镜下清理配合透明质酸钠注射治疗膝骨关节炎

目的探讨关节镜下清理配合关节腔内注射透明质酸钠治疗膝关节骨关节炎的临床疗效。方法自2003年9月至2005年6月,对26例32膝膝骨关节炎病人行关节镜下清理术配合关节腔注射透明质酸钠治疗。采用Yang的膝关节疼痛及功能评分方法,观察治疗前后关节疼痛与关节功能改善程度。结果所有病例随访6-18个月,平均12.5个月。疗效优11例15膝（46.9%）,良8例10膝（31.3%）,可6例6膝（18.7%）,差1例1膝（3.1%）。优良率为78.2%,取得了满意的疗效。26例中无手术并发症发生。结论关节镜下清理并用透明质酸钠注射治疗早、中期膝骨关节炎有明显疗效。     

关节镜手术治疗膝骨性关节炎的体会

[目的]探讨膝关节镜下有限清理联合透明质酸钠注射治疗骨性关节炎的疗效。[方法]本院2003年9月～2004年10期间治疗的45例（52膝），采用关节镜下清理术联合透明质酸钠注射治疗，术后早期功能锻炼。[结果]参照Lyscholm评价标准，经1a随访，优良率93．3％，未出现感染、血肿、血管及神经损伤等并发症。[结论]关节镜术下有限清理联合透明质酸钠注射治疗膝骨关节炎，术后疗效满意，笔者认为在把握好手术适应证的基础上，该方法应该作为膝骨性关节炎的首选治疗方法。     

关节镜清理加术后透明质酸钠注射治疗膝关节骨性关节炎

目的：评价关节镜下清理加术后透明质酸钠注射治疗膝关节骨性关节炎的疗效。方法：对56例（64膝）骨性关节炎行镜下清理,术后每周关节腔内注射透明质酸钠2ml,共5周。结果：术后平均随访18个月,根据关节疼痛、活动度、步态及行走功能进行评分,优58例,良17例,可27例。结论：关节镜下清理加术后注射治疗膝关节骨性关节炎有较好疗效。     

关节清理加术后注射透明质酸钠治疗膝骨性关节炎

目的：观察关节清理术加术后注射透明质酸治疗膝骨关节炎的疗效，方法：对24例膝骨性关节炎和关节清理术，后术每周关节腔内注1%身南酸钠2.5ml，结果：术后平均随访1．5年，优8膝，良12膝，可4膝，差0膝，优良率83．3％，结论：关节清理加术后注射透明质酸钠治疗骨性关节炎，效果满意。     

镜下清理并注射玻璃酸钠治疗膝骨关节炎

目的探讨关节镜有限清理加局部注射玻璃酸钠对中重度软骨退变的膝关节骨关节炎的治疗作用。方法25例中重度软骨退变的膝关节骨关节炎患者,根据关节镜下软骨退变的不同程度,行不同程度和范围的膝关节腔内有限清理术,术后关节腔内注射玻璃酸钠,并辅以较完善的术前、术后康复训练以及出院康复指导。结果随访5个月～3年,平均21个月。良好20例（23膝）,尚可3例（5膝）,差2例（2膝）。结论关节镜下膝关节有限清理加局部注射玻璃酸钠配合完善的康复训练措施对中重度软骨退变的膝关节骨关节炎有一定的治疗效果。     

降钙素臭氧透明质酸钠联合治疗膝骨关节炎疗效观察

[目的]探讨分析降钙素、臭氧、透明质酸联合治疗膝骨关节炎的临床疗效。[方法]150例膝骨关节炎患者,随机分为A、B两组,A组采用膝关节腔内注射臭氧和透明质酸钠治疗;B组采用肌肉注射鲑降钙素联合关节腔内注射臭氧和透明质酸钠治疗。两组患者疗程均为5周。[结果]所有病例都获得12个月随访。治疗5周及12个月后,两组统计资料差别有统计学意义(P<0.05)。[结论]肌肉注射降钙素联合关节腔内注射臭氧和透明质酸钠治疗膝骨关节炎有显著疗效。     

应用关节镜清理和透明质酸钠注射治疗膝关节骨关节炎

目的：比较2例治疗膝关节骨关节炎方法的效果。方法：2组病人分别采用关节镜清理和透明质酸钠注射治疗膝关节骨关节炎，结果：术后随访2年以上，根据关节疼痛，积液肿胀，关节活动度，行走功能四个项目及综合评价。关节镜组随访结果，半年－1年，优良率为96．2％，1－2年，优良率84．6％，2年以上优良率为73％，透明质酸钠组随访结果：半年－1年，优良率为94．9％，1－2年，优良率86．4％，2年以上优良率为74．6％，。结论：关节镜清理和透明质酸钠注射治疗膝关节炎2种方法都有一定的效果，2组之间无明显差别。     

关节内注射透明质酸钠预防兔骨关节炎的实验研究

本实验以成年新西兰兔为实验对象，观察透明质酸钠关节内注射预防骨关节炎的效果。以Ｈｕｌｔｈ法建立膝关节骨关节炎模型，术毕及术后每隔１周关节内注射１％透明质酸钠１ｍｌ，分别于术后４周、８周、１２周处死动物，作大体标本手术显微镜观察并取股骨内髁软骨标本进行光镜及透射电镜观察。结果显示实验组之骨关节炎改变较对照组明显减轻。这一结果提示外源性透明质酸钠能有效地减轻关节软骨的退变，降低关节手术后创伤性骨关节炎的发生率。     

医用壳聚糖与透明质酸钠关节腔内注射治疗膝骨关节炎的疗效比较

目的研究医用壳聚糖对比透明质酸钠关节腔注射治疗膝骨关节炎病人的疗效和安全性。方法选择2015年1月至2015年4月,在上海交通大学附属第六人民医院骨科门诊就诊的34例膝骨关节炎患者,其中男11例,女23例,侧别:单侧8例,双侧26例。平均年龄60岁。根据随机、双盲、平行对照、非劣性比较临床试验的原则,受试患者分别随机分入壳聚糖注射组和透明质酸钠注射组。在治疗结束后6周,及治疗结束后12周基于VAS评分;WOMAC评分:包括WOMAC疼痛、关节僵硬、关节生理功能评分;受试者总体评分来评估对于研究侧膝关节疗效,以及壳聚糖和透明质酸钠注射液的安全性。观察治疗后关节疼痛、关节腔积液及肿胀与关节功能改善程度。结果患者膝关节腔注射壳聚糖或透明质酸钠后,在访视时研究侧膝关节在平地行走时的疼痛程度减轻,上述相关评分均升高,壳聚糖注射组疗效相比透明质酸注射组无明显差异。结论关节内注射壳聚糖对膝骨关节炎有良好疗效,与透明质酸对比无明显差异,但是注射次数减少,安全性增高。     

关节镜下骨性关节炎清理术后注射透明质酸钠疗效分析

目的 分析膝骨性关节炎患者关节镜术后注入透明质酸钠的疗效.方法 对40例膝骨性关节炎关节镜下清理术后注射透明质酸钠,另20例对照.手术前、后采用Lysholm膝关节功能评分评定.结果 术后Lysholm评分,"疼痛"评分和"上楼"评分较术前明显提高(P<0.001).两组之间术后Lysholm评分有明显差异(P<0.05).结论 术后注入透明质酸钠可明显增强疗效.     

Debridement arthroscopy. 10-year followup.

The treatment of osteoarthritis of the knee is a difficult problem. In the senior author's opinion, nonaggressive arthroscopic debridement of the knee is an effective procedure to relieve pain and restore function in patients with osteoarthritis of the knee. A subjective telephone interview of patients done 10 or more years after arthroscopic debridement evaluated the long term results of this treatment in patients with osteoarthritis of the knee. The patients all were candidates for total knee replacement who selected arthroscopy as a temporizing procedure. Of the 191 knees in patients undergoing arthroscopic debridement, 77 patients (91 knees) were contacted for followup. Sixty-seven percent of the 91 knees did not have total knee arthroplasty at an average of 13.2 years followup. The Tegner activity score averaged 3.5 and patient satisfaction averaged 8.6 on a 0 to 10 scale. Twenty-one patients (30 knees) or (33%) had total knee arthroplasty at an average of 6.7 years. Seven of these had total knee arthroplasty within 2 years of arthroscopic debridement. Six of these seven knees had Outerbridge Grade 4 articular cartilage changes and clinically significant meniscus tears. Seven of the 19 knees (37%) with Outerbridge Grade 4 changes in 80% of one knee compartment did not require total knee arthroplasty after greater than 10 year followup. The difficulties in long term followup in this patient population is evident, yet the number of patients who had a functional lifestyle after arthroscopic debridement was notable.     

关节镜清理术治疗膝关节骨关节炎

目的：探讨关节镜下清理术对膝关节炎的诊断价值及治疗效果。方法：作者自1995年5月至1999年5月采用关节镜下清理术治疗膝关节骨关节炎患者56例（70膝）,随访6月－4年。结果：本组病人56例（70膝）,经关节镜检查均证实有关骨节炎存在,而术前X线片有关破坏的仅36膝,符合率为51．4％。本组病人术后疼痛明显减轻,2－3周即下床活动,随访1年优良率91％,2年以后优良率67．8％。结论：关节镜下清理术膝关节骨关节炎可以有效缓解病人的疼痛,可以早期恢复关节的功能,延迟骨关节炎的病程,全面提高诊断的准确率。     

Treatment of infected total knee arthroplasty. Irrigation and debridement versus two-stage reimplantation

The results of 24 cases of deep wound infection after total knee arthroplasty were reviewed. Twenty-one knees were initially treated with irrigation and debridement. Infection recurred in 15 knees. An increased infection rate occurred after irrigation and debridement in patients in whom the index prosthesis was in place more than 2 weeks. Nine knees (including 7 that had removal after irrigation and debridement) were treated with removal of the infected prosthesis, intravenous antibiotics, and delayed reimplantation. Immediate exchange was done in one knee. There were no recurrences in this group (P less than .001). The final status of the patients included 8 with fusions or resection arthroplasties and 16 with a prosthesis. The average Hospital for Special Surgery knee rating was 41 in patients without a prosthesis and 75 in patients with a prosthesis (P less than .001). The authors conclude that irrigation and debridement is not likely to be successful for treatment of infections when used more than 2 weeks after the initial arthroplasty. Also, two-stage reimplantation for the treatment of infected total knee arthroplasties gives a reliably low recurrence rate and provides a superior clinical result, compared to arthrodesis or resection arthroplasty.     

Role of arthroscopy in osteoarthritis of the knee.

We compared arthroscopic partial menisectomy with limited debridement versus arthroscopic abrasion arthroplasty in patients with osteoarthritis. Group I consisted of 131 knees in 131 patients treated by partial meniscectomy and debridement of loose articular cartilage or removal of loose bodies. All patients had grade 3 or 4 chondromalacia in the affected compartment. The patients were followed for a mean of 3 +/- 1 years. Group II consisted of 28 knees in 28 patients treated by debridement with abrasion arthroplasty of exposed bone. The mean age of this group of patients was 63 years and they were followed for a mean of 3.8 years. The Group I patients noted 80% improvement by 1 year but this fell to 67% by 5 years after meniscectomy. Overall, 104 were improved, 16 unchanged, and 15 worse at the time of last evaluation compared to their preoperative status. In the Group II patients, 11 were improved, 8 unchanged, and 9 worse. Fifty percent of Group II subsequently underwent a total knee arthroplasty for salvage at a mean of 3 years following the abrasion procedure. Abrasion arthroplasty appears to offer little benefit over partial meniscectomy and debridement in the degenerative knee. Results of abrasion arthroplasty are unpredictable.     

关节镜下清理和钻孔治疗膝关节软骨退变的疗效分析

目的探讨关节镜下清理和钻孔治疗膝关节软骨退变的临床疗效。方法 2009年1月至2013年2月,87例膝关节软骨退变患者随机分为两组,A组含45例(56侧),予关节镜下清理术治疗;B组含42例(51侧),行关节镜下清理+软骨下骨钻孔术,术后予对症治疗。观察两组患者治疗后的效果。结果 A组治疗后6个月时优良率为64.29%,B组6个月后优良率为84.31%,差异有统计学意义(P<0.01)。两组患者术后均随访2年,B组术后6个月、1年和2年的优良率分别为89.29%、80.36%和75.00%,术后2年时的疗效显著低于6个月时(P=0.04)。结论关节镜清理+钻孔术治疗膝关节软骨退变疗效优于单纯关节镜清理术,但其疗效随时间延长而降低。     

后稳定型全膝关节假体置换术后疗效分析

目的　分析后稳定型全膝关节假体置换术的处理方式、手术经验及疗效。方法　对 14例15膝行关节置换 ,使用Apollo后稳定型假体 ,单膝关节置换 13例 ,双膝同期置换 1例。原发疾病为类风湿性关节炎 3例 4膝 ,骨关节炎 11例 11膝。术后随访时间平均 11个月。结果　 15个膝关节术前伸曲活动度平均 75°,全膝关节置换术后 2个月关节活动度恢复至平均 10 0°。 14例患者均可自如行走、上下楼梯 ,膝关节稳定性好。 1膝术后脂肪液化致表层伤口裂开 ,清创后愈合 ,余膝术后伤口均愈合良好。结论　后稳定型假体植入的全膝关节置换手术方式简单、疗效肯定、术后并发症少。     

Arthroscopic debridement for grade III and IV chondromalacia of the knee in patients older than 60 years

Arthroscopic debridement has been used to treat patients with degenerative knee osteoarthritis, although there is sometimes conflicting evidence documenting its efficacy. This study evaluates the success of arthroscopic debridement in elderly patients with grade III and IV chondromalacia of the knee as measured by patient satisfaction and the need for additional surgery. From December 1998 to August 2001, a total of 102 consecutive cases of knee arthroscopy in 99 patients > 60 years were performed. Average follow-up was 34 months (range: 7-104 months). Patients were asked about their satisfaction using a visual analog scale, and the presence of meniscal lesions during arthroscopy and the treatment for these lesions were evaluated. Knees also were assessed for articular surface degeneration using Outerbridge's classification for chondromalacia. The need for and type of additional surgery was evaluated. During arthroscopy, meniscal lesions requiring a partial meniscectomy were found in 95 knees. Chondromalacia was found in 92 knees; 53 knees had grade I or II chondromalacia and 39 knees had grade III or IV chondromalacia. Additional surgery was performed in 17 knees. Mean patient satisfaction score was 73 (range: 50-100) in the 39 knees with grade III or IV chondromalacia after arthroscopic debridement was performed. These findings suggest arthroscopic debridement in elderly patients has a place in the treatment algorithm for grade III or IV chondromalacia of the knee.     

Implant salvage in infected total knee arthroplasty

In a retrospective study of 60 infected total knee arthroplasties (TKAs), attempted implant salvage of 39 knees was performed with surgical debridement and antibiotic therapy. In seven of the 39 knees (17.9%), infection was successfully eradicated, with a mean follow-up examination of 4.1 years. In comparing knees with successful salvage to those with persistent infection, the following factors strongly correlated with successful salvage: (1) short duration of symptoms of infection (less than 2 weeks); (2) susceptible gram-positive organism (Streptococcus or Methicillin-sensitive Staphylococcus aureus); (3) absence of prolonged postoperative drainage or the development of a sinus tract; and (4) no prosthetic loosening or roentgenographic evidence of infection. Only five knees in this series satisfied all these criteria, and in each case, implant salvage with eradication of infection and maintenance of good knee function was achieved. Although a higher salvage rate was obtained with the less-constrained prostheses, an infected hinge prosthesis did not preclude successful implant salvage. No patient with a draining sinus tract (0/17), infection with a virulent organism (0/9), or earlier revision arthroplasty (0/9) had successful salvage of the infected implant. Of the 22 knees with postoperative drainage for longer than two weeks or failure of primary wound healing at the time of TKA, only two were successfully salvaged and both required a local muscle flap. Therefore, early aggressive management of persistently draining wounds after TKA is imperative. In TKA complicated by infection, implant salvage with aggressive surgical debridement and antibiotic therapy should be strongly considered, provided that these strict criteria for attempted salvage are adhered.     

人工全膝关节置换术后感染的治疗

目的：探讨人工全膝关节置换术后感染的治疗方法及效果。方法：6例TKA术后感染患者。感染发生时间为TKA术后1个月－11年,2例为早期感染,4例迟发性感染,平均4年2月。其中骨关节炎4例,类风湿性关节炎2例。单纯清创、抗感染治疗3例;清创、一期假体再置术1例;清创、二期假体再置换术1例;关节融合术1例。结果：在3例单纯清创、抗感染治疗中,1例经5次清创后痊愈,1例2次清创后感染未控制,改行关节融合术,1例3次清创,感染未愈;2例关节再置换术病例痊愈,功能恢复满意;2例关节融合术后痊愈。所有病例平均随访4年,除1例失去随访外,其余感染均未复发。结论：对全膝关节置换术后感染可行的治疗包括：单纯清创、抗感染治疗;清创、一期或二期假体再置换术;关节融合术等方法。每种方法都有其适应证,应根据患者的具体病情采用合适的治疗方法。     

关节镜技术在化脓性膝关节炎治疗中的应用

目的探讨应用关节镜下膝关节清理加置管持续冲洗术治疗化脓性膝关节炎的疗效。方法应用关节镜下膝关节清理加置管持续冲洗术治疗14例化脓性膝关节炎患者。结果14例均获随访,时间为12-18个月。患者均治愈,无复发。根据HSS评分标准评价膝关节功能：优11例,良2例,中1例。结论关节镜下膝关节清理加置管持续冲洗术是治疗化脓性膝关节炎的有效方法,具有损伤小,恢复快,膝关节功能恢复好的优点。