Objective: Traditional Chinese medicines (TCMs) are efficacious against ulcerative colitis (UC). In recent years, the number of randomized
clinical trials (RCTs) of TCM has increased. Thus, it is very important to summarize the basic characteristics, quality, and types of TCM
interventions in published RCTs. This scoping review was performed to systematically identify and describe the current situations about RCTs
of TCMs for treating UC. Hope to express the focus and specifics of nowadays research in TCM interventions in RCTs and evaluate their
common disadvantages exposed to help advance in TCM researching. Materials and Methods: Ascoping review was conducted according to
the PRISMA extension for scoping reviews. We searched two English databases and four Chinese databases from the date of establishment of
each database to January 2020. Data from RCTs focusing on any TCM treatment for patients with UC were extracted and evaluated. Selection
and characterization were performed by two independent reviewers using predefined forms. All discrepancies were resolved by consensus
discussion with a third reviewer. Microsoft Excel 2010 was used to extract the following data from the included studies: (1) basic information
of the included studies including research ID, article title, publication language, journal, year of publication, and funding information; (2)
patient information including gender, age, disease course, disease stage, severity, sample size; and (3) information on intervention measures,
types of intervention measures, drug dosage forms, and treatment courses. Results: The search identified 2225 RCTs published between
1987 and 2020. These studies covered 36 provinces in China. The time frame of the RCTs was <28 days in approximately one-third of the
RCTs (647, 29.08%). Only one RCT was published in English. Nearly three-quarters of RCTs (1665, 74.83%) did not report the severity of
the disease. Three types of interventions were included in the RCTs: pharmacotherapy (2028, 91.15%), nonpharmacotherapy (57, 2.56%),
and a combination of the two (140, 6.29%). The administration modes of the intervention groups were evaluated. Drug therapy involved 12
types of TCM dosage forms, which were decoctions, troches, powders, capsules, granules, pills, suppositories, ointments, injections, gels,
oral liquids, and substitute tea according to the frequency of use. Nondrug intervention measures involved 10 treatment options, namely,
acupuncture, moxibustion, hemospasia, auricular point, acupoint catgut embedding, acupoint injection, scrapping, tuina, acupoint application,
and five?tone therapy according to the frequency of use. Most studies included in this review were low in quality. This underscores the need
for improvement in the quality of trial methodology in TCM RCTs. 相似文献
Introduction: Child-appropriate drug formulations are mandatory for an efficient and safe drug therapy in children. Since the implementation of supportive legislations development of novel drug formulations has significantly been enforced despite the fact that children are a heterogeneous group of patients with varying needs according to age, maturation and disease.
Areas covered: In this review, recent advances and current strategies are evaluated how to overcome the specific hurdles in pediatric drug development. For cardiovascular diseases as an example, EMA’s decisions on pediatric investigation plans (PIPs) have been evaluated. New developments with innovative platform technologies such as mini-tablets and orodispersible preparations have been identified indicating a clear shift from liquid preparations to small-sized solid (multiparticulate) or orodispersible dosage forms. Reasons for this shift of paradigm are discussed.
Expert opinion: Innovative platform technologies for solid drug dosage forms such as mini-tablets, orodispersible tablets or film preparations will continue to conquer the pharmaceutical market. Still, there are some major issues to be resolved, e.g. how to ensure quality of the new dosage forms and dose accuracy in flexible dosing, but the governmental incentives will continue to accelerate development of pediatric medicines and will bridge the still existing gaps in the near future. 相似文献