甘油三酯对中老年高血压患者血糖胰岛素水平及左室舒张功能的影响

目的：探讨甘油三酯（ＴＧ）对中老年高血压患者血糖、胰岛素水平及左室舒张功能的影响。方法：观察了１０５例ＴＧ水平不同的中老年高血压患者胰岛素、血糖和左室舒张功能并计算胰岛素敏感指数（ＩＳＩ）。结果：正常ＴＧ组空腹血糖低于高ＴＧ组（Ｐ〈０．０５），胰岛素水平正常ＴＧ组高于对照组（Ｐ〈０．０５），低于高ＴＧ组（Ｐ〈０．０５）。ＩＳＩ正常ＴＧ组和高ＴＧ组均低于对照组（Ｐ〈０．０５），正常ＴＧ组高于高ＴＧ组     

原发性高血压病人正常血压后代血糖、胰岛素和血脂变化

测定４０例父母均患原发性高血压的正常血压后代（实验组）的血清胰岛素、葡萄糖和脂蛋白含量，与父母为正常血压的非高血压后代（对照组）比较。结果显示：实验组空腹胰岛素水平，空腹血糖含量，血清总甘油三酯、总胆固醇，低密度脂蛋白胆固醇、极低密度脂蛋白胆固醇、高密度脂蛋白胆固醇与总胆固醇之比值均较对照组明显增高（Ｐ＜０．０５或０．０１）。７５ｇ糖负荷后，实验组血清胰岛素，血糖浓度显著高于对照组。提示父母均患原发性高血压的正常血压后代潜伏存在胰岛素诱导葡萄糖利用的损害，高胰岛素血症，高脂血症的倾向     

肝硬化患者血浆胰岛素和血糖的变化及其临床意义

该文以正常人作为对照，检测了代偿期及失代偿期肝硬化患者空腹血浆胰岛素及空腹血糖伍。结果发现：１）失代偿期肝硬化患者血浆胰岛素明显高于正常（Ｐ＜０．０１），空腹血糖明显低于正常（Ｐ＜０．０５）；２）代偿期肝硬化这两项指标与正常对照的差异无显著性（Ｐ＜０．０５）；３）这些结果提示肝硬化患者存在胰岛主及糖代谢的异常，血桨胰岛素及空腹血糖的检测对判断肝硬化的病情有一定的价值。     

胰岛素抵抗与老年冠心病关系探讨

目的：探讨胰岛素抵抗（ＩＲ）与老年冠心病的关系；方法：对４８例老年冠心病患者及４５例老年非冠心病患者进行空腹血胰岛素、血糖、总胆固醇（ＴＣ）、甘油三酯（ＴＧ）、高密度脂蛋白（ＨＤＬ）、血管紧张素（Ａｎｇ）Ⅰ、Ⅱ检测及对比分析。结果：老年冠心病组胰岛素、ＴＧ和ＡｎｇⅡ显著高于非冠心病组（分别为Ｐ＜０．０１，Ｐ＜０．０５，Ｐ＜０．０５），冠心病组血糖、ＴＣ、ＨＤＬ和ＡｎｇⅠ与非冠心病组无明显差异（Ｐ＞０．０５）。结论：老年冠心病患者存在高胰岛素血症和ＩＲ。     

中老年高血压与高胰岛素血症关系的初步研究

本文分析４５例高血压病空腹血糖，血清胰岛素和Ｃ肽水平，与正常血压组比较，血清胰岛素明显升高（Ｐ＜０．０１），胰岛素释放指数也明显增高（Ｐ＜０．０１），胰岛素敏感指数明显低于对照组，（Ｐ＜０．０５）。证实中老年期高血压患者也存在高胰岛素血症和胰岛素抵抗状态。     

高血压病的某些代谢异常及药物干预研究

目的：研究高血压病的某些代谢异常及药物干预后情况。方法：２０例非肥胖的高血压病（ＥＨ）患者用卡托普利治疗前及治疗１年后，测定血胆固醇、甘油三酯、尿酸、尿素氮、肌酐等，并进行ＯＧＴＴ，测定治疗前后的血糖、血浆胰岛素，与１４例正常人比较。结果：两组空腹血糖及糖耐量均正常，无差异性（Ｐ＞０．０５）。ＥＨ组治疗前血胆固醇、甘油三酯、尿酸较对照组明显升高（Ｐ均＜０．０５），空腹及ＯＧＴＴ后血浆胰岛素显著升高，而空腹血糖与胰岛素乘积倒数（ＩＡＩ）显著降低（Ｐ均＜０．０５）；卡托普利治疗１２个月后，空腹及ＯＧＴＴ后３０、６０ｍｉｎ血浆胰岛素值下降，ＩＡＩ升高（Ｐ＜０．０５），血胆固醇、甘油三酯、血尿酸亦有一定程度降低。结论：ＥＨ患者存在脂肪等代谢紊乱及胰岛素抵抗，卡托普利治疗后降压的同时，上述改变得到了某些改善。     

果糖胺测定在糖尿病诊断中的应用

通过对正常对照组１５０例、糖尿病组７４例、隐性糖尿病组５６例的空腹血糖及果糖胺的测定，发现糖尿病组空腹血糖及果糖胺明显高于正常对照组（Ｐ＜０．０１），而隐性糖尿病组空腹血糖与正常对照组比无显著差异（Ｐ＞０．０５），果糖胺明显高于正常对照组（Ｐ＜０．０１）。５６例隐性糖尿病患者糖耐量试验阳性，餐后２ｈ血糖明显增高。提示：果糖胺诊断糖尿病是一个较稳定的指标，对隐性糖尿病的监测有重要意义。     

贵阳地区高血压病患者的高胰岛素血症和胰岛素抵抗现象

对贵阳地区２３例正常人和２５例高血压病（ＥＨ）患者在予葡萄糖（Ｇ）负荷的同时测定血糖和血胰岛素（Ｉｎ）的变化，并对比分析。两组人腹及糖负荷后血糖变化差异无显著性（Ｐ＞０．０５）；而血Ｉｎ水平及Ｉｎ／Ｇ比值等指标ＥＨ组均高于正常组（Ｐ＜０．０５，）＜０．００１）。结果表明：贵阳地区ＥＨ患者亦存在高胰岛素血症和胰岛素抑抗现象。     

原发性高血压对器官损害与胰岛素抵抗

目的：探讨原发性高血压病（ＥＨ）血压昼夜节律及靶器官损害与胰岛素抵抗（ＩＲ）的关系。方法：选择原发性高血压Ⅰ,Ⅱ,Ⅲ期患者及正常对照者,测定空腹血糖、胰岛素水平,计算胰岛素敏感性指数,作对比研究。所有原发性高血压患者均作２４小时动态血压测定,按照昼夜节律正常及昼夜节律消失／分组比较其空腹血糖及胰岛素水平和胰岛素敏感性指数。结果：原发性高血压组空腹血胰岛素水平明显高于正常对照组（Ｐ〈０．０１）,合并     

冠心病与高胰岛素血症关系的探讨

为了探讨冠心病（ＣＨＤ）与高胰岛素血症（ＨＩＳ）的关系，本文分析了３４例冠心病和１５例正常人口服葡萄糖耐量试验（ＯＧＴＴ）前后血清胰岛素（ＩＳ）以及血清胰岛素／血糖比值（ＩＳ／ＳＧ），结果发现ＣＨＤ组服糖后１ｈ、２ｈ，ＩＳ水平均明显高于对照组（Ｐ＜０．０５），而空腹时ＩＳ无明显增高（Ｐ＞０．０５）；ＣＨＤ组ＨＩＳ发生率显著高于对照组（Ｐ＜０．０１），ＩＳ／ＳＧ却无明显增高（Ｐ＞０．０５）。提示：有ＨＩＳ的ＣＨＤ患者并不一定有胰岛素抵抗（ＩＲ），ＨＩＳ可以是ＣＨＤ发病的一种独立危险因素，可不通过血糖、血脂代谢异常、高血压发病。     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Dr.Zhang Ren''''s Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

Luo Lingjie''''s Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

猪肺磷脂注射液联合经鼻持续气道正压通气对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性的影响

目的 探讨猪肺磷脂注射液联合经鼻持续气道正压通气(NCPAP)对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性(CK-MB)的影响.方法 选取呼吸衰竭早产儿80例,分为观察组和对照组各40例.对照组采用NCPAP给氧治疗,观察组给予NCPAP给氧联合猪肺磷脂气管内给药.观察两组患儿治疗前及治疗12h、24 h后PaO2、PaCO2、血氧饱和度(SaO2)、pH的变化情况,检测治疗前及治疗5d后血清CK-MB水平;评估两组患儿的临床治疗效果.结果 两组患儿PaO2、PaCO2、SaO2、pH比较,差异均有统计学意义(P＜0.05),其中观察组治疗后的PaO2、SaO2、pH均高于对照组,PaCO2则低于对照组.两组的PaO2、SaO2、pH均随观察时间延长而升高(P＜0.05),PaCO2均随观察时间的延长而降低(P＜0.05).观察组治疗有效率为87.5％,显著高于对照组的70.0％ (P ＜0.05).治疗5d后两组患儿血清CK-MB水平均较前降低(P＜0.05),且观察组明显低于对照组(P＜0.05).结论 猪肺磷脂注射液气管内给药联合NCPAP可以显著降低呼吸衰竭早产儿CK-MB的含量,提高治疗有效率,起到很好的呼吸循环支持作用.     

Survey and practice of reporting quality of randomized controlled clinical trials on traditional Chinese medicine

Evidence obtained from randomized controlled trials （RCTs） has been generally accepted as the gold standard in the evaluation of clinical effectiveness. Readers need to understand the trial design, implementation, results, analysis and interpretation, so as to fully Jnderstand the results of RCTs. Thus, the investigators of RCTs have to report these items in a complete, accurate and clear manner. Since 1998, we have conducted several evaluations on the reporting quality of RCTs published in Chinese journals on traditional Chinese medicine （TCM） and results have shown that there is an urgent need for higher quality RCTs on TCM.     

TCM Treatment of Ankylosing Spondylitis by Tonifying the Kidney and Strengthening the Governor Vessel

Ankylosing spondylitis is a chronic and progressive disorder with inflammation mainly involving the central axis joints. It mainly affects the cervical spine and the lumbosacral area, with the pathogenesis closely related to the kidney and the Governor Vessel (GV). TCM holds that the syndrome is deficiency in origin and excess in superficiality, which is due to insufficiency of the kidney, deficiency of GV, and blocking of the channels with the invasion of exogenous evil, leading to poor circulation of qi and blood and malnutrition of the bones, muscles and joints. The TCM method of tonifying the kidney and strengthening GV to regulate circulation of qi and blood and check the arthralgia pain should be adopted, with the Kidney-Tonifying and GV Strengthening Decoction (益肾强督汤) prescribed.     

IMPROVING P-gp EXPRESSION IN HUMAN MONONUCLEAR CELLS IN VITRO TRANSFECTED BY MULTIDRUG RESISTANCE-1 mRNA

CHEMOTHERAPY playsa greatrolein the treat- ment of malignanttumors,especiallyingynecolo- gicalones.But inanticancerchemotherapy,leuko-cytopeniaisfrequentlytheprimarydose-limitingsideeffect factor.Moreover,cancersarefrequentlychemoresistantbe-causeof overexpressionof P-glycoprotein(P-gp), which isencodedby multidrugresistancegene (MDR1 ) and detectableinup to50% ofhuman cancersand renderscellsresistancetoanticancerdrugs.The safetyand potentialtherapeuticbenefitof mdr1 gene transferredto h…