MIPPO技术结合锁定接骨板在胫骨远端骨折手术治疗中的应用

目的：总结微创经皮接骨板固定技术（MIPPO）结合胫骨远端锁定加压接骨板（LCP）在治疗胫骨远端骨折中的手术方法和疗效。方法：回顾性分析28例胫骨远端骨折使用胫骨远端内侧锁定加压钢板结合MIPPO 技术内固定治疗的临床资料。结果：28例患者均得到随访6～12个月，骨折均愈合，未出现延迟愈合及不愈合。疗效按Johner-Wruhs评分评定：优20例，良6例，可2例，优良率92.9%。结论：MIPPO技术结合LCP治疗胫骨远端骨折具有手术创伤小，保护骨折端血供，利于骨折愈合和功能恢复。     

微创经皮钢板内固定治疗胫骨Pilon骨折

目的探讨微创经皮钢板内固定（MIPPO）治疗胫骨Pilon骨折的方法和疗效.方法49例胫骨Pilon骨折23例采用微创经皮钢板内固定,26例采用传统切开复位钢板内固定,进行对比研究.结果MIPPO治疗组的手术失血量和并发症较传统钢板内固定治疗组显著减少,骨折愈合更快,踝关节功能恢复更满意.结论微创经皮钢板内固定治疗胫骨Pilon骨折符合生物学内固定要求,降低软组织手术损伤,有利于骨折的愈合和踝关节功能的恢复,是治疗胫骨Pilon骨折的有效方法.     

微创经皮钢板内固定治疗Pilon骨折20例分析

目的探讨微创经皮钢板内固定（MIPPO）技术治疗Pilon骨折疗效。方法采用MIPPO技术治疗20例Pilon骨折;按Euedi—Allgower分型,I型7例,Ⅱ型10例,Ⅲ型3例。11例采用胫骨远端解剖型钢板,9例采用胫骨远端解剖型LCP钢板,4例对内踝空心螺钉固定,16例同时对腓骨骨折固定。术后平均随访时间9个月。结果采用Mazur方法评价踝关节功能：优12例,良8例,优良率100％;无骨折不愈合、内固定失败、切口感染或延迟愈合等并发症发生。结论正确选择手术时机,同时采用MIPPO技术,术中良好复位,治疗Pilon骨折有可靠的疗效。     

微创经皮钢板内固定治疗Pilon骨折20例分析

目的探讨微创经皮钢板内固定(MIPPO)技术治疗Pilon骨折疗效。方法采用MIPPO技术治疗20例Pilon骨折;按Ruedi-Allgower分型,I型7例,II型10例,III型3例。11例采用胫骨远端解剖型钢板,9例采用胫骨远端解剖型LCP钢板,4例对内踝空心螺钉固定,16例同时对腓骨骨折固定。术后平均随访时间9个月。结果采用Mazur方法评价踝关节功能:优12例,良8例,优良率100%;无骨折不愈合、内固定失败、切口感染或延迟愈合等并发症发生。结论正确选择手术时机,同时采用MIPPO技术,术中良好复位,治疗Pilon骨折有可靠的疗效。     

微创经皮钢板内固定治疗胫骨骨折12例分析

目的 评价及比较微创经皮钢板固定技术治疗胫骨骨折的临床疗效.方法 采用微创接骨板同定技术治疗胫骨骨折12例,对其进行分析评定.结果 本组12例患者伤口I期愈合,骨折如期愈合,功能恢复良好,无感染及内同定松动等并发症.结论 用MLPPO技术治疗胫骨骨折,具有手术简便易行、手术损伤小、出血少、手术时间短、骨折固定牢靠、愈合快、不易产生并发症、关节功能恢复良好、易被患者接受等优点,是一种较好的治疗胫骨骨折的方法.     

微创经皮钢板内固定治疗Pilon骨折20例分析

目的 探讨微创经皮钢板内固定(MIPPO)技术治疗Pilon骨折疗效.方法 采用MIPPO技术治疗20例Pilon骨折,按Ruedi-Allgower分型,I型7例,II型10例,III型3例.11例采用胫骨远端解剖型钢板,9例采用胫骨远端解剖型LCP钢板,4例对内踝空心螺钉固定,16例同时对腓骨骨折固定.术后平均随访时间9个月.结果 采用Mazur方法评价踝关节功能:优12例,良8例,优良率100%;无骨折不愈合、内固定失败、切口感染或延迟愈合等并发症发生.结论 正确选择手术时机,同时采用MIPPO技术,术中良好复位,治疗Pilon骨折有可靠的疗效.     

MIPPO技术结合LCP治疗胫骨远端骨折疗效分析

目的 评价微创经皮钢板内固定术(MIPPO)结合锁定加压钢板(LCP)在胫骨远端骨折中的治疗效果.方法 35例胫骨远端骨折患者行微创经皮钢板固定技术,骨折按AO分型:A2型10例,A3型9例,B2型8例,C1型8例.观察手术耗时、术中输血、术后疼痛程度、伤口愈合情况、Mazur评分、骨折愈合时间及并发症.结果 按Mazur评分标准,优20例,良14例,中1例,差0例,优良率97.1%.无伤口感染、皮肤坏死病例.结论 MIPPO技术结合LCP治疗胫骨远端骨折具有创伤小,美观,固定可靠,愈合率高,能最大限度地保护骨折部位血供,促进骨折愈合和患肢功能恢复.     

微创疗法治疗胫骨远端骨折54例临床观察

目的探讨微创经皮钢板固定技术（MIPPO）治疗胫骨远端骨折的方法和临床疗效。方法我院2008年6～12月期间收治胫骨远端骨折30例,采用间接复位,经皮植入AO新型干骺端锁定加压钢板内固定治疗,术后不辅以其它固定,随访观察其临床效果。结果该组患者经治疗后,29例切口达到一级愈合,29例在术后3～6个月骨折愈合,踝关节评分优16例,良20例,总优良率为86.7%。结论 MIPPO治疗胫骨远端骨折具有创伤小、恢复快、可早期进行功能锻炼的优点,是治疗胫骨远端骨折的有效方法。     

微创经皮钢板内固定治疗Pilon骨折

目的:探讨微创经皮钢板内固定(MIPPO)技术治疗Pilon骨折疗效。方法:采用MIPPO技术治疗20例Pilon骨折,其中开放性骨折6例,闭合性骨折14例,按Ruedi-Allgower分型,I型8例,Ⅱ型9例,Ⅲ型3例。术后平均随访时间12个月。结果:采用Mazur方法评价踝关节功能:优11例,良8例,可1例,优良率为95%;无骨折不愈合、内固定失败、切口感染或延迟愈合等并发症发生。结论:正确选择手术时机,同时采用MIPPO技术治疗胫骨远端Pilon骨折,创伤小、并发症少、骨愈合率高,是治疗Pilon骨折的有效方法。     

微创钢板内固定联合锁定加压钢板治疗胫骨远端骨折的临床疗效

目的:探讨微创钢板内固定(MIPPO)联合锁定加压钢板(LCP)治疗胫骨远端骨折的疗效。方法:对38例行MIPPO+LCP治疗胫骨远端闭合性骨折患者的临床资料进行回顾性分析。结果:38例患者均获得随访,随访时间6～18个月。按Johner-Wruhs评分标准评定疗效:优31例,良4例,中3例,差0例,优良率92.1%,患者骨折愈合时间10～20周,所有患者均无畸形愈合、感染、血栓形成等并发症。结论:采用MIPPO+LCP治疗胫骨远端骨折,具有操作简单、固定牢靠、骨折愈合快、功能恢复好及预后整体优良率高等特点,值得临床推广。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.