例,男:女为1.5:1。诊断心电图均表现为p波消失代之以f波,P-R间期极不相等。急性或快速型心房颤动者均有明显的心悸、憋气、恶心、疲乏不适等症     

基于网络药理学探讨玉屏风散治疗支气管哮喘的作用机制

目的:运用网络药理学筛选玉屏风散治疗支气管哮喘的作用靶标及信号通路,为临床治疗提供有力依据。方法:利用TCMSP筛选中药活性成分和有效成分靶点信息。利用Uniprot数据库和Excel找出有效成分靶点信息基因名。在Gene Cards、OMIM、Drugbank数据库搜集疾病相关靶标,采用Venny软件对中药靶点基因与疾病靶点基因取交集,得到Venny交集图。将各个中药靶点基因共同输入Cytoscape软件,得到中药-靶标调控网络。通过String软件构建中药-疾病共同靶标的蛋白互作网络。将中药-疾病共同靶点基因进行GO和KEGG功能富集分析,采用Cytoscape软件做出共同靶点通路。结果:筛选得到玉屏风散治疗支气管哮喘的主要活性成分17个,中药-疾病共同靶点基因114个,推断其作用机制可能与糖尿病并发症中的AGE-RAGE信号通路、癌症途径、IL-17信号通路、PI3K-Akt信号通路等相关,并且可能起到关键作用。结论:基于网络药理学探讨玉屏风散治疗支气管哮喘的作用机制,有利于临床治疗。     

常染色体隐性遗传小脑性共济失调一家系报道

<正>本文报道新近发现一个小脑性共济失调家系,兄妹两人发病,均表现为共济失调,并进行性加重。其父母为近亲结婚,呈常染色体隐性遗传,现报道如下。一、先证者临床资料     

癫痫患者认知障碍程度与NSE、L-EK的关系研究

目的观察86例癫痫患者的认知功能状况,同时检测患者组及对照组血清神经元特异性烯醇化酶(NSE)及亮氨酸-脑啡肽(L-EK)水平变化,以探讨NSE、L-EK与癫痫患者认知障碍的关系。方法采用洛文斯顿作业疗法认知评定量表(LOTCA)对86例癫痫患者及33名健康人进行测评;应用电化学发光免疫测定法测定血清NSE、L-EK水平,对数据进行统计学分析。结果患者组的LOTCA评分为(66.17±16.39)分,对照组为(102.25±7.34)分,患者组明显低于对照组(P<0.01)。患者组血清NSE为(39.98±11.25)ng/ml、L-EK为(136.74±66.51)pg/ml,均高于对照组(P<0.05);且血清L-EK、NSE水平随认知障碍程度加重而提高,各不同认知程度组比较,差异有统计学意义。结论癫痫患者存在认知障碍的倾向,测定患者血清L-EK及NSE水平对判断患者认知障碍程度具有重要价值。     

颅底骨折合并脑脊液鼻漏治疗体会

脑脊液(CSF)鼻漏是因为颅底骨折的同时撕破了硬脑膜和蛛网膜，以致脑脊液由骨折缝经鼻腔流出，使颅腔与外界交通形成漏孔，同时空气亦可逆行逸入颅腔形成气颅。如对本病认识不足，治疗不及时，处理不得当，极易引起严重后果，如颅内感染、严重气颅、严重低颅压综合征等，甚至危及患者生命。近年我院收治颅底骨折合并脑脊液鼻漏患者34例，效果满意，现就治疗体会介绍如下。     

甘肃省神经外科状况的调查报告

目的 统计分析甘肃省神经外科的床位、医师数量、住院患者基本分布及流行病学特点,为神经外科疾病的预防及诊治提供依据.方法 对省内独立建制的神经外科发放表格,统一汇总、统计分析.结果 17家三级医院和7家二级医院参与调查,平均每位神经外科医师年收治患者71.18位,每10万人有0.59名神经外科医师和2.71张神经外科床位.神经外科患者及手术数量逐年增多.颅脑肿瘤、脑动静脉畸形、动脉瘤及癫痫的外科诊治主要集中在省级大医院,下级医院主要诊治颅脑外伤、高血压脑出血等.结论 甘肃省神经外科实力薄弱,尤其是基层医院,神经外科疾病逐年增加,给社会和家庭带来沉重的负担.     

蛞蝓治蝼蛄疖

蝼蛄疖多发生在酷热的夏季,好发于儿童头皮和眼睑等处,由疮、疖等失治或误治,转为本病。疖根脚坚硬,破溃后脓液虽排出,而根脚不散,疮口迁延不愈,表面色红,下面互相沟通,如蝼蛄所筑     

《国外医学》浅析

《国外医学》是我国读者检索国外医学文献最重要的情报检索刊物之一,载止至 1987年底已出版44个分册。其分别由全国有关高等医药院校、附属医院和省级医学     

肠内输入高渗电解质葡萄糖液对犬35%总体表面积烧伤复苏效果的研究

Objective To study the resuscitative effect of hypertonic electrolyte glucose solution (HEGS) in enteral resuscitation of burn shock. Methods Eighteen Beagle dogs with 35% TBSA full-thickness flame injury were used in this study. They were randomized to a control group (no-fluid resuscitation, N group), a HEGS resuscitation group (H group) or an isotonic electrolyte glucose solution (IEGS) resuscitation group (Ⅰ group). The solution enterally was given for resuscitation from half an hour after burn. The volumes and rates of fluid infusion in the H group were basically in accordance with 2 ml/ TBSA)]. The hacmedynarnie parameters, global end-diastolic volume index, plasma volume, osmotic pressure of plasma, intestinal absorptive rates of water and Na+, and intestine mueosa blood flow were continuously assessed. Results The cardiac output index, global end-diastolic volume index, plasma volume and intestine blood mucosa flow reduced markedly after burn in the three groups, and then gradually returned from 2 h after burn in two resuscitation groups, which were higher than that in the N group (P < 0.05). The activities of diamine oxidase in plasma in the two resuscitation groups were higher than that in N group (P<0.05). The intestinal absorption rates of water and Na+ reduced markedly after burn in two resuscitation groups with the lowest levels, and then returned from 6 h after burn. The rates of water in H group were lower than that in Ⅰ group (P < 0.05); the rates of Na+ in H group were higher than in Ⅰ group (P < 0.05). Conclusion The results indicated that 35% TBSA Ⅲ°burn-injury dogs be resuscitated effectively with 1.8% hypertonic electrolyte-glucose solution by enteral, which 1/2 volume of an isotonic electrolyte glucose solution.