生精益气汤治疗精液异常不育症临床研究

目的:观察生精益气汤治疗精液异常不育症的临床疗效。方法:将120例精液异常不育症患者随机分为两组,对照组60例给予口服黄精赞育胶囊治疗;治疗组60例煎服生精益气汤治疗,疗程均为90d。结果:临床总有效率治疗组为86.67%,对照组为83.33%,精液各项参考指标两组治疗后,差异均没有统计学意义(P>0.05),治疗组治疗前后差异有极显著性差异(P<0.01)。结论:生精益气汤治疗精液异常不育症疗效显著,可明显提高精子数量、活力及成活率。     

电针配合复方玄驹胶囊治疗少、弱精子男性不育症的临床研究

目的探讨电针配合复方玄驹胶囊治疗少、弱精子男性不育症的临床效果。方法 60例少、弱精子男性不育症患者随机分为治疗组和对照组,对照组给予常规西医治疗,治疗组采用电针配合复方玄驹胶囊治疗,连续治疗3个月后评价临床疗效。结果治疗组临床疗效总有效率为93.3%,显著高于对照组(63.3%)(P=0.004,χ2=5.983);治疗组精液液化临床疗效总有效率为96.7%,显著高于对照组(70.0%)(P=0.012,χ2=4.870);治疗后,治疗组精子活动率和精子密度显著升高,与治疗前和对照组比较均有显著性差异(P0.05)。结论电针配合复方玄驹胶囊治疗少、弱精子男性不育症能改善男性不育症患者的精液质量,对提高精子密度和精子活动率效果显著。     

海马巴戟胶囊与左卡尼汀口服液治疗特发性少弱精子症的疗效比较

目的 对比海马戟胶囊及左卡尼汀口服液治疗特发性少弱精子症的效果.方法 选取我院2015年2月—2016年10月收治的特发性少弱精子症患者150例,随机分成对照组(给以左卡尼汀口服液治疗)75例与治疗组(给以海马巴戟胶囊治疗)75例,观察2组疗效.结果 治疗组总有效率略高于对照组,但2组比较差异无统计学意义(P>0.05);服药3个月后,2组精液参数各项指标均比给药前显著改善(P<0.05);2组PR级精子比例比较差异无统计学意义(P>0.05),治疗组的精子浓度、精液量均明显高于对照组(P<0.05).结论 对于特发性少弱精症,采用海马巴戟胶囊及左卡尼汀口服液治疗均能取得较好的疗效,但在提高精子密度和精液量方面,前者优于后者.     

自拟中药生精逐瘀汤治疗特发性少弱精子症的临床疗效观察

目的观察经验方生精逐瘀汤治疗特发性少弱精子症的临床疗效。方法 120例特发性少弱精子症患者,随机分为治疗组和对照组,治疗组口服生精逐瘀汤,对照组口服五子衍宗丸。3个月1个疗程,观察患者的精液情况及患者妻子妊娠情况。结果治疗组与对照组治疗后的精液各项参数比治疗前都有明显好转（P〈0.05）;但是治疗后治疗组精液参数中a级精子、畸形率及密度较对照组改善更明显（P〈0.01）;治疗组妻子临床妊娠率较对照组妻子妊娠率高,P〈0.01差异有统计学意义;两组妻子妊娠者胎儿发育情况、新生儿生产及智力发育未见异常。结论生精逐瘀汤能提高精子的活力、活动率及密度,可提高患者妻子的临床妊娠率,且无明显毒副作用,用药安全,对治疗特发性少弱精子症有良好的临床疗效,值得推广。     

克罗米芬联合生精胶囊治疗少、弱精症的临床观察

目的 探讨克罗米芬联合生精胶囊治疗少、弱精症的临床疗效.方法 96例男性少、弱精子不育症患者随机分为治疗组50例,口服克罗米芬＋生精胶囊;46例对照组单纯口服克罗米酚治疗,2组均以3个月为1个疗程.结果 治疗组总有效率84%,对照组总有效率60.86%,治疗组疗效优于对照组（P〈0.05）.结论 克罗米芬联合生精胶囊治疗少、弱精症能明显提高疗效.     

强精助育汤治疗特发性弱精子不育症的临床研究

目的:观察强精助育汤对男性特发性弱精子症的治疗效果。方法:收集120例男性特发性弱精子症患者,按随机数字表法分为两组各60例。治疗组服用强精助育汤,对照组口服复方玄驹胶囊,两组均治疗3个月。比较两组间的治疗效果,观察精子活力与精子活动率的改变情况。结果:治疗后,两组的精子活力、精子活动率与治疗前比较差异均有统计学意义(P0.01);两组的显效率比较差异有统计学意义(P0.05)。结论:强精助育汤对男性特发性弱精子症的疗效肯定。     

复方玄驹胶囊加五子衍宗丸治疗少、弱精子症的临床研究

目的：比较复方玄驹胶囊加五子衍宗丸口服、单用复方玄驹胶囊、五子衍宗丸口服治疗少、弱精子症的临床效果。方法：选择本院男科门诊确诊的少、弱精子症患者120例,随机分为三组,每组40人。A组：复方玄驹胶囊＋五子衍宗丸＋维生素E;B组：复方玄驹胶囊＋维生素E;C组：五子衍宗丸＋维生素E;共治疗3个月。于治疗前和治疗结束后进行计算机辅助分析（CASA）精液样本,用放射免疫法测定血浆性激素。结果：治疗3个疗程后,三组患者精液中精液量、精子密度、活率、a级和（a＋b）级精子百分率等有明显改善,血清睾酮值比治疗前显著增高（P〈0.01）。A组与B、C两组比较在治疗后精液参数、血清睾酮水平均有统计学意义（P〈0.05）,而B、C两组间比较差异无统计学意义。结论：应用复方玄驹胶囊加五子衍宗丸能显著改善少、弱精子症患者的精液质量,提高血清睾酮水平,是治疗男性不育症的一种有效的方法。     

黄精赞育胶囊治疗男性不育弱精子症40例疗效观察

目的:观察黄精赞育胶囊治疗男性不育弱精子症的临床疗效。方法:80例男性不育弱精子症患者随机分为两组,每组40例。对照组口服生精胶囊治疗,治疗组口服黄精赞育胶囊治疗,疗程均为3个月。结果:两组病例治疗后总有效率比较差异无统计学意义,治疗组治疗后精子活力指标较对照组治疗后显著改善(P<0.01)。结论:黄精赞育胶囊治疗男性不育弱精子症疗效确切,可以明显提高精子活力。     

育精丸治疗男性精液异常不育症临床疗效观察

目的:探讨中药育精丸在治疗男性精液异常导致的不育症的临床效果。方法:选择98例男性不育症患者,按照患者自愿原则,将患者分为观察组与对照组,每组49例,观察组给予育精丸治疗,对照组给予克罗米酚治疗,两组患者均以4周为1个治疗周期,1个疗程结束后观察两组患者的临床疗效。结果:观察组与对照组的临床总有效率分别为93.88%(46/49)、77.55%(38/49),两组比较,差异有统计学意义(P<0.05);观察组药物治疗后精子密度和精子活动率提高程度与对照组治疗后结果比较,差异有统计学意义(P<0.05)。结论:育精丸用于治疗男性精液异常导致的不育症中,通过增加精子的密度,提高精子的活力,改善患者不育的临床症状,取得了较好的临床疗效。     

精安胶囊对雄性小鼠生精作用及其生育功能的影响

引起不育症的原因很多。据报道［１］,美国约１０％的夫妇不育,其中２０～２５％是男方原因。国外男性不育症的发病率有逐年增加的倾向。但国内有关男性不育症的发病率报道不多。有人分析２０８７例男性不育症的病因。其中少精子或无精子症占２５．１％,精子活动率低下者占９．８２％。对因少精症及精子活力不足导致男性不育症的治疗在于使用药物恢复睾丸生精功能,以提升精液精子数及其活力。本研究显示精安胶囊对小鼠有生精作用,能提升小鼠精液的精子数及生育力,为临床应用精安胶囊治疗上述原因引起的男性不育症提供实验依据。１　材…     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.