原发性卵巢甲状腺肿类癌合并成熟性畸胎瘤临床病理分析

目的探讨原发性卵巢甲状腺肿类癌合并成熟性畸胎瘤的临床病理特征、诊断及鉴别诊断。方法收集原发性卵巢甲状腺肿类癌合并成熟性畸胎瘤3例，观察和分析临床病理组织学及免疫表型特点。结果镜下特点：3例病例均表现为肿瘤由类癌和甲状腺组织混合组成，证实为卵巢甲状腺肿类癌，甲状腺组织显示正常甲状腺组织的形态。成熟性畸胎瘤显示皮脂腺、成熟性鳞状上皮和平滑肌成分。类癌区域与不同大小的滤泡密切混合，肿瘤细胞有相对一致的嗜酸性胞浆、扁平核、“胡椒盐”样染色质，滤泡内充满嗜酸性甲状腺样的胶质，这两种成分有移行，通常是密切混合存在。免疫组化：3例病例的类癌区域的肿瘤细胞均表达synaptophysin，chromogranin A，CD56和CK19；含有胶质的滤泡表达甲状腺球蛋白。所有细胞均不表达calcitonin。结论原发性卵巢甲状腺肿类癌罕见，可能合并成熟性畸胎瘤，具有～定的组织形态学特点，生物学行为中间性，但可能转移甚至致命。     

卵巢成熟性囊性畸胎瘤合并甲状腺肿类癌1例报告

<正>卵巢成熟性囊性畸胎瘤是女性最为常见的生殖细胞肿瘤,但合并甲状腺肿类癌较为罕见,其治疗尚无统一标准。南昌大学第一附属医院2019年11月收治1例卵巢成熟性囊性畸胎瘤合并类癌,且伴有甲状腺成熟性囊性畸胎瘤患者,现对其临床资料进行回顾性分析,报告如下。1 病例资料患者,女,29岁,因"体检发现盆腔肿物1年"于2019年11月23日至本院就诊,B超检查提示双附件区囊实性回声(左侧5.4 cm×2.8 cm, 右侧     

卵巢甲状腺肿11例诊治分析

目的探讨卵巢甲状腺肿患者的临床特征及其治疗与预后。方法回顾性分析东阳市人民医院2006年6月至2019年10月13年间收治的卵巢畸胎瘤1135例,经两位病理科高年资医师重新读片,以卵巢甲状腺肿成分占肿瘤成分50%以上为卵巢甲状腺肿诊断标准,筛选出卵巢甲状腺肿9例和恶性甲状腺肿2例（卵巢甲状腺乳头状癌1例,卵巢高分化滤泡癌1例）,分析其临床资料、影像学检查及治疗与预后。结果9例卵巢甲状腺肿患者经卵巢肿瘤剥离术或附件切除术治疗,随访11～158个月（中位随访时间69个月）均无复发与远处转移;1例卵巢甲状腺乳头状癌伴畸胎瘤患者经子宫全切除+双侧附件切除术,术后随访65个月行左侧甲状腺乳头状癌根治性切除;1例卵巢高分化滤泡癌伴畸胎瘤患者经子宫全切除+双侧附件切除术,术后随访10个月,未见复发与远处转移。结论卵巢甲状腺肿是一种畸胎瘤的单胚层发育,即畸胎瘤中甲状腺组织过度生长,超越其他所有组织或仅有甲状腺组织发育,影像学检查具有一定特征。卵巢甲状腺肿少见且多为良性肿瘤,极少数可进展为恶性甲状腺肿,以甲状腺乳头状癌和滤泡癌最为常见,在临床生物学行为上恶性程度低,外科手术是最佳治疗方式。     

卵巢类癌2例

目的探讨卵巢原发性类癌的临床病理特点。方法对2例2007年1～7月间无锡市妇幼保健院的卵巢原发性类癌病例进行光镜及免疫表型检测,并结合临床病理特征进行分析。结果例1为右卵巢伴有成熟性囊性畸胎瘤的类癌,镜下见囊性区为成熟性畸胎瘤的病变,实性区由排列成岛状、梁状结构的类癌组成。例2为右卵巢粘液性囊腺瘤伴类癌。镜下见囊性区为粘液性囊腺瘤的病变,囊壁增厚区由排列成岛状、梁状及甲状腺肿结构的类癌组成。免疫表型:类癌细胞CKpan、Syn、NSE均阳性;CgA、CD99、Inhibin、ER、PR均阴性。结论卵巢类癌分为岛状型、小梁型、甲状腺肿型、粘液型和混合型。诊断时应注意与转移性类癌、颗粒细胞瘤、Sertoli细胞瘤、分化差的腺癌、卵巢Brener瘤、卵巢粘液性肿瘤、甲状腺髓样癌等鉴别。     

卵巢成熟性囊性畸胎瘤合并甲状腺乳头状癌一例

目的 探讨卵巢成熟性畸胎瘤合并甲状腺乳头状癌治疗方法。方法 回顾性分析1例卵巢成熟性畸胎瘤合并甲状腺乳头状癌患者病例资料并检索相关文献。结果 患者于2020年行腹腔镜下左卵巢肿瘤剥除术,术后病例诊断为卵巢成熟性畸胎瘤合并甲状腺乳头状癌IA期;后补充行保留生育功能的全面分期手术,术后恢复良好,预后良好。结论 本例卵巢成熟性囊性畸胎瘤合并甲状腺乳头状癌患者预后良好,结合文献以提高对该疾病的认识,从而减少漏诊或误诊。     

卵巢囊性成熟性畸胎瘤恶变成鳞形细胞癌临床病理观察

目的探讨卵巢鳞形细胞癌的临床病理特征。方法对1例卵巢囊性成熟性畸胎瘤恶变成鳞形细胞癌的临床、病理和免疫学表型进行观察、分析及文献复习。结果患者临床表现为腹痛。镜下见成熟鳞形细胞与鳞形细胞癌细胞相移行。免疫组化瘤细胞34βE12和CK14阳性,ER、PR、HRE-2均阴性。结论卵巢囊性成熟性畸胎瘤恶变成鳞形细胞癌是一种极其少见的现象。其诊断依赖于组织病理学、免疫组化,并须结合其临床资料。     

卵巢甲状腺肿类癌

目的 探讨卵巢甲状腺肿类癌的诊断及病理组织学特征.方法 对2例卵巢甲状腺肿类癌用常规切片,HE染色,免疫组化染色及光学显微镜观察进行病理分析.结果 肿瘤主要由类癌和甲状腺肿两种成分构成,免组标记类癌细胞NSE、CgA、SYN均为（＋）,滤泡上皮TTF1（＋）.结论 卵巢甲状腺肿类癌是一种单胚层肿瘤且伴有甲状腺滤泡分化的神经内分泌癌.     

卵巢成熟性囊性畸胎瘤恶变临床病理分析及人类乳头瘤病毒检测

目的：分析卵巢成熟性囊性畸胎瘤恶变的临床病理学特征及其与人类乳头瘤病毒感染的关系。方法：回顾性研究了１４例卵巢成熟性囊性畸胎瘤恶变临床及病理学特征,并且应用ＰＣＲ技术对其中７例的瘤体组织及宫颈组织进行了人类乳头瘤病毒检测。结果：１４例卵巢畸胎瘤恶变病例发病年龄为３０～８２岁（平均６１．７岁）,组织学类型包括鳞状细胞癌（１１例）、腺癌、甲状腺乳头状腺癌及甲状腺类癌（各１例）。人类乳头瘤病毒检测没有发现阳性病例。结论：卵巢成熟性囊性畸胎瘤恶变是一种少见的病变,发病年龄以绝经后妇女为主,组织学类型以鳞状细胞癌最为多见,未发现ＨＰＶ感染与其的关系。     

卵巢成熟性囊性畸胎瘤恶变临床病理分析及人类乳头瘤病毒 …

目的：分析卵巢成熟性囊性畸胎瘤恶变的临床病理学特征及其与人类乳头瘤病毒感染的关系。方法：回顾性研究了１４例卵巢成熟性囊性畸胎瘤恶变临床及病理学特征,并且应用ＰＣＲ技术对其中７例的瘤体组织及宫颈组织进行了人类乳头瘤病毒检测。结果：１４例卵巢畸胎瘤恶变病例发病年龄为３０￣８２岁（平均６１．７岁）,组织学类型包括鳞状细胞癌（１１例）、腺癌,甲状腺乳头状腺癌及甲状腺类癌（各１例）。人类乳头瘤病毒检测没有发     

卵巢甲状腺肿类癌临床病理观察

目的探讨卵巢甲状腺肿类癌临床病理特征、鉴别诊断和预后。方法报道我院首例卵巢甲状腺肿类癌的临床资料,作临床病理分析及HE、免疫组织化学染色,并随防。结果巨检示:灰红色结节状肿物,切开呈囊实性,实性区切面呈灰红色,局部区域呈灰黄、灰白色,均质状。镜下示:肿瘤由卵巢成熟性畸胎瘤成分合并有甲状腺组织构成,瘤细胞呈梁状、或岛屿状分布,胞质丰富,核小,染色质均匀,核分裂像不易查见。免疫组化示:滤泡区甲状腺球蛋(TG)、甲状腺转录因子(TTF-1)阳性;类癌区细胞角蛋白(CK)、铬素A(CgA)、突触素(Syn)、神经元特异性烯醇化酶(NSE)均阳性,抑制素(inhibin-a)阴性。结论卵巢甲状腺肿类癌是一种伴有甲状腺滤泡分化的、罕见的低度恶性肿瘤。病变局限于年轻患者,行单侧病变卵巢切除即可;年龄较大者行全子宫加双附件切除,必要时补充化疗,一般预后较好。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.     

Possible Spread of adenovirus type 3 from poultry to humans ：indirect evidence from an outbreak in China

Objective:To explore the epidemiology and etiology for an outbreak of acute respiratory tract infection that occurred in one county of Jiangsu Province, China 2004. Methods: Only cases meeting the case definition were included in the study. We reviewed the medical records of the cases who were admitted to the local hospitals, interviewed cases by a standard questionnaire, and then described the epidemiotogic features and analyzed risk factors by means of a case-control study. We collected pharyngeal swab specimens and sent them to different laboratories for isolation and culture. The laboratory used different detection methods such as DIP, PCR, electron microscope examination and microneutralization assay, to identify and then type the positive specimens. Results:A total of 871 cases were reported during the period from April 18 to July 4,2004. The distribution of onset times presented two peaks, one in late May and another in middle June. The epidemic occurred mainly in the elementary and junior high schools in ten townships of one county, and the mean age of the cases was 12 years (range 7 months to 18 years). The course of the disease was acute, and was characterized by fever accompanied with sore throat and tonsillitis. The WBC count of cases was normal or elevated. The mean duration of illness was 5 days (range 2 to 12 days). No fatalities from illness were reported. A case-control study indicated that the possible risk factors were close contact with a case and/or poultry before onset and sharing of towels among members of the family. The typical CPE was observed through inoculating pharyngeal swab specimens into the HEP-2 cell cultures in different laboratories. An infection of adenovirus type 3 was verified by detecting positive specimens in different methods. Conclusion:This investigation demonstrated that the acute respiratory infection in cases was caused by adenovirus type 3. Cases occurred in over 70 schools in ten townships in 2004, and the route of transmission was possibly close contact with cases or droplet transmission.