血脂康对2型糖尿病合并高脂血症患者血清高敏C反应蛋白及血脂的影响

目的探讨血脂康胶囊对2型糖尿病合并高脂血症患者血清高敏C反应蛋白（hsCRP）及血脂的影响。方法选择86例合并高脂血症的2型糖尿病患者,在原降糖治疗基础上随机分为2组,治疗组48例加服血脂康胶囊,对照组38例不服血脂康,疗程12周。检测2组患者服药前后血甘油三酯（TG）、胆固醇（TC）及高敏C反应蛋白水平。结果治疗组治疗后血TG、TC、hsCRP较对照组及治疗前显著降低（P〈0.05）。结论血脂康有良好的降脂作用,在糖尿病合并高脂血症患者的早期治疗中有重要作用。     

内皮素、一氧化氮 消化性溃疡患者发病机制中的作用

目的：研究ET－1／NO在消化性溃疡患者发病机制中的作用。方法：测定45例胃溃疡（GU）患者（治疗前）,49例十二指肠溃疡DU患者（治疗前）和正常人群对照组血浆ET－1、NO水平。结果：GU组较正常对照组血浆ET－1水平显著升高（P＜0．05）,NO水平显著降低（P＜0．05）。而DU组血浆ET－1、NO水平与正常对照组无显著性差异（P＞0．05）。结论：内源性ET－1／NO失衡是胃溃疡形成的始动因子之一。而在十二指肠溃疡患者中无明显作用。     

血脂康对2型糖尿病并高脂血症的疗效观察

目的　观察血脂康对 2型糖尿病合并高脂血症患者的调脂作用及对血浆内皮素 - 1 (ET1 )、 2 4小时尿白蛋白排泄量的影响。方法　 2型糖尿病合并高脂血症患者应用血脂康治疗 1 6周 ,0 6g/次、 2次 /d。测定服药前和服药后的血脂、ET1 、 2 4小时尿白蛋白排泄量 ,并测定对照组、 2型糖尿病血脂正常组的血浆ET1 、 2 4小时尿白蛋白排泄量。结果　 2型糖尿病并高脂血症患者血脂各指标治疗前后比较 ,TC、TG、LDL -C、LP (a)间的差别均有显著性意义 (P <0 0 5) ;治疗前 3组血浆ET1 及 2 4小时尿白蛋白排泄量间的差别均有显著性意义 (P<0 0 1 ) ;2型糖尿病并高脂血症患者血脂康治疗前后ET1 间的差别有显著性意义 (P <0 0 1 )。结论　血脂康具有调脂及减少血浆ET1 的作用。     

辛伐他汀对2型糖尿病合并冠心病患者血管内皮功能的影响

目的：研究辛伐他汀对2型糖尿病合并冠心病患者血管内皮功能的影响。方法：分析检测64例2型糖尿病合并冠心病患者给予辛伐他汀治疗前后血糖、血脂、血浆一氧化氮（NO）与内皮素（ET）水平，用高分辨血管外彩色多普勒测定肱动脉内皮依赖性舒张功能均有显著性改善（P＜0．01），血脂正常组治疗前后比较血脂无显著性变化（P＞0．05），肱动脉内皮依赖性舒张功能显著改善（P＜0．05），治疗前后ET水平明显降低（P＜0．05，P＜0．01），NO水平明显升高（P＜0．05，P＜0．01），血脂异常组肱动脉内皮依赖性舒张功能改善的程度与患者血TC和LDL降低的程度呈正相关关系（相关系数分别为0．532和0．503，均P＜0．001）；与血ET降低程度呈正相关关系（相关系数为0．58，P＜0．01），与患者血NO升高程度呈正相关关系（相关系数为0．79，P＜0．01），结论：辛伐他汀通过降脂和平衡NO／ET的比值等途径保护内皮功能，对治疗糖尿病合并冠心病病人（高血脂或血脂正常）有一定的应用价值。     

糖尿病混合型高脂血症临床治疗分析

目的观察血脂康与罗格列酮联合用药对2型糖尿病合并混合型高脂血症的影响。方法56例门诊厦住院的2型糖尿病合并混合型高脂血症的病人随机分成治疗组28例，应用血脂康胶囊0．6g／2）L／d，罗格列酮片4ms／1次／d；对照组28例，单独使用血脂康胶囊0．6昏／2挺／d。治疗16周，抽血查治疗前与治疗后血清胆固醇（代）、高密度脂蛋白（HDL—C）、低密度脂蛋白（LDL—C）、甘油三脂（TG）厦前脂蛋白-a（IjP—a）水平。结果两组治疗后TC、HDL—C、LDL—C、LP—a水平较治疗前均有显著下降（P〈0．01），两组间TG下降幅度差异有显著性（P〈0．05），治疗组较对照组TG下降幅度明显增大。蛄论血脂康与罗格列酮联合治疗2型糖尿病合并混合型高脂血症效果较好，尤其是合并有高甘油三脂血症者。     

辛伐他汀对2型糖尿病高脂血症的疗效

目的：探讨辛伐他汀20mg/d治疗2型糖尿病高脂血症的疗效及安全性。方法：60例2型糖尿病高脂血症患者随机分为2组，各30例，分别予辛伐他汀1片（每片5mg或20mg).qn，用药4wk，结果：辛伐他汀20mg/d组降低TC33％，降低LDL－C 46％，降低TG26％，升高HDL－C21％，且降低TC／HDL－C44％，组间比较，2组的血清TG，LDL－C降低幅度及HDL－C上升幅度有显著性差异（P＜0．01）。TC降低幅度无明显差异（P＞0．05）。对血糖水平无不良影响。结论：20mg/d治疗2型糖尿病高脂血症患者安全，有效。     

肺心汤对慢性肺心病患者一氧化氮、内皮素及肾上腺髓质素的影响

目的：探讨复方中药制剂肺心汤治疗肺心病急性发作期的疗效及对一氧化氮（NO）、内皮素－1（ET－1）、肾上腺髓质素（ADM）的影响。方法：将46例肺心病发作期患者随机分为肺心汤治疗组和西药治疗组，各23例，分别给予肺心汤和常规西药（抗炎、解痉、扩血管等）治疗14天，以硝酸还原酶法测血清NO含量；用放射免疫法测血浆ET－1和ADM水平，结果：肺心汤与西药治疗肺心病急性发作期临床疗效无明显差异（P＞0．05）；两组治疗后PaO2均升高，PaCO2降低（P均＜0．01），两组之间差异无显著性（P＞0．05）。但肺心汤治疗组血清NO含量较治疗前明显增加（P＜0．01），血浆ET－1、ADM则明显降低（P＜0．01），而西药治疗组治疗后NO、ET－1、ADM无明显变化，两组之间差异有非常显著性意义（P＜0．01）。结论：肺心汤治疗肺心病急性发作期具有较好的临床疗效。其可能部分通过调节患者NO、ET－1、ADM平衡而起作用。     

2型糖尿病合并肾病患者血清内皮素含量的临床分析

目的探讨2型糖尿病合并肾病患者尿微量白蛋白（UM）和内皮素（ET）的变化及其临床意义。方法选择2型糖尿病合并肾病患者30例（A组），并与2型糖尿病无血管并发症者（B组）、糖耐量受损（IGT）者（C组）作比较；同时选择有2型糖尿病家族史健康人（D组）和无2型糖尿病家族史健康人（E组）各30例作为对照，分别检测UM、ET并进行统计分析。结果A组与其他4组比较，UM含量有显著差异（P〈0．05），而B、C、D、E组间UM含量无显著性差异（P〉0．05）；A组ET含量明显高于其他4组（P〈0.01），E组明显低于其他4组（P〈0.01）。结论2型糖尿病患者存在内皮功能损伤，且随着病程的进展而发展，合并肾病并发症与内皮功能损伤，两者变化同步，提示血管内皮损伤与肾病并发症有关，同糖尿病病程进展相关。     

血脂康对高脂血症患者血脂及血管内皮功能的影响

目的:观察血脂康对高脂血症患者血脂水平及血管内皮功能的影响.方法:98例高脂血症患者随机分为观察组49例和对照组49例.观察组口服血脂康胶囊,每天1.2g,连用8周;对照组口服普伐他汀片,每天20mg,连用8周.测定治疗前后两组血甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及内皮素(ET)、一氧化氮(NO)水平.结果:治疗后,两组TG、TC、LDL-C、ET降低,HDL-C、NO升高,与治疗前比较,差异均有显著性意义(P<0.01或<0.05).观察组与对照组比较,治疗后TG、TC、LDL-C降低及HDL-C升高差异均无显著性意义,但ET降低和NO升高差异有显著性意义(P<0.05).结论:血脂康在改善高脂血症患者血脂异常同时可降低血内皮素、升高血一氧化氮水平,对血管内皮功能有改善作用.血脂康每天1.2g调脂程度与普伐他汀每天20mg相同,但改善血管内皮功能作用强于普伐他汀每天20mg.     

外科手术后血管内皮细胞结构及功能变化

目的：探讨外科手术对血管内皮细胞的影响。方法：健康大24只，麻醉后进行学生外科实验手术操作，手术前和手术后分别抽血测循环内皮细胞（CEC），一氧化氮（NO），内皮素（ET）。CEC用Percotl密度梯度离心法分离测定，NO用紫外分光度计测定，ET用放射免疫法测定。结果：术前各实验犬的NO、ET、CEC无明显变化，手术后NO含量明显降低，ET含量明显升高（P＜0．05），CEC数量明显增多（P＜0．05），形态明显改变，出现有核细胞。结论：手术或创伤可导致内皮细胞功能紊乱，并引起内皮细胞结构损伤。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.