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The effect of antihypertensive drugs on in vivo platelet activity in essential hypertension. 总被引:4,自引:0,他引:4
OBJECTIVE: To investigate whether antihypertensive drugs have a beneficial effect upon the abnormal in vivo platelet function found in patients with essential hypertension. DESIGN: A cross-sectional study in which plasma beta-thromboglobulin, a marker of in vivo platelet activation, was measured in patients with essential hypertension on various antihypertensive drugs. All were free from any other diseases which might affect platelet function. METHODS: Plasma beta-thromboglobulin was measured in 24 patients with untreated essential hypertension, 21 normotensive control patients, 16 patients receiving angiotensin converting enzyme (ACE) inhibitors, 16 patients receiving a beta-adrenoceptor blocker, 12 patients receiving calcium antagonists and 12 patients receiving a diuretic alone. RESULTS: Untreated hypertensives had significantly elevated plasma beta-thromboglobulin levels compared with controls. Plasma beta-thromboglobulin levels in patients receiving beta-blockers and diuretics were not significantly different from untreated hypertensives. Treatment with calcium antagonists was associated with lower plasma beta-thromboglobulin levels, but this difference was not statistically significant. In contrast, treatment with ACE inhibitors was associated with significantly lower plasma beta-thromboglobulin levels compared with untreated hypertensives. CONCLUSION: These results suggest that antihypertensive drugs have different effects upon abnormal in vivo platelet function in patients with essential hypertension. The apparent beneficial effect of ACE inhibitors may mean that they have more impact than other drug groups in the prevention of coronary heart disease. 相似文献
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Pikis Stylianos Mantziaris Georgios Islim Abdurrahman I. Peker Selcuk Samanci Yavuz Nabeel Ahmed M. Reda Wael A. Abdelkarim Khaled El-Shehaby Amr M. N. Tawadros Sameh R. Emad Reem M. Delabar Violaine Mathieu David Lee Cheng-chia Yang Huai-che Licsak Roman Hanuska Jaromir Alvarez Roberto Martinez Patel Dev N. Kondziolka Douglas Bernstein Kenneth Moreno Nuria Martinez Tripathi Manjul Speckter Herwin Albert Camilo Bowden Greg N. Benveniste Ronald J. Lunsford Dade L. Jenkinson Michael D. Sheehan Jason 《Journal of neuro-oncology》2022,157(1):121-128
Journal of Neuro-Oncology - The optimal treatment strategy of asymptomatic, convexity meningiomas, remains unclear. The purpose of this study was to define the safety and efficacy of stereotactic... 相似文献
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Okan Akhan Filiz Islim Sinan Balci Aysun Erbahceci Burcu Akpınar Turkmen Ciftci Devrim Akinci 《Cardiovascular and interventional radiology》2016,39(6):902-908
Purpose
The purpose of our study is to evaluate results of percutaneous aspiration with alcohol sclerotherapy in symptomatic patients with simple hepatic cysts by employing single-session techniques either by a needle or a catheter.Materials and Methods
We retrospectively included 39 simple hepatic cysts in 35 patients treated via percutaneous aspiration and single-session alcohol sclerotherapy between years 1993 and 2012. Indications were pain (n = 28) or ruling out cystic echinococcus (CE) disease (n = 7). 29 cysts in 26 patients were treated by needle technique (Group A) and ten cysts in nine patients were treated by single-session catheter technique (Group B). Patients were followed for 4–173 months (median: 38 months).Results
All patients were successfully treated. Before procedure, cyst volumes were 21–676 cc (median: 94 cc). Post-procedure cyst volumes at last follow-up were 0-40 cc (median: 1 cc). The mean decrease in cyst volume was 95.92 ± 2.86 % in all patients (95.96 ± 3.26 % in Group A and 95.80 ± 6.20 % in Group B). There was no statistically significant difference between the volume reduction rates of Group A and Group B. Only one patient, in Group B, developed a major complication, an abscess. Hospitalization period was 1 day for all patients.Conclusions
For patients with symptomatic simple hepatic cysts smaller than 500 cc in volume by using puncture, aspiration, injection, and reaspiration (PAIR) technique with only needle, single-session alcohol sclerotherapy of 10 min is a safe and effective procedure with high success rate.5.
Mantziaris Georgios Pikis Stylianos Samanci Yavuz Peker Selcuk Nabeel Ahmed M. Reda Wael A. Tawadros Sameh R. El-Shehaby Amr M. N. Abdelkarim Khaled Emad Reem M. Delabar Violaine Mathieu David Lee Cheng-chia Yang Huai-che Liscak Roman Hanuska Jaromir Alvarez Roberto Martinez Moreno Nuria Martinez Tripathi Manjul Speckter Herwin Albert Camilo Benveniste Ronald J. Bowden Greg N. Patel Dev N. Kondziolka Douglas Bernstein Kenneth Lunsford L. Dade Jenkinson Michael D. Islim Abdurrahman I. Sheehan Jason 《Journal of neuro-oncology》2022,156(3):509-518
Journal of Neuro-Oncology - The optimal management of asymptomatic, skull-based meningiomas is not well defined. The aim of this study is to compare the imaging and clinical outcomes of patients... 相似文献
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Filiz Islim Aysun Erbahceci Salik Sibel Bayramoglu Koray Guven Halil Alis Ahmet Nuray Turhan 《Abdominal imaging》2014,39(3):472-481
Purpose
The purpose of this study was to evaluate the contribution of diffusion-weighted magnetic resonance imaging (DW-MRI) to the detection of infection in acute pancreatitis-related collections.Methods
A total of 21 DW-MRI, and computed tomography (CT) were performed on 20 patients diagnosed as acute pancreatitis with acute peri-pancreatic fluid or necrotic collections. Collections were classified as infected or sterile according to the culture and follow-up results. Collections with gas bubbles on CT images were considered to be infected. Collections with peripheral bright signals on DW-MRI images were considered to be positive, whereas those without signals were considered to be negative. Apparent diffusion coefficient (ADC) values of the peripheral and central parts of the collections were measured. Student’s t test was used to compare the means of ADC values of independent groups.Results
Apart from one false positive result, the presence of infection was detected by DW-MRI with 95.2% accuracy. The sensitivity and accuracy of DW-MRI were higher than CT for the detection of infection. The ADC values in the central parts of the collections were significantly different between the infected and sterile groups.Conclusion
DW-MRI can be used as a non-invasive technique for the detection of infection in acute pancreatitis-associated collections. 相似文献7.
The effect of quinapril and nifedipine on platelet aggregation, vascular endothelial function and coagulation system activity, was compared in a parallel-group, investigator-blind study carried out on patients with mild to moderate hypertension but no other diseases or receiving medication which might affect platelet function, vascular endothelium or coagulation. Forty patients (two groups of 20 patients each) and 20 control subjects were recruited. Patients were randomised to receive either quinapril or nifedipine retard and the dose escalated to control hypertension. Platelet aggregation studies were assessed serially and g -thromboglobulin, angiotensin-converting enzyme (ACE), von Willebrand factor (vWF) coagulation factors VIIIc, XII and fibrinogen were measured at the beginning and end of the 12-week period. Blood pressure was adequately controlled in all patients in both groups. Platelet function was impaired in certain parameters (slope of the reaction with ADP and collagen and maximum aggregation with collagen) in the patient group compared to controls before treatment and this improved in patients on quinapril but not on nifedipine; likewise g -thromboglobulin was higher in the patient group and fell significantly in the quinapril group but not those on nifedipine. Measurements of endothelial function and coagulation were normal before treatment and showed no alteration during the study, except in the expected fall in plasma ACE in the quinapril group. The results indicate that the ACE inhibitor, quinapril, has a beneficial effect on platelet function unlike the calcium channel blocker, nifedipine. 相似文献
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Gillespie Conor S. Islim Abdurrahman I. Taweel Basel A. Millward Christopher P. Kumar Siddhant Rathi Nitika Mehta Shaveta Haylock Brian J. Thorp Nicola Gilkes Catherine E. Lawson David D. A. Mills Samantha J. Chavredakis Emmanuel Farah Jibril Osman Brodbelt Andrew R. Jenkinson Michael D. 《Journal of neuro-oncology》2021,153(2):239-249
Journal of Neuro-Oncology - Radiation induced meningioma (RIM) incidence is increasing in line with improved childhood cancer survival. No optimal management strategy consensus exists. This study... 相似文献
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Gillespie Conor S. Richardson George E. Mustafa Mohammad A. Evans Daisy George Alan M. Islim Abdurrahman I. Mallucci Conor Jenkinson Michael D. McMahon Catherine J. 《Neurosurgical review》2022,45(5):3193-3200
Neurosurgical Review - Long-standing overt ventriculomegaly in adults (LOVA) is a heterogenous group of conditions with differing presentations. Few studies have evaluated success rates of... 相似文献
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The effect of quinapril and nifedipine on platelet aggregation, vascular endothelial function and coagulation system activity, was compared in a parallel-group, investigator-blind study carried out on patients with mild to moderate hypertension but no other diseases or receiving medication which might affect platelet function, vascular endothelium or coagulation. Forty patients (two groups of 20 patients each) and 20 control subjects were recruited. Patients were randomised to receive either quinapril or nifedipine retard and the dose escalated to control hypertension. Platelet aggregation studies were assessed serially and beta-thromboglobulin, angiotensin-converting enzyme (ACE), von Willebrand factor (vWF) coagulation factors VIIIc, XII and fibrinogen were measured at the beginning and end of the 12-week period. Blood pressure was adequately controlled in all patients in both groups. Platelet function was impaired in certain parameters (slope of the reaction with ADP and collagen and maximum aggregation with collagen) in the patient group compared to controls before treatment and this improved in patients on quinapril but not on nifedipine; likewise beta-thromboglobulin was higher in the patient group and fell significantly in the quinapril group but not those on nifedipine. Measurements of endothelial function and coagulation were normal before treatment and showed no alteration during the study, except in the expected fall in plasma ACE in the quinapril group. The results indicate that the ACE inhibitor, quinapril, has a beneficial effect on platelet function unlike the calcium channel blocker, nifedipine. 相似文献