半月神经节射频热凝治疗第Ⅱ支受累的三叉神经痛(附21例报告)

目的 探讨半月神经节射频热凝治疗第Ⅱ支受累的三又神经痛的方法 及其效果.方法 先以定位架帮助,后在CT定位下采用卵圆孔前入路穿刺,行半月神经节射频热凝术:80℃维持2～3 min.结果 第Ⅱ支受累的三叉神经痛患者21例,全部病例术后当日三又神经痛发作完全消失.随访3～26个月,其中1例18个月后、2例24个月后疼痛复发.结论 定位架帮助和CT定位下,经卵固孔前入路穿刺,半月神经节射频热凝术治疗第Ⅱ支受累的三又神经痛是一种安全、疗效好的方法 .     

半月神经节射频热凝治疗难治性三叉神经痛

目的探讨半月神经节射频热凝治疗难治性三叉神经痛效果和安全性。方法对三叉神经第Ⅱ支合并第Ⅰ、Ⅲ支或Ⅰ、Ⅱ、Ⅲ支并存疼痛者应用改良的前入路卵圆孔穿刺法行射频热凝毁损术。应用C型臂定位下行卵圆孔穿刺。射频温度控制在75-90℃。结果优良46例，良好1例，总有效率为100％。无严重并发症，随访42例3～18个月，无复发患者。结论在C型臂引导下射频热凝半月神经节毁损术治疗难治性三叉神经痛疗效可靠、定位准确，时患者更安全。     

CT引导下经皮穿刺半月神经节射频热凝术治疗三叉神经痛35例

目的 观察在CT引导下经皮穿刺卵圆孔半月神经节射频治疗原发性三叉神经痛的穿刺成功率及临床效果。方法选择原发性Ⅱ、Ⅲ支三叉神经痛患者35例,CT扫描确定卵圆孔位置及穿刺角度和深度,并给予电生理引导确证,静脉全麻下每分支分别给予65℃和75℃射频热凝各90s。结果所有患者成功经卵圆孔穿刺入半月神经节,射频热凝后7d总有效率97%,随访6个月3例患者复发,复发率为86%.未见明显的严重并发症.结论 CT引导下经皮穿刺卵圆孔半月神经节射频热凝治疗原发性三叉神经痛穿刺成功率高,疗效确切,安全性高.     

CT引导射频热凝术治疗三叉神经痛320例

目的探讨半月神经节射频热凝术治疗三叉神经痛的方法及效果。方法经皮穿刺达卵圆孔内三叉神经半月神经节处,连接射频温控热凝仪及相配套的电极做温控热凝至60-75℃,毁损三叉神经的相关感觉支。结果疼痛完全消失者301例、疼痛缓解17例、无效2例,总有效率99.4%。结论 CT引导下半月神经节射频热凝术治疗三叉神经痛安全,适应证广,效果显著。     

CT引导经皮穿刺半月神经节射频热凝术治疗三叉神经痛的效果与手术技巧

目的总结在CT引导下穿刺半月神经节行标准射频热凝术治疗三叉神经痛患者49例的临床效果和技巧。方法在CT三维或导航引导下对第V颅神经第Ⅱ支痛、Ⅰ＋Ⅱ支痛、Ⅱ＋Ⅲ支痛或Ⅰ＋Ⅱ＋Ⅲ支全痛患者应用改良的Hartel法经前入路卵圆孔穿刺半月神经节,术中验证靶点,并在全身麻醉下进行标准射频靶点温控毁损。结果术后即刻显效,优46例,良2例,差1例,总优良率98．0％（48例）。全组随访,1～6个月内复发率为1．9％（1例）,6个月～1年内复发率为1．9％（1例）。全组均无严重并发症。结论CT引导下穿刺半月神经节行标准射频温控热凝毁损术的疗效可靠、安全,注意手术技巧可减少穿刺过程因深度或方向掌握不当产生的并发症。     

CT引导下半月神经节射频热凝术治疗三叉神经痛96例

目的探讨半月神经节射频热凝术治疗三叉神经痛的方法。方法经皮穿刺达卵圆孔内三叉神经半月神经节处，连接射频温控热凝仪及相配套电极做温控热凝至70℃-75℃，毁损三叉神经相关感觉支。结果疼痛完全消失者96例，总有效率96.0%，无效1例（1.0%），复发1例（1.0%）。结论CT引导下半月神经节射频热凝术治疗三叉神经痛安全，适应证广，效果显著，特别对伴有心血管疾病的三叉神经痛患者，该方法安全可靠。     

侧方入路半月神经节靶点射频治疗三叉神经痛的效果

目的 探讨经侧方入路三维CT卵圆孔靶点定位,射频热凝治疗三叉神经痛的效果.方法 三叉神经痛患者26例采用本治疗方法,以评估术后治疗效果.结果 本组患者术后优良者21例（80.8％）,好转者5例（19.2％）,未见严重并发症.结论 经侧方入路三维CT引导卵圆孔半月神经节靶点射频热凝术可有效治疗三叉神经痛.     

CT引导下半月神经节射频热凝治疗三叉神经痛

目的观察CT引导下半月神经节射频热凝术治疗原发性三叉神经痛的临床疗效。方法 40例三叉神经痛患者在CT引导下,经前入路法穿刺三叉神经半月节后行射频热凝毁损治疗,温度控制在65-80℃持续时间3min,共3-4次。结果 40例患者中,32例疗效Ⅰ级,5例疗效Ⅱ,2例疗效Ⅲ级;一次性治疗显效率92.5%,总有效率97.5%。1例为Ⅳ级无效。结论 CT引导行三叉神经半月神经节射频热凝术是一种安全、可靠、有效的微创治疗技术,具有临床推广应用价值。     

CT定位下射频温控热凝术治疗三叉神经痛疗效分析

目的：探讨CT定位下射频温控热凝治疗原发性三叉神经痛的方法及临床效果。方法：分析用CT引导下经皮穿刺卵圆孔半月神经节,射频温控热凝术（温度设定65～80℃,时间设定为30～60秒治疗三叉神经痛患者32例,对临床资料进行疗效评定。结果：所有操作过程均十分顺利无1例失败。所有患者的疼痛获得缓解,除1例因穿刺起始过程出现血肿外,均无严重的并发症出现。尤其通过C T定位及分层计算,对患者均无第1支的损伤。结论：CT引导下经皮穿刺卵圆孔疗法对三叉神经痛具有定位准确,无痛苦,操作简单、安全,并发症少的优点,具有临床推广应用价值。     

射频热凝术治疗三叉神经痛258例的体会

目的:阐述射频热凝术治疗三叉神经痛的方法及适应证。方法:用射频穿刺针经皮穿刺达卵圆孔内半月神经节处,连接射频热凝仪及相配套电极作控温加热VⅠ支70°C以下射频热凝(为了预防麻痹性角膜炎发生,我们一般采用眶上孔处眶上神经射频热凝术,一般给予75~80°C射频热凝.这样比较安全。),VⅡ、VⅢ支一般70~75°C射频热凝,热凝三叉神经相关感觉支。结果:总有效率99.33%,无效0.77%,复发率1.94%。结论:射频热凝术治疗三叉神经痛安全,适应证广,效果显著。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.