TGFα-PE40对兔颈总动脉损伤后内膜增生的抑制作用

目的：探讨基因重组转化生长因子α－绿脓杆菌外毒素融合蛋白（ＴＧＦα－ＰＥ４０；ＴＰ４０）对动脉损伤后内膜增生的抑制作用。方法：４８只兔随机分为治疗组（ｎ＝２４）和对照组（ｎ＝２４），均高脂饲养；行右颈总动脉球囊内膜剥脱术后２４ｈ，治疗组于动脉损伤段局部给予ＴＰ４０ ３０μｇ治疗，对照组给予生理盐水；治疗后第２，４和８周取实验动脉段行光镜观察及计算机图像分制，管腔无狭窄；计算机图像分析显示动脉损伤后     

重组TGF_α-PE40对动脉球囊损伤后内膜增生的抑制作用(英文)

目的:探讨基因重组转化生长因子α-绿脓杆菌外毒素融合蛋白(TGF_α-PE40;TP40)对动脉球囊损伤后内膜增生的抑制作用。方法:40只雄性兔随机分为TP4015μg、30μg、60μg、正常动脉及生理盐水对照组(n=8),均高脂饲养。在兔右颈总动脉行球囊内膜剥脱术后24h,治疗组于动脉损伤段局部给予TP40 15μg、30μg及60μg治疗;对照组给予生理盐水。正常动脉组局部给予TP40 60μg。于治疗后第2周取实验动脉段行光镜、电镜观察及计算机图像分析。结果:光镜观察见对照组动脉内膜不规则增厚,新生内膜可见大量平滑肌细胞(SMC),管腔狭窄;TP40治疗组动脉内膜增生被明显抑制,管腔无狭窄;TP40对正常动脉影响不大;电镜观察见TP40 60μg治疗组的动脉中膜有较多变性、坏死的SMC;计算机图像分析显示动脉损伤后第2周TP40治疗组内膜截面积及内膜与中膜截面积的比值显著小于生理盐水对照组(P<0.01)。结论:TP40对动脉球囊损伤后的内膜增生具有抑制作用。     

泌尿系统淀粉样变性病（附三例报告并文献复习）

报告肾盂输尿管、膀胱及尿道淀粉样变性病各１例，其中膀胱淀粉样变性病合并腺性膀胱炎和尿道淀粉样变性病属于国内首次报告。复习文献讨论了泌尿系统淀粉样变性病的分类、病因、病理、发生率、临床症状，治疗以及预后。     

下颌骨骨腔煅石膏颗粒植入效果的实验研究

本文报告用石膏颗粒进行动物颌骨骨腔植入的实验研究,用18条动物,分为2组,A组为兔,9只,B组为犬,9条。所有动物均以右侧下颌骨作为实验侧,左侧下颌骨为对照侧,均于术后1、3、6月取材检查。实验发现煅石膏颗粒植入颌骨骨腔是安全的,对组织有相容性,能被吸收,且可刺激新骨形成。     

颈侧(第三或四鳃沟咽囊)瘘管(附二例报告)

鳃器的先天性畸形,文献中已有不少报道,均以来源于第一或第二鳃沟者为多,来源于第三或第四鳃沟者国内外文献中均属少见。我院最近曾遇2例,报告如下。 例1,女,22岁。于1983年10月因在颈部瘘管不愈2月余而入院。13年前发现左颈部肿块,曾于当地用中药拔毒治疗,流出脓液后逐渐愈合,颈     

Difference in microvascular structure between benign and malignant pulmonary nodules and its relationship with CT enhancement

Objective: To investigate the enhancement basis and the mechanisms of solitary pulmonary nodules (SPNs) by comparing the differences in microvascular structure between benign and malignant lesions. Methods: Dynamic contrast-enhanced CT scan was performed on 53 patients with SPNs (diameter<3 cm. 38 peripheral lung cancers, 5 hamartomas, 10 inflammatory lesions) using a Siemens Plus S or a Marconi MX8000 multi-slices spiral CT scanner. The time-attenuation curves were interpreted. The microvascular density (MVD) and the continuity of the microvessels' basemental membrane in the dissected specimens were observed with the ABC (avidin-biotin-complex) immuno-histochemical method in all patients. ResultS:The CT enhancement values of lung cancer (49. 05±16. 08 HU) and inflammatory lesions (49. 59±21. 30 HU) were significantly higher than those of hamartoma (8. 98±4. 56 HU) (t = 7. 48. P<0. 05; t = 8. 35, P<0. 05). But the enhancement of lung cancer was similar to that of inflammatory lesions (t = 0. 76. P>0. 05). The time-attenuation curve of inflammatory lesions tended to increase faster and reached a higher peak compared to the lung cancer, and both of them maintained a high plateau after crossing. The hamartoma showed a slight increase in the time-attenuation curve and demonstrated a low-plateau curve. The MVD of SPNs was positively correlated with CT enhancement (r=0. 8051). The microvascular counts of peripheral lung cancer (48. 45±10. 09) and inflammatory lesions (19. 60±19. 94) were significantly higher than those of hamartoma (8.70±7.30) (t = 11.64, P<0.001;t = 6. 09. P< 0. 001). but no significant difference was found between lung cancer and inflammatory lesions (t= -0. 26, P = (). 799). There was no difference in the continuity of basement membrane between nodules with an enhancement less than 30 HU and those with an enhancement higher than 30HU (x2 = 3. 13, P>0. 05 ). Conclusion: The microvascular counts mainly contribute to the enhancement value of SPNs. The basement membrane is not related to nodule enhancement, but it might influence the pattern of the time-attenuation curve.     

溶胶-凝胶生物活性玻璃/胶原复合多孔支架的力学性能研究

目的研究溶胶-凝胶生物活性玻璃/胶原组织工程支架的力学性能及降解性能,为胶原基复合支架的进一步应用,提供理论基础。方法以纳米溶胶-凝胶生物活性玻璃为添加相,利用冷冻干燥法制备了4种溶胶-凝胶生物活性玻璃/胶原基复合多孔组织工程支架。结果(1)溶液中胶原纤维的聚集状态,制备出具有直径约为400～600nm的粗胶原纤维束支架材料,这种粗胶原纤维束对改善胶原基组织工程支架的力学强度和减慢其降解速度具有重要作用,其中胶原与生物活性玻璃质量比为40∶60时,具有最高的抗压强度(1.5469±0.0995)MPa。(2)利用FTIR和Raman等技术综合分析研究了溶胶-凝胶生物活性玻璃对胶原蛋白的二级结构的影响,当复合材料中胶原含量小于20%时,胶原蛋白二级结构破坏严重。结论当胶原与生物活性玻璃质量比为40∶60时,所制备的复合支架具有最好的抗压性能和降解性能,为进一步应用提供了研究基础。     

肺良性纤维组织细胞瘤(附1例报告)

患者 ,男 ,39岁。右侧胸痛半年余 ,1周来症状加重 ,于1995 -0 1-11入院。无咳嗽、咯血、消瘦等症状 ,在外院经抗炎治疗后无缓解。查体 :体温 36 .8℃ ,全身表浅淋巴结无肿大 ,气管居中 ,右侧胸廓呼吸运动减弱 ,右肺叩诊呈实音 ,未闻及罗音。实验室检查 :血红蛋白 113ｇ/Ｌ ,红细胞 3 .5 9× 10 12 /Ｌ ,白细胞 9.4× 10 9/Ｌ ,多核细胞 83 % ,淋巴细胞 17%。平片示右肺中叶肿块 (图 1)。ＣＴ检查 :见右下肺野 10ｃｍ× 10ｃｍ× 8ｃｍ肿块 ,密度均匀 ,平扫ＣＴ值 35ＨＵ左右 ,增强后 6 0ＨＵ左右 ,有强化 (图 2 )。纵隔内未见肿大淋巴结 ,无…