Effect of Shengmai Injection (生脉注射液) on cardiac function and inflammatory reaction in patients with acute coronary syndrome

Objective： To confirm the effect of Shengmai Injection （生脉注射液, SMI） in improving cardiac function in patients with acute coronary syndrome （ACS） and to explore its influence on inflammatory reaction in patients. Methods： Ninety ACS patients were randomized into two groups, the control group treated with conventional therapy and the SMI group treated with SMI. The patients＇ cardiac function was noted and the content of high sensitive C-reactive protein （hs-CRP） in venous blood was measured before treatment and 1 week and 3 weeks after treatment, so as to observe and compare their changes between the two groups. Results： The cardiac output, stroke volume and ejection fraction in the SMI group after 3 weeks of treatment were all higher than those in the control group （P〈0.05）. The serum content of hs-CRP was reduced in both groups （P〈0.05）, but the reduction in the SMI group was more significant than that in the control group （P〈0.05）. Conclusion： SMI could improve the cardiac function and further inhibit the inflammatory reaction in patients with ACS.     

经皮顺行和逆行主动脉球囊瓣膜成形术:血流动力学效果的对照观察

经皮主动脉球囊瓣膜成形术(PAV)已成为主动脉瓣狭窄的手术治疗之外的又一方法。作者采用穿越房间隔导管进行顺行PAV,并与逆行PAV的结果作比较。方法:对象为55例严重主动脉狭窄患者。因高龄、合并心脏以外疾病、终末期心力衰竭或肺动脉高压,进行主动脉瓣膜置换术均有高度危险性。顺行PAV技术:经右股静脉插入8FrMullin穿隔套管,穿过房间隔后拔出改良的Brockenbrough针和扩张器,于左房内留置一长套管。7Fr球囊嵌压导管(critikon)由套管进入左房并经二尖瓣口达左室,测定左室压和跨主动脉瓣压差。用弯曲的     

老年人急性心肌梗塞

本文就210例急性心肌梗塞患者(自1969年1月～1980年12月,共11年中经心电图确诊为急性心肌梗塞,并有完整病史和病程记录者。)进行了临床表现、并发症以及预后等对比分析。发现急性心肌梗塞的典型症状以非老年组为多(P<0.01),老年组则以非典型症状、消化道症状(恶心、呕吐)及晕厥居多,故易造成误诊。且老年组的并发症显著多于非老年组,死亡率亦高。但经积极治疗后仍能长期存活。所以对老年人急性心肌梗塞的不典型症状应提高认识,及时诊断,积极治疗,以期提高老年人的存活时间。     

对程序心室刺激的反应:敏感性,特异性,以及与心脏病的关系

本文的目的是:(1)确定在有或无心脏病的患者,由程序刺激诱发的反复性室性反应、非持续性室性心动过速和持续性室性心动过速的发生率,以及(2)确定在伴有或不伴有基础心脏疾病的患者,由程序心室刺激诱发的反复性室性反应和室性心动过速对检出自发性室性快速心动过速的敏感性和特异性.方法:100例患者,分成有或无基础心脏病二组.第Ⅰ组29例无缺血性、心肌性、瓣膜性、高血压性或先天性心脏病,年龄16～78岁(平均53岁).第Ⅱ组71例有器质性心脏病,年龄12～87岁(平     

Influence of Shengmai Capsule (生脉胶囊) on recovery of living capacity in patients after myocardial infarction

ABSTRACT Objective： To observe the effect of long-term application of Shengmai Capsule （生脉胶囊, SMC） on recovery of patients after myocardial infarction. Methods： A total of 120 myocardial infarction patients were assigned into two groups. Changes of angina pectoris, electrocardiogram （ECG）, living capacity and heart function in patients were observed after 6-month treatment. Results： The total effective rate in alleviating angina pectods was 90.0% and that in improving ECG figure was 93.3% in the treatment group, both were significantly higher than those in the control group, 73.4% and 70.0% respectively （P〈0.05）. The Karnofsky Performance Status scores of heart function were increased and the Activity of Daily Living scores in living capacity decreased in both groups, but the improvements were better in the treatment group （P〈0.01 and P〈0.05）. The parameters of cardiac function, including cardiac output, stroke volume, cardiac index and ejection fraction, were increased in both groups, but the increments in the treatment group were more significant （P〈0.01 or P〈0.05）. Conclusion： Long-term application of SMC could effectively prevent and treat angina pectoris, improve the living capacity and accelerate the recovery of heart function in patients after myocardial infarction.     

生脉散对急性心肌梗塞患者的抗脂质过氧化作用

本文探讨了３０例心绞痛和６８例急性心肌梗塞（ＡＭＩ）患者与脂质过氧化损伤的关系，并观察了中药生脉散颗粒剂对ＡＭＩ患者的抗脂质的过氧化作用。发现冠心病（ＣＨＤ）患者较健康人血中超氧化物歧化酶（ＳＯＤ），谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活性明显降低，而丙二醛（ＭＤＡ）显著升高（Ｐ＜０．００１）。当给ＡＭＩ患者口服生脉散颗粒９ｇ／ｄ２周，血中ＳＯＤ和ＧＳＨ－Ｐｘ明显升高，ＭＤＡ显著降低（Ｐ＜０．０５）     

女性急性心肌梗塞的临床特点

121例女性急性心机梗塞(AMI)者与同期入院的347例男性AMI者进行了对比研究。女性组≥56岁者占总数的95.0％,男性组80.1％(P<0.01)。女性组发病从60岁进入高峰,男性组为50岁。以典型胸痛和不典型胸痛发病两组间无显著差异。女性组以心律失常和胃肠道不适为发病疟状明显高于男性组(P<0.05～0.01)。两组的主要并发症及住院死亡率也有程度不同的差别。     

维生素C防治阿霉素心肌损伤的实验和临床研究

本文旨在探讨维生素C对受阿霉素损伤的原代培养的大鼠心肌细胞的保护作用及其临床意义。培养3天的心肌细胞用1．8μmol／L的阿霉素处理作为研究模型，然后在培养基中加入不同浓度的维生素C培养4小时。结果观察到合适浓度的维生素C能显著减少受损心肌细胞乳酸脱氢酶（LDH）释放，减少细胞内丙二醛（MDA）的形成，并改善细胞超微结构的变化，显示其具有抑制脂质过氧化，保护心肌细胞的作用。观察了10例接受阿霉素治疗的白血病和淋巴瘤患者，合用维生素C治疗一周后血中超氧化物歧化酶（SOD）和MDA的变化，发现维生素C能显著提高患者的SOD水平。     

颈动脉粥样硬化与冠状动脉狭窄程度的关系

探讨颈动脉粥样硬化病变的性质、程度及其与冠状动脉狭窄程度的关系。选择200例冠状动脉造影患者，并经颈动脉DSA及B超检查。根据造影结果分为冠心病组和非冠心病组(对照组)。根据冠状动脉狭窄直径，冠心病组再分成三个亚组。结果发现，颈动脉粥样硬化与冠状动脉狭窄之间呈线性正相关，颈动脉狭窄较冠状动脉狭窄发生率低，但随着冠状动脉狭窄程度加重，颈动脉粥样斑块的发生率明显增加，且颈动脉狭窄亦有加重趋势。结果提示，颈动脉粥样硬化与冠状动脉狭窄密切相关。对中年以上人群，尤其是有多种危险因素者，常规进行颈动脉超声检查，可为早期发现和筛选心脑血管疾病高危患者提供依据。     

维生素C与冠心病

ＡＳ与脂质过氧化反应及体内ＶｉｔＣ缺乏有关，而诱发ＣＡＤ的许多危险因素亦引起血浆ＶｉｔＣ浓度降低。补充自由基清除剂ＶｉｔＣ能改善ＣＡＤ临床症状，ＶｉｔＣ防治ＣＡＤ的机理可能是通过抗脂质过氧化作用。