Evaluation of clinical and financial outcomes of a new no‐sting barrier film and barrier cream in a large UK primary care organisation

The study involves 95 subjects within a UK Primary Care Organisation and was undertaken in two arms. The objective was to determine the clinical outcomes and clinical acceptability of a newly available range of no‐sting barrier film and no‐sting barrier cream products offering significant financial benefits. The importance of undertaking this study is underpinned by evidence in the literature relating to the use of no‐sting barrier preparations within clinical practice. The first part of the study (arm 1) involved extensive evaluation of either the film or cream barrier in 36 patients and was compared to existing standardised barrier protection care within the organisation. The results indicated that the new product range met all the criteria for formulary inclusion and following this the barrier range was further evaluated in arm 2, 33 patients with barrier cream and 26 patients with barrier film. The entire study was conducted over a 3‐month period with patient treatment lasting a minimum of 2 days to a maximum 4‐week period adhering to the agreed evaluation protocol as approved by clinical governance. In arm 1 (n = 36), the clinical expectation of the product was met in 32 cases relating to ease of use, conformability, no‐sting, quick drying, ease of absorption, compatibility with devices, frequency of application, prevention and management including visual skin improvement resulting in a recommendation for formulary listing in 31 of 36 cases. In arm 2 (n = 59), barrier film and barrier cream performance was consistently rated same as, better than or much better than the existing barrier used. A formulary listing recommendation was made in 51 of 59 cases.     

自拟疏肝清肺饮治疗成年女性轻中度痤疮的临床观察

目的 探讨自拟方疏肝清肺饮治疗成年女性轻、中度痤疮的临床效果.方法 选取首都医科大学良乡教学医院皮肤科门诊年龄25～ 45岁的女性轻、中度痤疮患者86例,按患者单双日就诊次序随机分为2组单日就诊为对照组,双日就诊为观察组.对照组40例口服红霉素肠溶胶囊0.5g/次,2次/d;同时外用0.025％的维A酸乳膏,1次/晚.观察组46例口服自拟疏肝清肺饮,每日1剂,分2次服用;同时也外用0.025％的维A酸乳膏,1次/晚.疗程6周,每周随访1次.疗程结束后分别比较2组患者的治疗效果.结果 对照组患者有效率为75.0％ （30/40）;观察组患者有效率为87.0％ （40/46）,2组的有效率比较差异无统计学意义（P＞0.05）.结论 自拟方疏肝清肺饮配合外用维A酸乳膏治疗成年女性轻、中度痤疮与红霉素肠溶胶囊加维A酸乳膏具有相近的疗效,为临床治疗这类痤疮患者提供了新的选择.     

芪人抗皱霜祛皱作用的临床研究

目的：探讨芪人抗皱霜祛除皮肤皱纹的临床疗效。方法：将90例符合纳入标准的受试对象随机分为试验组和对照组。试验组使用芪人抗皱霜,对照组使用普通祛皱霜,分别于皮肤皱纹测试部位外涂,每日早晚各涂一次,使用周期为40天。试验前后均拍照进行皮肤皱纹等级及积分评价,同时用硅橡胶复制皮肤皱纹模型,应用图象分析软件对其进行分析处理。结果：临床观察结果表明,芪人抗皱霜能够降低受试对象的皱纹积分,降低皮肤皱纹深度及皮肤皱纹粗糙度,并优于对照组（P〈0.01）。结论：芪人抗皱霜有较好的祛皱美容作用,未发现任何不良反应,不失为一种安全有效的美容产品。     

复方白及乳膏的质量控制

目的建立复方白及乳膏的质量控制方法。方法观察性状;以a-萘酚硫酸法鉴别白及多糖;以硫酸铜显色法鉴别尿素;以蒽酮染色法测定白及多糖含量;以苯甲醛染色法测定尿素含量。结果复方白及乳膏为白色的乳膏;α-萘酚硫酸鉴别显白及多糖的阳性反应;硫酸铜显色鉴别显尿素的阳性反应;白及多糖在1.88~33.75μg·mL-1范围内呈良好的线性关系,y=0.039X-0.0069(r=0.9998),平均回收率为98.3%,RSD为1.81%,平均含量应为4.0mg·g-1(±10%);尿素在10.0~120.0μg·mL-1范围内呈良好的线性关系,Y=0.0077X+0.0019(r=0.9995),平均回收率为99.1%,RSD为1.49%,平均含量应为0.1g·g-1(±10%)。结论所建立质量控制方法可操作性强,结果重现性好,适用于复方白及乳膏的质量控制。     

The implementation of a Hazard Analysis and Critical Control Point management system in a peanut butter ice cream plant

To ensure the safety of the peanut butter ice cream manufacture, a Hazard Analysis and Critical Control Point (HACCP) plan has been designed and applied to the production process. Potential biological, chemical, and physical hazards in each manufacturing procedure were identified. Critical control points for the peanut butter ice cream were then determined as the pasteurization and freezing process. The establishment of a monitoring system, corrective actions, verification procedures, and documentation and record keeping were followed to complete the HACCP program. The results of this study indicate that implementing the HACCP system in food industries can effectively enhance food safety and quality while improving the production management.     

厚朴乳膏处方筛选及制备工艺的研究与开发

目的厚朴酚性成分具有杀菌、消炎、燥湿、止痒等作用,通过制备乳膏对其提取物进行开发利用。方法根据厚朴酚、和厚朴酚的特点及乳膏基质的特点,筛选处方组成,并对制备工艺进行研究,通过对乳膏的外观性状、透皮、稠度和稳定性等指标进行考察,筛选最佳的处方组成,并制备厚朴乳膏。结果由该比例的组成制备的厚朴乳膏,重现性好,乳膏色泽较纯正,均匀细腻,稠度适宜,易涂布,稳定性好、透皮吸收等均较好,可以作为最佳配比来制备厚朴乳膏。结论厚朴乳膏可以作为一种新制剂进行开发利用。     

曲安奈德益康唑乳膏联合氯雷他定治疗外耳湿疹的疗效观察

目的：探讨曲安奈德益康唑乳膏联合氯雷他定治疗外耳湿疹的疗效。方法选取2012年3月—2014年3月韶关市第一人民医院收治的外耳湿疹患者108例,随机分为对照组与试验组,各54例。对照组患者给予曲安奈德益康唑乳膏治疗,试验组患者在对照组基础上加用氯雷他定治疗。观察两组患者临床疗效及不良反应发生情况。结果试验组患者总有效率为94.5%,高于对照组的81.5%,差异有统计学意义（ P<0.05）;两组患者不良反应发生率比较,差异无统计学意义（ P>0.05）。结论曲安奈德益康唑乳膏联合氯雷他定治疗外耳湿疹的疗效显著,且不良反应少,安全性高。     

卡泊三醇搽剂联合糠酸莫米松乳膏序惯疗法治疗头皮银屑病临床疗效观察

目的观察卡泊三醇搽剂联合糠酸莫米松乳膏序惯疗法治疗头皮银屑病的疗效及安全性。方法 62例头皮银屑病患者,采用随机对照的方法分为治疗组和对照组,每组31例。治疗组采用卡泊三醇搽剂联合糠酸莫米松乳膏序贯疗法治疗,对照组采用卡泊三醇搽剂治疗。比较两组患者临床疗效、皮损面积评分,并分析其不良反应发生情况。结果治疗2周后,治疗组有效率为45.16%,对照组有效率为32.26%,两组比较差异无统计学意义(χ2=1.09, P>0.05)。治疗4周后,治疗组有效率为67.74%,高于对照组的41.94%,差异有统计学意义(χ2=4.17, P<0.05)。治疗6周后,治疗组有效率87.10%显著高于对照组的64.52%,差异有统计学意义(χ2=4.31, P<0.05)。两组患者治疗前及治疗2周后皮损面积评分比较差异无统计学意义(P>0.05);治疗4、6周后,治疗组患者的皮损面积评分均低于对照组,差异具有统计学意义(P<0.05)。两组患者在治疗过程中均未见严重不良反应,治疗组中2例(6.45%)患者出现局部皮肤轻微烧灼感和疼痛,对照组中2例患者(6.45%)自觉局部轻微灼热不适和疼痛,均未影响治疗,未予处理。结论卡泊三醇搽剂联合糠酸莫米松乳膏序惯疗法治疗头皮银屑病疗效好,安全性高。     

Cytotoxic and Antibacteriial Actiivity of the Mixture of Olive Oil and Lime Cream in Vitro Conditions

The mixture of olive oil and lime cream has been traditionally used to treat external burns in the region of Hatay/Antakya and middle Anatolia. Olive oil and lime cream have been employed by many physicians to treat many ailments in the past. A limited number of studies have shown the antibacterial effect of olive oil and that it does not have any toxic effect on the skin. But we did not find any reported studies on the mixture of olive oil and lime cream. The aim of this paper is to investigate the cytotoxic and antibacterial activity of olive oil and lime cream individually or/and in combination in vitro conditions, by using disk-diffusion method and in cell culture. The main purpose in using this mixture is usually to clear burns without a trace. Agar overlay, MTT (Cytotoxicity assay) and antibacterial susceptibility tests were used to investigate the cytotoxic and antibacterial activity of olive oil and lime cream. We found that lime cream has an antibacterial activity but also cytotoxic on the fibroblasts. On the other hand olive oil has limited or no antibacterial effect and it has little or no cytotoxic on the fibroblasts. When we combined lime cream and olive oil, olive oil reduced its cytotoxic impact. These results suggest that mixture of olive oil and lime cream is not cytotoxic and has antimicrobial activity.     

多中心完全随机、标准治疗平行对照评价京万红软膏治疗糖尿病足慢性创面的临床研究

目的：：通过多中心完全随机、标准治疗平行对照方法评价京万红软膏治疗糖尿病足慢性创面的疗效。方法：本研究共有11家医院参加,采用多中心完全随机、标准治疗平行对照、前瞻性临床研究设计。131例糖尿病足溃疡患者随机分为京万红软膏组67例和对照组64例,两组创面面积分别为(16.7±6.1)cm2和(15.9±8.3) cm2,创面形成时间(45.7±68.3)d和(52.5±79.6)d 。两组分别用京万红软膏或复方磺胺嘧啶锌凝胶涂于创面,观察疗程均为20周。结果：两组患者年龄、糖尿病病程、血常规、肝功能、肾功能等数据差异无统计学意义。京万红组于2、5、10、15周创面愈合速率明显优于复方磺胺嘧啶锌凝胶组,以第5周、10周最为明显(P<0.01)。京万红组创面达到完全上皮化平均时间为(46.5±15.6)d,复方磺胺嘧啶锌凝胶组为(67.9±17.9)d,差异显著(P<0.05)。结论：京万红软膏与复方磺胺嘧啶锌凝胶均有促进糖尿病足创面愈合的作用,京万红软膏作用更优。