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目的 探讨二甲双胍联合水飞蓟宾胶囊对糖耐量减低(IGT)合并非酒精性脂肪肝病(NAFLD)患者的影响。方法 选取IGT合并NAFLD患者72例。对照组36例,予以饮食及运动治疗;观察组36例,在饮食及运动治疗基础上,联合使用二甲双胍片及水飞蓟宾胶囊口服,疗程均为12周。治疗前及治疗12周后,所有患者进行肝脏CT检查,比较两组临床指标、肿瘤坏死因子-α(TNF-α)、肝脂肪变等的变化。结果 治疗12周后,与治疗前及对照组治疗后比较,观察组体重指数(BMI)、空腹血糖(FBG)、空腹血浆胰岛素(FIN)、糖化血红蛋白(HbA1c)、三酰甘油(TG)、胆固醇(TC)、胰岛素抵抗指数(HOMA-IR)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、TNF-α均明显改善(P <0.05);观察组总有效率高于对照组(P <0.05)。观察组肝脂肪变的程度与BMI、HOMA-IR、TG、TC、TNF-α呈正相关(P <0.05)。结论 二甲双胍联合水飞蓟宾胶囊能够有效改善胰岛素抵抗、降低肝酶及炎症因子TNF-α水平,减少肝脏脂肪变程度。
相似文献2.
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AIM To investigate in vitro effects and mechanisms of silibinin on hepatocellular carcinoma (HCC) cell growth. METHODS Human HCC cell lines were treated with different doses of silibinin. The effects of silibinin on HCC cell growth and proliferation, apoptosis, cell cycle progression, histone acetylation, and other related signal
transductions were systematically examined. RESULTS We demonstrated that silibinin significantly reduced the growth of HUH7, HepG2, Hep3B, and PLC/PRF/5 human hepatoma cells. Silibinin-reduced HuH7 cell growth was associated with significantly upregulated p21/CDK4 and p27/CDK4 complexes, downregulated Rb-phosphorylation and E2F1/DP1 complex. Silibinin promoted apoptosis of HuH7 cells that was associated with down-regulated survivin and upregulated activated caspase-3 and -9. Silibinin's anti
angiogenic effects were indicated by down-regulated metalloproteinase-2 (MMP2) and CD34. We found that silibinin-reduced growth of HuH7 cells was associated with increased activity of phosphatase and tensin homolog deleted on chromosome ten (PTEN) and decreased p-Akt production, indicating the role of PTEN/ PI3K/Akt pathway in silibinin-mediated anti-HCC effects. We also demonstrated that silibinin increased acetylation of histone H3 and H4 (AC-H3 and AC-H4), indicating a possible role of altered histone acetylation in silibininreduced HCC cell proliferation.CONCLUSION Our results defined silibinin's in vitro anti-HCC effects and possible mechanisms, and provided a rationale to further test silibinin for HCC chemoprevention. 相似文献
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Eun-Mi Noh Mi Suk Yi Hyun Jo Youn Byoung Kil Lee Young-Rae Lee Ji-Hey Han Hong-Nu Yu Jong-Suk Kim Sung Hoo Jung 《JOURNAL OF BREAST CANCER》2011,14(1):8-13
Purpose
Chemotherapies for breast cancer generally have strong cellular cytotoxicity and severe side effects. Thus, significant emphasis has been placed on combinations of naturally occurring chemopreventive agents. Silibinin is a major bioactive flavonolignan extracted from milk thistle with chemopreventive activity in various organs including the skin, prostate, and breast. However, the mechanism underlying the inhibitory action of silibinin in breast cancer has not been completely elucidated. Therefore, we investigated the effect of silibinin in MCF-7 human breast cancer cells and determined whether silibinin enhances ultraviolet (UV) B-induced apoptosis.Methods
The effects of silibinin on MCF-7 cell viability were determined using the MTT assay. The effect of silibinin on PARP cleavage, as the hallmark of apoptotic cell death, and p53 protein expression in MCF-7 cells was analyzed using Western blot. The effect of silibinin on UVB-induced apoptosis in MCF-7 cells was analyzed by flow cytometry.Results
A dose- and time-dependent reduction in viability was observed in MCF-7 cells treated with silibinin. Silibinin strongly induced apoptotic cell death in MCF-7 cells, and induction of apoptosis was associated with increased p53 expression. Moreover, silibinin enhanced UVB-induced apoptosis in MCF-7 cells.Conclusion
Silibinin induced a loss of cell viability and apoptotic cell death in MCF-7 cells. Furthermore, the combination of silibinin and UVB resulted in an additive effect on apoptosis in MCF-7 cells. These results suggest that silibinin might be an important supplemental agent for treating patients with breast cancer. 相似文献5.
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[摘要]目的:探讨水飞蓟宾胶囊在结核病治疗中预防药物肝损害的价值。方法:我院2007年7月~2009年1月期间住院治疗112例肺结核患者,治疗组(47例)在采取抗结核方案基础上应用水飞蓟宾胶囊(70mg,口服,tid)护肝,对照组(65例)未应用水飞蓟宾胶囊,采取抗结核方案与治疗组相同,观察两组肝功能损害的情况。结果:抗结核治疗期间治疗组发生肝功异常比例明显低于对照组,两组比较有统计学差异(P<0.05)。治疗组发生肝功能异常停用抗结核药物给予保肝治疗,肝功能恢复正常平均时间低于对照组,两组比较有统计学差异(P<0.05)。结论:结核病患者在常规抗结核治疗的同时应用水飞蓟宾胶囊可以降低肝损害的发生率,发生肝损害的程度也可减轻。 相似文献
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目的 观察水飞蓟宾胶囊对艾滋病患者抗病毒治疗后出现肝损害的疗效.方法 将82例诊断为因高效抗逆转录病毒治疗后出现药物性肝炎的艾滋病初治患者随机分成对照组40例和治疗组42例,对照组予口服葡醛内酯片(每次0.2 g tid);治疗组在此基础上加用口服水飞蓟宾胶囊(每次70 mg tid),疗程2周.结果 治疗后两组患者的丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、谷氨酰转肽酶(GGT)均明显下降,治疗组总有效率与对照组相比差异有统计学意义(P 〈 0.05),而且治疗组的ALT、AST、GGT恢复率与对照组相比差异有统计学意义(P 〈 0.05).结论 水飞蓟宾治疗抗艾滋病病毒药物引起的药物性肝炎疗效显著,且用药安全. 相似文献
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研究临床常用抗肝纤维化药物水飞蓟宾胶囊单用及联合肝龙胶囊对大鼠肝星状细胞(HSC)增殖活性的影响,评价肝龙胶囊在体外对水飞蓟宾抗肝纤维化作用的影响。方法采用2 因素5 水平完全实验,单独或联合使用不同剂量水飞蓟宾胶囊和肝龙胶囊在不同时间作用于HSC,并用MTT 比色法测定HSC 增殖影响。结果水飞蓟宾胶囊与肝龙胶囊合用增强水飞蓟宾胶囊对HSC 的抑制作用,尤其是0.063、0.125 和0.250 mg/ml 浓度的水飞蓟宾胶囊与不同浓度肝龙胶囊合用后,水飞蓟宾胶囊的作用明显增加,与单用水飞蓟宾胶囊组比较差异均有统计学意义(p <0.05)。水飞蓟宾胶囊联合不同浓度肝龙胶囊的IC50 值与单用水飞蓟宾胶囊的IC50 值相比较,在24、48 和72 h时均有降低,且水飞蓟宾胶囊与不同浓度肝龙胶囊联合后,其合用指数CI<1.0,呈现出协同作用,增强了水飞蓟宾胶囊对HSC 细胞的抑制作用。结论肝龙胶囊在体外能增强水飞蓟宾胶囊的抗肝纤维化作用。 相似文献
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目的:基于系统评价,比较水飞蓟宾胶囊与护肝片在改善脂肪肝相关生化指标方面的有效性和安全性.方法:计算机检索万方数据库、中国生物医学文献数据库、中国知网、the Cochrane Library、Embase和PubMed等数据库,纳入水飞蓟宾胶囊与护肝片治疗脂肪肝的随机对照试验(研究组的治疗方案为水飞蓟宾胶囊,对照组为... 相似文献