切开挂线对口引流术对高位复杂性肛瘘患者术后肛门括约肌功能及生活质量的影响

目的研究高位复杂性肛瘘患者应用切开挂线对口引流术对其术后肛门括约肌功能及生活质量的影响。方法选取禹州市人民医院治疗的高位复杂性肛瘘患者74例,按随机数表法分为两组,各37例。予以对照组传统切开挂线术治疗,予以观察组切开挂线对口引流术治疗。统计对比两组术后肛门括约肌功能及手术前后生活质量水平变化。结果术后观察组肛门括约肌功能优良率[94.59%(35/37)]高于对照组[70.27%(26/37)],差异有统计学意义(P<0.05);与对照组相比,观察组术后生活质量评分较高,差异有统计学意义(P<0.05)。结论切开挂线对口引流术可有效改善高位复杂性肛瘘患者肛门括约肌功能,提高其生活质量。     

切开挂线对口引流术治疗高位复杂性肛瘘60例

目的探讨高位挂线对口引流术治疗高位复杂性肛瘘的临床疗效。方法将90例高位复杂性肛瘘患者分为对照组与治疗组,对照组30例,采用低位切开高位挂线术;治疗组60例,采用高位挂线对口引流术。结果两组总有效率比较无显著性差异（P〉0.05）;两组患者在创面愈合时间及术后并发症方面比较,治疗组优于对照组（P〈0.05,P〈0.01）。结论高位挂线对口引流术能明显缩短疗程,降低术后并发症的发生率。     

对口切开旷置垫棉法结合高位松挂线术治疗高位复杂性肛瘘的临床观察

目的:观察对口切开旷置垫棉法结合高位松挂线术治疗高位复杂性肛瘘的临床疗效。方法:将70例高位复杂性肛瘘患者随机分为治疗组和对照组,每组35例。治疗组采用对口切开旷置垫棉法结合高位松挂线术治疗,对照组采用切开挂线术治疗。比较两组患者的治愈时间、住院时间、治愈率及复发情况,评价两组患者的肛门功能。结果:两组患者的治愈率比较,差异无统计学意义(P0.05)。治疗组患者的术后住院时间及皮筋外肛缘创面愈合时间较对照组明显缩短(P0.01)。术后,治疗组患者的肛管最大收缩压高于对照组(P0.05),肛管最长收缩时间长于对照组(P0.05)。结论:对口切开旷置垫棉法结合高位松挂线术治疗高位复杂性肛瘘可较好地保护肛门功能,缩短住院时间和治愈时间,具有微创化治疗的特点。     

切开挂线术治疗高位复杂性肛瘘的效果观察

目的探讨切开挂线术治疗高位复杂性肛瘘的治疗体会.方法60例高位复杂性肛瘘患者随机分为试验组和对照组,各30例.试验组采用切开挂线术,对照组采用切开旷置引流术.记录两组患者手术后疼痛程度,术后肛门功能,并根据观察指标评分标准进行评分.结果试验组和对照组在治愈时间、疼痛程度、肛门功能方面差异有统计学意义.结论挂线法治疗高位复杂性肛瘘,具有疗效好、痛苦小、对术后肛门功能保护好等优点.     

2种手术方式治疗高位肛瘘的疗效比较

目的 比较切开挂线选择性缝合术与切开挂线治疗高位复杂性肛瘘的临床疗效,探讨治疗高位肛瘘较为可靠有效的手术方法。 方法 选择2010年10月—2014年10月在淮南市第一人民医院治疗的高位复杂性肛瘘患者60例,采用数字表法随机分为2组,观察组(30例)采用切开挂线选择性缝合术治疗,对照组(30例)采用切开挂线治疗,比较2组治愈时间、治愈率、肛门功能评分及并发症发生情况。 结果 观察组治愈时间为(22±4) d,对照组治愈时间为(24±5) d,2组治愈时间比较差异有统计学意义(t=3.240,P＜0.01);观察组治愈率为96.7%,对照组治愈率为86.7%,2组治愈率比较差异有统计学意义(χ2=3.857,P＜0.05);观察组术后肛门功能评分为(4.8±1.2)分,对照组术后肛门功能评分为(6.8±1.3)分,2组术后肛门功能评分比较差异有统计学意义(t=2.671,P＜0.01);随访半年,对照组复发4例,观察组无复发,2组均无肛门失禁者。 结论 切开挂线选择性缝合术与切开挂线均可有效治疗高位复杂性肛瘘,与切开挂线比较,切开挂线选择性缝合术治疗高位肛瘘治愈时间短、治愈率高、肛门功能恢复好,是治疗高位肛瘘较好的手术方法之一。肛瘘管道切除缝合加肛瘘主管挂线法用于高位复杂性肛瘘的治疗可获得较好的效果。      

切开双挂线对口引流术治疗蹄铁型肛周脓肿36例临床分析

目的 分析切开双挂线对口引流术治疗蹄铁型肛周脓肿的临床疗效。方法将72例蹄铁型肛周脓肿患者随机分为观察组和对照组,每组各36例,观察组采取“切开双挂线对口引流”术式,对照组采取“放射状多切口挂线引流”术式。对两组近期疗效：术后疼痛、术后排尿、创面明显渗血、创面平均愈合时间及治愈率;远期疗效：肛门湿疹、缺损、排便异常及复发等指标进行观察。结果 观察组与对照组比较,术后疼痛时间、创面愈合时间短,肛门后遗症发生率低（P〈0.05）。术后复发率两组相比统计学无显著差异（P〉0.05）。结论 切开双挂线对口引流术治疗蹄铁型肛周脓肿疗效显著。     

定向挂线法治疗36例高位复杂性肛瘘的疗效分析

目的：探讨定向挂线法与传统切开挂线法治疗高位复杂性肛瘘之疗效对比。方法将该院肛肠中心2013年1月至2013年12月收治的高位复杂性肛瘘患者72例分为对照组和治疗组,每组36例。对照组采用传统切开挂线法,治疗组采取定向挂线法,比较两组术后创面完全愈合时间、住院天数、复发率、疼痛及手术对肛门括约功能的影响情况。结果两组创面完全愈合时间、住院天数和复发情况比较,差异无统计学意义（P＞0．05）;治疗组术后2 d视觉模拟疼痛评分（VAS）与肛门括约功能指标检测,与对照组比较,差异有统计学意义（P＜0．05）。结论定向挂线法相比于传统切开挂线法治疗高位复杂性肛瘘,具有对肛门括约功能影响小和减轻术后疼痛的优势。     

同期多切口切开挂线引流术治疗高位复杂性肛瘘58例临床观察

目的探讨一次性治疗高位复杂性肛瘘手术方式。方法将83例高位复杂性肛瘘患者分为两组,治疗组58例,采用同期多切口切开挂线引流术;对照组25例,采用单侧分期挂线术。结果术后随访半年～6年,两组创面愈合时间、术后并发症差异有统计学意义。结论同期多切口切开挂线引流术治疗高位复杂性肛瘘能明显缩短疗程,降低术后并发症和复发率。     

切开挂线旷置术治疗高位复杂性肛瘘56例疗效观察

为了观察主管切开挂线支管旷置术治疗高位复杂性肛瘘的临床疗效,将56例高位复杂性肛瘘患者随机分为2组,治疗组56例采用主管切开挂线支管旷置术,对照组43例采用传统切开挂线术,术后排便后均以中药熏洗换药。结果显示:治疗组有效率96.4%,对照组有效率93.0%(P0.05)。治疗组患者术后肛门收缩功能明显优于对照组,平均治疗疗程较对照组明显缩短(P0.05)。结果显示,主管切开挂线支管旷置术治疗高位复杂性肛瘘具有治愈率高、痛苦小、疗程短、损伤小等优点。     

移管挂线配合胶管引流术治疗高位复杂性肛瘘80例

目的 明确移管挂线配合胶管引流术治疗高位复杂性肛瘘的优异性.方法 将160例高位复杂性肛瘘患者随机分为治疗组80例,采用"移管挂线配合胶管引流术";对照组80例,采用传统切开挂线引流术进行对比观察.结果 治疗组与对照组显愈率分别为95%和90%,无明显差异,但两组间的创口愈合时间、肛门功能情况、肛门畸形及术后复发率存在显著差异.结论 在治疗高位复杂性肛瘘时,"移管挂线配合胶管引流术"与传统切开挂线引流术相比,具有创伤小、痛苦少、痊愈快、并发症少、复发率低及肛门功能保护好等优点,该术式的应用,使高位复杂性肛瘘的治疗更加安全、有效.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.