拇指桡掌侧动脉为蒂的大鱼际逆行岛状皮瓣修复拇指指腹缺损

目的　介绍应用拇指桡掌侧动脉为蒂的大鱼际逆行岛状皮瓣修复拇指指腹缺损的手术方法。方法　1 996年至 2 0 0 1年 ,共修复拇指指腹缺损 1 5例。皮瓣设计在大鱼际区 ,以拇指桡掌侧动脉为蒂 ,旋转点在指间关节以近。皮瓣面积最小为 1 5cm× 3 0cm ,最大为 3 0cm× 3 .5cm。结果　所有皮瓣全部成活。术后随访半年到 1年 ,指腹外观 ,皮肤弹性、色泽均良好。指腹二点分辨觉为 8～ 1 0mm。结论　拇指桡掌侧动脉逆行岛状皮瓣操作简单、血供可靠 ,是修复拇指指腹软组织缺损的较好方法。     

游离大鱼际穿支皮瓣修复指腹软组织缺损

目的 探讨应用游离大鱼际皮瓣修复指腹软组织缺损的方法和临床效果.方法 对2009年9月至2011年1月收治的13例指腹软组织缺损,应用游离大鱼际皮瓣修复.以桡动脉掌浅支及其构成的血管网为血管蒂重建供血,以正中神经掌皮支或桡神经浅支重建皮瓣感觉.皮瓣切取面积为4.7 cm× 3.0 cm～ 2.0 cm× 2.0 cm.结果 术后2例皮瓣出现血管危象,经对症处理后存活;余11例皮瓣顺利存活.13例均获得随访,时间为3～ 12个月,平均4个月.仅1例皮瓣略显臃肿,经再次整形后臃肿消失;其余皮瓣外观及弹性良好,感觉恢复至S3～S4.结论 以桡动脉掌浅支及其构成的血管网为血管蒂的大鱼际皮瓣,其血管解剖表浅、皮肤穿支丰富、感觉重建满意,是修复指腹中小面积缺损的有效方法.     

拇指桡背侧皮神经营养皮瓣修复拇指皮肤软组织缺损

目的探讨拇指背桡侧皮神经营养血管蒂的岛状皮瓣修复拇指软组织缺损的临床效果。方法对19例拇指软组织缺损患者利用拇指背桡侧皮神经营养血管皮瓣修复,其中修复感觉神经15例。缺损面积：1.5cm×1.0cm～2.5cm×2.5cm;皮瓣面积：2.0cm×1.5cm～3.0cm×2.5cm。结果19例皮瓣全部成活。随访5～30个月,皮瓣外观及感觉良好,指腹两点分辨觉为6～10mm。指间关节活动范围0°～80°。结论该皮神经皮瓣手术操作简单,皮瓣外形好,部分皮瓣能恢复感觉,是修复拇指软组织缺损的理想方法。     

拇指尺背侧动脉逆行岛状皮瓣修复拇指远节软组织缺损

目的应用拇指尺背侧动脉逆行岛状筋膜皮瓣修复拇指远节软组织缺损。方法根据拇指尺背侧动脉的解剖特点,于拇指尺背侧和掌指关节处设计皮瓣,拇指尺背侧距指背正中线1.0 cm的纵行线为皮瓣轴心线。旋转点距甲上皮约2.5 cm处。切取的皮瓣内含拇指尺背侧神经,以便重建感觉。应用该术式修复拇指远节软组织缺损伴骨外露共12例。皮瓣面积3.0 cm×1.5 cm~4.0 cm×2.5 cm。结果皮瓣全部成活。术后12例均得到随访。修复后的指端外观良好,质地柔软、耐磨,无明显触痛,静止两点辨别觉达3.0~5.5 mm。供区无明显并发症。结论此术式不损伤手指主要血管、神经,操作简单,成功率高,重建的指腹感觉恢复满意。     

带血管神经蒂的大鱼际桡侧皮瓣修复拇指指腹缺损

目的介绍一种修复拇指指腹缺损的新皮瓣.方法设计以拇指桡掌侧动脉为蒂并带桡神经浅支分支的大鱼际桡侧逆行岛状皮瓣,修复12例拇指指腹缺损患者.皮瓣最大面积为4 cm × 3.2 cm. 结果所有皮瓣全部成活.术后随访3 ～ 19个月,伤指指腹饱满,外形美观,二点分辨觉平均为6.5 mm. 拇指指间关节和掌指关节的活动范围为81.25°和32.31°.结论以拇指桡掌侧动脉为蒂的大鱼际桡侧皮瓣是修复拇指指腹缺损的理想皮瓣之一.     

同指带指神经血管拇背尺侧岛状皮瓣修复拇指腹缺损

目的探讨拇指指腹缺损的显微修复方法。方法对9例拇指指腹缺损的患者,采用同指带指神经血管拇背尺侧岛状皮瓣移位修复。皮瓣缺损面积为2．0cm×1．5cm～3．0cm×3．0cm。结果 9例皮瓣全部成活,术后随访3～6个月,皮瓣外形满意,质地柔软,弹性好,两点分辨觉达6mm～10mm,拇指屈伸活动良好。结论同指带指神经血管蒂拇背尺侧岛状皮瓣移位,手术方法简单,术后功能、外形满意,是一种修复拇指指腹缺损较理想的术式选择。     

拇指指腹缺损的显微外科修复

目的 探讨含感觉神经的微型皮瓣修复拇指指腹缺损的临床疗效.方法 2000年2月-2010年3月,采用食指背岛状皮瓣、中指侧方岛状皮瓣、以桡侧指动脉为蒂逆行岛状皮瓣、桡动脉掌浅支为蒂的逆行皮瓣、拇指尺背侧动脉逆行皮瓣、拇指背皮神经营养血管皮瓣、第2趾趾腹皮瓣、？？趾甲皮瓣、大鱼际部浅静脉动脉化逆行皮瓣共9种皮瓣修复重建拇指指腹缺损134例.结果 3例皮瓣坏死,131例成活,6个月～1.5年随访108例,皮瓣外形血供充分,质地柔软,感觉测定S2～S4＋,两点辫别觉6～11mm.结论 采用含感觉神经的微型皮瓣修复拇指指腹缺损,对供区影响小、效果佳、为理想的术式选择.     

六种皮瓣修复拇指腹缺损的远期疗效观察

目的评价6种皮瓣修复拇指腹缺损的远期疗效.方法对2001年12月前,在我科接受6种皮瓣修复拇指腹缺损（锁骨下带蒂皮瓣、手指掌侧推进皮瓣、示指背侧皮瓣、带血管神经蒂的大鱼际近端皮瓣及趾腹游离皮瓣）共142例患者,进行了远期随访.随访内容有术后拇指腹色泽、外形、质地、出汗情况、拇指的痛觉、触觉、两点分辨觉、综合质地感觉及运动功能等.结果142例均获得了完整资料.6种皮瓣中,其中锁骨下带蒂皮瓣与示指背侧皮瓣修复的拇指腹,从皮肤色泽、外形、质地、出汗情况等均比其它4种皮瓣差,综合质地感觉优良率也明显低于其它4种皮瓣.结论手指掌侧推进皮瓣、指侧方血管蒂岛状皮瓣、带血管神经蒂的大鱼际近端皮瓣及趾腹游离皮瓣修复拇指腹缺损远期临床效果良好,但指侧方血管蒂岛状皮瓣对手部创伤较大,影响患手美观及供区手指的感觉.     

拇指桡侧逆行筋膜皮瓣修复拇指软组织缺损

目的　介绍拇指桡侧逆行筋膜皮瓣修复拇指软组织缺损的手术方法。方法　 1998年 8月至 1999年 12月 ,对 7例患者用拇指桡侧逆行筋膜皮瓣 ,分别修复拇指指腹、背侧及拇桡侧软组织缺损。皮瓣设计在拇指桡侧 ,以指侧正中线为轴线 ,其蒂部转折点在软组织缺损区以近 0 .5cm～ 1.0cm处。皮瓣面积最大 4.3cm× 3 .0cm ,最小 2 .5cm× 1.5cm。结果　 7例的皮瓣全部成活 ,术后随访 5～ 8个月 ,外形美观 ,质地柔软 ,指腹二点分辨觉 (2 PD)为 7～ 12mm。结论　拇指桡侧逆行筋膜皮瓣具有操作简便、质地良好、血供可靠等优点 ,是修复拇指软组织缺损的较好方法     

四肢带皮神经营养血管蒂岛状皮瓣的临床应用

目的探讨四肢各类型皮神经营养血管蒂岛状皮瓣修复组织缺损的临床效果.方法临床分别应用了5种皮神经营养血管蒂岛状皮瓣修复皮肤、软组织缺损8例的实践.皮瓣最大面积15cm×10cm,最小面积3.5cm×2.5cm.结果8例皮瓣均成活良好,创面Ⅰ期愈合,经6～12月随访,效果满意.结论四肢带皮神经营养血管蒂岛状皮瓣血供可靠,不牺牲主要血管,是修复四肢皮肤软组织缺损的一种好方法.     

Vasopressor hormone response following mesenteric traction during major abdominal surgery

Background : We investigated the vasopressor hormone response following mesenteric traction (MT) with hypotension due to prostacyclin (PGI₂) release in patients undergoing abdominal surgery with a combined general and epidural anesthesia. Methods : In a prospective, randomized, placebo-controlled study we administered 400 mg ibuprofen (i.v.) in 42 patients scheduled for abdominal surgery. General anesthesia was combined with epidural anesthesia (T4-L1). Before as well as 5, 15, 30, 45, and 90 min after MT we recorded plasma osmolality, hemodynamics and measured 6-keto-PGFlα (stabile metabolite of PGI₂), TXB₂ (stabile metabolite of thromboxane A₂) active renin, and arginine vasopressin (AVP) plasma concentrations by radioimmunoassay. Catecholamine levels were assessed by high-pressure liquid chromatography (HPLC) with electrochemical detection. Results : Following MT, arterial hypotension occurred along with a substantial PGI₂ release. This was completely abolished by ibuprofen administration. Although plasma levels of 6-keto-PGF_1α (1133 (708) vs. 60 (3) ng/L, median (median absolute deviation), P=0.0001, placebo vs. ibuprofen) remained significantly elevated, blood pressure was restored within 30 min after MT in the placebo group. At the same point in time plasma concentrations of TXB² (164 (87) vs. 58 (1) ng/L, P=0.0001), epinephrine (46 (33) vs. 14 (6) ng/L, P=0.001), AVP (41 ± (18) vs. 12 (7) ng/L, P=0.0004), and active renin (27 (12) vs. 12 (4) ng/L, P = 0.001) were significantly higher in placebo-treated patients. Conclusion : Under combined general and epidural anesthesia arterial hypotension following MT due to endogenous PGI₂ release is associated with enhanced release of AVP, active renin, epinephrine and thromboxane A₂, presumably contributing to hemodynamic stability within 30 min after MT.     

A comparison of the inhibitory effects of four volatile anaesthetics on the metabolism of chlorzoxazone, a substrate for CYP2E1, in rabbits

Background: Halothane inhibits in vitro and in vivo activity of cytochrome P-450 (CYP) 2E1. There are several fluorinated volatile anaesthetics besides halothane, and most of them are defluorinated by CYP2E1. It is unclear whether other fluorinated anaesthetics inhibit the in vivo activity of CYP2E1.
Methods: We compared the inhibitory effects of therapeutic concentrations of four inhalational anaesthetics, halothane, enflurane, isoflurane, and sevoflurane, on chlorzoxazone metabolism in rabbits receiving artificial ventilation.
Results: All four inhalational anaesthetics decreased arterial blood pressure and increased plasma chlorzoxazone concentration. However, no significant differences in the plasma chlorzoxazone concentration were found between the four anaesthetics. The estimated chlorzoxazone clearance increased after beginning inhalation with all four agents, but no significant difference in clearance was noted between agents.
Conclusions: At therapeutic concentrations, the in vivo inhibitory effect on chlorzoxazone metabolism was similar for all four inhalational anaesthetics examined, even though their chemical characteristics and extent of hepatic metabolism differ considerably.     

A Teaspoon Pump for Pumping Blood with High Hydraulic Efficiency and Low Hemolysis Potential

Abstract: Virtually all blood pumps contain some kind of rubbing, sliding, closely moving machinery surfaces that are exposed to the blood being pumped. These valves, internal bearings, magnetic bearing position sensors, and shaft seals cause most of the problems with blood pumps. The original teaspoon pump design prevented the rubbing, sliding machinery surfaces from contacting the blood. However, the hydraulic efficiency was low because the blood was able to "slip around" the rotating impeller so that the blood itself never rotated fast enough to develop adequate pressure. An improved teaspoon blood pump has been designed and tested and has shown acceptable hydraulic performance and low hemolysis potential. The new pump uses a nonrotating "swinging" hose as the pump impeller. The fluid enters the pump through the center of the swinging hose; therefore, there can be no fluid slip between the revolving blood and the revolving impeller. The new pump uses an impeller that is comparable to a flexible garden hose. If the free end of the hose were swung around in a circle like half of a jump rope, the fluid inside the hose would rotate and develop pressure even though the hose impeller itself did not "rotate"; therefore, no rotating shaft seal or internal bearings are required.     

Microspheres Based Detoxification System: A New Method in Convective Blood Purification

Abstract: A variety of protein-bound or hydrophobic substances, accumulating as a result of pathologic conditions such as exogenous or endogenous intoxications, are removed poorly by conventional detoxification methods because of low accessibility (hemodialysis), insufficient adsorption capabilities (hemosorption), low efficiency (peritoneal dialysis), or economic limitations (high-volume plasmapheresis). Combining advantages of existing methods with microspheric technology, a module-based system was designed. Major operating parameters of the latter can be modified to allow for adjustment to individual clinical situations. An extracorporeal blood circuit including a plasmafilter is combined with a secondary high-velocity plasma circuit driven by a centrifugal pump. Different microspheric adsorbers can be combined in one circuit or applied in sequence. Thus, a prolonged treatment can be tailored using specially designed selective adsorber materials. Comparing this system with existing methods (high-flux hemodialysis, molecular adsorbent recycling system), results from our in vitro studies and animal experiments demonstrate the superior efficiency of substance removal.     

Is the recovery profile of mivacurium independent of the rate of decay of its plasma concentration in patients with normal plasma cholinesterase activity?

Background: The duration of action of muscle relaxants is poorly correlated to the rate of decay of their plasma concentration. The plasma concentration of mivacurium may rapidly decrease below its active concentration because of the extensive hydrolysis of mivacurium. By inflating a tourniquet on one upper limb for 3 min after the administration of atracurium, mivacurium or vecuronium, we studied the influence of the initial decline of their plasma concentration on their effect. Methods: In 50 patients anaesthetised with thiopental, isoflurane and fentanyl, the effect of bolus doses of 0.15 or 0.25 mg . kg^?1 mivacurium (MIV 15, MIV 25), 0.3 or 0.5 mg . kg^?1 atracurium (ATR 30, ATR 50) and 0.06 or 0.1 mg . kg^?1 vecuronium (VEC 06, VEC 10) were measured on both arms (evoked response of the adductor pollicis to train-of-four stimulation every 12 s), a tourniquet being applied on one arm just before and during 3 min after the muscle relaxant bolus. Results: Tourniquet inflation of 3 min almost abolished the neuromuscular effect of mivacurium. In the vecuronium groups and in the ATR 50 group, tourniquet inflation did not modify the maximum degree of depression of the twitch response. Also, the duration of action of vecuronium was unaffected by the tourniquet. In the ATR 30 group, times to return of the twitch response to 25% (duration 25%) and 75% (duration 75%) of control response were significantly shorter in the cuffed arm, 23 min vs 27 min, and 41 min vs 45 min, respectively. In the ATR 50 group, only duration 25% was significantly shorter in the cuffed arm (41 min vs 45 min). Conclusion: The results suggest that the rate of decline of the plasma concentration of mivacurium is so rapid, that a very low and almost clinically ineffective concentration is present as soon as 3 min after its administration. The results also indicate that the recovery from a mivacurium-induced neuromuscular blockade is not influenced by the rate of decay of its plasma concentration in patients with genotypically normal plasma cholinesterase.     

Membranes in Artificial Organs

Abstract: Membrane processes play a pivotal and enabling role in modern replacement therapy for acute and chronic organ failure and in the management of immunologic diseases. In fact, virtually all contemporary extracorporeal blood purification methods employ membrane devices, and the next generation of artificial organs and tissue engineering therapies are almost certain to be similarly grounded in membrane technology. In this short essay, we comment on the similarities and differences among synthetic membranes and their natural counterparts and also provide a critical overview of the demographics and technology of hemodialysis, hemofiltration, apheresis, oxygenation, and emerging membrane technologies and applications.     

Tissue perfusion in relation to cardiac output during continuous positive-pressure ventilation and administration of propranolol or verapamil

Background : Our objective was to determine whether administration of propranolol or verapamil modifies the hemodynamic adaptation to continuous positive-pressure ventilation (CPPV), in particular the regional distribution of cardiac output (CO).
Methods : General hemodynamics and regional blood flows assessed by microsphere technique (15 (μm) were recorded in 16 anesthetized pigs during spontaneous breathing (SB) and CPPV with 8 cm H₂O end-expiratory pressure (CPPV8) before and after intravenous administration of propranolol (0.3 mg · kg⁻¹ followed by 0.15 mg · kg⁻¹ · h⁻¹, n=8) or verapamil (0.1 mg · kg⁻¹ followed by 0.3 mg · kg⁻¹ · h⁻¹, n=8).
Results : CPPV8 depressed CO by 25% without shifts in its relative distribution with the exception of a noteworthy increase in adrenal perfusion. Propranolol increased arterial blood pressure, and due to a fall in heart rate, CO dropped by 25%. The kidneys and, to a lesser extent, the splanchic region and central nervous system received increased fractions of the remaining CO at the expense of skeletal muscle flow. Similar patterns were seen during SB and CPPV8 such that the combination of propranolol and CPPV8 depressed CO by 50%. The circulatory effects of verapamil were less evident but myocardial perfusion tended to increase.
Conclusions : The combination of propranolol or verapamil with CPPV does not result in any specific hemodynamic interaction in anesthetized pigs, except that the combined effect of propranolol and CPPV may severely reduce CO.     

Volatile anaesthetics reduce adhesion of blood platelets under low-flow conditions in the coronary system of isolated guinea pig hearts

Background : Inhibitory effects of volatile anaesthetics on platelet aggregation have been demonstrated in several studies. However, the influence of volatile anaesthetics on intracoronary platelet adhesion has not been elucidated so far.
Methods : Isolated hearts of guinea pigs were perfused with buffer in the absence or presence of volatile anaesthetics (0.5 and 1 MAC) at constant coronary flow rates of 5 ml/min for 25 min, then 1 ml/min for 30 min and again 5 ml/min for 10 min. Before, during and after low-flow perfusion, a bolus of human platelets was applied into the coronary system. To simulate thrombogenic conditions, 0.3 U/ml human thrombin was infused during low-flow perfusion and reperfusion. The number of platelets sequestered to the endothelium was calculated from the difference between coronary in- and output of platelets. The myocardial production of lactate and consumption of pyruvate and coronary perfusion pressure were also determined.
Results : At a flow rate of 5 ml/min only about 3% of the applied platelets did not emerge from the coronary system, in any group. In contrast, 13.1±1.2% (mean±SEM) of infused platelets became adherent in low-flow perfusion in the control group without anaesthetic. The adherence was reduced with each 1 MAC isoflurane (to 6.2±1.2%), sevoflurane (to 4.4±0.9%) or halothane (to 3.2±1.5%) (each P <0.05 vs. control). Volatile anaesthetic, 0.5 MAC, did not inhibit platelet adhesion to a statistically significant extent in any case. Perfusion pressure and metabolic parameters were not statistically different between the control and the hearts exposed to anaesthetics.
Conclusion : Volatile anaesthetics in a concentration of 1 MAC can reduce the adhesion of platelets in the coronary system under reduced flow conditions. This action does not arise from vasodilation or inhibition of ischaemic stress.     

Bariatric Surgery in Some "Central and East-European (former Eastern bloc)"Countries - Current Status and Prediction for the Next Millennium

Background: Obesity is increasing globallly, including in the formerly "Eastern Bloc" countries. Methods: A survey was made of obesity and bariatric surgery. Results: In the 8 East and Central European countries studied, with total population 300 million, roughly 43% of the population was overweight (BMI 25-30), 23% obese (BMI > 30), with about 15 million people morbidly obese (BMI > 40). From 0-10 morbidly obese individuals/100,000/year undergo bariatric surgery. Conclusion: Most countries were found to provide inadequate treatment for obesity.The majority of the morbidly obese are not treated effectively. However, health-care awareness of obesity and bariatric surgeons are slowly increasing.     

Dilemma of Membrane Biocompatibility and Reuse

Abstract: Numerous articles have been published on the multiple use of dialyzers and on the effect of different reprocessing chemicals and techniques on the dialyzer biocompatibility and performance. The results often appear contradictory, especially those comparing standard biocompatibility parameters. Despite this confusion, a discerning review of the published works allows certain limited conclusions to be drawn. Reprocessing of used hemodialyzers changes the biocompatibility profile of a dialyzer as defined by the parameters complement activation. leukopenia, and cytokine release. The effect of reprocessing depends on the chemicals and reprocessing technique applied and also on the type of membrane polymer being subjected to the reprocessing procedure. Reports of pyrogenic reactions indicate that the flux of the membrane also influences how suitable it is for safe reuse. An increased risk of allergic and pyrogenic reactions appears to be associated with dialyzer reuse. Furthermore, there has been a lack of investigations into the immunologic effect of the layer of adsorbed and chemically altered proteins that remains on the inner surface of reprocessed dialyzers. We conclude that the clinical benefit of dialyzer reuse cannot be generally accepted from a biocompatibility point of view.