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1.
Thesteroidhormone 1,2 5 dihydroxyvitaminD3 (1,2 5(OH) 2 D3 )isbiologicallythemostactiveformofvitaminD3 andplaysanimportantroleintheregulationofcalciumandbonemetabolism Theeffectsof1,2 5(OH) 2 D3 aremediatedbyvitaminDreceptors (VDR)intargettissues Inthelastdecade,VDRwasno…  相似文献   

2.
INTRODUCTION  Chinahasgotgreatachievementsinleprosycontrolwiththeimplementationofmultidrugtherapy (MDT)inthewholecountry .Inordertosolvetheleprosyproblemscompletely ,ChinesegovernmentnotonlyfocusesoncasefindingandMDT ,butalsopreventionofdisability (POD)and…  相似文献   

3.
INTRODUCTIONDisabilityAdjustedLifeYear(DALY)isanewmeasurementofburdenofdisease(BOD)introducedbyC.Murrayandhiscolleagues(Murray,1994;MurrayandLopez,1994).ThismeasurementconsistsofYearsofLifeLost(YLL)andYearsLivedwithDisability(YLD).DALYismorereasonableandcomprehe…  相似文献   

4.
Dilatedcardiomyopathy(DCM)andischemiccardiomyopathy(CADCM)mayhavesimilarclinicalpresentations,suchascardiomegaly,impairedleftventricularfunctionandcongestiveheartfailureThedifferentiationofDCMfromCADCMsometimesisdifficultbutimportant,sinceprognosisandtr…  相似文献   

5.
Dendriticcells (DCs)havedrawnwideattentioninrecentyears ,becausetheyarethemostefficientantigen presentingcells (APC)intheactivationofnaiveTcellsofbothCD4 andCD8 types ThisabilityofDCstopresentantigenstoTcellsandtoinitiateimmuneresponseshasbeensuccessfullyu…  相似文献   

6.
Theriskofosteoporosisiscloselyrelatedtobonemineraldensity (BMD ) ,whichisunderstronggeneticcontrol Morrisonetal1 haveshownastrongrelationshipbetweenpolymorphismatthevitaminDreceptor (VDR)geneandBMD InadditiontoBsmⅠ ,restrictionfragmentlengthpolymorphismatth…  相似文献   

7.
Hypercoagulationandthromboembolismwerecommoncomplicationsinnephroticsyndrome (NS) .1 However ,pulmonaryembolism (PE )inNSchildrenisseldomreported.Herewereported 8outof 2 0NSchildrenwithelevatedplasmaD dimerinwhomPEwasdiscoveredbypulmonaryperfusionimaging (PPI) .…  相似文献   

8.
INTRODUCTIONVascularendothelialgrowthfactor (VEGF)receptorFlt 1isakindofglucoproteinwithamolecularweightof 1 80KD .Asafamilymemberoftyrosineproteinkinasereceptorsub typeⅢ ,itconsistsofextracellular,transmembraneandintracellulardomains.TherearesevenIg likeloop…  相似文献   

9.
Purpose Toreviewthepathogenesis ,clinicalpresentation ,diagnosticassessmentandtreatmentregimensofsteroid inducedboneloss .Datasources AnEnglish languageliteraturesearch(MEDLINE 1966- 1999)andbibliographicreviewsoftextbooksandreviewarticles .Studyselection Cross …  相似文献   

10.
Theeukaryoticcellcycleiscontrolledbyproteincomplexescomposedofcyclinsandcyclin dependentkinases(CDK)andtheactivityofCDKisregulatedbyassociation dissociationwithcyclin dependentkinaseinhibitors(CDKI) 1 Twofamilies (p16andp2 1)oftheseinhibitorshavebeenidentifi…  相似文献   

11.
AnalysisofthesignificanceofCD4 4geneproductex pressionforcancerdiagnosishasrevealedthathumantumorsfromthebreast,colon ,andthyroidexpressmanyalternativespliceCD4 4geneproducts.Theaimofthisstudyistoin vestigatetheexpressionofCD4 4splicevariant 6 (CD4 4v6 )ingastri…  相似文献   

12.
Thepublichealthworkershavelongedforanidealmethodtoevaluatepeople′sdietarypatterns,whichcanbeusedtoanalyzethedi etarypatterngrosslyandcomprehensivelyus ingrathersimplecalculations,yetmustbeeasyforthemassestounderstand .Thedesireddietarypattern (DDP) ,propo…  相似文献   

13.
Lowplasmahighdensitylipoproteincholesterol(HDLC)anditsconstituentapolipoproteins(apoAIandapoAII)levelshavebeenfoundtobeindependentriskfactorsforcoronaryheartdisease(CHD)inseveralstudiesandhigherconcentrationsofHDLCandtheconstituentapolipoproteinsofferpr…  相似文献   

14.
皮质发育障碍与癫痫发作   总被引:13,自引:8,他引:5  
晏勇 《重庆医学》2001,30(5):444-446
皮质发育障碍 (disordersofcorticaldevelopment,DCDs) ,又称作皮质发育不良 (corticaldysplasias)、皮质发育畸形 (malfor mationofcorticaldevelopment,MCD)、灰质异位症、神经元移位症 (neuronalmigrationdisorders,NMD)等。近两年来在癫痫的病因诊断中DCDs迅速占领了中心位置。这是因为在过去的10年中 ,我们对脑发育紊乱及其基因调控、临床表现和DCDs致痫机制等方面取得了令人鼓舞的进展。1 分  类…  相似文献   

15.
·Source “FormulariesoftheBureauofPeople’sWelfarePharmacies” ,compiledbyChenShi wen (陈师文 )etal.,inSongDynasty ,in 115 1A .D .,in 10volumes ,788recipes ,mostofwhichwerepillandpowderform ,readyforuseandstorage .Carriedin “HeilongjiangDrugStandard”(1980 )·ChiefIngredients Rhi…  相似文献   

16.
Parkinson′sdisease (PD)isaneurodegenera tivedisordermanifestedclinicallybytremor,slow nessofmovement,increasedmuscletone ,andpos turalinstability ,andpathologicallybyselectivelossofdopaminergic (DAergic)neuronsinthesub stantianigra[1,2 ] .Althoughthecauseofthedi…  相似文献   

17.
INTRODUCTION  CD9antigen(Ag)isa 2 4 kDmembraneglycoproteinexpressedonthesurfaceofhumanplateletsaswellasonthesurfaceoflymphoidprogenitorcells ,pre Bcellleukemiaandothercelltypes.Thisproteinbelongstoarecentlydelin eatedfamilyofcell surfaceAgsthatspanthemembra…  相似文献   

18.
INTRODUCTION  Natriureticpeptideisafamilyofhormoneinvolvedintheregulationoffluidbalance .Atrialnatriureticpeptide(ANP)andbrainnatriureticpeptide(BNP)aretwomembersofthisfamilywhichhadbeenseparatedfromatriaandbrain .C typenatriureticpeptide (CNP)isthenewlyid…  相似文献   

19.
Dendriticcells (DCs)arethemostpowerfulantigen presentingcells (APCs) DCshavetheuniquecapacitytostimulatenaiveTcellstoinduceanantigen specificprimaryimmuneresponse ,whereasotherAPCscanonlyactivatealreadystimulatedTcells 1 Atthistime ,themechanismunderlyingth…  相似文献   

20.
INTRODUCTION  Graves’disease(GD)isoneoftheautoimmunethyroiddiseases(AITD) ,andischaracterizedbyhypermetabolicandhyperthyroidsyndromecausedbyTSHreceptor stimulatingantibody TheetiologyandpathogenesisofGDarestillnotfullyclarified TheroleofTcellswaswidelyst…  相似文献   

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