全文获取类型
收费全文 | 1731篇 |
免费 | 25篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 25篇 |
妇产科学 | 11篇 |
基础医学 | 237篇 |
口腔科学 | 14篇 |
临床医学 | 129篇 |
内科学 | 232篇 |
皮肤病学 | 25篇 |
神经病学 | 381篇 |
特种医学 | 207篇 |
外科学 | 146篇 |
综合类 | 18篇 |
预防医学 | 56篇 |
眼科学 | 24篇 |
药学 | 154篇 |
中国医学 | 1篇 |
肿瘤学 | 90篇 |
出版年
2023年 | 12篇 |
2022年 | 7篇 |
2021年 | 9篇 |
2020年 | 6篇 |
2019年 | 9篇 |
2018年 | 14篇 |
2017年 | 21篇 |
2016年 | 19篇 |
2015年 | 22篇 |
2014年 | 23篇 |
2013年 | 46篇 |
2012年 | 109篇 |
2011年 | 116篇 |
2010年 | 58篇 |
2009年 | 55篇 |
2008年 | 150篇 |
2007年 | 129篇 |
2006年 | 136篇 |
2005年 | 142篇 |
2004年 | 143篇 |
2003年 | 131篇 |
2002年 | 140篇 |
2001年 | 18篇 |
2000年 | 14篇 |
1999年 | 32篇 |
1998年 | 25篇 |
1997年 | 25篇 |
1996年 | 15篇 |
1995年 | 8篇 |
1994年 | 13篇 |
1993年 | 10篇 |
1992年 | 6篇 |
1991年 | 4篇 |
1990年 | 6篇 |
1989年 | 5篇 |
1988年 | 5篇 |
1987年 | 7篇 |
1985年 | 5篇 |
1983年 | 3篇 |
1980年 | 9篇 |
1975年 | 2篇 |
1974年 | 3篇 |
1973年 | 6篇 |
1972年 | 2篇 |
1971年 | 2篇 |
1970年 | 3篇 |
1964年 | 3篇 |
1963年 | 2篇 |
1956年 | 3篇 |
1954年 | 4篇 |
排序方式: 共有1758条查询结果,搜索用时 125 毫秒
1.
Michels Guido Horn Rudolf Helfen Andreas Hagendorff Andreas Jung Christian Hoffmann Beatrice Jaspers Natalie Kinkel Horst Greim Clemens-Alexander Knebel Fabian Bauersachs Johann Busch Hans-Jörg Kiefl Daniel Spiel Alexander O. Marx Gernot Dietrich Christoph F. 《Der Anaesthesist》2022,71(4):307-310
Die Anaesthesiologie - 相似文献
2.
Bartz Hans-Jürgen 《Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz》2022,65(3):293-301
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz - Das klinische Risikomanagement (kRM) unterstützt Mitarbeitende im Gesundheitswesen dabei, Risiken bei der... 相似文献
3.
Julia M. Kröpfl Fernando G. Beltrami Markus Rehm Hans-Jürgen Gruber Ingeborg Stelzer Christina M. Spengler 《Journal of Science and Medicine in Sport》2021,24(7):689-695
ObjectivesRegular physical exercise is known to protect endothelial integrity. It has been proposed that acute exercise-induced changes of the (anti-)oxidative system influence early (glycocalyx shedding) and sustained endothelial activation (shedding of endothelial cells, ECs) as well as endothelial-cell repair by circulating hematopoietic stem and progenitor cells (HPCs). However, results are not conclusive and data in trained participants performing different exercise modalities is lacking.DesignEighteen healthy, well-trained participants (9 runners, 9 cyclists; age: 29.7 ± 4.2 yrs) performed a strenuous acute exercise session consisting of 4 bouts of 4-min high-intensity with decreasing power profile and 3-min low-intensity in-between.MethodsAverage power/speed of intense phases was 85% of the peak achieved in a previous incremental test. Before and shortly after exercise, total oxidative and antioxidative capacities (TAC), shedding of syndecan-1, heparan sulfate, hyaluronan, ECs, and circulating HPCs were investigated.ResultsTAC decreased from 1.81 ± 0.42 nmol/L to 1.47 ± 0.23 nmol/L post-exercise (p = 0.010) only in runners. Exercise-induced early and sustained endothelial activation were enhanced post-exercise- syndecan-1: 103.2 ± 63.3 ng/mL to 111.3 ± 71.3 ng/mL, heparan sulfate: from 2637.9 ± 800.1 ng/mL to 3197.1 ± 1416.3 ng/mL, both p < 0.05; hyaluronan: 84.3 ± 21.8 ng/mL to 121.4 ± 29.4 ng/mL, ECs: from 6.6 ± 4.5 cells/μL to 9.5 ± 6.2 cells/μL, both p < 0.01; results were not different between exercise modalities and negatively related to TAC concentrations post-exercise. HPC proportions and self-renewal ability were negatively, while EC concentrations were positively associated with circulating hyaluronan concentrations.ConclusionsThese results highlight the importance of the antioxidative system to prevent the endothelium from acute exercise-induced vascular injury – independent of exercise modality – in well-trained participants. Endothelial-cell repair is associated with hyluronan signaling, possibly a similar mechanism as in wound repair. 相似文献
4.
Angela Rosenbohm Jan Kassubek Patrick Weydt Nicolai Marroquin Alexander E. Volk Christian Kubisch Hans-Jürgen Huppertz Markus Weber Peter M. Andersen Jochen H. Weishaupt Albert C. Ludolph 《Journal of neurology》2014,261(2):283-290
A recent staging effort for amyotrophic lateral sclerosis (ALS) has demonstrated that the TDP-43 neuropathology may initiate focally in the motor cortex in the majority of patients. We searched our data bank for patients with lesions of the motor cortex which preceded disease onset. We performed a search of our patient- and MRI-data bank and screened 1,835 patients with amyotrophic lateral sclerosis for frontal lobe/motor cortex lesions. We found 18 patients with definite ALS who had documented and defined lesions of the motor cortex, which preceded the initial ALS symptoms by 8–42 years. In the vast majority (15/18) of the patients, the onset of ALS was closely related to the focal lesion since it started in a body region reflecting the damaged cortical area. The findings suggest that initial lesions to the motor cortex may be a contributing initiating factor in some patients with ALS or determine the site of onset in individuals pre-disposed to ALS. 相似文献
5.
Gerwin A. Bernhardt Gerald Gruber Benjamin S. Molderings Herwig Cerwenka Mathias Glehr Christian Giessauf Peter Kornprat Andreas Leithner Hans-Jörg Mischinger 《Surgical endoscopy》2014,28(2):439-446
Background
Sportsmen’s groin (SG) is a clinical diagnosis of chronic, painful musculotendinous injury to the medial inguinal floor in the absence of a groin hernia. Long-term results for laparoscopic inguinal hernia repair, especially data on health-related quality of life (HRQOL), are scant and there are no available data whatsoever on HRQOL after SG. The main goal of this study was to compare postoperative QOL data in the long term after transabdominal preperitoneal hernioplasty (TAPP) in groin hernia and SG patients with QOL data of a normal population.Methods
This study included all patients (n = 559) who underwent TAPP repair between 2000 and 2005. Forty seven patients (8.4 %) were operated on for SG. We sent out the Short Form 36 Health Survey (SF-36) questionnaire for QOL evaluation. QOL data were compared with data from an age- and sex-matched normal population.Results
Ultimately, 383 completed questionnaires were available for evaluation (69 % response rate). The mean follow-up time was 94 ± 20 months. In the SG group there were statistically significant differences in three subscales of the SF-36 and the mental component summary measure, showing better results for the SG group compared to the sex- and age-matched normal group data. There were no statistically significant differences between groin hernia patients and the sex- and age-matched normal population.Conclusion
TAPP repair for SG as well as groin hernia results in good HRQOL in the long term. Results for SG patients are comparable with QOL data of a normal population or even better. 相似文献6.
Jens Hoeppner Birte Kulemann Garbriel Seifert Goran Marjanovic Andreas Fischer Ulrich Theodor Hopt Hans-Jürgen Richter-Schrag 《Surgical endoscopy》2014,28(5):1703-1711
Background
Anastomotic leakage of esophagogastric and esophagojejunal anastomoses is a severe complication after esophagectomy and gastrectomy associated with a high mortality. We conducted this non-randomized observational study to evaluate the outcomes and clinical effectiveness of covered self-expanding stents (CSESs) in treating esophageal anastomotic leakage.Methods
From 2002 to 2013, consecutive patients with anastomotic leakage after esophagogastrostomy or esophagojejunostomy who received CSESs were analyzed concerning leakage characteristics, leakage sealing rate, success and failure rates of CSES treatment, stent-related complications, and mortality.Results
In 35 patients, anastomotic leakage originating from 5 cervical esophagogastrostomies, 6 thoracic esophagogastrostomies, 12 mediastinal esophagojejunostomies and 12 abdominal esophagojejunostomies were treated with 48 CSESs (16 fully CSES, 32 partially CSES). Of 35 patients, 24 received one stent, 9 received two consecutive stents, and 2 received three consecutive stents. Stent-related complications occurred in 71 % of patients (25/35). The most frequent complications were leakage persistence (44 %) and stent dislocation (19 %). Sealing of the anastomotic leakage was achieved in 24 (69 %) patients after a median (range) stenting time of 19 (1–78) days. Sealing rates differed significantly with 20 % (cervical esophagogastrostomies), 50 % (thoracic esophagogastrostomies), 92 % (mediastinal esophagojejunostomies) and 67 % (abdominal esophagojejunostomies) of patients (p = 0.023). Moreover, clinical success rates differed among these groups (60 vs. 67 vs. 92 vs. 58 %; p = 0.247). Clinical failure of stent treatment was more likely to be recognized in early postoperative leakage (median postoperative day 3 vs. 8; p = 0.098) compared with successful treatment, whereas no difference for clinical success rates was found comparing leakage ≤10 versus >10 mm (68 vs. 64 %; p = 0.479).Conclusion
CSESs are an effective treatment for anastomotic leakage in patients with esophagogastrostomies and esophagojejunostomies. Best results can be achieved in patients with anastomotic leakages following mediastinal esophagojejunostomy, and in leakages occurring after the very early postoperative phase. 相似文献7.
Alexander Stahl Hinrich Wieder Morand Piert Hans-Jürgen Wester Reingard Senekowitsch-Schmidtke Markus Schwaiger 《Molecular imaging and biology》2004,6(4):214-224
Growing knowledge of the molecular mechanisms of oncological disease plays a key role in the improvement of prevention, diagnosis and treatment of malignant tumors. In this review, positron emission tomography (PET) is described as a mediator between molecular oncological research and clinical management of tumor patients. The most promising applications of PET in the near future include tumor imaging with newly developed tracers for diagnosis, staging and grading purposes, therapy monitoring with proliferation and apoptosis markers and definition of the tumor environment (e.g. hypoxia, neoangiogenesis) prior to therapy. Many of these applications will greatly benefit from the use of integrated PET/CT due to its precise spatial and morphological assignment of functional information. In conclusion, PET is both capable and necessary for the transference of new biological knowledge to clinical practice. Thus, PET constitutes a strong basis for an advanced and individually tailored approach to tumor patients. 相似文献
8.
Repression of cytochrome P450 activity in human hepatocytes in vitro by a novel hepatotrophic factor, augmenter of liver regeneration 总被引:6,自引:0,他引:6
9.
Pauls S Fischer AC Brambs HJ Fetscher S Höche W Bommer M 《European journal of radiology》2012,81(5):974-978