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1.
Objective To investigate anethol trithione therapic efficiency on dry eye. Methods It was a prospective random double-blind controlled study. Eighty cases diagnosed dry eye in Ocular Surface Out-patient Clinic of Xiamen University Affiliated Xiamen Eye Center from 2006 to 2008 were divided into two groups: anethol trithione group and control group, 40 cases in each group. Every group was then divided into two subgroups: weak dry eye subgroup, middle and severe dry eye subgroup. All groups had been added with 0.05% refresh drops. All patients had been detected and evaluated by subjective symptoms of dry eye, visual acuity,corneal fluorescent staining(F1), break-up time(BUT) and Schirmer Ⅰ test (SⅠT) at pre-therapy and 3,7,28 d of post-therapy. All groups had been compared and analyzed by F test and sample mean difference (SMD) or median difference (MD) comparison between pre-therapy and post-therapy. Results Except of tear and red eye, the other subjective symptoms of dry eye, F1, BUT and SⅠT of weak dry eye subgroup of both groups had been improved at 7 d after therapy. Only those of middle and severe dry eye subgroup of anethol trithione group had been improved at 7 d after therapy compared with those of pre-therapy: SMD=0.96 (visual tiredness), 1.26 (dry and unsmooth sensation), 0.82 (foreign body sensation), 1.28 (burning sensation), 1.05 (photophobia), 1.48 ( pain ) ; MD=0.30 (visual acuity), 4.00 (F1) ,5.00 (BUT), 5.00 (SⅠT) [F=15.30 (visual tiredness), 15.68 (dry and unsmooth sensation ), 13.56 (foreign body sensation), 20. 91 ( burning sensation ), 18.90 (photophobia), 27.22 ( pain ), 10.54 (visual acuity), 188.21 (F1) ,261.76 (BUT) ,269.05 (SⅠT) ;P<0. 05]. Those of middle and severe dry eye subgroup of control group hadn't significantly been improved at 28 d after therapy: SMD=0.10 (visual tiredness) ,0.16 (dry and unsmooth sensation) ,0.09 (foreign body sensation) ,0.38 ( burning sensation ), 0.24(photophobia) ,0.36 (pain) ,0.23 (red eye) ; MD=0.10 (visual acuity) ,0.50(F1) ,0.50(BUT), 0.50(SⅠT) [F=1.76 (visual tiredness), 1.61 (dry and unsmooth sensation), 1.02 (foreign body sensation),2.39 (burning sensation), 2.42 (photophobia), 2.73 ( pain ), 2.55 ( red eye ), 1.46 ( visual acuity) ,2.35 (F1) ,2.90 (BUT) ,2.76 (SⅠT) ; P>0.05]. SⅠT of anethol trithione group had been improved more significantly after therapy (F=13.77, P<0.05). Conclusion Anethol trithione could significantly improve middle and severe dry eye patients' symptoms and signs whose lacrimal gland function survival and it has clinical application value.  相似文献   
2.
Objective To investigate anethol trithione therapic efficiency on dry eye. Methods It was a prospective random double-blind controlled study. Eighty cases diagnosed dry eye in Ocular Surface Out-patient Clinic of Xiamen University Affiliated Xiamen Eye Center from 2006 to 2008 were divided into two groups: anethol trithione group and control group, 40 cases in each group. Every group was then divided into two subgroups: weak dry eye subgroup, middle and severe dry eye subgroup. All groups had been added with 0.05% refresh drops. All patients had been detected and evaluated by subjective symptoms of dry eye, visual acuity,corneal fluorescent staining(F1), break-up time(BUT) and Schirmer Ⅰ test (SⅠT) at pre-therapy and 3,7,28 d of post-therapy. All groups had been compared and analyzed by F test and sample mean difference (SMD) or median difference (MD) comparison between pre-therapy and post-therapy. Results Except of tear and red eye, the other subjective symptoms of dry eye, F1, BUT and SⅠT of weak dry eye subgroup of both groups had been improved at 7 d after therapy. Only those of middle and severe dry eye subgroup of anethol trithione group had been improved at 7 d after therapy compared with those of pre-therapy: SMD=0.96 (visual tiredness), 1.26 (dry and unsmooth sensation), 0.82 (foreign body sensation), 1.28 (burning sensation), 1.05 (photophobia), 1.48 ( pain ) ; MD=0.30 (visual acuity), 4.00 (F1) ,5.00 (BUT), 5.00 (SⅠT) [F=15.30 (visual tiredness), 15.68 (dry and unsmooth sensation ), 13.56 (foreign body sensation), 20. 91 ( burning sensation ), 18.90 (photophobia), 27.22 ( pain ), 10.54 (visual acuity), 188.21 (F1) ,261.76 (BUT) ,269.05 (SⅠT) ;P<0. 05]. Those of middle and severe dry eye subgroup of control group hadn't significantly been improved at 28 d after therapy: SMD=0.10 (visual tiredness) ,0.16 (dry and unsmooth sensation) ,0.09 (foreign body sensation) ,0.38 ( burning sensation ), 0.24(photophobia) ,0.36 (pain) ,0.23 (red eye) ; MD=0.10 (visual acuity) ,0.50(F1) ,0.50(BUT), 0.50(SⅠT) [F=1.76 (visual tiredness), 1.61 (dry and unsmooth sensation), 1.02 (foreign body sensation),2.39 (burning sensation), 2.42 (photophobia), 2.73 ( pain ), 2.55 ( red eye ), 1.46 ( visual acuity) ,2.35 (F1) ,2.90 (BUT) ,2.76 (SⅠT) ; P>0.05]. SⅠT of anethol trithione group had been improved more significantly after therapy (F=13.77, P<0.05). Conclusion Anethol trithione could significantly improve middle and severe dry eye patients' symptoms and signs whose lacrimal gland function survival and it has clinical application value.  相似文献   
3.
目的:观察异体角膜体外对人外周血T细胞及其亚群CD25分子表达的影响。方法: 异体角膜与外周血淋巴细胞体外共同培养后,进行单克隆抗体标记和流式细胞分析。结果: 对照组T细胞CD25表达为25.2%;受角膜或沸波醇酯(PDB)激活后T细胞CD25表达分别为56.8%和80.9%;受角膜和沸波醇酯共同激活后T细胞CD25表达为70.2%;受异体角膜激活后,CD4和CD8 T淋巴细胞CD25表达分别为67.3%和52.3%。结论: 异体角膜组织体外能够刺激人外周T细胞CD25表达和T细胞活化,CD4 T细胞比CD8 T细胞活化更明显。  相似文献   
4.
目的探讨术后抗炎汤对白内障患者手术后血清与泪液白细胞介素2(SIL-2R)的影响及其临床意义.方法15例正常健康老人和47例白内障超声乳化加人工晶状体植入术患者随机分为正常组、对照组和中药组,中药组是在对照组药物基础上加用术后抗炎汤.检测白内障患者手术前后血清和泪液SIL-2R水平的变化.结果对照组和中药组术后血清SIL-2R均比术前明显升高(P<0.05),中药组术后泪液SIL-2R与术前相比差异无统计学意义(P>0.05),对照组术后SIL-2R水平明显高于中药组和正常组(P<0.01).结论术后抗炎汤能有效减轻白内障术后的炎症反应,其机理可能是调节眼局部免疫功能.  相似文献   
5.
患者,女,38岁,因左眼外伤(塑料片弹伤)后红痛、畏光流泪、视力下降1个月,加重10d,于2006年9月2日来我院门诊以“左眼角膜溃疡”收入院。入院前曾在外院用大剂量抗生素(具体药名不详)静脉滴注12d。全身体检:心、肺、肝、肾正常。血液常规检查:嗜酸性粒细胞百分比(7.8%)及绝对值(0.55×109/L)均升高。眼科检查:视力右眼1.2,无明显异常;左眼光感,光定位不确切,混合性充血,角膜中央和旁中央区灰白色混浊,欠光泽,表面粗糙不平,微隆起呈盖状,溃疡面积约7mm×7mm,周边区尚透明,交界处呈浅沟状,有稀薄白色分泌物,前房积脓深2mm。入院第1d左眼角膜组…  相似文献   
6.
刘莲  钟敬祥 《眼科新进展》2006,26(11):875-876
热休克蛋白70(heat shock protein70,HSP70)在正常细胞中水平较低,而在应激后表达显著增高,是HSP中重要的成员。HSP的功能涉及细胞的结构维持、更新、修复、免疫等,但其基本功能为帮助蛋白质的正确折叠、移位、维持和降解。我们就热休克蛋白70的主要功能及其与白内障发病的相关研究进展作一简要概述。  相似文献   
7.
患者 女 37岁 2004年7月20日来我院就诊,主诉左眼视物不清3天,无视物变形,无眼痛或畏光流泪,否认家族中有类似发作史。视力:右眼1.5,左眼0.1,光定位:左眼上方三个象限光感消失,右眼正常。双眼前段检查末见异常,散瞳后查眼底可见:右眼视盘鼻侧可见灰黄色隆起病灶,约3PD大小,边界较清,局部视网膜脱离(图1);左眼颞侧,下方可见视网膜大片灰黄色隆起,视网膜脱离,视网膜下方可见6PD大小隆起病灶,高约6mm,病变波及黄斑区(图2)。  相似文献   
8.
角膜移植患者外周血中T细胞CD28分子的表达及其意义   总被引:3,自引:0,他引:3  
目的 探讨角膜移植患者外周血T细胞及亚群CD2 8分子表达的变化及其意义。方法 于术前1d、术后第1、2、3、4周,应用流式细胞仪检测2 5例角膜移植患者外周血中CD2 8分子表达水平的变化。结果 角膜高血管化植床组患者术后外周血T细胞CD2 8分子表达比角膜无血管化植床组患者明显增高,也比术前明显增高(P <0 .0 1) ;6例发生排斥反应的患者均出于高血管化植床组;术后早期外周血T细胞中以CD4 + 细胞为主。结论 外周血T细胞CD2 8分子表达与角膜移植排斥反应关系密切,检测角膜移植患者外周血中的CD2 8分子表达可更早监测免疫排斥反应的发生  相似文献   
9.
目的 探讨MRI、视诱发电位(VEP)和视野(Vision Field,VF)在视神经炎中的临床应用价值。方法 临床诊断为视神经炎者60例分别行MRI、VEP和视野检查,每例所有检查均在一周内完成,并将检查结果进行统计学处理和分析。结果 MRI阳性率最高(96.67%),其次是视野和VEP(86.96%和75.58%)。同时发现MRI具有定位和一定的鉴别诊断作用。结论 VEP和VF结合MRI检查,三者相辅相成,将有助于视神经炎更早、更准确地诊断和治疗。  相似文献   
10.
实验性异种穿透性角膜移植的免疫学研究   总被引:1,自引:0,他引:1  
本文以鸡给兔的穿透性角膜移植为实验模型,运用微量全血~3H-TdR掺入法和ELISA,对术后动物机体的细胞和体液免疫功能状态变化进行了10周动态观察.发现:(1)术后同种和异种组外周血中淋巴细胞转化程度均增高,以3~4周最明显.(2)异种组术后2~8周血清中明显出现特异性抗角膜抗体,第3周达峰值,结合形态学观察证明:(1)术后免疫排斥反应主要是细胞介导的免疫应答,也有体液免疫的参与,异种移植体液免疫参与更明显,(2)运用微量全血~3H-TdR掺入法可有效监测术后机体免疫功能状态的变化.(3)使用免疫抑制剂应该重视术后3~4周.  相似文献   
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