Pilon骨折的手术治疗体会

目的:回顾性分析治疗Pilon骨折的最佳手术时机、适宜手术方法及其术后疗效。方法:对2004~2008年接受手术治疗的50例单侧Pilon骨折患者进行随访,平均年龄36.5岁。骨折类型:Ⅰ型4例、Ⅱ型36例、Ⅲ型10例。其中40例行切开复位胫骨远端解剖型钢板内固定;10例行有限切开内固定并辅以外固定,其中应用单臂外固定架者3例,应用石膏托外固定者7例。术后平均随访16个月。结果:采用Mazur评分系统评估手术疗效,50例患者中,优41例,良7例,可2例。术后并发症包括创面不愈合1例,感染1例,延迟愈合1例和关节退行性变5例。结论:根据皮肤软组织条件正确选择手术时机,根据骨折类型选择适当固定方式是取得良好手术效果的关键。     

手术治疗Pilon骨折临床体会

目的：探讨Pilon骨折的适宜手术方法、最佳手术时机及其手术疗效。方法：对19972007年接受手术治疗的48例Pilon骨折患者进行随访,根据Ruedi-Allgower分型：I型4例、Ⅱ型32例、Ⅲ型12例。48例手术患者中37例行切开复位三叶型或胫骨远端钢板内固定,11例行有限切开固定并辅以外固定。术后平均随访26个月。结果：采用Mazur评分系统评估手术疗效,48例手术患者中,优13例,良29例,可5例,差1例。结论：正确选择手术时机,根据骨折类型和条件灵活选择固定方式是取得良好手术效果的关键。     

Ⅱ、Ⅲ型Pilon骨折内固定治疗体会

目的:回顾性分析了治疗Pilon Ⅱ、Ⅲ型骨折的适宜内固定方法、最佳手术时机及其手术疗效.方法:对2000年2月至2005年9月接受手术治疗的33例单侧Pilon骨折患者进行随访,平均年龄38 5岁,伤后至手术时间平均6.8d.骨折类型:Ⅱ型15例、Ⅲ型18例.11例行切开复位胫骨远端内侧解剖钢板内固定;22例行胫骨远端外侧解剖钢板固定.术后平均随访26个月.结果:采用Mazur评分系统评估手术疗效,33例患者,优18例,良9例,可5例,差1例.结论:正确选择手术时机,根据骨折类型和条件选择胫骨远端外侧或内侧解剖钢板内固定是取得良好手术效果的关键.     

胫骨Pilon骨折治疗体会

目的探讨Pilon骨折切开复位应用各种内固定物治疗的临床效果。方法 2008年1月—2011年12月我院收治18例Pilon骨折患者,平均年龄40岁,伤后至手术时间平均8.5 d,均为单侧肢体。按照Ruedi-Allgower分型：Ⅰ型3例,Ⅱ型11例、Ⅲ型4例。5例行切开复位胫骨远端解剖板内固定,9例行胫骨解剖板＋腓骨固定,3例行胫骨内侧支撑板＋胫骨解剖板＋腓骨固定,1例行有限切开内固定并辅以外固定。结果术后随访5个月～36个月,平均19.8个月。采用Mazur评分系统评估手术疗效,优11例,良5例,可1例,差1例,优良率为89%。结论正确把握手术时机,根据骨折类型和条件灵活选择固定方式是胫骨Pilon骨折取得良好手术效果的关键。     

Pilon骨折39例治疗分析

目的探讨P ilon骨折治疗方法及影响疗效的相关因素。方法对2004年1月—2009年10月的39例P ilon骨折（Rued i-A llgower分型：Ⅰ型5例,Ⅱ型13例和Ⅲ型21例）中的6例采用非手术治疗,12例采用有限内固定结合外固定治疗,21例肿胀消退后切开复位内固定术,其中25例以植骨修补骨缺损。结果按照M azur评分标准,优14例,良21例,可3例,差1例。结论 P ilon骨折类型及周围软组织损伤程度对预后有重要影响。是否根据骨折分型及软组织条件选择合适的手术时机及合理的治疗方式、干骺端缺损区充分植骨,术后早行功能锻炼,晚负重是治疗成功的关键。     

复杂胫骨Pilon骨折的手术治疗

目的探讨复杂胫骨P ilon骨折的手术方法及疗效。方法1998年1月至2005年12月手术治疗胫骨Pilon骨折Ⅱ型8例、Ⅲ型23例。结果采用M azur等制定的踝关节症状与功能评分系统评分,并进行了14～60个月（平均29.3个月）的随访,本组中优17例,良10例,中3例,差1例,优良率达84.38%。结论正确选择手术时机,先复位固定腓骨,胫骨关节面尽可能解剖复位,骨缺损充分移植骨填充及钢板支撑固定,能降低胫骨P ilon骨折术后的并发症,并获得满意的疗效。     

胫骨Pilon骨折的手术治疗

目的回顾性分析治疗胫骨Pilon骨折的手术方法及其疗效。方法我院骨伤科2002年9月～2009年10月间手术治疗Pilon骨折患者58例,均获得随访。45例行切开复位胫骨远端解剖钢板内固定;13例行有限切开内固定并辅以外固定,其中应用外固定支架者5例。结果采用Mazur评分系统评估手术疗效,优26例;良26例;可4例;差2例;优良率89.7%。结论根据骨折类型,正确选择手术时机和合适的固定方式是治疗Pilon骨折取得良好效果的关键。     

严重胫骨Pilon骨折手术治疗78例临床分析

手术治疗78例严重胫骨Pilon骨折，68例行切开复位胫骨三叶草钢板或T型钢板＋腓骨1／3管型钢板和／或克化针固定，胫骨超关节外固定支架固定，10例行有限切开内固定并辅以石膏托外固定。探讨严重胫骨Pilon骨折手术治疗的有效方法。结果：术后随访12～48个月，平均28个月。骨愈合的时间13～38周，平均14．2周。采用Tenny评分系统评估疗效，优42例，良10例，可10例（Ⅱ型6例、Ⅲ型4例），差16例（Ⅱ型1例、Ⅲ型15例）。术后发生切口感染6例，4例为开放性骨折出现表浅感染，2例为局部软组织坏死后继发感染；骨折延迟愈合4例；关节退行性变14例，其中2例出现较严重的踝关节内翻；关节僵硬9例。提示影响胫骨Pilon骨折手术疗效的相关因素有骨折类型、治疗方式、胫骨关节面的复位情况和手术时机的选择、腓骨骨折的复位和固定因素。     

开放胫骨Pilon骨折的手术疗效比较

目的:总结分析了开放性胫骨Pilon骨折的各种内固定手术方法,器械、手术时机及其手术疗效。方法:对1998年3月至2001年10月接受急诊手术治疗23例胫骨Pilon骨折患者进行随防。平均45岁,伤后至手术时间,最早1小时~9.8小时,平均1天。骨折类型按Ruedi分类,I型5例、Ⅱ型10例、Ⅲ型-B4例,III-C2例。23例中,18例行AO三叶钢板(Cloveleuf-plute)内固定,3例其它钢板内固定,2例行克氏针及张力带钢丝内固定,3例行跟骨牵引1周后再行三叶钢板内固定术。术后II-III型骨折全部用石膏托外固定。术后平均随防1.5个月。结果:参照Maxur评分评估手术疗效:优12例,良7例,差4例。术后并发症包括创面不愈合4例,骨质疏松及退变5例,感染2例。结论:根据骨折分型,掌握内固定器械,植骨时机,坚强内固定是治疗胫骨Pilon骨折的关键。     

开放胫骨Pilon骨折的手术疗效比较

目的：总结分析了开放性胫骨Pilon骨折的各种内固定手术方法，器械．手术时机及其手术疗效。方法：对1998年3月至2001年10月接受急诊手术治疗23例胫骨Pilon骨折患者进行随防。平均45岁，伤后至手术时间，最早1小时～9．8小时，平均1天．骨折类型按Ruedi分类，Ⅰ型5例、Ⅱ型10例、Ⅲ型-B4例，Ⅲ-C2例。23例中，18例行AO三叶钢板（Cloveleuf-plutel内固定，3例其它钢板内固定，2例行克氏针及张力带钢丝内固定，3例行跟骨牵引1周后再行三叶钢板内固定术．术后Ⅱ-Ⅲ型骨折全部用石膏托外固定。术后平均随防1．5个月。结果：参照Maxur评分评估手术疗效：优12例，良7例，差4例．术后并发症包括创面不愈合4例，骨质疏松及退变5例，感染2例。结论：根据骨折分型，掌握内固定器械，植骨时机，坚强内固定是治疗胫骨Pilon骨折的关键．     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.