慢性肺心病病人血清锌、铜、铁含量和锌铜比值的变化及临床意义

对60例慢性肺心病病人血清微量元素锌、铜、铁含量及锌/铜比值变化进行了测定,并与60例相同年龄组的正常人进行对比.结果表明,慢性肺心病组铜含量明显增高、锌/铜比值和铁含量明显降低(均为P<0.01).提示肺心病病人血清锌、铜、铁含量及锌/铜比值变化与心衰和低血氧症有关且与病情相关,对其变化机理及其临床意义进行探讨.     

慢性肺心病病人细胞免疫功能的研究

应用~3H—TdR掺入法测试30例正常人和37例(次)肺心病病人的淋转及血清抑制试验。结果显示,急发期病人淋转明显低下;病人的血清可抑制正常人淋转;血pH异常及呼吸衰竭病人的淋转更为低下;病人血ClC阳性率增高;肺心病低锌组的淋转低于正常锌组。     

血清及红细胞中微量元素与肺心病的关系

用原子吸收光谱法测定了34例肺心病急性发作期患者血清和红细胞中锌、铜、镉、砷、硅的含量。结果提示:肺心病患者红细胞和血清锌明显降低而铜显著增高,严重低氧血症组血清铜显著增高,相关分析表明,血清铜与PaO_2呈负相关。肺心病患者红细胞及血清中砷、硅含量明显高于健康对照组;镉含量在血清中显著降低,可是在红细胞中与对照组比较并无明显差异。简略地分析探讨了肺心病患者中PaO_2、PaCO_2和某些免疫指标与上述元素之间的关系。     

老年肺心病缓解期患者头发中微量元素含量

测定27例慢性肺心病缓解期患者(绝大多数为老年人)头发中8种微量元素及镁含量,并以26例可比健康者作对照。发现肺心病患者发锌、锌/铜比值低于健康者,发锰、铝含量高于健康者。并初步讨论了这些变化的可能机制。     

高血压病病人血清微量元素的观察

运用中阶梯光谱仪测定31例高血压病病人血清锌、铜、钙、镁、铁、锶、镍、铬8种微量元素的含量。高血压病病人锌、铜含量高于正常人,而钙、镁、铁、锶低于正常人。     

45例肺心病患者血清铜锌铅镉的测定

用电化学2.5次微分阳极溶出伏安法测定了45例肺心病患者血清中微量元素铜锌铅镉的含量并和27例健康人进行比较,结果发现肺心病组血清铜和镉高于对照组(P<0.01),血清锌低于对照组(P<0.01),而血清铅含量在两组无明显差异。探讨了肺心病微量元素间变化的关系并提出保持人体内微量元素的平衡有助于疾病的好转。     

肺心病和冠心病患者头发中微量元素的研究

报告63例肺心病与159例冠心病患者头发中钙及七种微量元素的测定结果,并分别与对照组进行比较。发现肺心病组头发中八种元素值均低于冠心病组,尤以铜、镍、铅为明显(P<0.001)。而锌/铜比值,肺心病组高于冠心病组,其原因可能与冠心病组发铜值偏高有关。老年男性肺心病组患者头发中铜、镍、锌明显低于老年男性冠心病组患者;而老年女性肺心病组患者铜、镍、铁也明显低于老年女性冠心病组患者。对铜、镍等微量元素在肺心、冠心病中的病理生理意义,进行了初步讨论。     

慢性肾功能衰竭病人血清微量元素铜、锌、铬含量的变化

应用原子能吸收光谱测定了正常人和各期慢肾功能衰竭(GRF)及血液透析病人的血清钢、锌、铬含量。结果表明,CRF病人血清铜含量明显增高,血清锌降低,铜/锌比值增大,而血清铬无明显变化。血液透析病人血清锌含量进一步降低。作者就其变化机理及临床意义作了初步探讨。     

原发性视网膜色素变性患者血清铜和锌的测定

用原子吸收分光光度计分别对15例原发性视网膜色素变性患者、15例患者亲属和23例正常人,进行了血清铜和锌含量的测定。结果表明,原发性视网膜色素变性患者组及其亲属组的血清铜含量低于正常人(P<0.01),血清锌含量与正常人无显著差异(P>0.05)。     

肺心病患者血清几种微量元素测定分析

通过三电极直流等离子体原子发射光电直读光谱仪测定30例肺心病患者血清微量元素锌、锰、镉、铝、铜,钴、铬含量,并设健康对照组进行对比,结果表明肺心病组血清锌低于对照组(P<0.01),血清铜高于对照组(P<0.01),血清铅亦低于对照组(P<0.05),血清镉、锰、钴、铬两组间无明显差异。指出肺心病患者血清微量元素变化规律对肺心病的诊断,治疗,预后判断有重要意义。     

肺心病患者尿视黄醇结合蛋白测定及临床意义

目的探讨肺心病患者尿视黄醇结合蛋白的变化及临床意义。方法采用酶联免疫法检测24例肺心病患者尿视黄醇结合蛋白(RBP)的变化,并以26例健康体检为对照,同时测定其血尿素氮(BUN)、肌酐(Cr)。结果肺心病患者尿RBP水平较对照组显著升高(p<0.01),其中合并心衰患者较无合并心衰者的尿RBP水平有显著性差异(p<0.01),合并呼吸衰竭患者较无合并呼吸衰竭者的尿RBP水平有显著性差异(p<0.01),其中15例重度呼衰患者血气恢复正常后复查尿RBP有改善。结论肺心病患者确实存在肾功能的损害,动态观察尿RBP水平变化是判断其早期肾功能损害的敏感方法,能够早期发现肺心病患者的肾功能损害及程度。     

肺心病患者血清碱性成纤维细胞生长因子水平的变化及其与肺动脉压的关系

目的　探讨碱性成纤维细胞生长因子 (b FGF)在低氧性肺动脉高压发病中的作用。方法　采用酶联免疫吸附法对具有低氧性肺动脉高压的肺心病患者 2 1例、无低氧性肺动脉高压的慢性阻塞性肺疾病 (COPD)患者 2 3例和 2 4例正常人血清 b FGF水平进行检测 ,以多普勒超声心动仪测定肺心病和 COPD患者的平均肺动脉压 (m PAP)。结果　肺心病组 m PAP水平 (33.33± 7.0 3m m Hg)明显高于 COPD组 (13.13± 2 .34mm Hg) ,P<0 .0 0 1;肺心病组血清 b FGF水平 (6 9.84± 16 .2 9pg/m l)明显高于 COPD组 (43.94± 7.5 7pg/ml)和正常对照组(44 .6 4± 6 .31pg/m l) ,P<0 .0 0 1;肺心病血清 b FGF水平与 m PAP之间呈明显正相关 ,r=0 .730 ,P<0 .0 0 1。结论慢性肺心病患者血清 b FGF水平明显升高 ,可能与其慢性低氧性肺动脉高压的形成有一定的关系。     

肺心病患者血清肌酸磷酸激酶测定的临床意义

The values obtained from the measurement of serum creatine phosphokinase (SCPK) in 70 cases of chronic cor pulmonale in exacerbation and 72 cases in remission were compared with the normal value as measured in 160 healthy adults at the same period. The results showed that the normal value of SCPK was 46.50 +/- 12.71 u/L in male, while 32.51 +/- 10.8 u/L in female. The differences of the values of SCPK in male and female are highly significant statistically (P less than 0.001). Although the values of SCPK were within normal limits (M +/- 2SD) in most patients with chronic cor pulmonale (72.38-84.10%) in this paper, the values of SCPK of some of them (13.60-22.36%) were higher than normal. But in a few of the patients in exacerbation (2.27-5.26%) the SCPK values were lower than normal. The increased activity of SCPK in patients with chronic cor pulmonale may be related to the vigorous movement of the respiratory muscles. While the level of SCPK decreased to extremely low degree may indicate that the respiratory muscles may be excessively fatigue. So we suggest that the levels of SCPK which are markedly higher or lower than normal could be served as an reference index for the excessive activity or fatigue of the respiratory muscles respectively in chronic cor pulmonale.     

肺心病患者甲状腺激素及皮质醇变化的意义

分析６６例慢性肺心病患者甲状腺激素和肾上腺皮质激素水平，慢性肺心病急发期组Ｔ３，Ｔ４均值明显低于缓解期组及正常组；ｒＴ３均值明显高于后二组，ＴＳＨ均值三组相比无显著差异；慢性肺心病急发期组皮质醇明显高于缓解期及正常组。以上变化对肺心病的病情观察和治疗有一定意义。     

Changes of angiotensin II and angiotensin-converting enzyme in cor pulmonale with respiratory failure

Angiotensin II (ATII), angiotensin-converting enzyme (ACE) and plasma renin activity (PRA) were measured by radioimmunoassay and fluorometry in 55 cases of cor pulmonale with type II respiratory failure, 48 healthy people and 46 COPD patients. The results: 1. The concentration of ATII in respiratory failure group was higher than that in the healthy people and in the COPD patients. The activity of ACE was lower and PRA was higher in the respiratory failure group than those in the other groups. 2. ATII in the dead was higher than that in the remittent. 3. After oxygen treatment, ATII of the patients with PaO2 greater than 8.0 kPa was lower than that of the patients with PaO2 less than 8.0 kPa, but ACE and PRA of the former were lower than those of the latter. 4. ATII and ACE of the respiratory failure group were closely related to PaO2. It was concluded that during hypoxemia one of the responses to high ATII in the human body was the decrease of ACE. But both the increase of PRA and the insufficient decrease of ACE in the patients with respiratory failure enhance the concentration of ATII. Also the concentration of ATII was related to the prognosis of the patients, and merely supplying the patient with oxygen cannot restore normal ATII. So, in addition to oxygen treatment, it is significant to inhibit PRA and ACE and use ATII as an indicator while dealing with cor pulmonale with cardiac and respiratory failure.     

肾上腺髓质素在缺氧性肺动脉高压及肺心病患者中变化的观察

目的:探讨肾上腺髓质素(ADM)在肺动脉高压(HPH)和肺心病发病过程中的作用。方法:HPH病人、肺心病急性发作组和缓解组病人与正常对照组者血清ADM含量测定,用组间比较,t检验。结果:HPH组与正常组对照,ADM显著升高(P <0 . 0 0 2 )。肺心病急性发作组及缓解组与正常组对照,ADM均显著升高(P <0 . 0 0 1 )。缓解组与急性发作组比较,ADM显著降低(P <0 .0 0 1 )。结论:ADM参与HPH的形成过程,可能是对肺动脉高压时血液动力学变化的一种反应。肺心病患者ADM升高可能是对肺动脉压的一种主动调节作用,随着病情的缓解,肺动脉压的降低,ADM含量也随之降低。     

肺心病患者甲状腺激素水平的临床观察

采取放射免疫分析法检测了100例肺心病患者甲状腺激素水平,结果表明:①肺心病患者血清T_3、T_4、FT_3、T_3/rT_3均低于对照组,差异有高度显著性(P均<0.001),rT_3高于对照组,差异有显著性(P0.05)。②肺心病不同病期比较:T_3、FT_3在肺心病各组均低于对照组,差异有显著性(P均<0.05),且T_3在发作期、缓解期各组间比较差异均有显著性(P均<0.05);rT_3在肺脑组均高于各组,差异有显著性(P均<0.05);FT_4及TSH肺心病各组间比较差异无显著性(P均>0.05)。结果提示T_3值的降低与病情及预后有关。     

滋养细胞肿瘤患者血清和头发中六种元素含量的变化

本文报告了滋养细胞肿瘤患者血清(36例)和头发(42例)中 Zn、Cu、Fe、Mn、Ca 和 Mg的测定结果。与当地同期正常妊娠者比较,患者血清 Zn 降低,Cu、Cu/Zn 值明显升高,并随病情加重而加剧、随病情好转明显回复;患者头发中 Zn 显著减少、Cu/Zn 值亦明显升高。结果提示:发 Zn 结合血 Zn 的测定。对此病的早期发现和诊断有一定价值;血清 Cu、Zn、Cu/Zn 值结合 Cp、HCG 的测定,可作为病情变化、治疗、预后的依据和参考。患者血清 Mn、发 Mn 均明显高于正常妊娠者,值得注意。     

慢性肺心病病人红细胞免疫功能及血清补体变化

目的　探讨慢性肺心病病人红细胞免疫功能及血清补体变化。②方法　应用免疫黏附花环法和免疫单扩散法 ,对 43例慢性肺心病病人和 41例健康人红细胞免疫功能及血清补体进行检测。③结果　慢性肺心病病人红细胞C3b受体及免疫复合物花环率显著低于正常对照组 (t=11.40 15 ,9.5 0 72 ,P <0 .0 0 5 ) ,补体C5,CINH,BF显著高于正常对照组 (t=2 .45 72～ 5 .6 433,P <0 .0 5 ,0 .0 1) ,补体C1q,C3 ,C4 ,C9与正常对照组比较无显著差异 (t=0 .875 4～ 1.930 0 ,P >0 .0 5 )。慢性肺心病病人红细胞免疫功能改变与低氧有关 (t=3.0 370 ,4.46 32 ,P <0 .0 0 5 )。④结论　红细胞免疫功能及补体改变对慢性肺心病的病理生理过程有一定影响。