浅谈小医院临床检验分析前质控

我们检验科每次更换新的批号的试裁都会及时的做质控,质控的结果也很好,由于我们的标本量少,患者来得时间不统一,检验的结果有时候会和大医院有差距,我们分析7原因,我们应当注意检验分析前的质控。     

利用安卓智能移动设备助力医院设备管理

以医院信息网络为基础,利用安卓（Android）智能移动设备,开发平板电脑与无线局域网无缝连接的移动设备管理系统。系统的应用确保了设备的安全使用,提高了医疗设备的完好率和利用率,促进了医院数字化建设的发展。     

药品应急检验管理理论基础研究

近年来我国药品突发事件频发,药品检验机构作为药品监管的技术支撑,迫切需要提升此方面的应对能力。通过从应急管理、药品常规检验、应急检验等3方面对药品应急检验管理的理论基础进行研究,阐释了应急管理在药品应急检验中的运用思路,为制定处置应急检验事件的有效措施打下坚实基础。     

Analysis of the cause of pregnancy failure with combined MLPA assay for subtelomeric regions and ultrasonography北大核心CSCD

Objective To explore the value of multiplex ligation-dependent probe amplification (MLPA) for thedetection of chromosome abnormalities in miscarriage tissues, and to correlate the result with ultrasoundfindings. Methods A total of 421 cases of spontaneous abortions and fetal deaths were detected with the MLPAmethod. Results Among the 421 samples, 232 (55. 11%) had an abnormal MLPA result. For the 286 cases derivedfrom < 13 weeks pregnancy, 206 (72.03%) were abnormal. For the 49 cases from 14 ~ 19 weeks pregnancy, 14(28. 57%) were abnormal. For the 86 cases derived after 20 weeks pregnancy, 12 (13. 95%) were abnormal. Amongthe 117 cases with abnormal ultrasound findings, 33 cases (28. 21%) had an abnormal MLPA result, 28 out of the33 cases were numerical chromosome abnormality, 4 cases were chromosome microdeletion and/or micro duplication, 1 case had both numerical abnormality and microduplication. For those with abnormal ultrasound findings for the neck region, fetal edematous syndrome, multiple malformations and digestive system, the detection rates forMLPA were 71. 4% , 58. 8% , 37. 8% , and 9.1% , respectively. For those with abnormal finding of cardiacsystem, nervous system, face, skeletal system and urinary system, none was found with positive results of MLPA. Conclusion Numerical chromosomal abnormalities account for the majority of cases with spontaneous abortion.With the increase of gestational age, the occurrence of chromosomal abnormalities gradually declines. Combinedultrasound and MLPA assay can improve the detection rate and accuracy for chromosomal abormalities.     

英国药物警戒检查简介及启示

为促进药品安全第一责任人即药品生产企业上市后监测责任的落实,英国于2003年启动了药物警戒检查项目,目前已经形成了一套完整的检查体系。通过对英国药物警戒检查类型、检查流程、检查结果等内容介绍,提出了对我国生产企业药品不良反应报告和监测的检查分工、检查指南、自我检查指标体系以及信息沟通方面的思考和建议。     

2013年度江苏省药品生产企业新版GMP认证检查缺陷项目分析

对江苏省药品生产企业在2013年新版药品GMP认证检查中存在的缺陷项目进行分析,为药品监管部门的认证检查、日常监管和药品生产企业完善GMP工作提供参考。     

四种检验方法在细菌性阴道炎诊断的临床价值

目的探讨4种检验方法对细菌性阴道炎的临床诊断作用与应用价值。方法选取该院2012年7月至2014年5月80例疑似细菌性阴道炎患者,分别使用胺试验、线索细胞检查、乳酸杆菌检查、细菌性阴道炎(BV)快速检测法进行检测,并对4种方法的检测结果作比较分析。结果乳酸杆菌检测阳性率为80.0%,线索细胞检查为78.75%,传统检查法(胺试验、pH值)为62.50%与61.25%、BV快速检测法为77.50%。BV快速检测法检出阳性率显著高于传统检测法,差异有统计学意义(P0.05);传统检测法检测结果与其他3种比较,诊断结果最差。结论 BV快速检测法对细菌性阴道炎的检测速度较快且检出率较高,具有临床价值。     

追踪方法学在评价住院患者院内检查安全管理流程的应用

目的：总结应用追踪方法学改善住院患者院内检查流程安全管理的效果。方法采用护理部组织的专项检查追踪小组运用追踪方法学全程追踪住院患者院内检查流程的环节质量、安全措施落实情况。结果改善后的院内检查流程、安全管理措施和患者满意度明显高于追踪方法学实施前,差异有统计学意义( P<0．01)。结论应用追踪方法学评价住院患者院内检查流程科学、规范,能够提高安全管理质量和患者满意度。     

九项呼吸道病原体检测在小儿呼吸道感染中的诊断价值

目的探讨呼吸道病原体九联检在小儿呼吸道感染中的临床应用价值。方法对2012年3月—2013年4月期间在该院住院的呼吸道感染的患儿(共104例)采用九项呼吸道感染病原体Ig M抗体检测试剂(间接免疫荧光法)同时检测九项病原体的Ig M抗体。结果在小儿呼吸道感染患者中,九种病原体检出的阳性率为57.69%,其中主要以肺炎支原体最为常见,占阳性例数的56.7%,其次为腺病毒40%、嗜肺军团菌23.3%;混合感染占感染比例的33.3%。结论呼吸道病原体九联检在小儿呼吸道感染检测中检出阳性率高,检测的病原体种类多,发现病原体时间早,对临床的及时诊断、治疗及用药有十分重要的意义。     

Visual Inspection with Acetic Acid (VIA) Screening Program: 7 Years Experience in Early Detection of Cervical Cancer and Pre-Cancers in Rural South India

Cervical cancer continues to be a major public health problem in India in the absence of wide spread organised cervical screening programs. Visual inspection of the cervix with acetic acid (VIA) is an effective, inexpensive screening test that can be combined with simple treatment procedures for early cervical lesions, provided by trained health workers. We report 7 years experience in early detection of cervical cancer and pre-cancers using the VIA test in a community-based program in rural Andhra Pradesh, India where there are no existing organised cervical screening programs.

Materials and Methods:

Eligible women aged between 26 and 60 were opportunistically screened by trained health wor kers using the VIA test. Women who tested positive were further evaluated and those with cervical lesions were treated either by cryotherapy in the screening clinic or referred to a higher center.

Results:

A total of 18,869 women were screened by a single round of VIA testing with a positive rate of 10.75%. Biopsy proven high-grade squamous intraepithelials (HSILs) were 90 (0.48%) and low-grade squamous intraepithelials (LSILs) were 43 (0.28%). The overall prevalence of cervical intraepithelial neoplasia (CIN) 2+ lesion rate is 1.05%. A total of 312 (1.65%) cryotherapies were done and 49 women underwent hysterectomy.

Conclusions:

VIA by trained female health workers is a safe, acceptable, and effective test that can save lives from cervical cancer even in remote areas with few resources. These results have important implications for efficient service delivery in cervical screening programs in low-resourced settings.