全文获取类型
收费全文 | 1355872篇 |
免费 | 105203篇 |
国内免费 | 2799篇 |
专业分类
耳鼻咽喉 | 19348篇 |
儿科学 | 46716篇 |
妇产科学 | 37301篇 |
基础医学 | 192120篇 |
口腔科学 | 35755篇 |
临床医学 | 117848篇 |
内科学 | 275143篇 |
皮肤病学 | 29805篇 |
神经病学 | 107784篇 |
特种医学 | 54576篇 |
外国民族医学 | 679篇 |
外科学 | 207870篇 |
综合类 | 28561篇 |
现状与发展 | 1篇 |
一般理论 | 418篇 |
预防医学 | 99864篇 |
眼科学 | 29211篇 |
药学 | 101388篇 |
5篇 | |
中国医学 | 2807篇 |
肿瘤学 | 76674篇 |
出版年
2019年 | 10858篇 |
2018年 | 15296篇 |
2017年 | 11589篇 |
2016年 | 12657篇 |
2015年 | 14427篇 |
2014年 | 19905篇 |
2013年 | 29986篇 |
2012年 | 41251篇 |
2011年 | 43335篇 |
2010年 | 26140篇 |
2009年 | 24781篇 |
2008年 | 41172篇 |
2007年 | 43957篇 |
2006年 | 43963篇 |
2005年 | 42697篇 |
2004年 | 42023篇 |
2003年 | 40567篇 |
2002年 | 39852篇 |
2001年 | 66380篇 |
2000年 | 68775篇 |
1999年 | 58032篇 |
1998年 | 15204篇 |
1997年 | 13641篇 |
1996年 | 13960篇 |
1995年 | 14033篇 |
1994年 | 13271篇 |
1993年 | 12243篇 |
1992年 | 45672篇 |
1991年 | 44596篇 |
1990年 | 43181篇 |
1989年 | 41043篇 |
1988年 | 37744篇 |
1987年 | 37029篇 |
1986年 | 34433篇 |
1985年 | 32984篇 |
1984年 | 24694篇 |
1983年 | 20706篇 |
1982年 | 12029篇 |
1981年 | 10913篇 |
1979年 | 21694篇 |
1978年 | 15087篇 |
1977年 | 12746篇 |
1976年 | 11910篇 |
1975年 | 12904篇 |
1974年 | 15019篇 |
1973年 | 14460篇 |
1972年 | 13245篇 |
1971年 | 12040篇 |
1970年 | 11330篇 |
1969年 | 10298篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
Ruscitti Piero Di Cola Ilenia Berardicurti Onorina Conforti Alessandro Iacono Daniela Pantano Ilenia Rozza Gelsomina Rossi Silvia De Stefano Ludovico Balduzzi Silvia Vitale Antonio Caso Francesco Costa Luisa Prete Marcella Navarini Luca Atzeni Fabiola Guggino Giuliana Perosa Federico Cantarini Luca Frediani Bruno Montecucco Carlomaurizio Ciccia Francesco Giacomelli Roberto Cipriani Paola 《Clinical rheumatology》2022,41(11):3597-3597
Clinical Rheumatology - 相似文献
2.
Marco N. Iannone Stefano Stucchi Elia A. Turolla Chiara Beretta Samuele Ciceri Clizia Chinello Lisa Pagani Sergio Todde Patrizia Ferraboschi 《Journal of labelled compounds & radiopharmaceuticals》2022,65(3):48-62
In the last decade, the development of new radiopharmaceuticals for the imaging and therapy of prostate cancer has been a highly active and important area of research, especially focusing on the prostate-specific membrane antigen (PSMA), an antigen which is upregulated in prostate, as well as in other tumor cells. A large variety of PSMA ligands have been radiolabeled, to date. Among the various derivatives, PSMA-617 resulted to be one of the most interesting in terms of interaction with the antigen and clinical properties, and its lutetium-177 labeled version has recently been approved by regulatory agencies for therapeutic purposes. For this reasons, the radiolabeling with fluorine-18 of a PSMA-617 derivative might be of interest. Beside other methodologies to radiolabel macromolecules with fluorine-18, the “click-chemistry” approach resulted to be very useful, and the copper-catalyzed azide-alkyne cycloaddition (CuAAC) is considered one of most efficient and reliable. This paper proposes the synthesis of a suitable precursor for the radiolabeling with fluorine-18 of a new PSMA-617 derivative. The whole radiosynthetic procedure has been fully automated, and the final product, which proved to be stable in plasma, has been obtained with radiochemical yield and purity suitable for subsequent preclinical studies. 相似文献
3.
4.
Nicla La Verde Agostino Riva Maria Silvia Cona Arianna Gabrieli Monica Cattaneo Cinzia Fasola Giuseppe Lipari Claudia De Stradis Valentina Favorito Benedetta Lombardi Stocchetti Davide Chizzoniti Alice Covizzi Eliana Rulli Francesca Galli Lorenzo Ruggieri Anna Gambaro Sabrina Ferrario Davide Dalu Maciej S. Tarkowski 《International journal of cancer. Journal international du cancer》2023,152(4):661-671
Previous studies on the immunogenicity of SARS-CoV-2 mRNA vaccines showed a reduced seroconversion in cancer patients. The aim of our study is to evaluate the immunogenicity of two doses of mRNA vaccines in solid cancer patients with or without a previous exposure to the virus. This is a single-institution, prospective, nonrandomized study. Patients in active treatment and a control cohort of healthy people received two doses of BNT162b2 (Comirnaty, BioNTech/Pfizer, The United States) or mRNA-1273 (Spikevax, Moderna). Vaccine was administered before starting anticancer therapy or on the first day of the treatment cycle. SARS-CoV-2 antibody levels against S1, RBD (to evaluate vaccine response) and N proteins (to evaluate previous infection) were measured in plasma before the first dose and 30 days after the second one. From January to June 2021, 195 consecutive cancer patients and 20 healthy controls were enrolled. Thirty-one cancer patients had a previous exposure to SARS-CoV-2. Cancer patients previously exposed to the virus had significantly higher median levels of anti-S1 and anti-RBD IgG, compared to healthy controls (P = .0349) and to cancer patients without a previous infection (P < .001). Vaccine type (anti-S1: P < .0001; anti-RBD: P = .0045), comorbidities (anti-S1: P = .0274; anti-RBD: P = .0048) and the use of G-CSF (anti-S1: P = .0151) negatively affected the antibody response. Conversely, previous exposure to SARS-CoV-2 significantly enhanced the response to vaccination (anti-S1: P < .0001; anti-RBD: P = .0026). Vaccine immunogenicity in cancer patients with a previous exposure to SARS-CoV-2 seems comparable to that of healthy subjects. On the other hand, clinical variables of immune frailty negatively affect humoral immune response to vaccination. 相似文献
5.
Clinical & Experimental Metastasis - 相似文献
6.
Lykov A. P. Uvarov I. P. Gevorgiz R. G. Zheleznova S. N. 《Bulletin of experimental biology and medicine》2022,172(3):301-304
Bulletin of Experimental Biology and Medicine - We studied the effect of microalgae of various systematic groups added to the ration on the biochemical parameters of blood serum and liver and... 相似文献
7.
8.
Moskaleva P. V. Shnayder N. A. Dmitrenko D. V. Shilkina O. S. Neznanov N. G. Nasyrova R. F. 《Neuroscience and behavioral physiology》2022,52(3):462-469
Neuroscience and Behavioral Physiology - The question of the involvement of impairments to the metabolism of melatonin and its precursors (tryptophan and serotonin) in the development of... 相似文献
9.