合肥地区农民桡骨骨矿含量调查研究

为探讨我国农民骨矿含量正常值,本文采用中国测试技术研究院生产的SPA-Ⅲ型骨密度仪对合肥地区372例标准体重的农民进行测试。发现各组均值男性大于女性,表明正常值须男女分别建立。按10岁分组见男性各组均值在20岁后进入峰值期且持续稳定于40岁以后,表明峰值期长。女性从17岁到29岁为持续无显著性,峰值期在30～39岁。且以后有显著性低落(P<0.05)。讨论认为本文95%正常值下限男性取17～19岁(青春期)和20～49岁(青壮年);女性取17～29岁(青年期)和30～39岁(壮年)的各自(?)—1.645s为合理。     

汕头市广沃开发区小学生头发中五种微量元素的调查分析

作者报告汕头市广沃开发区303名8岁～12岁小学生头发中Pb、Hg、Cd、Zn、AsS种微量元素的调查结果,资料分布全属正偏态。发铅中位数14.66μg/g,发汞中位数为0.7μg/g,发镉中位数为0.13μg/g,发锌中位数为152.5μg/g,发砷中位数为0.65μg/g.并以第95百位数为Pb、Hg、Cd和As的正常值上限,以第2.5和第97.5百分位数为发辞的正常值上下限。广沃区4个乡镇按照正常值界限计算超标率,结果以达濠超标率(5.76％)为高,统计处理差异有高度显著性(x~2=19.656,p<0.005)。     

肺癌病人头发自由基电子自旋共振波谱(ESR)饱和特性研究——139例报道

本文报道用电子自旋共振波谱(ESR)技术测定129例原发性支气管肺癌患者头发自由基的饱合功率特性并与1000例正常人结果比较,发现肺癌患者ESR-SP值大多较低,139例次中除1例为2.5mw以外,其余均在2.5mw以下;无3mw以上病例,81.3％低于2mw,而正常人96.1％在2mw以上。肺癌组的ESR-SP值中位数及95％上下限与正常人差异有极显著性。     

超声估测小儿各年龄组肠系膜淋巴结参考值

目的:超声估测小儿各年龄组肠系膜淋巴结参考值范围,诊断不同年龄组肠系膜淋巴结炎;探讨不同年龄段腹痛组与对照组淋巴结大小是否有差异。方法:高频彩超观察0～14岁小儿肠系膜淋巴结,按年龄分段,设腹痛组与对照组。结果:不同年龄组正常值不同;且0～1岁,1～2岁,7～14岁腹痛组与对照组淋巴结大小无显著性差异(P>0.05);2～7岁腹痛组与对照组淋巴结大小有显著性差异(P<0.05)。结论:超声对诊断2～7岁小儿肠系膜淋巴结炎敏感,临界值下限长径11mm;短径6mm较合适。     

脑出血发病状况及其病死率与死因的临床研究

目的 :揭示脑出血患者年龄、性别分布规律及其病死率、死因与好发部位的临床特点。方法 :对近5年1107例脑出血住院患者临床资料进行统计分析。结果 :<40岁组发病例数较少 ,从40～岁组开始发病例数明显升高 ,至50～和60～岁组达高峰 ,分别为32.70 %和34.51%,与其它各年龄组对比 ,差别有高度显著性 (P<0.01)。男女发病构成比分别为63.69%和36.31 %(P<0.01)。病死率≥70岁组为8.53 %。与其它各年龄组对比 ,差别有高度显著性 (P<0.01)。男女病死率分别为3.40 %和2.99%(P>0.05)。死因中呼吸衰竭占58.33 %(P<0.01)。其好发部位52.66 %(P<0.01)为基底节。结论 :脑出血发病存在年龄、性别的分布规律 ;且年龄越大病死率越高。故对重点人群应积极采取有效的防治措施 ,以期减少或避免脑出血的发病。     

中老年人腰椎骨密度变化的临床观察

目的了解中老年人随着年龄增长骨密度变化规律及骨量减少和骨质疏松患病率。方法用双能X线骨密度测定仪测量40岁以上人群正位腰椎骨密度2 325例,按年龄、性别分组统计。结果男女骨密度值均随年龄增加而逐渐降低。中老年男性骨量减少患病率为42.2%,骨质疏松为37.3%;中老年女性骨量减少为19.8%,骨质疏松为66.5%;50岁以后女性骨质疏松患病率显著高于男性(P<0.05),男性骨量减少患病率显著高于女性(P<0.05)。老年男性骨质疏松患病率为42.3%,女性为79.7%,老年女性骨质疏松患病率显著高于老年男性(P<0.05)。结论随着年龄增长,骨质疏松患病率逐年增加,女性比男性更易患骨质疏松,低骨量是导致骨质疏松骨折的一个重要危险因素。     

300例健康成人心室晚电位分析

本文对300例正常健康成人体表信号叠加心电图检测结果作了分析。判别心室晚电位的三项参数即滤波后总QRS时限(TQRSD);QRS波终末低于40μV的时限(Under 40μV);QRS波终末40ms电压之均方根值(Last40ms)在各年龄组男女性别间差异无显著性(P>0.05)。TQRSD在25、40、80 Hz频响滤波时,60岁以上组与40岁以下组间差异均有极显著性(P<0.001)。TQRSD有随年龄增长而增宽倾向。将本文正常值与国外研究作了对比,提出心室晚电位阳性判别标准。     

贵阳市460例1～3岁幼儿气质特点分析

目的:探讨1～3岁幼儿的气质类型及气质维度特点,为早期干预提供理论依据。方法:采用Carey和McDevitt等人设计,经张劲松等人修订的幼儿气质问卷对在贵阳市儿童医院保健科体检的460名1～3岁幼儿进行气质测评,分别按年龄、性别进行分析。结果:幼儿的气质类型构成比为:易养型50.23%,中间偏易养型22.6%,中间偏难养型15.87%,难养型10.43%,启动缓慢型0.87%。幼儿气质类型在性别、年龄上差异没有显著性(P>0.05)。幼儿气质维度性别上差异没有显著性(P>0.05),活动水平和反应强度随着年龄的增长差异有显著性(P<0.05)。结论:1～3岁婴幼儿气质类型在性别及年龄上无明显差异,且以易养型、中间偏易养型为主。     

不同年龄与性别高血压病患者血脂特点分析

目的:分析不同年龄与性别之间高血压病患者血压和血脂差异,为高血压病患者的防治提供依据。方法:947例高血压患者按入院时年龄大小分为5组;A组89例,为≤50岁;B组128例,为51～60岁;C组302例,为61～70岁;D组342例,为71～80岁;E组86例,为≥81岁。每组按性别分为男、女组,分析各组之间男女患者血压和血脂特点。结果:1随年龄的增长,男女组收缩压(SBP)变化不大,但舒张压(DBP)逐渐减低(均P<0.01)。2总胆固醇(TC)和甘油三酯(TG)在男性逐渐减低(P<0.05～P<0.01),在女性先增加后下降(P<0.05);在每一年龄组,均女性高于男性,B组和C组以后均有显著性意义(P<0.05～P<0.01)。3高密度脂蛋白胆固醇(HDL-C)和载脂蛋白A(apoA)均表现为在每一年龄组女性高于男性。其中HDL-C在C组和D组有显著性意义(P<0.05～P<0.01);apoA为在A组至D组均有显著性意义(均P<0.01)。HDL-C在男性有随年龄先增加而后下降趋势(P>0.05),apoA在女性随年龄增加而下降(P<0.05)。4低密度脂蛋白胆固醇(LDL-C)和载脂蛋白B(apoB)在男女性均先增加,男性在B组达高峰,女性在B组和C组达高峰,以后均逐渐下降;总体上两者均表现为女性高于男性,以C组以后有显著性差异(P<0.05～P<0.01)。5将全部高血压患者按男女两组之分,表现为女性较男性DBP低(P<0.01),各项血脂高(均P<0.01)。结论:高血压病患者随年龄增加,DBP下降,但女性较男性下降更明显,而女性较男性血脂高,血脂高峰男性多在60岁以前,女性多在60岁以后。高峰水平女性较男性晚约10年。     

1738例健康人群QT离散度正常值

目的:调查不同年龄、性别健康人群的QTd正常值。方法:1738例健康人按年龄段15岁一组,分为5组,测量他们的常规12导联ECG的QTd,并计算QTcd、QTrd、JTd,然后再按性别分为两组,分别统计上述参数。结果:各年龄组的QTd平均值(x±s)分别为12.1±13.81、21.8±11.48、22.36±12.21、23.165±11.85、24.47±13.84、除<15岁组有显著差异外,其它各组均无明显差异(P>0.05),QTd95％单侧正常值上限约为40～50ms,8岁以下儿童约为20ms;同时计算QTcd、QTrd、JTd,结果相似。不同性别组的上述参数男性>女性,有统计学意义,但只有2～3ms,临床意义不大。结论:健康人除8岁以下儿童外,QTd随年龄增加稍有增大,但差异不显著,男性QTd值>女性,但差值较小,QTd总的正常值为:平均20～25ms,上限<50ms。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.