全文获取类型
收费全文 | 127808篇 |
免费 | 49972篇 |
国内免费 | 4076篇 |
专业分类
耳鼻咽喉 | 1882篇 |
儿科学 | 5062篇 |
妇产科学 | 1096篇 |
基础医学 | 20784篇 |
口腔科学 | 5922篇 |
临床医学 | 20231篇 |
内科学 | 29447篇 |
皮肤病学 | 8073篇 |
神经病学 | 15698篇 |
特种医学 | 4254篇 |
外国民族医学 | 27篇 |
外科学 | 18190篇 |
综合类 | 11680篇 |
现状与发展 | 18篇 |
一般理论 | 30篇 |
预防医学 | 8871篇 |
眼科学 | 2648篇 |
药学 | 11995篇 |
78篇 | |
中国医学 | 4898篇 |
肿瘤学 | 10972篇 |
出版年
2024年 | 74篇 |
2023年 | 884篇 |
2022年 | 1554篇 |
2021年 | 3992篇 |
2020年 | 7361篇 |
2019年 | 12608篇 |
2018年 | 11922篇 |
2017年 | 13244篇 |
2016年 | 13708篇 |
2015年 | 14405篇 |
2014年 | 15127篇 |
2013年 | 15377篇 |
2012年 | 8730篇 |
2011年 | 8929篇 |
2010年 | 12271篇 |
2009年 | 8012篇 |
2008年 | 5264篇 |
2007年 | 4156篇 |
2006年 | 4056篇 |
2005年 | 3436篇 |
2004年 | 2725篇 |
2003年 | 2683篇 |
2002年 | 2347篇 |
2001年 | 2041篇 |
2000年 | 1602篇 |
1999年 | 1141篇 |
1998年 | 691篇 |
1997年 | 689篇 |
1996年 | 460篇 |
1995年 | 432篇 |
1994年 | 396篇 |
1993年 | 240篇 |
1992年 | 257篇 |
1991年 | 214篇 |
1990年 | 149篇 |
1989年 | 136篇 |
1988年 | 124篇 |
1987年 | 102篇 |
1986年 | 67篇 |
1985年 | 55篇 |
1984年 | 40篇 |
1983年 | 24篇 |
1982年 | 14篇 |
1981年 | 28篇 |
1980年 | 10篇 |
1979年 | 16篇 |
1978年 | 9篇 |
1975年 | 9篇 |
1973年 | 8篇 |
1970年 | 6篇 |
排序方式: 共有10000条查询结果,搜索用时 17 毫秒
1.
2.
目的 了解芦山地震5年后雅安市高血压患者心理卫生问题检出率及其影响因素,为促进地震灾区高血压患者心理健康提供参考。方法 采用分层整群随机抽样方法,于2018年12月选取雅安市高血压患者800例作为研究对象。采用自编居民基本信息调查表收集患者的基本资料,采用12项一般健康问卷(GHQ-12)评定患者近期是否存在心理卫生问题,采用Logistic回归分析其影响因素。结果 回收有效问卷744份(93.00%),检出存在心理卫生问题者79例(10.62%)。单因素分析结果显示,不同婚姻状况(P?0.01)、家庭人均月收入(P=0.012)、是否接受社会救助(χ2=25.194,P?0.01)的高血压患者心理卫生问题检出率差异均有统计学意义。Logistic回归分析显示,未婚/分居/离异/丧偶(OR=3.879,P=0.015)以及接受社会救助(OR=4.705,P?0.01)是高血压患者存在心理卫生问题的危险因素。结论 雅安市高血压患者心理卫生问题检出率较低,未婚/分居/离异/丧偶者以及接受社会救助的高血压患者心理卫生问题可能更突出。 相似文献
3.
Xi Tian Yue Wang Wenhao Xu Haidan Tang Shuxuan Zhu Aihetaimujiang Anwaier Wangrui Liu Wenfeng Wang Wenkai Zhu Jiaqi Su Yuanyuan Qu Hailiang Zhang Dingwei Ye 《International journal of cancer. Journal international du cancer》2023,152(1):66-78
In clear cell renal cell carcinoma (ccRCC), glycolysis is enhanced mainly because of the increased expression of key enzymes in glycolysis. Hence, the discovery of new molecular biomarkers for glycolysis may help guide and establish a precise system of diagnosis and treatment for ccRCC. Expression profiles of 1079 tumor samples of ccRCC patients (including 311 patients treated with everolimus or nivolumab) were downloaded from public databases. Proteomic profiles of 232 ccRCC samples were obtained from Fudan University Shanghai Cancer Center (FUSCC). Biological changes, tumor microenvironment and prognostic differences were explored between samples with various glycolysis characteristics. There were significant differences in CD8+ effector T cells, epithelial-to-mesenchymal transition and pan-fibroblast TGFb between the Low and High glyScore groups. The tumor mutation burden of the Low glyScore group was lower than that of the High glyScore group. And higher glyScore was significantly associated with worse overall survival (OS) in 768 ccRCC patients (P < .0001). External validation in FUSCC cohort also indicated that glyScore was of strong ability for predicting OS (P < .05). GlyScore may serve as a biomarker for predicting everolimus response in ccRCC patients due to its significant associations with progression-free survival (PFS). And glyScore may also predict overall survival in patients treated with nivolumab. We calculated the glyScore in ccRCC and the defined glyScore was of strong ability for predicting OS. In addition, glyScore may also serve as a biomarker for predicting PFS in patients treated with everolimus and could predict OS in patients treated with nivolumab. 相似文献
4.
5.
Qiang Liu Zhongbiao Xu Kaixuan Zhao W. Scott Hoge Xinyuan Zhang Yingjie Mei Qiqi Lu Thoralf Niendorf Yanqiu Feng 《NMR in biomedicine》2022,35(5):e4652
The purpose of this study was to investigate the feasibility of two-dimensional (2D) navigated, interleaved multishot echo-planar imaging (EPI) to enhance kidney diffusion-weighted imaging (DWI) in rats at 7.0 T. Fully sampled interleaved four-shot EPI with 2D navigators was tailored for kidney DWI (Sprague–Dawley rats, n = 7) on a 7.0-T small bore preclinical scanner. The image quality of four-shot EPI was compared with T2-weighted rapid acquisition with relaxation enhancement (RARE) (reference) and single-shot EPI (ss-EPI) without and with parallel imaging (PI). The contrast-to-noise ratio (CNR) was examined to assess the image quality for the EPI approaches. The Dice similarity coefficient and the Hausdorff distance were used for evaluation of image distortion. Mean diffusivity (MD) and fractional anisotropy (FA) were calculated for renal cortex and medulla for all DWI approaches. The corticomedullary difference of MD and FA were assessed by Wilcoxon signed-rank test. Four-shot EPI showed the highest CNR among the three EPI variants and lowest geometric distortion versus T2-weighted RARE (mean Dice: 0.77 for ss-EPI without PI, 0.88 for ss-EPI with twofold undersampling, and 0.92 for four-shot EPI). The FA map derived from four-shot EPI clearly identified a highly anisotropic region corresponding to the inner stripe of the outer medulla. Four-shot EPI successfully discerned differences in both MD and FA between renal cortex and medulla. In conclusion, 2D navigated, interleaved multishot EPI facilitates high-quality rat kidney DWI with clearly depicted intralayer and interlayer structure and substantially reduced image distortion. This approach enables the anatomic integrity of DWI-MRI in small rodents and has the potential to benefit the characterization of renal microstructure in preclinical studies. 相似文献
6.
7.
摘要:目的 探讨儿童肺炎克雷伯菌血流感染(Klebsiella pneumoniae bloodstream infection, KPBSI)临床特征及肺炎克雷伯
菌(Klebsiella pneumoniae, KP)对常用抗菌药物的敏感性,为儿童KPBSI合理治疗提供参考。方法 回顾性分析2014年1月至2019
年12月在重庆医科大学附属儿童医院住院的KPBSI患儿临床资料。结果 共纳入110例患儿,64例(58.2%)为院内感染,72例
(65.5%)有基础疾病,以血液系统肿瘤最多见。110例患儿PRISM Ⅲ评分为16.0(7.0~20.8),其中74例(67.3%)发生脓毒症,15例
(13.6%)发生脓毒性休克,18例(16.4%)发生呼吸衰竭,15例(13.6%)需有创机械通气,院内死亡共13例(11.8%)。KP菌株对阿米卡
星、碳青霉烯类抗菌药物敏感率>90%,对头孢噻肟、头孢曲松和头孢他啶的敏感率分别为58.3%、60.9%和70.9%,对头孢哌
酮/舒巴坦和哌拉西林/他唑巴坦的敏感率分别为59.5%和82.7%。检出ESBLs+菌株39株(39/86,45.3%),耐碳青霉烯类肺炎克雷
伯菌(CRKP)菌株10株(10/110,9.1%),ESBLs+KP菌株和CRKP在各年龄组间分布无统计学差异。结论 儿童KPBSI多见于有基
础疾病的患儿,脓毒症、脓毒性休克和呼吸衰竭发生率高;KP菌株对头孢他啶和哌拉西林/他唑巴坦敏感性较高,可经验性治
疗轻症KPBSI患儿。 相似文献
9.
10.