吗啡和芬太尼用于剖宫产术后镇痛效果比较

目的 比较吗啡、芬太尼用于子宫下段剖宫产病人术后自控硬膜外镇痛效果比较.方法 选择2005～2006年住院行剖宫产手术患者40例.ASAⅠ-Ⅱ级.随机分为二组,每组20例,A组选用(0.01%吗啡+0.01%氟哌利多+0.01%地塞米松+0.01%布比卡因).B组选用(0.0002%芬太尼).A、B二组均用100ml的PCA泵,以LGP模式(负荷剂量5ml+持续剂量2ml/h+PCA每次0.5ml)进行镇痛.结果1、A组与B组在镇痛效果上无明显差异,(P＞0.05);2、A组恶心、呕吐、皮肤瘙痒、低血压等发生率比B组高(P＜0.01).结论 吗啡、芬太尼用于病人术后自控硬膜外镇痛都可取得满意效果,但芬太尼比吗啡的不良反应少,更适合术后镇痛.     

吗啡和芬太尼用于术后镇痛的比较

目的比较吗啡、芬太尼用于病人自控硬膜外镇痛(PCEA)的镇痛效果及不良反应。方法40例择期手术患者,ASAⅠ～Ⅱ级,随机分为两组,每20例。A组选用0.01%吗啡 0.01%氟哌利多 0.01%地塞米松 0.01%布比卡因;B组选用0.0002%芬太尼代替A组配方中的0.01%吗啡。均用PCA泵(100ml),以LCP模式(负荷剂量5ml 持续剂量2ml/h PCA每次0.5ml)进行镇痛。结果(1)综合镇痛质量,A组与B组无明显差异(P>0.05);(2)A组尿潴留、恶心、呕吐、皮肤瘙痒、嗜睡、低血压等发生率较B组高(P<0.01)。结论吗啡、芬太尼PCEA用于术后镇痛均可取得满意的效果,但芬太尼较吗啡的不良反应少,更适合术后镇痛。     

吗啡和芬太尼用于妇科术后硬膜外镇痛的效果比较

目的观察吗啡、芬太尼用于妇科病人术后硬膜外镇痛（PCEA）的镇痛效果及不良反应。方法80例择期妇科手术患者,ASAI-Ⅱ级。随机分为两组,每组40例。A组选用0．004％吗啡＋0．02％甲氧氯普胺＋0．01％地塞米松＋0．1％罗比卡因;B组选用0．0003％芬太尼代替A组配方中的0．004％吗啡。均用PCA泵（200ml）行PCEA,以LCP模式（负荷剂量A组吗啡1．5mg,B组芬太尼0．05mg均稀释成5ml首次注入,持续输注剂量4ml／h＋PCA每次0．5ml）。结果（1）综合镇痛质量。A组与B组无明显差异（P〉0．05）;（2）A组尿潴留、恶心、呕吐、皮肤瘙痒、嗜睡等发生率较B组高（P〈0．01）。结论吗啡、芬太尼PCEA用于妇科术后镇痛均可取得满意的效果,但芬太尼较吗啡的不良反应明显少。     

吗啡和芬太尼分别用于PCEA术后镇痛的比较

目的　比较吗啡、芬太尼分别用于病人自控硬膜外镇痛 (PCEA)的镇痛效果及不良反应。方法　6 0例择期手术患者 ,ASAⅠ～Ⅱ级 ,随机分为两组 ,每组 30例。A组选用 0 .0 0 5 %吗啡 +0 .0 0 5 %氟哌利多 +0 .187%布比卡因 ;B组选用 0 .0 0 0 5 %芬太尼 +0 .0 0 5氟哌利多 +0 .187%布比卡因。均用PCA泵 (10 0ml) ,以LCP模式 (负荷剂量 0 .5 %布比卡因 5ml+持续剂量 2ml h +PCA每次 0 .5ml)进行镇痛。结果　①A组与B组在镇痛质量方面无明显差异 (P >0 .0 5 ) ;②不良反应如尿潴留、恶心、呕吐、皮肤瘙痒、嗜睡、低血压等的发生率 ,A组较B组高 (P <0 .0 1)。结论　吗啡、芬太尼用于术后止痛均可取得满意的效果 ,但芬太尼较吗啡的不良反应少 ,更适合术后镇痛     

吗啡和芬太尼用于硬膜外术后镇痛的效果比较

目的 比较吗啡、芬太尼用于自控硬膜外镇痛(PCEA)的镇痛效果及不良反应.方法 40例择期下肢手术患者,ASA Ⅰ～Ⅱ级,随机分为两组,每组20例.吗啡组选用0.006 7%吗啡 0.02%胃复胺 0.15%布比卡因,芬太尼组用0.000 4%芬太尼代替吗啡组配方中的0.006 7%吗啡.均用PCA泵(150ml),以LCP模式:负荷量8ml,持续剂量3 ml/h,PCA0.5 ml镇痛.结果 ①综合镇痛质量,两组比较差异无统计学意义(P＞0.05);②尿潴留、恶心、呕吐、皮肤瘙痒、嗜睡、低血压等不良反应发生率吗啡组高于芬太尼组(P＜0.01).结论 吗啡、芬太尼PCEA用于术后镇痛均可取得满意的效果,但不良反应少芬太尼比吗啡,更适合术后镇痛.     

芬太尼复合曲马多用于小儿术后静脉镇痛临床观察

目的观察芬太尼复合曲马多用于小儿术后持续静脉镇痛的效果与安全性。方法ASAⅠ~Ⅱ级60例腹部、四肢手术患儿,随机分为A组和B组,每组30例。于手术结束前10min60例患儿均静脉注射格拉司琼0.1mg/kg,A组选用芬太尼20μg/kg＋格拉司琼0.1mg/kg＋0.9%氯化钠至100ml;B组选用芬太尼10μg/kg＋曲马多10mg/kg＋格拉司琼0.1mg/kg＋0.9%氯化钠至100ml。均静脉连接PCIA泵,持续输注速度2ml/h,PCA0.5ml,锁定时间15min。术后镇痛48h。结果两组均获得满意的镇痛效果,各时点VAS评分无显著性差异（P〉0.05）;各时点镇静评分A组明显高于B组（P〈0.01）;术后嗜睡、尿潴留、皮疹等不良反应发生率A组明显高于B组;两组均无呼吸、循环功能抑制的表现。结论芬太尼、芬太尼加曲马多PCIA用于小儿术后镇痛均取得满意的镇痛效果,但单用芬太尼不良反应发生率高,芬太尼与曲马多复合应用,不良反应明显降低,既提高小儿术后镇痛的安全性,又可达到满意的镇痛效果,是小儿术后良好的镇痛方法。     

剖宫产术后镇痛三种方法的效果比较

目的观察吗啡与芬太尼两种药物的三种不同给药途径对剖宫产术后镇痛效果及副作用的比较。方法ASA1或2级剖宫产术产妇60例分为三组,术后PCIA芬太尼16-18μg/kg＋氟哌利多2.5mg＋生理盐水至100ml,背景输注量2ml/h,单次PCA0.5ml,锁定时间15min,持续镇痛48h（A组）;硬膜外腔推注吗啡2mg＋氟哌利多2.5mg＋NS至5ml（B组）;脊麻用0.75%布比卡因1.7ml中加入吗啡0.2mg共2.7ml（C组）。记录术后4、8、12、24、48h镇痛评分（VAS）,镇静评分及不良反应。结果C组术后4、8、12、24、48h镇静程度明显低于A、B两组;镇痛效果也明显好于A、B两组（P〈0.05）。结论三种镇痛方法用于剖宫产术后镇痛效果都确切有效,但吗啡0.2mg加入脊麻药液的术后镇痛效果更好,镇静程度浅,不良反应发生率高。     

佳苏仑、氟哌利多、吗啡用于硬脊膜外腔术后镇痛的临床观察

目的观察佳苏仑、氟哌利多、吗啡联合用于硬膜外腔病人自控镇痛（PCEA）的镇痛效果及不良反应。方法600例手术患者，ASAⅠ～Ⅱ级，随机分为两组，每组300例。A组选用0．01％吗啡＋0．1％布比卡因。B组在A组基础上增加0．1％佳苏仑＋0．01％氟哌利多。两组均采用PCA泵（100m1），以LCP模式（负荷剂量10ml＋持续剂量2ml／h＋PCA每次0．5m1）进行镇痛。结果（1）综合镇痛质量，A组与B组无明显差异（P〉0．05）；（2）A组呼吸抑制、恶心、呕吐、瘙瘁、嗜睡、低血压等发生率较B组高（P〈0．01）。结论佳苏仑、氟哌利多、吗啡用于硬脊膜外腔病人自控镇痛（PCEA）取得了满意的效果，不良反应少。更适合术后镇痛。     

不同剂量雷莫司琼预防术后静脉镇痛恶心呕吐的临床效果观察

目的比较不同剂量雷莫司琼预防术后静脉镇痛（PCIA）恶心呕吐的临床效果。方法选择ASAⅠ～Ⅱ级手术患者114例,随机分为A、B、C三组,每组38例。A组PCA配方为吗啡10 mg＋芬太尼0.8 mg＋雷莫司琼0.3 mg;B组PCA配方为吗啡10 mg＋芬太尼0.8 mg＋雷莫司琼0.6 mg;C组PCA配方为吗啡10 mg＋芬太尼0.8mg。结果A、B两组患者术后恶心呕吐发生率（5/38例,13.2%;4/38例,10.5%）均低于C组（13/38例,34.2%）且其差异有统计学意义（P〈0.05,P〈0.01）。A组恶心呕吐发生率（5/38例,13.2%）与B组恶心呕吐发生率（4/38例,10.5%）比较差异无统计学意义（P〉0.05）。结论雷莫司琼0.3 mg即可达到预防吗啡和芬太尼术后PCEA恶心呕吐的效果。     

芬太尼复合吗啡用于剖宫产术后硬膜外腔镇痛临床观察

目的通过硬膜外腔芬太尼复合吗啡用于剖宫产术后镇痛的观察，探讨更安全有效的用药方法。方法选择行剖宫产手术产妇200例，分为A组100例，B组100例。PCA泵镇痛液配方，A组为芬太尼0．4mg＋吗啡2mg＋丁卡因100mg＋维生素B121mg，用生理盐水稀释到100ml。B组为吗啡4mg＋丁卡因100mg＋维生素B12 1mg稀释到100ml，镇痛泵输注速度为2ml／h。结果A、B两组镇痛效果均满意，无显著性差异；A组恶心、呕吐发生率少于B组，差异显著（P〈0．01）。结论芬太尼复合吗啡用于剖宫产术后持续硬膜外镇痛是较为理想的术后镇痛方法。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.