猪颈动脉粥样硬化性狭窄模型的建立

目的建立稳定的模拟人类颈动脉粥样硬化性狭窄的动物模型。方法普通猪10头，采用血管内膜热空气损伤法在猪的颈总动脉上造成特定条件的损伤，然后以特定高脂饲料喂养2个月，评价猪血管狭窄程度和病理改变特点。结果实验动物无死亡，共20根血管有19根血管狭窄率≥70％，病理检查证实高脂喂养2个月后颈动脉的粥样硬化病理改变已属于较成熟的纤维斑块期。结论猪的颈动脉与人类相似程度高，按本实验方法，损伤后喂养2个月的猪颈动脉粥样硬化性狭窄程度和病理改变均较好符合颈动脉狭窄研究之实验需要。     

肾旁主动脉粥样硬化的外科治疗经验和结果

作者1976～1983年共收治肾旁主动脉粥样硬化90例。全组进行主动脉肾动脉联合重建手术。术前进行主动脉造影,摄侧位片了解内脏血管情况,下肢缺血病人需检查下肢动脉的输出道。氮血症和难控制的高血压病人要进行肾功能检查。选择部份病人进行排泄性尿路造影,同位素肾扫描和静脉肾素测定。病人分为三组,三组都有肾动脉闭塞。此外,第一组有肾旁主动脉闭塞性疾病47例;第二组肾旁主动脉动脉病30例,第三组内脏动脉闭塞伴肾旁主动脉闭塞或动脉瘤。72例采用标准经腹手术径路,18例经胸后腹膜显露主动脉,其中6例治疗胸腹主动脉瘤,12例有内脏动脉病变。施行最多的是主动脉人造血管重建术计     

彩色多普勒对肾血管病变诊断价值探讨

以双功能和彩色多普勒超声诊断５５例肾血管病变，包括肾动脉狭窄、肾小动脉硬化、肾动脉发育不良、肾动静脉畸形、急性肾静脉血肾静脉曲张。与其中３８例有完整肾血管造影检查资料的结果对照，超声诊断符合率９５％。结果认为综合多普勒定量指标、典型的多普勒频谱形态和征象各的彩色血流图象，能够对多种肾血管病变出准确诊断。     

粥样硬化性肾动脉狭窄的诊治指南

约90％肾动脉狭窄（Renal arterial stenosis，RAS）是由动脉粥样硬化引起的。一组对65岁以上老年人行肾动脉超声检查发现，肾血管疾病的患病率是6．8％，粥样硬化性肾动脉狭窄以平均每年7％的速度增加。患者预后研究显示，呈进展性者临床预后通常较差，可以出现肾功能受损、肾脏萎缩、存活率降低，即2、5、10年的生存率分别是56％、18％、5％。为规范该病的治疗，延缓患者的存活年限，编辑部特邀请中国人民解放军总医院老年心肾科的赵佳慧、程庆砾医师将循环杂志（Circulation），2006年，113期有关肾动脉狭窄的诊治指南编译整理，以敬读者。     

肾移植中供受者血管变异的处理

在肾移植中,常会遇到供受者动脉病变及多支血管变异,如处理不当,常导致移植肾失败或肾功能不全.本院共施行肾移植350例,其中受者髂内动脉严重粥样斑块硬化、管腔接近闭塞者30例,供肾多支动脉变异36例,供肾动脉与髂内动脉管径悬殊较大8例,均作了合理的处理.术后移植肾血供良好,1年后随访,吻合血管通畅,肾功能正常,现将其处理经验介绍如下.1 处理方法1.1 髂内动脉严重粥样斑块硬化的处理髂内动脉管腔很小,接近闭塞.这种髂内动脉如与肾动脉吻合,开放血流后移植肾常供血不足,肾色虽鲜艳,但充盈张力差,术后常发生急性肾衰及无尿,导致肾移植失败.对此,我们有沉痛的失败教训.后来我们对25例粥样斑块硬化患者采取髂内动脉斑块切除,然后与肾动脉作端端吻合,开放血流后移植肾充盈张力良好.对5例斑块不能切除者,采取肾动脉与髂外动脉端侧吻合,同样取得良好效果.术后随访1年,肾功能正常,肾动脉无血管杂音,B超、彩色多普勒血流图、肾动脉造影(部分患者)未发现异常变化.     

Toll样受体4及NF-κB与动脉粥样硬化关系的实验研究

目的 观察球囊损伤后动脉粥样硬化兔颈动脉干Toll样受体4(TLR4)、NF-κB及其表达变化.方法 本实验首先通过球囊损伤颈总动脉的方法在高脂饲养的兔子体内引起一个持续性的低水平的局部炎性介质反应,建立双因素干预的动物粥样硬化模型,以促进兔颈总动脉的血管病变,同时将全部动物分为对照组、高脂饲养组和模型(双因素)组,8...     

周围血管动脉粥样硬化与冠状动脉粥样硬化相关性的研究

目的应用超声方法检测外周动脉内-中膜厚度（IMT）及斑块情况,探讨外周动脉与冠状动脉粥样硬化的相关性,评价超声检测外周动脉粥样硬化对冠状动脉病变的预测价值及其临床意义。方法对110例天津医科大学第二医院心脏科住院行冠状动脉造影（CAG）的患者术后1—2周内,行外周动脉（包括颈总、颈内、颈外、股总、股浅、股深、胭、足背动脉）粥样硬化情况进行超声检查,以动脉IMT和粥样硬化斑块厚度作为观测指标,对各组病例外周动脉粥样硬化的情况进行比较,进行统计学分析,探讨动脉粥样硬化发生的危险因素,外周动脉与冠状动脉粥样硬化的相关性。结果（1）CCA IMT、颈动脉IMT、CFA IMT、SFA IMT、DFA IMT、下肢动脉IMT在冠脉未见异常组与其余三组任一组均差异有统计学意义（P〈0．05）,冠脉未见异常组IMT值小于其余三组。（2）随着冠状动脉粥样硬化血管的数量增加,颈动脉和下肢动脉动脉粥样硬化情况加重,斑块形成呈明显增加趋势。（3）多因素Logistic回归分析（STEPWISE）,CFAIMT和P下肢与冠状动脉粥样硬化具有显著相关性,有统计学意义（P〈0．05）。结论（1）颈动脉、下肢动脉和冠状动脉粥样硬化的趋势一致。（2）颈部和下肢血管的IMT及斑块对冠状动脉粥样硬化有很好的预测价值;P下肢、CFAIMT可作为预测冠状动脉粥样硬化的重要指标。（3）年龄、吸烟时间、患有高血压及高血压患病时间、甘油三酯、空腹血糖、胰岛素水平是动脉粥样硬化的高危因素。     

53例双肾不等大的病因分析

目的通过彩超双肾扫描或影像学检查发现双肾不等大,患侧肾较对侧。肾缩小1．5cm的患者进行分析,探讨双肾不等大的病因,为临床诊疗提供依据。方法对53例双肾不等大患者的临床、实验室、影像学资料进行回顾性分析。结果因感染所致32例（肾结石梗阻返流性肾病16例,慢性肾盂肾炎11例,肾结核5例）;缺血性肾病11例（肾动脉粥样硬化斑块栓塞6例,肾动脉狭窄5例）;先天性单侧肾发育不良10例。结论除先天性一侧肾发育不良外,慢性肾盂肾炎特别是伴结石梗阻返流性肾病,仍然是单侧肾萎缩的主要病因,而近年来肾动脉粥样硬化斑块栓塞、肾结核的发病率有增加趋势。     

肾动脉狭窄的治疗

肾血管性高血压是一综合征,是指由于肾血管损伤造成肾脏灌注压下降、血压升高。肾血管疾病包括肾动脉狭窄（reno—artery stenosis,RAS）,肾动脉或肾静脉血栓、栓塞及其梗阻等,其中以RAS居多。引起RAS的常见病因为动脉粥样硬化性肾动脉狭窄（atherosclerotic renal artery stenosis,ARAS）、多发性大动脉炎和肌纤维发育不良。     

在活体猪模型中用以射频为基础的热疗技术治疗小肾癌的研究

作者在大动物模型中研究射频技术治疗小肾癌的有效性和安全性。在 7头猪的正常肾中产生 2 2处病变。通过开放暴露肾脏或超声引导下经皮应用射频能量。以灰阶和能量超声检测病变的变化。在肾与肾周筋膜之间注入盐水 (水间隔 )或ＣＯ2 (气间隔 )避免周围组织的热损伤。超声和病理     

X线造影剂对高胆固醇血症大鼠的肾毒性及己酮可可碱的保护作用

目的 比较不同渗透浓度X线造影剂对高胆固醇血症大鼠的肾毒性，探讨己酮可可碱（PTX）对造影剂肾毒性是否有保护作用。 方法 48只健康雄性SD大鼠，随机分为正常饮食组8只（NN组）和高胆固醇饮食组40只（H组，4%胆固醇+1%胆酸钠）。8周末，高胆固醇饮食组随机分为5组，每组8只，分别为高胆固醇饮食组（HN组）、高胆固醇+低渗造影剂组（HL组）、高胆固醇+等渗造影剂组（HI组）、高胆固醇饮食+高渗造影剂组（HH组）、高胆固醇+高渗造影剂+PTX组（HHP组）。在注射造影剂后48 h测定各组大鼠的血清总胆固醇、三酰甘油、血清肌酐、内生肌酐清除率（Ccr）、钠钾排泄分数及血管紧张素Ⅱ（AngⅡ）的浓度；光镜下观察肾组织学改变；免疫组化法检测肾组织NF-κB的蛋白表达；原位细胞调亡（TUNEL）染色检测肾小管上皮细胞的凋亡。 结果 所有给予高胆固醇饮食的大鼠血清总胆固醇水平明显增高（P < 0.05）。HH组的血清肌酐、钠钾排泄分数及血浆Ang Ⅱ水平均分别明显高于HHP组、HL组及HI组（P < 0.05）；HH组Ccr水平[（0.11±0.02） ml·min-1·（100 g）-1]则明显低于HHP组[（0.43±0.03） ml·min-1·（100 g）-1]、HL组[（0.25±0.02） ml·min-1·（100 g）-1]和HI组[（0.27±0.03） ml·min-1·（100 g）-1]（P < 0.05）。组织病理显示，HH组大鼠肾小管上皮细胞发生明显的变性和坏死，肾小管上皮细胞凋亡率（89.60%±6.40%）明显高于其他各组[NN组（2.40％±0.77％）、HN组（5.60％±1.08％）、HHP组（8.91％±1.44％）、HL组（63.34％±11.97％）、HI组（61.50％±9.40％）]（P < 0.05）。肾组织NF-κB阳性细胞的平均灰度值明显低于其他各组（P < 0.05）；而HL组和HI组间上述指标比较差异无统计学意义 （P > 0.05）。 结论 高胆固醇血症环境下注射不同渗透浓度X线造影剂均可致造影剂肾损害。PTX对高胆固醇血症环境下所致的造影剂肾毒性有保护作用。     

血管介入治疗移植肾动脉狭窄的疗效分析

目的探讨血管介入治疗对移植肾动脉狭窄(transplanted renal arterial stenosis,TRAS)的疗效。方法回顾性分析本中心513例肾移植患者中并发TRAS的患者资料,比较血管介入治疗前、后的1周、1个月、3个月、6个月,患者的肌酐、血压及移植肾血流动力学指标的变化。结果513例肾移植患者中有9例并发TRAS,发生率为1.75%,9例患者均行血管介入治疗,其中8例患者单纯行球囊扩张术,1例患者行球囊扩张后置入血管支架。8例球囊扩张术的患者有3例术后2个月内再次出现狭窄,二次狭窄率为33.3%,再次给予球囊扩张均成功。所有患者随访6个月,1例患者血管介入治疗后4个月因肺部感染死亡。治疗前患者血肌酐为(142.3±59.6)μmol/L,治疗后1周、1个月、3个月、6个月分别为(133.5±57.2)μmol/L、(131.8±35.6)μmol/L、(127.0±29.9)μmol/L、(125.7±37.1)μmol/L,与术前相比,无统计学差异,但有下降趋势。治疗前患者收缩压为(149.7±19.3)mmHg(1 mmHg=0.133 kPa),治疗后1周、1个月、3个月、6个月分别为(131.3±4.1)mmHg、(136.2±7.9)mmHg、(128.5±6.6)mmHg、(127.1±3.6)mmHg,与术前相比,收缩压明显降低,具有统计学差异。治疗前患者移植肾主动脉峰值流速(peak systolic velocity,PSV)为(297.2±105.3)cm/s,治疗后1周、1个月、3个月、6个月分别(171±56.3)cm/s、(185.8±64.8)cm/s、(197.5±69.1)cm/s、(178.8±75.4)cm/s,与术前相比,均具有统计学差异。治疗后1周、1个月、3个月、6个月的叶间PSV、叶间动脉阻力指数,与术前相比,无统计学差异。结论血管介入治疗的疗效确切,能有效改善TRAS患者移植肾功能。     

Renal injury of diet-induced hypercholesterolemia in rats

Abnormalities in lipid metabolism frequently accompany renal disease and may be important in the pathogenesis of progressive renal injury. In the present study, the effects of a high cholesterol diet on renal histology, cortical lipids, and glomerular hemodynamic function were examined in normal rats with and without reduced renal mass. Cholesterol feeding for 19 weeks increased serum cholesterol from 66 +/- 10 mg/dl to 256 +/- 93 mg/dl in two-kidney rats, and from 73 +/- 15 mg/dl to 407 +/- 274 mg/dl in nephrectomy rats (P less than 0.01). Both sham-operated and unilateral nephrectomy rats fed a high cholesterol diet had a greater amount of glomerulosclerosis and tubulointerstitial damage than rats fed standard chow. Cortical cholesteryl esters were increased by the cholesterol diet, and correlated with the amount of glomerulosclerosis (r = 0.90, P less than 0.01) and tubulointerstitial injury (r = 0.64, P less than 0.05). Cholesterol feeding and nephrectomy both caused alterations in tissue essential fatty acids, and a panel of specific monoclonal antibodies indicated that renal injury and cortical lipid alterations were associated with an increase in glomerular macrophages. Finally, micropuncture experiments carried out in a separate group of rats fed high cholesterol for 8 to 10 weeks demonstrated increases in glomerular capillary pressure. These results suggest that additional investigations may ultimately determine how cholesterol deposition, altered fatty acid metabolism, macrophages, and increased glomerular pressure might combine to cause chronic progressive renal injury.     

In vivo human comparison of intravascular ultrasonography and angiography

This study evaluates the in vivo correlation of intravascular ultrasonography and uniplanar angiography in determining the luminal dimensions of normal and moderately atherosclerotic human arteries. Five French and 8F rotating A scan intravascular ultrasound catheters were used to obtain 48 images in four superficial femoral arteries, five iliac arteries, and one aorta in eight patients undergoing vascular surgery. Cross-sectional areas measured by intravascular ultrasonography were compared to cross-sectional areas calculated by uniplanar angiography of the same location in the vessel. Maximum and minimum luminal diameters were also measured from intravascular ultrasound images. An ellipticity index was defined as the maximum/minimum diameter ratio (max/min) and ranged from 1.0 to 1.8 (mean, 1.2). Comparison of the cross-sectional areas measured from intravascular ultrasound images and those calculated from uniplanar angiography showed no significant difference at any level of ellipticity studied. However, when the values of cross-sectional areas were analyzed in groups corresponding to the diameter of the vessel, that is, aortic, iliac, and femoral, the values for the iliac arteries calculated from uniplanar angiography were significantly greater by 9.8% +/- 0.7% (n = 29, p = 0.03) when compared to those measured by intravascular ultrasonography. In addition to providing accurate luminal determinations, intravascular ultrasound images displayed transmural morphology, the location and character of the atherosclerotic lesions, and the thickness of the vessel wall. We conclude that intravascular ultrasound imaging provides accurate, novel information regarding human vessels and that this technology may play a significant role in future diagnostic and interventional therapies.     

Role of leukotriene B4 in accelerated hyperlipidaemic renal injury

Aim: Glomerular infiltration of macrophages is a characteristic alteration of renal pathology in hyperlipidaemic renal injury. Leukotriene B4 (LTB4) is a bioactive eicosanoid and macrophage and has two key enzymes for LTB4 synthesis, 5‐lipoxygenase and leukotriene A4 (LTA4) hydrolase. The purpose of this study was to evaluate the role of LTB4 in accelerated hyperlipidaemic renal injury. Methods: To induce accelerated hyperlipidaemic renal injury, 8 week old male spontaneously hypercholesterolaemic (SHC) rats were fed with a high cholesterol diet for 6 weeks. LTA4 hydrolase activities in the kidney and urine LTB4 levels were examined. The effects of LTB4 antagonist (ONO‐4057) were also evaluated. Results: Urinary protein and LTB4 excretion was increased by a high cholesterol diet for 6 weeks. The scores of glomerular foam cell accumulation and sclerosis, numbers of infiltrated macrophages in glomeruli and interstitial area, LTA4 hydrolase activity in renal cortex were higher in the high cholesterol diet group than the normal diet group. LTB4 antagonist treatment reduced urinary protein and LTA4 activity and attenuated renal pathological changes. Conclusion: These results suggest that LTB4 directly contributes to accelerated hyperlipidaemic renal injury and the therapeutic potential of LTB4 antagonist for renal damage induced by hyperlipidaemia.     

Gadolinium as an alternative contrast agent for diagnostic and interventional angiographic procedures in patients with impaired renal function.

BACKGROUND: The study was designed to investigate the safety and feasibility of gadopentetate dimeglumine, a gadolinium-based contrast medium, as an alternative angiographic contrast agent in patients with impaired renal function and high risk for iodinated contrast-induced nephropathy. METHODS: Gadopentetate dimeglumine was used as the radiographic contrast agent in 32 diagnostic or interventional angiographic procedures in 29 patients (59% diabetics) with severe renal insufficiency (average serum creatinine of 3.6+/-1.4 mg/dl). The average dose of gadopentetate dimeglumine was 0.34+/-0.06 mmol/kg body weight. Gadopentetate dimeglumine was used either alone (n=20) or in conjunction with carbon dioxide (n=12). RESULTS: Thirty-two angiographic procedures (24 diagnostic angiographies and 8 interventional procedures) were performed in 29 patients. For diagnostic purposes, eleven selective renal arteriographies, six angiographies of the iliac arteries and lower extremities, and seven venous angiographies of the upper extremity and central veins were performed. Interventional procedures consisted of two percutaneous transluminal renal angioplasties with stenting, four percutaneous peripheral vascular interventions, and two balloon angioplasties of a dialysis fistula. None of the patients, except one, had evidence of post-procedure contrast material-induced renal failure (increase in serum creatinine >0.5 mg/dl within 72 h) or other complications. This patient had a clinically important increase in serum creatinine level after percutaneous transluminal renal angioplasty and stenting, probably due to cholesterol embolism. Gadopentetate dimeglumine had sufficient radiographic density to allow adequate diagnostic visualization with digital subtraction equipment in all cases. CONCLUSIONS: Gadopentetate dimeglumine is an alternative and safe radiographic contrast agent for angiography and interventional procedures in patients with severe pre-existing renal impairment. In this population with high risk for contrast-induced acute renal failure, it is obviously less nephrotoxic than iodinated contrast media.     

Renal vascular function in hypercholesterolemia is preserved by chronic antioxidant supplementation

Hypercholesterolemia impairs systemic vascular reactivity in response to endothelium-dependent vasodilators, which may be mediated partly through increased formation of lipid peroxides. However, it is unclear whether these pathophysiological mechanisms play a role in renal vascular impairment in experimental hypercholesterolemia. Hence, pigs were studied after a 3-mo normal (n = 7) or high cholesterol (HC) (n = 7) diet, HC diet supplemented daily with antioxidant vitamins E (100 IU/kg) and C (1000 mg; HC+vitamins, n = 5), or normal diet supplemented with vitamins (N+vitamins, n = 5). Renal blood flow was measured with electron-beam computed tomography before and during infusion of acetylcholine (Ach). Endothelial function, endothelial and inducible nitric oxide synthase (NOS), and nitrotyrosine immunoreactivity were studied in renal arteries ex vivo. Despite similar cholesterol levels, LDL oxidizability (lag time, malondialdehyde, and relative electrophoretic mobility) was increased in pigs that were fed the HC diet but was significantly decreased in pigs that were fed the HC+vitamins diet. Renal blood flow response to Ach was blunted in pigs that were fed the HC diet but was preserved in pigs that were fed the HC+vitamins diet. Maximal relaxation to Ach was attenuated in pigs that were fed the HC diet compared with those that were fed the normal diet (51.5 +/- 6.4% versus 97.0 +/- 2.9%; P < 0.01) but was preserved in pigs that were fed the HC+vitamins diet (103.1 +/- 3.0%; P = 0.39) and N+vitamins diet (87.7 +/- 3.0%; P = 0.1), as were relaxation responses to calcium ionophore A23187. Vascular smooth-muscle relaxation to diethylamine was enhanced in endothelium-denuded HC vessel but was restored in pigs that were on the HC+vitamins regimen. In HC, immuno-reactivity of endothelial NOS was decreased, that of inducible NOS was increased, and both were preserved in pigs that were fed the HC+vitamins and N+vitamins diets, whereas nitrotyrosine was not detected. The present study demonstrates that antioxidant intervention in experimental HC reduces LDL oxidizability and preserves renal vascular responses to endothelium-dependent vasodilators. Therefore, this beneficial effect potentially can protect the kidney from hypercholesterolemia-induced damage.     

肾动脉狭窄的介入治疗分析

目的 分析介入治疗肾动脉狭窄（RAS）的疗效。方法自2003年3月至2008年3月共收治45例RAS患者,53支肾动脉中单纯行腔内球囊扩张术（PTA）治疗11支,行球囊扩张及内置支架术（PTA／Stent）治疗者42支,随访9～48个月,检测患者的血压与血肌酐水平,并作肾动脉彩超。结果手术成功率为100％。手术后高血压治愈者9例,改善28例,肾功能改善12例。肌纤维发育不良及多发性大动脉炎的血压改善有效率均为100％,高于动脉粥样硬化的有效率65．1％（P〈0．05）。行彩色多普勒超声检查肾动脉18支,发现再狭窄者7支。结论PTA和PTMStent治疗肾动脉狭窄具有微创、安全、有效的优点。     

Ezetimibe ameliorates cholecystosteatosis

BACKGROUND: Cholecystosteatosis is the accumulation of gallbladder wall fats leading to decreased gallbladder emptying. Ezetimibe inhibits intestinal fat absorption and prevents murine gallstone formation. However, the influence of ezetimibe on gallbladder emptying and cholecystosteatosis has not been studied. Therefore, we tested the hypothesis that ezetimibe would improve gallbladder motility by preventing the buildup of fats in the gallbladder wall. METHODS: Forty lean female mice were fed either a control diet or a lithogenic diet for 6 weeks. Half of the mice on each diet received ezetimibe. At 11 weeks of age, all mice were fasted overnight and underwent gallbladder ultrasonography to determine ejection fraction. One week later, the mice were fasted and underwent cholecystectomy. Bile was examined for cholesterol crystals. The gallbladders were snap-frozen for lipid analysis. RESULTS: The lithogenic diet significantly (P < 0.05) increased serum cholesterol, biliary crystals, gallbladder wall cholesterol and cholesterol/phospholipid ratio, and decreased gallbladder ejection fraction. All of these abnormalities were reversed (P < 0.05) by the addition of ezetimibe to the diet. CONCLUSIONS: These data suggest that ezetimibe lowers serum cholesterol, prevents biliary crystals, and normalizes gallbladder wall fat and function. We conclude that ezetimibe ameliorates cholecystosteatosis and may be an effective agent for gallstone prevention.     

豚鼠胆囊胆固醇结石形成过程中小肠动力的变化

目的 观察豚鼠胆囊胆固醇结石形成过程中小肠动力的变化,探讨其在胆囊结石形成中的作用.方法 将40只豚鼠随机分为实验组与对照组,每组20只,实验组给予致石饲料(胆固醇含量2％),对照组给予正常颗粒饲料,8周造模结束后,利用多通道生理记录仪分别记录实验组与对照组豚鼠离体小肠肌条慢波和张力变化,分析其与胆囊胆固醇结石形成的关系,组间比较采用t检验.结果 豚鼠小肠离体肌条慢波频率实验组为5.70±1.05次／min,对照组为17.45±1.50次／min,振幅实验组为0.23±0.31 mv,对照组为0.78 ±0.17 my,实验组数据较对照组明显降低,P值分别为:4.56×10-25,4.00×10-13,均＜0.05;组间比较t值分别为:-27.083,-13.236;豚鼠小肠离体肌条肌肉收缩频率实验组为5.94±1.25次／min,对照组为15.85±1.76次/min,张力效应值实验组为0.78±0.02g,对照组为1.20±0.11g,实验组数据较对照组明显降低,P值分别为2.41×10-20,1.55×10-13,均＜0.05;组间比较t值分别为:- 19.448,- 17.307.结论 致石组豚鼠小肠动力较对照组明显下降,提示小肠动力异常可能在胆囊胆固醇结石形成过程中发挥作用.