异位妊娠失血性休克的早期救护

目的 探讨异位妊娠失血性休克患者的抢救护理方法。方法对本院急诊入院的218例异位妊娠失血性休克患者成功抢救。采用一边从临床表现、休克指征、休克指数进行判断出血量；一边迅速建立静脉通道补充血容量纠正休克。实行二人分工合作制进行紧急抢救及术前准备。结果218例患者经及时补充血容量、紧急手术去除病因的治疗与护理，均痊愈出院。结论在异位妊娠失血性休克的抢救中，护士强烈的急诊抢救意识、娴熟的抢救技术、成熟的二人分工合作制的抢救流程，密切观察病情变化及有预见性的快、准、细的实施纠正休克进一步发展的救护措施，为医生进一步的手术抢救成功赢得了宝贵的时机。根本上提高护理质量和专业素质。     

急诊异位妊娠患者在手术室的抢救与护理

目的:探讨护理急诊异位妊娠患者在手术室的抢救及护理措施。方法:回顾性分析在我院2010年1月~2012年12月收治的急诊异位妊娠失血性休克的患者治疗,总结急救护理经验。结果:通过医护人员积极配合,及时抢救和精心护理,36名患者均抢救成功并痊愈出院。结论:异位妊娠是妇产科最常见的急腹症之一,由于病情严重,需急诊手术及抗休克治疗,加强围手术期的护理,并积极与医生配合,是提高异位妊娠失血性休克抢救成功的重要保障。     

39例异位妊娠失血性休克急诊预检分诊救护体会

目的探讨异位妊娠并失血性休克患者的急救处理及护理。方法对我科接诊的39例异位妊娠破裂致失血性休克病例急诊救护进行总结。结果39例患者经急诊紧急处置后,均安全送入手术室行急诊手术并抢救成功。结论通过急诊护士准确预检分诊,把可疑异位妊娠破裂的患者从急腹症患者中鉴别出来,配合专科医生尽快确诊,进行早期救护干预,稳定生命体征,为急诊手术争取先机。     

异位妊娠失血性休克围手术期护理1例

目的探讨异位妊娠失血性休克患者围手术期护理方法。方法对本例异位妊娠出血性休克患者行手术治疗,并给予积极抢救和精心护理。结果患者手术成功,无护理纠纷发生,患者及其家属对护理满意。结论密切观察病情变化,做好急救护理和围术期护理,是异位妊娠失血性休克患者抢救成功的关键。     

异位妊娠破裂的救护体会

目的 通过回顾性分析异位妊娠破裂患者的急救,以提高异位妊娠患者的抢救成功率,减少患者病死率.方法 对近4年来经急诊抢救后收入妇产科住院的74例异位妊娠破裂患者的急救及护理措施进行回顾性分析和总结.结果 经急诊紧急抢救后,行手术治疗者60例,其余患者给予保守治疗,均痊愈出院.结论 异位妊娠破裂的急诊救护中,要求护士在接诊时要认真细致地询问病史;要有敏锐的观察力,密切监测病情动态变化;果断而紧急的急救处理能力;抢救时分秒必争,医护配合密切,使患者转危为安.     

58例异位妊娠的抢救护理体会

我科自 2 0 0 1年 1月至 2 0 0 2年 6月收治异位妊娠破裂失血性休克 5 8例 ,由于手术前后重视了护理质量 ,及时抢救 ,无一例死亡。现将抢救及护理体会总结如下 :1　临床资料发病年龄 2 2～ 35岁 4 2例 ;36～ 39岁 13例 ;4 0岁以上 3例。病患部位 :输卵管妊娠 5 6例 ,宫角妊娠 2例。出血量最大者约 30 0 0ml,出血量超过 10 0 0ml者 37例 ,出血量在 5 0 0ml～ 10 0 0ml者 18例 ,出血量小于5 0 0ml者 3例 ;休克程度 :轻度休克 10例 ,中度休克 2 8例 ,重度休克 2 0例。平均住院日为 9d。2　抢救及护理2 .1　立即将患者送入抢救室 ,在通知医生的…     

66例异位妊娠破裂患者的心理护理体会

总结 6 6例异位妊娠破裂患有的心理护理 ,说明有的放矢地进行心理护理的重要性和效果 ;回顾 1998～ 1999年 6 6例异位妊娠破裂的患者 ,经过耐心细致的心理护理 ,都能较好地配合医生和护士做好术前准备 ,及时进行手术治疗 ,并且都能痊愈出院 ;异位妊娠破裂尤其合并失血性休克者 ,病情凶险 ,医护人员必须抓紧每一项检查及准备环节 ,争取时间积极处理 ,从速手术 ,这是成功挽救患者生命的关键。而要达到目的 ,就必须取得病人及其家属的配合 ,做好心理护理     

手术室护士在异位妊娠并失血性休克抢救中的作用

异位妊娠是妇产科的常见病 ,亦是妇产科急腹症之一。异位妊娠破裂常因失血过多危及生命。我院 1998年 1月至19 99年 10月共收治手术治疗异位妊娠破裂并出血患者 192例。本文就手术抢救中护理的作用分析如下。1　临床资料1.1　一般资料　 192例发病年龄 17～ 3 7岁 ,平均年龄 2 5.6岁。送入手术室时轻度休克 92例 ,中度休克 64例 ,重度休克 3 6例 ,其中血压测不到 2例。妊娠情况 :192例异位妊娠中 ,输卵管妊娠 177例 ,宫颈部妊娠 15例。首次妊娠 4 3例 ,第 2次妊娠 10 2例 ,第 3次妊娠 3 5例 ,第四次妊娠 12例。1.2　临床表现　病人入院时呈…     

腹部外伤大出血抢救的手术室配合探讨

目的:探讨研究腹部外伤大出血抢救的手术室护理配合方式,提高手术室护理配合效果。方法:回顾性分析我院急诊科自2012年3月至2013年5月之间接收诊治的32例腹部外伤大出血急诊抢救患者手术室护理情况,总结手术室抢救过程中护理配合方式,观察手术室配合后护理效果。结果:所有患者经手术室术前准备、术中配合急诊抢救取得成功,2例患者出现弥散性血管内凝血症状,临床及时治疗后摆脱生命危险,术后均痊愈并出院,手术室护理配合效果显著。讨论:腹部外伤大出血患者在急诊抢救过程中加强手术室配合可以有效控制出血量,提高患者生存质量,在临床手术室中护理中应充分开展术前准备、术中观察,护理人员积极配合急诊抢救提高抢救成功率,确保手术顺利进行。     

异位妊娠破裂休克的抢救和护理

异位妊娠是妇产科常见急症之一 ,破裂后可有腹腔内出血 ,严重者可出现休克症状 ,如抢救不及时将危及生命 ,因此 ,迅速扩容 ,及时手术治疗是抢救成功的关键。我院 1998年 6月至 2 0 0 0年 6月共收治异位妊娠破裂休克患者 13例 ,由于抢救及时 ,护理得当 ,全部治愈出院。现将抢救护理的体会报告如下。临床资料　　本组 13例 ,年龄在 18～ 44岁之间 ,其中首次异位妊娠破裂 11例 ,异位妊娠 2次破裂 2例。出血量 5 0 0～ 10 0 0ｍｌ 6例 ,>10 0 0～ 2 0 0 0ｍｌ 4例 ,>2 0 0 0ｍｌ 3例。临床表现为面色苍白 ,表情淡漠 ,反应迟钝 ,脉快而细弱 ,血压…     

表皮生长因子受体酪氨酸激酶抑制剂在非小细胞肺癌应用的瓶颈——获得性耐药

以表皮生长因子受体酪氨酸激酶抑制剂（epidermal growth factor receptor-tyrosine kinase inhibitor,EGFR-TKI）分子靶向治疗研究为肇始,转化性研究使基础实验和临床实践间的鸿沟迅速填平,改变着人们认识治疗肺癌的视角。无可否认,EGFR-TKI上市后极大地延伸了肿瘤学家治疗肺癌的手段,但不管从临床经验、临床研究数据、分子生物学层面还是文献计量学的角度,     

Liuwei Dihuang,a traditional Chinese herbal formula,suppresses chronic inflammation and oxidative stress in obese rats

OBJECTIVE： To investigate the anti-inflammatory, anti-oxidative stress, and adipokine-ameliorating effects of Liuwei Dihuang （LWDH）, a traditional Chinese herbal formula, in obese rats. METHODS： After 2 weeks of acclimation with free access to regular rodent chow and water, obese-prone-caesarean-derived （OP-CD） rats were fed a modified AIN-93G diet containing 60% energy from fat. Treatment was performed twice daily by gavage feeding with 500, 1 500, or 3 500 mg/kg body weight LWDH suspended in water （n=12 rats per group）. Twelve obese-resistant-CD （OR-CD） rats were fed the atherogenic diet and gavaged with water, and served as the normal control. Blood biomarkers of inflammation, oxidative stress and adiponectin were measured post-sacrifice and used to determine the treatment effect of LWDH and assess the suitability of OR/OP-CD rats for studying these parameters. RESULTS： After 9 weeks of treatment, LWDH lowered serum C-reactive protein （CRP） and tumour necrosis factor-α （TNF-α） levels. Serum interleukin-6 （IL-6） levels showed a tendency towards reduction, but were not significantly different from the OP-CD control. Liver superoxide dismutase （SOD） activity was increased in response to all three doses of LWDH, while the levels of reduced （GSH） and oxidized glutathione （GSSG） and thiobarbituric acid reactive substances （TBARS） were unchanged. Serum adiponectin levels were increased in response to oral administration of LWDH at the dose of either 500 or 1 500 mg/kg body weight. In addition, comparisons between OR-CD and OP-CD rats revealed differential, and for some biomarkers, conflicting characteristics of high-fat diet-fed OP-CD rats in reference to obese human subjects in terms of inflammatory and oxidative stress biomarkers and circulating adiponectin levels. CONCLUSION： The results show, for the first time, the anti-inflammatory, anti-oxidative stress and adiponectin-ameliorating effects of LWDH in obese rats. The suitability of the OP-JOP-CD rat model as     

益智健脑颗粒联合针灸对阿尔茨海默病大鼠学习记忆的影响

目的观察益智健脑颗粒联合针灸对阿尔茨海默病（Alzheimers disease,AD）大鼠学习记忆的影响。方法将大鼠随机分为假手术组（A组）、模型组（B组）、针灸组（C组）、益智＋针灸组（D组）各10只,B、C、D 3组分别以海马CA1区注射β淀粉样蛋白25-35（Aβ25-35）造模,A组注射等量的双蒸水,各组分别治疗20 d后行Morris水迷宫试验,观察大鼠学习记忆能力变化。结果B组较A组的平均潜伏期明显延长,差异具有统计学意义（P〈0.05）;与B组比较,C组、D组的平均潜伏期明显缩短,过台次数增多,差异具有统计学意义（P〈0.05,P〈0.01）;与C组比较,D组的潜伏期缩短,过台次数增多,差异具有统计学意义（P〈0.05）。结论益智健脑颗粒联合针灸能够提高Aβ25-35介导的AD模型大鼠的学习记忆能力。     

程丑夫教授论治情志病验案举隅

程丑夫是国家级名老中医,湖南中医药大学第一附属医院主任医师、教授、博士生导师,享受政府特殊津贴专家,出身于中医世家,从医40余年,经验丰富,对于内科系统及疑难杂症的治疗颇有心得,笔者有幸跟师学习,聆听教诲,受益匪浅,现将程师论治情志病的经典验案略陈一二。1思虑伤脾案患者肖某,女,27岁。初诊：2014年5月20日。半年前因婚变后出现忧心忡忡,多思多虑,近1月来反复腹部胀满,刻诊：腹胀,食后为甚,呃逆,无反酸,通气后可减轻,无腹痛,不欲食,夜寐不安,二便调。舌红苔厚白腻,脉弦,BP：110／70mmHg。     

补肾活血方对PCOS大鼠模型卵巢中PAI-1mRNA表达的影响

目的探讨补肾活血方对大鼠PCOS模型卵巢局部纤溶酶原激活物抑制因子-1（PAI—1mRNA）表达的影响。方法选用未成年24d龄SD雌性大鼠60只,随机分为模型组、克罗米酚组、补肾活血方高剂量组、补肾活血方低剂量组、正常对照组5组。用Bogovich法建立大鼠多囊卵巢病理模型。以克罗米酚为对照。用原位杂交法观察补肾活血方对多囊卵巢大鼠局部PAI—1mRNA的影响。结果模型组卵巢局部PAI—1mRNA存在卵泡膜间质细胞显著增高,用补肾活血方高、低剂量与克罗米酚药后,卵巢局部PAI-1mRNA的表达明显降低．差异具有统计学意义（P〈0．05、P〈0．01）。补肾活血方高剂量组与克罗米酚组比较,差异具有显著统计学意义（P〈0．01）;低荆量组与克罗米酚组比较差异无统计学意义（P〉0．05）,补肾活血方高、低剂量组比较,低剂量组卵泡膜间质细胞上PAI-1的基因表达增高更明显,但二者差异无统计学意义（P〉0．05）。结论PAI-1mRNA可能与多囊卵巢综合征的发病机制有关。以补肾活血立法的补肾活血方能降低多囊卵巢大鼠局部PAI—1mRNA的显著增高表达．降低PAI—1mRNA卵巢局部的作用。提示补肾活血方可能通过PAI—1mRNA途径促进卵巢排卵的机制。     

New Mechanism of Herb-herb Interaction between Ginseng and Trogopterus Based on CYPs in Rat Livers

The study was designed to investigate the potential mechanism of herb-herb interaction between ginseng and Trogopterus （Trg） based on Cytochrome P450 isozymes （CYPs） in rat livers. We estimated the influence on CYP1A2, CYP2E1, and CYP3A1/2 activity caused by ginseng and Trg used in combination. The CYP1A2 and CYP2E1 enzyme activity were induced by ginseng and Trg used in combination. And this induction effect was caused via inducing CYP1A2 and CYP2E1 protein expression which was supposed caused by inducing the gene expression of CYP1A2 and CYP2E1.     

UniPron is A Fully Effective Non-hormonal Reversible Contraceptive in Baboon Model （Papio Anubis）

Objective To determine the safety and efficacy of UniPron as a reversible contraceptive.
Methods Vaginal swabs were obtained before and after UniPron administration, cultured onto appropriate culture media and bacteria identification was done based on type of media used, Gram stain reactions, colony morphology and biochemical tests. Vaginal biopsy tissues were processed using paraffin wax method, stained with hematoxylin and eosin and examined under light microscopy to determine the effect of the product on vaginal tissues. The effect of UniPron on sperm was examined by mixing the product with electroejaculated spermatozoa in vitro at different concentrations. For efficacy studies, male baboons of proven fertility were mated with UniPron treated or untreated females of proven fertility during the fertile stages.
Results All the five females （100%） that were treated with UniPron did not conceive and they regained total fertility when the treatment was stopped while all the controls conceived. At a concentration of 40%, UniPron completely immobilized spermatozoa in an in-vitro system. UniPron mechanism of action was by lowering the vaginal pH and on application in baboon, the pH was lowered for at least 3 h after which it went back to normal.
Conclusions As we plan for a study to test UniPron as a microbicide to prevent STIs including HIV, our current study has established that this novel product is effective in contraception and harmless to vaginal tissues and vaginal microbial flora in a baboon model （Papio anubis）.     

Mechanical tests on the reconstructed anterior cruciate ligament fixed with allogenetic cortical bone cross-pin on the femoral side

Background Anterior cruciate ligament reconstruction （ACLR） has developed dramatically in the last century.Now,ACLR has become a reliable and productive procedure.Patients feel satisfied in 〉90% cases.The aim of this study was to evaluate the feasibility of allogenetic cortical bone cross-pin （ACBCP） used as a clinical fixation method in anterior cruciate ligament reconstruction on the femoral side based on biomechanical tests in vitro.Methods The specimens were provided by the bone banks of the First Affiliated Hospital of People＇s Liberation Army of General Hospital from September 2011 to June 2012.Fresh deep frozen human allogenetic cortical bone was machined into cross-pins which is 4.0 mm in diameter and 75.0 mm in length.Biomechanical parameters compared with Rigidfix were collected while cross-pins were tested in double-shear test.The load-to-failure test and cycling test were carried out in a goat model to reconstruct anterior cruciate ligament with Achilles tendon autograft on the femoral side fixed by human 4.0 mm ACBCP and 3.3 mm Rigidfix served as control.Maximum failure load,yield load,and stiffness of fixation in single load-to-failure test were compared between the two groups.Cycle-specific stiffness and displacement at cycles 1,30,200,400,and 1 000 were also compared in between.Results In double-shear test both maximum failed load and yield load of 4.0 mm humanACBCP were （1 236.998±201.940） N.Maximum failed load and yield load of Rigidfix were （807.929±110.511） N and （592.483±58.821） N.The differences of maximum failed load and yield load were significant between ACBCP and Rigidfix,P 〈0.05.The shear strength of ACBCP and Rigidfix were （49.243±8.039） MPa and （34.637±3.439） MPa,respectively,P 〈0.05.In the load-to-failure test ex vivo,yield load and maximum failed load of ACBCP fixation complexity （（867.104±132.856）N,（1 032.243±196.281） N） were higher than those of Rigidfix （（640.935±42.836） N,（800.568±64.890） N,P 〈0.05）.However,s     

中医疗法治疗运动性疲劳的研究进展

随着竞技体育的发展，运动员经常承受着大负荷、超强度的体力训练，因此极易产生运动性疲劳。疲劳的出现使肌内压增高，局部缺血，造成氧化代谢、H^＋排出率与pH值降低，血乳酸增高，从而影响肌纤维神经传导速度和肌内收缩力量，减弱了肌肉保护能力。致使较多的冲击力传到骨骼上，故易导致疲劳骨折的发生,严重影响了运动员的训练和比赛成绩，对运动员身心产生不必要的伤害。运动性疲劳消除手段的研究一直是竞技体育工作和运动医学关注和研究的焦点。     

Effects of tacrolimus and cyclosporine treatment on metabolic syndrome and cardiovascular risk factors after renal transplantation: a meta-analysis

Background The therapeutic success of renal transplantation has been largely attributable to the development of effective and balanced immunosuppressive treatment regimens.This study provides a meta-analysis of a series of randomized controlled trials that compared the effects of tacrolimus and cyclosporine on metabolic syndrome （MetS） and cardiovascular risk factors after renal transplantation.Methods We searched various electronic databases and bibliographies,including MEDLINE,the Cochrane Central Register of Controlled Trials,and EMBASE,for relevant studies published prior to October 2012.Results Our meta-analysis included five randomized controlled trials that examined a total of 923 patients.The tacrolimus group and the cyclosporine group exhibited no significant differences in MetS incidence after renal transplantation; risk ratio （RR）：1.06,95％ confidence interval （C/）：0.73-1.55,P=0.76.Cyclosporine treatment was associated with a higher incidence of hyperlipidemia （RR：0.50,95％ CI：0.39-0.64,P ＜0.01）.Although there were no statistically significant differences,cyclosporine treatment was associated with a higher incidence of hypertension （RR：0.91,95％ CI：0.83-1.00,P=0.06） after renal transplantation compared to tacrolimus treatment,and tacrolimus treatment was associated with a higher incidence of diabetes after renal transplantation （RR：1.79,95％ CI：0.98-3.27,P=0.06） compared to cyclosporine treatment.Conclusions Compared to tacrolimus treatment,cyclosporine treatment was associated with a higher incidence of hyperlipidemia.Future large-scale studies are expected to be conducted to further confirm our findings.