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Early pregnancy is commonly characterized by the disturbance of digestive function, characteristically manifested by nausea and vomiting. These symptoms during early pregnancy usually disappear spontaneously after about 12 weeks. In a minority of pregnant women,these symptoms are very severe, and are associated with 相似文献
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环孢素A血药浓度的影响因素 总被引:3,自引:0,他引:3
口服环孢素的生物利用度个体差异大,其影响因素较多。笔者通过总结给药方案、使用剂型、术后时间、胃肠功能、肝胆功能等对环孢素A血药浓度的影响,寻找影响血药浓度变化的可能因素,以降低其毒性和不良反应。 相似文献
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The expression of Attractin mRNA and protein in testis and semen of human and male mice was investigated. Human testis and semen samples were all collected from Reproductive Center of Reumin Hospital, Wuhan University in December, 2012. Testis samples were collected from 7 cases of obstructive azoospermias when they were subjected to diagnosed testis biopsy, and 30 nor- mal human semen samples were obtained from those cases of semen analysis. Adult mice testis tis- sues were obtained from 10 2-month-old male BALB/c mice, and 60 male mice at different ages were classified into 10 groups (day 1, 5, 10, 15, 21, 28, 35, 42, 56, and 120 respectively, n=6 each). The expression of Attractin mRNA and protein in testis was detected by RT-PCR and Western blotting re- spectively. Human semen samples were centrifuged into sperm plasma (SP) and sperm extract (SE), and mice sperm samples were collected from the epididymis of 10 adult male BALB/c mice. Western blotting was used to determine the Attractin protein expression level. Attractin mRNA and protein were expressed in the testis of both patients with obstructive azoospermias and adult Bcl/B mice. Quantitative RT-PCR revealed that no Attractin mRNA was detectable in day 1 male BALB/c mice group. The Attractin mRNA and protein levels were low on the day 10, and increased with age until day 56. On the day 120, the expression levels of Attractin were decreased. As for human semen sam- pies, Attractin protein was expressed in both SP and SE, but didn't exist in samples from the epidi- dymis of male BALB/c mice. It was suggested that Attractin acted as a novel active substance and was involved in male reproduction in both human and BALB/c mice, but it exerted a different ex- pression profile in different mammal species. 相似文献
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目的探讨常规X线钼靶摄像与乳腺MRI检查在乳腺癌筛查和早期诊断中的价值及其意义。方法选取2011年4月~2012年9月就诊的52例乳腺肿块患者,运用常规X线钼靶摄像与乳腺MRI对其进行检查。结果 X线钼靶与MRI摄影敏感性、特异性、准确度比较,差异有统计学意义(P0.05)。结论在X线钼靶摄像不能明确肿块是良恶性时,MRI检查结果明确,因此可以减少一些乳腺良性病变的活检率,并降低手术率,应广泛用于临床乳腺疾病的诊断。 相似文献