Dermaprotecting properties of sodium succinate under conditions of impaired circulation

Sodium succinate improves the survival of a skin graft in mice, rats, and dogs normalizes histamine and serotonin concentrations in the epidermis and blood, exhibits antitoxic activity, improves microcirculation in the skin, brain, heart, kidneys, and testes without any appreciable effect on systemic arterial pressure, cardiac function, and liver blood flow in rats. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 10, pp. 420–424, October, 1998     

Effect of cyclic GABA derivative TZ-146 on the content of neurotransmitters in rat brain stem

The effect of cyclic GABA derivative TZ-146 on the content of catecholamines, serotonin, their metabolites, and neurotransmitter amino acids in rat hypothalamus and brain stem was studied by high-performance liquid chromatography with electrochemical detection. Opposite changes in the content of homovanillic acid, aspartate, glutamate, and glycine in the examined structures were accompanied by inhibition of dopamine metabolism. Possible participation of cerebral glutamatergic system in the effect of TZ-146 is discussed. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 5, pp. 544–546, May, 2000     

Mass spectrometric determination of the gas content of blood

The operational principle of the new mass-spectroscopic device for determining the gas content in blood is based on extracting gases from blood samples into vacuum volume and measuring their content with mass spectrometer. The increased sensitivity and measurement accuracy are achieved by raising the pressure of gases during the process of freezing out the water vapors as well as by making use of calibrating gas. About 0.5-1.0 ml of blood are enough for the analysis. The low pressure in the extraction chamber favors complete removal of gases from the sample without using hemolyzing reagents. Besides O2 and CO2 it is possible to determine the content of other gases including narcotic and inert gases.     

Effects of Bradysole and Dibasole on Cerebral Bloodflow under Experimental Conditions

Bradysole (1 mg/kg intravenously) induced a moderate increase in cerebral bloodflow and a minor decrease in systemic blood pressure in narcotized rats. These effects were less pronounced compared to the effects of dibasole (bradysole structural analog) in the same dose.__________Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 139, No. 3, pp. 301–302, March, 2005