季节和高龄对妊娠期高血压疾病的发生及妊娠结局的影响

目的探讨季节和高龄对妊娠期高血压疾病(HDCP)的发生以及妊娠结局的影响。方法分析2009年1月至2016年12月在广州医科大学附属第三医院产科住院分娩、且常驻地为珠江三角地区的32 602例单胎孕产妇的临床资料。按胚胎着床季节进行分组分析。结果单胎孕产妇中,HDCP总发病率为5.89%(1 921/32 602)。期间HDCP发病率呈增高趋势(P0.05),其中轻度子痫前期发病率呈增高趋势(P0.05),而重度子痫前期发病率呈下降趋势(P0.05)。按产妇分娩年龄分层分析发现,适龄组(18～34岁)孕妇妊娠期高血压和重度子痫前期发病率春季显著高于夏季、秋季和冬季(P0.05),各季节的高龄组(≥35岁)孕妇发生妊娠期高血压、轻度子痫前期和重度子痫前期的发病率均显著高于适龄组(P0.05)。母儿近期结局比较,胎盘早剥发病率夏季显著高于春季、秋季和冬季(P0.05),胎儿生长受限发病率秋季显著高于春季和冬季(P0.05),新生儿轻度窒息和新生儿呼吸窘迫综合征发病率夏季显著高于春季和冬季(P0.05)。结论高龄是HDCP发病的高危因素之一,而适龄孕产妇HDCP的发病具有季节性,以春季着床的发病率最高,且HDCP合并胎盘早剥、胎儿生长受限、新生儿轻度窒息和呼吸窘迫综合征的发病也具有季节性。     

广州地区子痫的发生与季节的相关性

目的探讨广州地区41例子痫的发生与季节的关系,并分析母胎围产期结局。方法收集2013年1月1日至2014年12月31日广州市符合子痫诊断标准并且临床资料完整的41例患者各种数据,分析流行病学特点及与同期广州气温之间的关系。结果广州地区子痫发病率在12月份达高峰[3.09酃(7/22 674)],极端低温和平均低温达最低。春季发病占14.63%(6/41),夏季发病占21.95%(9/41),秋季发病占29.27%(12/41),冬季发病占31.15%(14/41),冬季发病率高于春季发病率,差异有统计学意义(P0.05)。春季最高收缩压(189.50±23.44)mm Hg高于夏季最高血压(164.00±12.37)mm Hg和秋季最高收缩压(163.33±15.59)mm Hg,冬季最高收缩压(179.14±22.88)mm Hg高于秋季最高收缩压(163.33±15.59)mm Hg,差异有统计学意义(P0.05);冬春季节最高收缩压比较差异无统计学意义(P0.05)。各季节气候与最高舒张压、子痫发病孕周比较差异无统计学意义(P0.05)。各季节气候与新生儿窒息率、围产儿死亡率、早产率比较差异无统计学意义(P0.05)。夏季新生儿体重(1 788.00±642.22)g低于秋季新生儿出生体重(2 600.25±730.06)g,差异有统计学意义(P0.05)。结论子痫发病具有季节性,以冬季发病率最高,且在12月份达高峰,冬春季节最高收缩压高于夏秋季节。建立广州子痫发病的季节模式,有助于从流行病学角度预防子痫的发生,提高产科质量,改善母儿预后。     

开封地区急性脑血管病与季节气候关联性研究

目的 观察急性脑血管病与季节气候的相关性,以期在急性脑血管疾病的高发期进行预报,使人们做好防护,降低急性脑血管病的发病率和死亡率.方法 将开封地区2008年1月～2011年9月收治的急性脑血管患者按季节进行分类计数,运用卡方检验不同的季节和气候因素条件下脑血管病发病率及不同年龄段发病率.一年按春、夏、秋、冬四个季节划分,12、1、2月为冬季,3、4、5月为春季,6、7、8月为夏季,9、10、11月为秋季.年龄段划分:30～80岁以上,10岁为1个年龄段,共划分6个年龄组.结果 不同季节脑血管病发病率差异有统计学意义(P＜0.01),其中冬季和夏季发病率高,冬季与春季比较差异有统计学意义(P＜0.01);夏季与秋季相比较差异有统计学意义(P＜0.05);冬季发病率高于夏季发病率,但无明显的统计学意义(P＞0.05).春、秋季节脑血管病发病率差异无统计学意义(P＞0.05).从年龄分布来看,不同年龄脑血管病发病率有显著差异(P＜0.01),其中51岁～60岁是脑出血高发年龄段(P＜0.05);71岁～80岁是脑梗死高发年龄段(P＜0.05).结论 开封地区急性脑血管病发病与季节气温有一定的相关性,急性脑血管病在冬季和夏季发病率高,脑出血受季节气候变换因素影响更大.人们要注意适应季节气候变化,冬天注意保暖,夏天多饮水,养成良好生活习惯,并注意基础病的治疗.     

新生儿硬肿症30例临床分析

新生儿硬肿症 ,现称新生儿皮脂硬化症。多发生在寒冷的冬季 ,其发生与寒冷、早产、缺氧和感染有关。本文通过 30例该病患儿的发病情况 ,就病因与治疗分析如下。1　资料与结果1 1　对象1990～ 2 0 0 0年 ,我院收治新生儿硬肿症 30例。诊断依据1990年全国新生儿学术会议制订的新生儿硬肿症诊断标准。1 2　方法对硬肿症患儿进行季节、胎龄、出生体重及年龄等相关因素分析。1 3　结果发病季节 :冬季发病 2 3例 ,占 76 .7% ;春季发病 4例 ,占13.3% ;秋季发病 3例 ,占 10 %。胎龄 :早产儿 16例 ,占 5 3.3%。出生体重 :低体重儿 11例 ,占 36 .6 %。…     

213例脑梗死四季发病分析

目的 分析笔者近5年接诊的213例脑梗死病人四季发病情况,从而揭示脑梗死发病的季节性.方法 回顾性分析213例脑梗死病人的临床资料,对其四季的发病率进行统计对比. 结果脑梗死四季发病率:春季39%、冬季33%、秋季17%、夏季11%; 脑梗死四季发病率排序:春季>冬季>秋季>夏季;冬春季总发病率大于夏秋季总发病率.     

湖北省水痘发病情况与气象因素的关系研究

目的　探讨湖北省气象因素对水痘发病情况的影响,从而为华中区域水痘传染病防治提供参考依据。方法　资料来源于湖北省孝感市疾病预防控制中心2008年以来水痘疫情报告卡,收集2009年1月—2012年12月患水痘的6 324例患者的临床资料。同期气象数据包括气温、相对湿度、降水量及日照时数,由湖北省孝感市气象局提供。统计分析考虑到气象数据严重的共线性且多元线性回归结果不理想,因此采用不同季节发病情况与单一气象因素构建回归模型来评估水痘发病情况与气象因素的关系。结果　2009—2012年,水痘年平均发病率为32.838/10万,无死亡病例。在夏季和冬季出现发病高峰,呈现典型的双峰曲线动态,分别占报告病例总数的34.69%（2 194/6 324）和32.84%（2 077/6 324）。夏季水痘发病例数高于春季和秋季（P<0.01）;冬季水痘发病例数高于春季和秋季（P<0.05）。水痘发病例数与气温、相对湿度、降水量及日照时数均不存在相关性（P>0.05）。春季与冬季气温、日照时数均与水痘发病率呈显著相关（P<0.05）,夏季各气象因子均与水痘发病率呈显著相关（P<0.05）,而秋季仅有日照时数与水痘发病率呈显著相关（P<0.05）。结论　湖北省水痘发病情况呈现显著的季节动态变化及季节差异,气象因素可以较好地解释不同季节水痘发病率的波动。     

对新生儿286例低体温原因的分析及护理对策

目的:探讨新生儿低体温的原因及低温与预后和死亡的关系,为新生儿低体温的护理提供对策。方法:采取入院时肛温<36℃的新生儿286例,对低体温与足月、早产、日龄、季节的关系及低体温与预后和死亡的关系进行分析。结果:新生儿低体温与足月、早产的关系中P<0.01。出生8~28d与出生~7d比较,P<0.01。低体温中非感染因素占75.87%,感染因素占24.13%。286例低体温中春季86例(30.07%),夏季44例(15.39%),秋季49例(17.13%),冬季107例(37.41%)。本组病例死亡34例,占11.88%,而同期入院时肛温>36℃新生儿572例,死亡14例,占2.45%,U=6.28,P<0.01。低温持续时间与死亡的关系中P<0.01。结论:新生儿低体温多见于早产儿,以新生儿早期,特别是出生后24h内为多见,好发于冬春季节,病因以非感染因素为主,并可明显影响新生儿病死率,且低温持续时间越长对预后的影响越大。在护理工作中,除了配合医疗工作外,尤应注意新生儿早期的保暖、喂养、预防感染以及复温的问题。     

新生儿肺炎149例分析报告

新生儿肺炎的死亡率占整个小儿阶段肺炎死亡率的首位。国内有关新生儿肺炎的报导,为数尚不多,更由于新生儿肺炎在临床表现上具有很多特点,为了总结这方面的经验,以便加强对新生儿肺炎各个方面的认识,特将本院自1955年至1957年6月收容住院治疗的149例新生儿肺炎加以分析如下。一发病率1.发病率与年龄、季节的关系:本文所分析的149例患儿,多数是在初生后二周以内发病的。如按季节来分析,春季发病占30%(共44例),夏季占5%(共9例),秋季占20%(67例),冬季占45%(67例),可见     

新乡市大气细颗粒物中细菌种群多样性及分布特征

目的研究新乡市大气细颗粒物(PM_(2.5))中细菌种群多样性及分布特征。方法采集4个季节PM_(2.5)样品,利用高通量测序技术分析种群结构及其多样性。结果冬季大气中PM_(2.5)浓度最高,其次为春季、秋季和夏季。在细菌门的水平上,4个季节相对丰度最高的是变形菌门。春季和夏季丰度相对较高的菌属均为乳杆菌属,秋、冬季丰度相对较高的菌属分别为未鉴定线粒体、未鉴定叶绿体。4个季节大气PM_(2.5)中细菌群落相对丰度依次为春季>冬季>夏季>秋季,4个季节大气PM_(2.5)中群落多样性依次为夏季>春季>冬季>秋季。春季、夏季、秋季大气PM_(2.5)中细菌群落Beta多样性指数两两比较差异均有统计学意义(P <0. 05),春季和冬季大气PM_(2.5)中细菌群落Beta多样性指数比较差异无统计学意义(P> 0. 05)。结论新乡市大气PM_(2.5)中细菌种群具有显著的季节变化特征,春季和冬季PM_(2.5)中细菌丰度也相对高于夏季和秋季。     

柳州地区新生儿VitD营养状况及影响因素的分析

目的探讨本地区新生儿维生素D(Vitamin D,VitD)营养状况及相关因素。方法选取本院分娩的687例新生儿为研究对象,行脐血25-羟基VitD[25(OH)D]检测,收集新生儿基本资料,用SPSS 20.0软件对脐血25(OH)D及相关因素进行分析。结果 687例新生儿脐血25(OH)D平均水平为(39.12±15.38)nmol/L;不同性别与不同出生方式之间的脐血25(OH)D水平差异无统计学意义(P>0.05),但有季节性差异(P<0.01),夏季高于春冬季,秋季高于春季;脐血25(OH)D水平与新生儿各项出生体征之间差异均无统计学意义(P>0.05),随脐血25(OH)D浓度逐渐上升,新生儿出生体重有增长的趋势。结论柳州地区新生儿VitD水平普遍偏低,春冬季出生的婴儿是VitD缺乏高危人群,应加强户外活动及适当的VitD补充。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.