全文获取类型
收费全文 | 61862篇 |
免费 | 5875篇 |
国内免费 | 3895篇 |
专业分类
耳鼻咽喉 | 703篇 |
儿科学 | 899篇 |
妇产科学 | 567篇 |
基础医学 | 5576篇 |
口腔科学 | 1004篇 |
临床医学 | 6852篇 |
内科学 | 7475篇 |
皮肤病学 | 701篇 |
神经病学 | 2753篇 |
特种医学 | 2697篇 |
外国民族医学 | 12篇 |
外科学 | 7089篇 |
综合类 | 13521篇 |
现状与发展 | 21篇 |
一般理论 | 4篇 |
预防医学 | 5584篇 |
眼科学 | 1076篇 |
药学 | 6487篇 |
74篇 | |
中国医学 | 4791篇 |
肿瘤学 | 3746篇 |
出版年
2024年 | 166篇 |
2023年 | 768篇 |
2022年 | 1626篇 |
2021年 | 2855篇 |
2020年 | 2262篇 |
2019年 | 1700篇 |
2018年 | 1756篇 |
2017年 | 1848篇 |
2016年 | 1689篇 |
2015年 | 2816篇 |
2014年 | 3430篇 |
2013年 | 4047篇 |
2012年 | 5802篇 |
2011年 | 6077篇 |
2010年 | 4753篇 |
2009年 | 3893篇 |
2008年 | 4386篇 |
2007年 | 4028篇 |
2006年 | 3710篇 |
2005年 | 2988篇 |
2004年 | 2241篇 |
2003年 | 2024篇 |
2002年 | 1572篇 |
2001年 | 1076篇 |
2000年 | 906篇 |
1999年 | 505篇 |
1998年 | 243篇 |
1997年 | 232篇 |
1996年 | 220篇 |
1995年 | 218篇 |
1994年 | 159篇 |
1993年 | 119篇 |
1992年 | 126篇 |
1991年 | 131篇 |
1990年 | 111篇 |
1989年 | 101篇 |
1988年 | 81篇 |
1987年 | 83篇 |
1986年 | 71篇 |
1985年 | 68篇 |
1984年 | 77篇 |
1983年 | 53篇 |
1982年 | 52篇 |
1981年 | 51篇 |
1980年 | 48篇 |
1979年 | 45篇 |
1978年 | 46篇 |
1975年 | 39篇 |
1974年 | 39篇 |
1973年 | 36篇 |
排序方式: 共有10000条查询结果,搜索用时 531 毫秒
71.
目的:探讨早期干预对高危儿在婴儿早期发育的影响。方法:采用自行设计的一套早期干预方法通过指导家长对实验组实施,分别在3个月、6个月时进行格体生长和行为发育的评估,另设对照组进行比较。结果:实验组和对照组在体重、身长、头围方面均无统计学差异,但实验组的5个能区行为发育商均值都高于对照组,除3个月的语言能区外,其余均有统计学差异。结论:早期干预在婴儿早期就能促进高危儿的行为发育,但对促进高危儿的体格生长无明显效果。 相似文献
72.
73.
Akihiko Bo Shinichi Imura Hironori Omori Yasuhiro Okumura Masao Ando Hisatoshi Baba Patrick White Al Zarnowski 《Journal of orthopaedic science》1997,2(5):301-312
The fit and fill of the femoral canal are critical to the success of cementless femoral stems in total hip arthroplasty. It
is difficult for conventional stems to provide a good fit and fill for the femora of patients with secondary osteoarthritis.
Based on measurements of 100 femora of these patients, we designed two types of Fukui Medical School (FMS) stems with a proximal
lateral flare that differed in the medial radius. We compared the fit and fill of the FMS stems with those of four conventional
stems, using computer simulation. The mean proximal fit and total fit of the FMS stems were 46% and 53% respectively, a significant
improvement compared with the other stems examined. The mean fill of FMS stems was 82% at the lower end of the lesser trochanter
and 84% at the upper end of the isthmus, values that were significantly higher than those of the other stems. Since September
1995, we have implanted FMS stems in 15 hips with secondary osteoarthritis. Radiographic evaluations showed that the canal
fill of the FMS stems was significantly greater in the proximal femur compared with other stems previously inserted at our
department.
A summary of this paper was presented at the 9th Symposium on Computer-Assisted Radiology; June 1995, Berlin, and at the 8th
International Symposium on Technology in Arthroplasty; September 1995, Puerto Rico. 相似文献
74.
本实验制作不同程度心肌缺血的动物模型,以声处理5%人血白蛋白为超声造影剂进行心肌灌注造影,探讨MCE时间-强度曲线各指标与心肌缺血程度间的关系。结果表明:心肌显影的峰值强度和曲线下面积均与缺血程度呈显著负相关(相关系数分别为r=-0.98,P值<0.005;r=-0.94,P值<0.05),且能区分轻度、中度和重度三种程度的心肌缺血;而三项时间指标与心肌缺血程度间未发现显著性差异。本实验的初步结果表明,MCE是一项活体评估局部心肌血流灌注的有效方法。 相似文献
75.
76.
Mikael Hellström Bo Jacobsson Ulf Jodal Jan Winberg Anders Odén 《Pediatric nephrology (Berlin, Germany)》1987,1(3):269-275
This study presents the result of 12–21 years' follow-up in a group of children with neonatal urinary tract infection (onset within 1 month after birth) in whom early renal growth retardation was noted without concomitant classical renal scarring. In all cases the neonatal infection was diagnosed and treated within a few days of onset and the patients were closely supervised thereafter. Renal length, parenchymal thickness and area were measured at urography. At first follow-up (22 children, mean age 4.1 years) a significant reduction of renal parenchymal thickness was noted. Long-term follow-up (18 patients, mean age 17 years) demonstrated a normalization of renal size in the entire group, although less complete in the subgroup with reflux. There were two major findings in the present study. Firstly, renal growth retardation was seen after neonatal infection, both with and without reflux. Secondly, normalization of renal size in previously small kidneys was demonstrated, suggesting that growth retardation can be a reversible phenomenon. The tendency for such normalization was slightly more marked in children without reflux. Reduction of parenchymal thickness without calyceal deformity, therefore, does not necessarily mean irreversible damage, and differentiation between permanent scarring and temporary growth retardation can thus only be made at later follow-up, possibly not until after puberty. The demonstration of renal growth retardation in spite of early diagnosis and treatment emphasizes the great vulnerability of the kidney in the newborn. 相似文献
77.
Galanin-like immunoreactivity has been visualized in nerve fibers in the islets of Langerhans, suggesting an involvement of
galanin in the neural regulation of islet function. In this study, we investigated the effects of galanin on basal and stimulated
insulin and glucagon secretion by infusing the peptide at three different dose rates in rats. We also studied the direct effect
of galanin on insulin secretion from freshly isolated rat islets. At 320 pmol/kg/min, but not at 20 or 80 pmol/kg/min, galanin
lowered basal plasma insulin levels. In contrast, basal plasma glucagon levels were lowered by galanin already at 20 and 80
pmol/kg/min. Furthermore, galanin inhibited both glucose- and arginine-induced insulin release at all three dose levels, whereas
arginine-induced glucagon release was not affected by galanin. Glucose-stimulated insulin secretion from isolated rat islets
was dose-dependently suppressed by galanin (10-6-10-8M). Therefore, it is concluded that galanin in rats inhibits insulin secretion, both in vivo and in vitro, and that at lower
dose levels, the peptide also inhibits basal glucagon release. 相似文献
78.
仙草消毒液为含 3 0 %乙醇的植物消毒剂 ,其中包括五味子、细辛、丁香等成分 ,p H6.0 1。为了解其杀灭微生物效果及其毒性 ,进行了载体定量杀菌试验及毒性试验。结果 ,1∶ 1的水稀释液对金黄色葡萄球菌作用2分钟 ,1∶ 2的稀释液对金黄色葡萄球菌作用 8分钟 ,以其原液对白色念珠菌作用 2 min,平均杀灭率均大于99.90 %。小牛血清对其杀灭效果有影响 ,原液经 5 4℃存放 14天 ,杀菌效果无明显变化。以其原液对雌、雄小鼠经口 LD50 >5 0 0 0 mg/Kg,对大耳白兔一次眼、皮肤刺激试验平均积分指数为 0 ,微核试验阴性 ,蓄积毒性试验为弱蓄积毒性 相似文献
79.
目的观察含补阳还五汤的药物血清对体外培养大鼠脑皮层神经元生长的影响,为补阳还五汤治疗缺血性脑损伤提供实验依据。方法以体外培养新生SD乳鼠大脑皮层神经元为观察对象,采用四唑盐(MTT)比色法测定细胞生长情况。观察含药血清对常规培养及在缺氧状态下神经元生长的影响。结果补阳还五汤对常规培养及在缺氧条件下培养的神经元有显著促进生长作用,与空白血清组比较有显著差(P<0.05)。结论大鼠以补阳还五汤灌胃给药后,其血清中的药物成份有促进体外培养神经元细胞生长的作用。 相似文献
80.
目的 构建大鼠MMP1 3重组腺病毒载体。方法 将MMP1 3cDNA目的片段插入腺病毒柯氏质粒中 ,再将此质粒与腺病毒DNA末端蛋白复合物共转染 2 93细胞 ,通过同源重组构建MMP1 3 重组腺病毒载体。结果 MMP1 3 重组腺病毒载体经PCR鉴定正确 ,包装纯化后 ,检测病毒滴度为 4× 1 0 9PFU/ml。结论 成功地构建了RatMMP1 3 重组腺病毒载体 ,为下一步行MMP 1 3转基因治疗低顺应性膀胱的研究提供了条件 相似文献