腹腔镜辅助下改良Soave根治术对先天性巨结肠患儿肠道微生态及便控功能的影响

目的探讨腹腔镜辅助下改良Soave根治术对先天性巨结肠患儿肠道微生态及便控功能的影响。 方法通过便利抽样法将96例先天性巨结肠患儿均分为两组,对照组行传统开腹手术,观察组行腹腔镜辅助下改良Soave根治术。比较两组手术相关指标、肠道菌群数量、肠道微生物定植抗力(B/E)、便控功能及术后并发症发生率。 结果观察组手术时间、术中失血量、禁食时间、肠蠕动恢复时间、住院时间等均优于对照组(P＜0.05)。观察组术后双歧杆菌、粪肠球菌、B/E以及便控功能优良率均高于对照组(P＜0.05)。观察组并发症发生率较对照组降低(P＜0.05)。 结论先天性巨结肠患儿接受腹腔镜辅助下改良Soave根治术治疗,可有效改善肠道菌群水平,术后便控功能良好,且术后并发症少,值得临床推荐。     

改良Swenson术和经肛门Soave术治疗小儿先天性巨结肠疗效比较

目的比较分析改良Swenson术和经肛门Soave术治疗小儿先天性巨结肠的临床效果.方法将我院2010年4月-2013年2月收治的90例小儿先天性巨结肠患者随机分为实验组和对照组,实验组实施改良Swenson术,对照组实施经肛门Soave术,比较两组患者术中出血量、手术时间、术后禁食时间及术后住院时间.结果实验组的术中出血量、手术时间、术后禁食时间及住院时间均显著低于对照组,差异有统计学意义.结论改良Swenson术对小儿先天性巨结肠患者的临床治疗效果要优于肛门Soave术.     

腹腔镜辅助经肛门改良Soave术治疗小儿先天性巨结肠的疗效及安全性分析

目的探讨腹腔镜辅助经肛门改良Soave术治疗小儿先天性巨结肠的临床效果。方法选取该院2013年4月‐2017年1月收治的先天性巨结肠患儿42例为研究对象,以随机数字表法将其分为观察组和对照组;观察组患儿给予腹腔镜辅助经肛门改良Soave术,对照组患儿给予单纯经肛门改良Soave术,观察两组患儿手术效果及术后并发症发生情况。结果观察组患儿术中出血量明显少于对照组患儿(P0.05);观察组患儿术后肛门排气时间和住院时间显著短于对照组患儿(P0.05);两组患儿手术时间比较差异无统计学意义(P0.05);观察组患儿术后3个月自主大便率为81.82%(18/22),略高于对照组患儿的75.00%(15/20)(P0.05);观察组患儿术后并发症发生率为4.55%(1/22),略低于对照组患儿的15.00%(3/20)(P0.05)。结论腹腔镜辅助经肛门改良Soave术治疗小儿先天性巨结肠疗效确切、术后恢复快且安全性高,值得临床推广。     

经肛门巨结肠根治术治疗126例儿童先天性巨结肠临床疗效研究

目的探讨经肛门巨结肠根治术治疗儿童先天性巨结肠临床疗效及手术技巧。方法回顾分析经肛门手术治疗126例先天性巨结肠患儿的临床资料,采用经肛改良Soave术95例,经肛改良Swenson术31例。结果除早期经肛Soave术中7例（5．6％）二期手术外,余均一期完成手术（94．4％）。辅助腹部小切口5例,腹腔镜12例。术后并发症35例,其发生率为27．8％,其中肛周糜烂15例,小肠结肠炎9例,吻合口狭窄5例,污粪2例,再手术4例,两种术式的术后并发症比较差异无统计学意义（P〉0．05）。103例获随访1—10（中位数2）年,痊愈96例（93．2％）,好转5例（4．9％）,无效2例（1．9％）,两种术式不同类型的术后排便功能优良率比较差异均无统计学意义（P〉0．05）。结论两种术式治疗先天性巨结肠临床疗效好,各有其优点,均存在一定的并发症,但经肛Swenson术较经肛Soave术操作更简单方便,术后不需扩肛。     

经肛门改良Soave术在小儿先天性巨结肠治疗中的效果研究

目的：探讨经肛门改良Soave术在小儿先天性巨结肠治疗中的临床效果。方法对该科收治的32例采用经肛门改良Soave术的先天性巨结肠患儿进行观察,并将同期收治的行传统Swenson手术的32例患儿作为对照组,比较两组在手术时间、术中出血量及术中、术后早期和晚期并发症的发生情况。结果观察组在手术时间、术中出血量和并发症均少于对照组,差异有统计学意义（P＜0.05）。结论经肛门改良Soave改良术治疗小儿先天性巨结肠安全有效,患儿排便的控制功能和生活质量明显提高,较传统Swenson改良法有明显优势,值得在临床推广。     

经肛门改良Soave术和经腹手术治疗先天性巨结肠疗效比较

目的 比较经肛门改良Soave术和经腹手术治疗先天性巨结肠的临床疗效.方法 选择2002年1月至2012年1月来我院住院治疗的54例先天性巨结肠患儿为研究对象,随机分为两组各27例,改良组予以经肛门改良Soave术,对照组予以经腹手术,比较两组术后并发症、排便功能及各项指标.结果 两组患者经治疗后均痊愈出院.改良组术后共出现2例并发症,占7.41％;对照组术后共出现8例并发症,占29.63％;经比较差异具有统计学意义(x2=4.418,P=0.036).改良组的完全自主大便率明显高于对照组,污粪率明显低于对照组,经比较差异均具有统计学意义(P＜0.05).改良组手术时间、胃肠功能恢复时间、住院时间均明显短于对照组,经比较差异均具有显著统计学意义(P＜0.01).结论 经肛门改良Soave术治疗先天性巨结肠较经腹手术具有术后并发症少、术后排便功能好、手术时间短、胃肠功能恢复快、住院时间短等特点,值得临床推广.     

经肛门Soave改良术和开腹根治术治疗先天性巨结肠疗效分析

目的观察经肛门Soave改良术和开腹根治术治疗小儿先天性巨结肠的疗效。方法 160例先天性巨结肠患儿中,80例接受经肛门Soave改良术（治疗组）,80例患者接受传统开腹根治手术（对照组）。分别对两组的手术时间、出血量、术后肠蠕动恢复时间、术后住院时间以及近期并发症进行分析,对患儿的肛门功能以及生活质量进行随访和问卷调查并评分。结果治疗组手术时间、手术出血量、住院时间以及肠功能恢复时间均低于对照组（P〈0.05）;治疗组术后并发症总发生率显著低于对照组（P〈0.05）。160例患儿经随访6个月～5年,治疗组患儿的肛门功能优良率以及生活质量优良率均明显高于对照组,差异有统计学意义（P〈0.05）。结论经肛门Soave改良术治疗小儿先天性巨结肠安全有效,且患儿排便控制功能和生活质量明显提高,值得临床推广使用。     

两种先天性巨结肠根治术疗效的对比研究

目的：探讨改良Swenson术和经肛Soave术在先天性巨结肠（Hirschsprung’sdisease,HD）的疗效方面的优劣性。方法：回顾分析1999年10月-2010年2月我院107例HD根治术的临床资料,根据手术方式的不同分为A组（改良Swenson术,共62例）和B组（经肛Soave术,共45例）,统计分析两组的出血量、手术时间、术后禁食时间、术后住院时间及术后肠粘连、小肠结肠炎、切口感染、吻合口瘘、污粪、复发等并发症的发生率。结果：A组的出血量（t=2．63,P〈0．05）、手术时间（t=2．08,P〈0．05）、术后禁食时间（t=2．89,P〈0．05）、术后住院时间（t=1．94,P〈0．05）及术后肠粘连（χ2=-9．33,P〈0．05）、切口感染（χ2=-9．19,P〈0．05）、吻合口瘘（χ2=4．37,P〈0．05）、污粪（χ2=-7．72,P〈0．05）发生率均明显大于B组,其余差异无统计学意义。结论：经肛Soave术在疗效上优于改良Swenson术,但适应证小。术后污粪可能与肛管直肠角的改变有关。     

分析腹腔镜辅助下巨结肠根治术治疗小儿先天性巨结肠的临床疗效

目的总结分析腹腔镜辅助下巨结肠根治术治疗小儿先天性巨结肠的临床疗效。方法选择2013年1月至2017年6月我院收治的127例先天性巨结肠患儿为研究对象,均给予腹腔镜辅助下改良Soave术治疗,回顾分析其临床治疗效果。结果 127例患儿手术时间平均(156.5±2.0)min;手术出血量平均(15.5±2.9)m L;住院平均(10.5±1.2)d。术后病理检查确实为狭窄段无神经节细胞。Soave术后扩肛4个月左右,其中2例反复出现巨结肠肠炎,4例术后大便次数增多。保持随访12个月,患儿均好转,无复发便秘病例,无污粪、大便失禁等不良情况。结论腹腔镜辅助下巨结肠根治术治疗小儿先天性巨结肠的临床疗效较好,值得推广使用。     

腹腔镜辅助改良Soave术根治小儿先天性巨结肠的围手术期护理

目的对小儿先天性巨结肠应用腹腔镜辅助改良Soave术进行治疗,对其围手术期的护理体会进行分析探讨。方法将本院收治的160例小儿先天性巨结肠患者应用腹腔镜辅助改良Soave术进行治疗,并在手术全程给予有针对性、精心的护理措施。结果160例患儿在腹腔镜辅助下顺利完成手术,160例患儿术后随访6~24个月,无并发症发生。结论腹腔镜辅助改良Soave术根治小儿先天性巨结肠能够取得较理想的治疗效果,在手术全程给予有针对性的精心护理可保证治疗效果,值得在临床推广应用。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Dr.Zhang Ren's Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.