美沙拉嗪+益阳愈溃汤治疗溃疡性结肠炎的临床效果评价

目的探讨美沙拉嗪+益阳愈溃汤治疗溃疡性结肠炎的临床效果评价。方法选取2015年5月至2015年7月在我院消化科治疗的160例溃疡性结肠炎的患者作为研究对象,随机分为观察组和对照组各80例。对照组给予美沙拉嗪治疗;观察组患者实施美沙拉嗪+益阳愈溃汤治疗。比较两组患者的临床用药效果。结果观察组临床症状、体征消失时间短于对照组,观察组治疗有效率明显优于对照组,观察组不良反应发生率明显低于对照组,(P0.05)。结论美沙拉嗪+益阳愈溃汤治疗溃疡性结肠炎疗效显著,十分安全有效,值得在临床上进一步应用。     

美沙拉嗪联合益生菌治疗溃疡性结肠炎的疗效及其对炎性因子、应激蛋白和氧化应激水平的影响

目的 探讨美沙拉嗪联合双歧杆菌三联活菌治疗溃疡性结肠炎的疗效及其对炎性因子、应激蛋白和氧化应激水平的影响。方法 选取2013年2月~2015年4月间于笔者医院消化内科诊治的溃疡性结肠炎128例为研究对象,采用数字表法随机将患者分为美沙拉嗪组（单独组）和美沙拉嗪+双歧杆菌三联活菌（联合组）,每组各64例。分别比较两组患者的疗效及其炎性因子、应激蛋白和氧化应激水平的变化。结果 治疗结束后,联合组的治疗有效率为92.19%（59/64）,显著高于单独组的78.13%（50/64）（χ²=5.006,P=0.025）;两组患者炎性因子IL-6、IL-8和TNF-α水平的水平逐渐降低（P<0.05）;IL-10和HSP70的水平逐渐升高（P<0.05）;MDA含量降低,GSH-Px和SOD活性明显升高（P<0.05）;重要的是联合组患者的炎性因子、氧化应激和热休克蛋白70水平的改善程度均明显优于单独组（P<0.05）。结论 美沙拉嗪联合双歧杆菌三联活菌治疗溃疡性结肠炎的疗效良好,且能降低氧化应激和炎症水平,增加HSP70表达水平,更有利于溃疡性结肠炎患者的恢复。     

美沙拉嗪肠溶片联合中药保留灌肠治疗远端活动期轻中度溃疡性结肠炎的临床观察

目的:为观察美沙拉嗪肠溶片联合中药保留灌肠治疗远端活动期轻中度溃疡性结肠炎的临床疗效.方法:将60例远端活动期轻中度溃疡性结肠炎患者随机分为两组:每组30例,对照组给予美沙拉嗪肠溶片口服,实验组在对照组基础上加用中药保留灌肠,疗程均为28天.观察治疗前后的临床症状改善及结肠镜下炎症缓解情况.结果:两组患者症状及肠镜检查结果均较治疗前改善,实验组疗效优于对照组.结论:美沙拉嗪肠溶片联合中药保留灌肠治疗远端活动期轻中度溃疡性结肠炎疗效优于单纯使用美沙拉嗪片,值得临床推广使用.     

思连康联合美沙拉嗪治疗轻中度溃疡性结肠炎的疗效分析

目的观察思连康联合美沙拉嗪治疗轻中度溃疡性结肠炎的临床疗效。方法将78例轻中度活动期溃疡性结肠炎(UC)患者随机分为治疗组和对照组,每组39例,治疗组在口服美沙拉嗪的基础上,同时口服思连康。对照组口服美沙拉嗪治疗。治疗6周后评价两组患者临床症状、疾病活动指数变化及结肠镜下分级积分。结果治疗后两组临床症状均有改善,治疗组粘液脓血便改善情况显著优于对照组,差异有统计学意义(P0.05)。治疗后治疗组Sutherland疾病活动指数、内镜下评分治疗效果较治疗前明显改善,差异有统计学意义(P0.05),且治疗组治疗前后变化较对照组更显著。结论思连康联合口服美沙拉嗪治疗轻中度UC近期疗效明显优于单独口服美沙拉嗪,且有较好的安全性。     

中药益气清肠汤治疗重症溃疡性结肠炎的疗效观察

目的:观察中药益气清肠汤治疗重症溃疡性结肠炎的疗效。方法:选取重症溃疡性结肠炎患者62例,依据治疗方法不同分为对照组和观察组各31例,对照组采用双岐杆菌三联活菌肠溶胶囊联合美沙拉嗪肠溶片治疗,观察组在对照组基础上加用中药益气清肠汤治疗,比较两组临床疗效、中医症状积分、炎症因子和随访结果。结果:治疗后观察组临床疗效、中医症状积分和细胞因子水平均优于对照组(P<0.05);观察组复发率低于对照组(P<0.05)。结论:在双岐杆菌三联活菌肠溶胶囊联合美沙拉嗪肠溶片治疗基础上,加用中药益气清肠汤治疗重症溃疡性结肠炎的疗效优于单纯双岐杆菌三联活菌肠溶胶囊联合美沙拉嗪肠溶片治疗疗效。     

培菲康联合美沙拉嗪治疗轻中度溃疡性结肠炎的临床疗效观察

目的评价培菲康联合美沙拉嗪治疗轻、中度溃疡性结肠炎(UC)的临床疗效及作用机制。方法选取活动期轻、中度UC患者60例,随机分成2组。联合用药组(n=30),采用培菲康联合美沙拉嗪治疗;美沙拉嗪组(n=30),单用美沙拉嗪治疗,疗程为8周。于治疗前后评估临床症状及结肠镜下病变活动性,并取结肠黏膜活检,免疫组织化学染色检测两组患者用药前后NF-κB的表达。结果治疗后联合用药组临床症状和结肠镜下病变活动性较美沙拉嗪组明显改善(P<0.05),患者结肠黏膜NF-κB表达亦明显低于美沙拉嗪组(P<0.05)。结论培菲康联合美沙拉嗪治疗活动期轻、中度UC较单用美沙拉嗪效果好,其机制可能是通过抑制NF-κB而起到治疗作用的。     

双歧杆菌三联活菌联合美沙拉嗪治疗溃疡性结肠炎效果分析

目的 探讨双歧杆菌三联活菌联合美沙拉嗪治疗溃疡性结肠炎的临床效果.方法 选取2014年—2015年我院治疗的溃疡性结肠炎患者96例平均分为2组,对照组单纯采用美沙拉嗪肠溶片进行治疗,观察组采用双歧杆菌三联活菌联合美沙拉嗪进行治疗,治疗结束后统计分析2组患者的治疗效果.结果 观察组患者临床总有效率与对照组相比明显升高,差异具有显著性(P<0.05).结论 双歧杆菌三联活菌联合美沙拉嗪治疗溃疡性结肠炎疗效显著,有利于改善患者的预后,值得临床推广应用.     

益生菌联合美沙拉嗪治疗溃疡性结肠炎的临床疗效观察

目的:评价益生菌联合美沙拉嗪对溃疡性结肠炎的临床疗效。方法:选择58例轻中度溃疡性结肠炎患者,随机分成治疗组和对照组,治疗组应用益生菌联合美沙拉嗪,对照组单用美沙拉嗪,治疗4周,4周后观察治疗前后肠镜和血清C-反应蛋白变化,分别统计两组完全缓解、有效例数及有效率,随访6个月统计复发病例数及复发率。结果:治疗组有效率高于对照组且有统计学意义,治疗组复发率低于对照组且有统计学意义。结论:在轻中度溃疡性结肠炎治疗中,联合应用美沙拉嗪和益生菌比单用美沙拉嗪治疗临床疗效好,并有效预防复发。     

美沙拉嗪单独和联合糖皮质激素治疗溃疡性结肠炎临床对照研究(英文)

目的:美沙拉嗪和糖皮质激素是治疗溃疡性结肠炎的常用药物,本文的目的是通过研究单独使用美沙拉嗪或联合糖皮质激素治疗溃疡性结肠炎的临床对照研究。方法:通过研究2003～2008年郑州大学第二附属医院的68例溃疡性结肠炎轻度-中度患者,随机分为两组。每组患者为34例,平均年龄分别为47.10,44.12岁。其中一组患者单独使用美沙拉嗪3 g/d,Tid,4 w;另一组患者使用美沙拉嗪3 g/d,Tid和糖皮质激素(氢化考的松200 mg,i.v.gtt 3～7 d后,改为口服的泼尼松30 mg/d),4 w。治疗前后通过Trueloveand Witts病理诊断和分级参照标准进行临床治疗评估。结果:68名患者用药4 w后,单独使用美沙拉嗪的34例患者有70.58%得到了完全缓解;另外使用美沙拉嗪和糖皮质激素的34例患者有88.23%完全缓解。通过临床试验发现美沙拉嗪联合糖皮质激素组缓解率明显高于单独使用美沙拉嗪组(P<0.05);并且明显减少了脓血便次数(P<0.05)。结论:通过美沙拉嗪和糖皮质激素联合应用更有效的提高溃疡性结肠炎活动期缓解率,减少临床症状。     

复方安肠液联合美沙拉嗪治疗轻中度溃疡性结肠炎的效果观察

目的：观察自制院内制剂复方安肠液联合美沙拉嗪治疗轻中度溃疡性结肠炎(UC)的临床效果。方法：选取98例轻中度溃疡性结肠炎患者，按照随机数字表法分为观察组和对照组，每组各49例,观察组给予复方安肠液联合美沙拉嗪治疗，对照组单用美沙拉嗪治疗。观察两组改良的Mayo评分、结肠内镜下评分、超敏C反应蛋白(hs-CRP)水平及相关不良反应。结果：治疗后，观察组改良的Mayo评分、结肠内镜下评分和超敏C反应蛋白(hs-CRP)水平均低于对照组(P<0.05),治疗过程中两组均未出现明显临床不良反应。结论：复方安肠液联合美沙拉嗪治疗轻中度UC,能有效抑制UC的炎性反应，改善患者临床症状，治疗效果显著，安全性高。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.