合肥市856名学龄前儿童睡眠问题分析

目的 分析合肥市学龄前儿童睡眠问题,为改善儿童睡眠健康提供依据。方法 合肥市妇幼保健计划生育服务中心于2018年4～6月采用儿童睡眠习惯问卷对合肥市瑶海区、新站区856名3～6岁儿童家长进行调查,观察比较学龄前儿童就寝时间及夜间睡眠时间,分析学龄前儿童睡眠问题及其危险因素。结果 合肥市学龄前儿童平均每日就寝时间为21：39,夜间睡眠时间为（9.72±0.62）h。23.01%儿童就寝时间晚于22：00,61.45%儿童夜间睡眠时间<10 h。总体睡眠问题发生率为790名（92.29%）,以睡眠焦虑774名（90.42%）、就寝习惯不良757名（88.43%）、睡眠持续时间不规律580名（67.76%）、白天嗜睡576名（67.29%）最常见,儿童与家人同床睡眠率高达667名（77.92%）。同床睡眠是儿童睡眠质量不良的独立危险因素（OR=11.288,P<0.001）。结论 合肥市学龄前儿童睡眠习惯不良较为普遍,应引起家长和社会重视。     

杭州市学龄前儿童的日间功能及其与睡眠质量的相关性研究

目的：了解杭州市学龄前儿童的日间功能、睡眠质量及其相关性。方法采取整群抽样的方法抽取杭州市5所幼儿园儿童共930例,采用一般情况问卷、儿童睡眠习惯问卷（CSHQ）及幼儿日间功能问卷收集资料,分析不同年龄、性别儿童的睡眠质量,及不同睡眠质量的儿童的日间功能表现。结果共914例3-6岁儿童纳入分析。42.0%（384/914）儿童存在睡眠质量不良,其中3-岁组儿童睡眠不良发生率明显高于其他年龄组（P＜0.05）,无性别差异（P＞0.05）。日间功能总得分随年龄增长逐渐下降,不同年龄组之间差异有统计学意义（P＜0.01）。白天倦怠、难以完成工作情况在不同年龄组之间差异有统计学意义（P＜0.01）,负性情绪及明显多动情况在各年龄组之间差异无统计学意义（P＞0.05）。睡眠质量良好组日间功能总得分及各分项得分均低于睡眠质量不良组,两组在总得分及完成工作上差异有统计学意义（均P＜0.05）。结论睡眠质量不良的学龄前儿童的日间功能较差,主要表现为白天难以完成工作。     

增视明目方联合低浓度阿托品治疗儿童假性近视的临床观察

目的 观察增视明目方联合低浓度阿托品治疗儿童假性近视的疗效。方法 选取2021年12月至2022年12月于湖南中医药大学第一附属医院眼科门诊收治的假性近视儿童患者100例作为研究对象，采用随机数字表法分为干预组和对照组，每组50例。对照组患儿予以一般生活干预及0.01%低浓度阿托品滴眼液滴眼，干预组患儿在对照组基础上予以增视明目方口服，在治疗前后，分别采用国际E视力表、检影验光等检测两组患儿裸眼视力、睫状肌麻痹前后屈光度，检测两组患儿眼轴长度、眼压，评估治疗效果。结果 治疗3个月后，干预组裸眼视力为（0.89±0.32），显著高于对照组的（0.81±0.30）（t=10.135，P<0.001），干预组治疗后屈光度（睫状肌麻痹后）为（–0.24±0.12）D，显著低于对照组的（–0.27±0.09）D（t=10.526，P<0.001），干预组治疗后眼轴长度为（23.02±0.12）mm，显著低于对照组的（23.34±0.45）mm（t=7.236，P<0.05）；干预组总有效率为92.00%，高于对照组的86.00%（χ2=18.422，P<0.05）。结论 增视明目方联合低浓度阿托品可对假性近视眼儿童的裸眼视力等有所改善，具有良好的防治效果，值得临床推广应用。     

艾司西酞普兰与心理干预联合治疗对焦虑症患者睡眠质量的影响研究

目的 探讨艾司西酞普兰与心理干预联合治疗对焦虑症患者睡眠质量的影响。方法 选取2020 年5—10月62 例焦虑症患者,依据随机摸球法分为对照组（n=31）和观察组（n=31）,对照组采取艾司西酞普兰治疗,观察组在对照组基础上联合心理干预治疗,观察两组患者睡眠质量、焦虑改善情况及生活质量。结果 治疗后观察组入睡时间、睡眠效率、睡眠时间、睡眠质量、睡眠障碍、催眠药物、日间功能障碍评分均低于对照组,差异有统计学意义（P<0.05）;治疗后观察组焦虑评分为（52.64±2.23）分,低于对照组的（57.28±2.16）分,差异有统计学意义（P<0.05）;治疗后观察组生活质量评分为（76.21±3.07）分,高于对照组的（71.42±3.18）分,差异有统计学意义（P<0.05）。结论 艾司西酞普兰与心理干预联合治疗焦虑症患者,可改善患者睡眠质量,缓解焦虑情绪,提高患者生活质量,应用价值高。     

慢性睡眠不足诱导小鼠大脑和肝脏氧化应激和炎症反应

目的：探讨慢性睡眠不足对小鼠肝脑功能的影响及作用机制。方法：20只4 周龄野生雌性C57BL/6J小鼠随机分为正常对照组（n=10）和睡眠剥夺组（n=10）,睡眠剥夺组小鼠睡眠剥夺45 d后,观察2组小鼠体质量变化;Morris水迷宫实验分析2组小鼠空间学习记忆能力的变化;测量各组小鼠肝重指数、脾重指数和肾重指数;ELISA法检测血清中肿瘤坏死因子-α（tumor necrosis factor-α,TNF-α）、白细胞介素-6（interleukin-6,IL-6）和白细胞介素-1β（interleukin-1β,IL-1β）的含量;酶标比色法检测海马和肝脏超氧化物歧化酶（superoxide dismutase,SOD）活力和还原型谷胱甘肽（reduced glutathione,GSH）含量;Western blot检测海马和肝脏TNF-α、P53、BCL-2相关X蛋白（Bcl-2-associated X protein,BAX）、B细胞淋巴瘤-2（B-cell lymphoma-2,Bcl-2）蛋白相对表达水平;免疫组化SP法检测海马Ki-67的表达水平。结果：睡眠剥夺组小鼠体质量较正常对照组增加缓慢,空间学习记忆能力减退,肝重指数和肾重指数均增高（t=4.274,P=0.000;t=3.629,P=0.002）,脾重指数明显降低（t=2.380,P=0.029）。与正常对照组相比,睡眠剥夺组小鼠血清TNF-α[（24.440±4.468） vs. （53.719±4.128）]、IL-6[（14.265±3.718） vs. （31.766±4.535）]和IL-1β[（20.383±3.230） vs. （41.916±4.819）]明显增高（t=10.762,P=0.000;t=6.673,P=0.000;t=8.229,P=0.000）,睡眠剥夺组海马和肝脏SOD活力和GSH含量明显降低（t=4.171,P=0.003;t=8.851,P=0.000;t=7.138,P=0.000;t=5.390,P=0.000）。Western blot结果显示,睡眠剥夺组海马和肝脏TNF-α[（0.702±0.088）,（0.818±0.074）]、P53[（0.626±0.103）,（1.225±0.116）]和BAX[（0.978±0.078）,（1.120±0.135）]蛋白相对表达量明显上调（t=13.688,P=0.000;t=11.682,P=0.000;t=6.991,P=0.000;t=10.023,P=0.000;t=13.721,P=0.000;t=10.422,P=0.000）,BCL-2蛋白相对表达量[（0.365±0.059）,（0.380±0.040）]明显下降（t=15.165,P=0.000;t=12.143,P=0.000）,海马齿状回和门区Ki-67蛋白的表达水平明显下降（t=4.171,P=0.003）。结论：慢性睡眠不足可诱导大脑和肝脏的氧化应激,增加血清中炎症因子的浓度,并通过细胞凋亡调节DNA损伤。     

基于路径分析的方法探讨抑郁症状对阻塞性睡眠呼吸暂停患者持续气道正压通气治疗依从性的影响

背景 持续气道正压通气（CPAP）治疗效果与阻塞性睡眠呼吸暂停（OSA）患者的使用依从性密切相关,心理社会特征是CPAP治疗依从性的重要影响因素之一,抑郁症状对CPAP治疗依从性的影响尚需进一步探讨。 目的 探讨OSA患者抑郁症状与CPAP治疗依从性及其中间变量间的作用通路。 方法 选取2019年5月至2021年7月在北京大学人民医院呼吸睡眠医学中心确诊并接受CPAP治疗的OSA患者177例,评估患者基本信息、疾病严重程度及CPAP治疗依从性。以流调中心抑郁水平评定量表-10（CES-D-10）评估患者抑郁症状,以失眠严重程度指数量表（ISI）评估失眠情况,以睡眠功能结局问卷-10（FOSQ-10）评估日间功能,以生存质量简表-12（SF-12）评估生存质量,运用路径分析的方法确定各变量之间的关系。 结果 OSA患者抑郁症状的检出率较高（19.7%,35/177）,OSA患者的抑郁症状与失眠呈正相关（r=0.65,P<0.05）,与日间功能（r=-0.51,P<0.05）及生存质量（rPCS=-0.27,P<0.05;rMCS=-0.72,P<0.05）呈负相关。抑郁症状与患者CPAP治疗依从性无直线相关关系（r=0.09,P>0.05）,但其能通过降低日间功能增加OSA患者对CPAP的治疗依从性（β=0.078,P<0.01）。 结论 抑郁症状与OSA患者的失眠、生存质量下降及日间功能降低相关,并可通过降低OSA患者日间功能增加其对CPAP的治疗依从性。     

中重度OSAHS患者日间过度嗜睡的影响因素研究

目的通过分析多导睡眠监测（PSG）相关参数,探讨中重度阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者日间过度嗜睡（EDS）的可能影响因素。方法应用Epworth嗜睡量表（ESS）评估272例中重度OSAHS患者的EDS,根据ESS将患者分为有EDS组（ESS＞10）和无EDS组（ESS≤10）,比较两组夜间低氧和睡眠结构相关参数的差异。结果EDS组95例,无EDS组177例,两组ESS分别为14±3和6±3。两组呼吸暂停低通气指数（AHI）差异无统计学意义（58.0±21.0vs54.7±17.7,P＞0.05）;EDS组夜间最低血氧饱和度较无EDS组更低[（63.1±15.8）%vs（67.5±14.0）%,P＜0.05],夜间氧饱和度＜90%的时间占睡眠时间的百分比（SIT90）较无EDS组更高[（39.3±30.5）%vs（28.2±25.3）%,P＜0.05]。多因素分析显示SIT90是OSAHS患者EDS的独立影响因素。两组间夜间平均血氧饱和度、氧减指数（ODI）和睡眠结构相关参数差异均无统计学意义（均P＞0.05）。结论有EDS的中重度OSAHS患者较无EDS的患者夜间低氧程度更重,且夜间低氧是中重度OSAHS患者EDS的独立危险因素。     

重度子痫前期并发HELLP综合征 炎症指标的变化研究

目的 分析重度子痫前期（severe preeclampsia,SPE）并发溶血肝功能异常血小板减少（hemolysis,elevated liver function and low platelet count,HELLP）综合征炎症指标的变化及危险因素。方法 采用回顾性研究方法,选取2012年1月至2021年12月温州市中西医结合医院收治的SPE患者52例,根据是否并发HELLP综合征将其分为观察组（n=20）和对照组（n=32）。观察组患者并发HELLP综合征,对照组无HELLP综合征。检测两组患者的白细胞计数（white blood cell,WBC）、中性粒细胞与淋巴细胞比值（neutrophil–to–lymphocyte ratio,NLR）、超敏C反应蛋白（hypersensitive C–reactive protein,hs–CRP）、白细胞介素–6（interleukin–6,IL–6）和肿瘤坏死因子–α（tumor necrosis factor–α,TNF–α）等炎症指标。采用t检验或Mann–Whitney U检验对数据进行比较,SPE并发HELLP综合征的影响因素评价采用多因素Logistic回归分析。结果 观察组患者的WBC、NLR、hs–CRP、IL–6及TNF–α水平均高于对照组[（12.0±3.3）×109/L vs（9.3±2.4）×109/L,t=3.413;（5.43±1.67） vs（4.27±1.27）,t=2.347;31.10（1.13~88.93）mg/L vs 5.38（0.50~17.99）mg/L,Z=–4.806;8.8（3.4~14.5）pg/ml vs 6.6（2.7~10.2）pg/ml,Z=–2.136;8.4（6.0~10.9）pg/ml vs 5.8（2.1~9.7）pg/ml,Z=–4.177],差异均有统计学意义（P<0.05）。观察组患者的IL–4及IL–10水平均低于对照组[（2.41±0.65）pg/ml vs（3.00±0.92）pg/ml,t=–2.505;（2.37±0.63）pg/ml vs（3.24±0.76）pg/ml,t=–4.291],差异均有统计学意义（P<0.05）。多因素Logistic回归分析发现,WBC、NLR、hs–CRP、IL–6及TNF–α水平的升高及IL–10水平的降低是SPE并发HELLP综合征的部分危险因素[校正后OR值（95%CI）分别为1.435（1.108~1.859）、1.466（1.034~2.078）、1.283（1.082~1.523）、1.317（1.029~1.686）、2.538（1.420~4.535）和6.663（1.912~23.004）,P均<0.05]。结论 在SPE患者中,WBC、NLR、hs–CRP、IL–6和TNF–α水平的升高及IL–10水平的降低可能是并发HELLP综合征的部分危险因素。     

社区中老年人午睡频率与夜间睡眠的关系

目的 探讨中老年社区居民午睡频率与夜间睡眠的关系。方法 2010年9月—2011年3月,在上海市2个区5个居委会中随机抽取478名45~80岁的中老年社区居民进行面对面询问调查。分别采用匹兹堡睡眠质量指数（PSQI）问卷评估受试者的睡眠质量,蒙特利尔认知评估（MoCA）问卷检测受试者的认知功能,自行设计问卷调查受试者的基本情况。根据午睡频率将受试者分为经常午睡组（≥3次/周）、偶尔午睡组（1~2次/周）和对照组（≤3次/月）。结果 发放问卷478份,其中有效问卷443份,有效率92.68%。经常午睡组受试者的平均年龄和腰围均明显大于对照组（P<0.01）,但认知总分明显低于对照组（P<0.01）;经常午睡组受试者的文化程度、在职状况以及慢性病自报率与对照组比较差异均有统计学意义（P<0.05或P<0.01）。在调整了受试者的年龄、文化程度、在职状况、腰围、慢性病自报率以及认知评分等因素后,经常午睡组的睡眠障碍评分、日间功能评分以及PSQI总分均明显高于偶尔午睡组和对照组（P<0.05或P<0.01）;经常午睡组和偶尔午睡组的夜间睡眠床上总时间均明显短于对照组（P<0.01）;三组的夜间上床到入睡时间、实际睡眠时间和睡眠效率比较差异无统计学意义（P>0.05）。结论 午睡频率增加和中老年人夜间睡眠质量自评差密切相关,无充分证据显示午睡频率与夜间睡眠时间特征指标有关。     

下尿路功能障碍患儿的临床特征及心理行为分析

目的 总结分析下尿路功能障碍（LUTD）患儿的临床及心理行为特征,为临床的精确诊断和个性化治疗提供参考依据。方法 回顾性分析四川大学华西医院于2020年7月—2021年10月就诊的382例排尿异常患儿的病情询问表、儿童行为量表及自我意识量表,对LUTD患儿相关临床特征和心理行为特征进行分析。结果 382例下尿路功能障碍患儿中,男性256例,女性126例;平均年龄（6.79±2.51）岁;有夜间尿床症状者265例,日间漏尿194例,尿频症状153例,尿急症状264例,特殊姿势排尿为89例,间断排尿症状44例,就诊时伴泌尿系感染者26例;主诉有排便异常82例,其中便秘55例,粪污27例。Achenbach儿童行为量表评分中,6~11岁组患儿行为学问题发生率最高（28.7%）,日间漏尿组得分（37.09±19.32）分显著高于无日间漏尿组得分（23.81±15.96）分（t=4.978,P＜0.05）。下尿路功能障碍患儿自我意识总分为（52.49±12.15）分;行为、智力与学校、躯体外貌、焦虑、合群、幸福与满足维度得分均较低。日间漏尿组得分（45.14±10.76）分显著低于无日间漏尿组得分（61.76±4.93）分（t=-6.564,P＜0.05）。结论 LUTD患儿的临床表现有广泛的差异性,患儿往往存在较为明显的心理行为问题,6~11岁以及有日间漏尿症状的患儿心理行为问题更为突出。因此,临床医护人员应选择适当的评估工具和方法,进行准确评估和判断,关注患儿的心理行为问题,多学科协作制定治疗方案,以获取最佳治疗效果     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.