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晚发性抑郁症与血管紧张素转化酶基因多态性关系研究 总被引:1,自引:0,他引:1
目的 探讨晚发性抑郁症(LOD)与血管紧张素转换酶(ACE)基因第16内含子中Alu重复序列的插入/缺失(Insertion/Deletion,I/D)多态性的关系。方法 入组183例60-86岁老年人,晚发性抑郁症组(93例,下称LOD组)和正常对照组(90例,下称对照组),用聚合酶链式反应(PCR)法进行ACE基因I/D多态性分型。结果LOD组和对照组间基因型频率及等位基因频率分布差异无显著(X^2=0.241,P=0.886;X^2=0.127,P=0.722),各基因型亚型患者在年龄、性别、发病次数、病程、HAMD评分、有无精神病性症状、有无自杀企图间差异无显著(P均〉0.05)。结论ACE基因I/D多态性与晚发性抑郁症无显著相关性。 相似文献
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即便进入了21世纪,青光眼这种致盲性疾病仍然会漏诊误诊,特别是发育性青光眼更为常见。我院眼科门诊在2004年至今遇到12例患者,现报告如下。 相似文献
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Objective To explore the effect of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism,environmental factor and their interactions on antidepressant treatment.Methods 340 patients of major depressive disorder (MDD) who met the diagnosis criteria of MDD ( DSM-Ⅳ Axis Ⅰ) were recruited.280 patients of them were finished 12 weeks antidepressant treatment.The severity of depression was measured with the Hamilton Depression Rating Scale (HDRS) before and after 12 weeks antidepressant treatment.Childhood Trauma Questionnaire,28-item Short Form (CTQ-SF) and Life Events Scale (LES) were used to evaluate childhood adverse and life stress before onset.Genotyping of BDNF Val66Met polymorphism was detected by Illumina GoldenGate assays.Results Male patients proportion were significantly higher in non-remitters than remitters (P =0.008 ).After adjusting by gender, the frequencies of genotype and allele for the BDNF Val66Met polymorphism were no significant difference between remitters (AA: AG: GG = 28: 79: 40, A:G = 135:159 ) and non-remitters (AA: AG: GG = 29:81:23 ,A: G = 139:127 ) (P >0.05 ).There was no significant difference of CTQ scores and LES scores between the two groups (P>0.05 ).The regression analysis showed that social intercourse problem and age were the risk factor for the severity of depression.The gender, HDRS baseline scores and mental disorder family history were associated with the efficacy of 12 weeks antidepressant.However,there was no significantly relationship between the interaction of BDNF Val66Met polymorphism and environment with the antidepressant treatment.Conclusion The older men with the mental disorder family history, severe depression symptom would be less-response to antidepressant treatment.However, BDNF Val66Met polymorphism, childhood trauma, life events stress and the interaction of BDNF Val66Met polymorphism and environment have no significantly effect on the 12 weeks antidepressant treatment. 相似文献
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史艳艳 《中华现代眼科学杂志》2006,3(3):255-256
急性虹膜睫状体炎是累及虹膜睫状体的急性疾病,是眼科常见的急重病症,也是致盲眼病之一。多发于青壮年且反复发作,久而久之视力渐降甚至可致失明,常规治疗包括散瞳、热敷、肾上腺皮质激素、抗生素及前列腺素抑制剂应用等。笔者于2005年3月-2006年3月用龙胆泻肝丸联合常规西药治疗本病42例,并与单纯用西药治疗30例进行了回顾性比较,结果前者疗效显著,能更有效地控制病情,减少复发,并且具有疗程短、费用低等特点。现报告如下。 相似文献
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2008年8月至2010年8月我院眼科门诊治疗先天性泪囊炎96例,其中男性52例(54.2%),单眼患病72例(75.0%)。年龄20天至18个月,6个月以下者76例(54.2%)。所有患儿在出生后5~10天出现流泪,15~60天眼部出现较多分泌物,排除倒睫、急性结膜炎,压迫泪囊区有黏液或脓液自泪点溢出。 相似文献
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抑郁症(major depressive disorder,MDD)以情感低落或兴趣减退为主要临床特征,并伴有认知、行为、生物学紊乱和躯体症状.抑郁症的终身患病率为15%~17%,年患病率6%~7%,全球患者高达3.4亿. 相似文献
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目的:探讨ABCB1基因rs1045642位点多态性对抗抑郁剂文拉法辛疗效的影响。方法:纳入统计的89例抑郁症患者服用抗抑郁剂文拉法辛75~150 mg并随访6周,其中88例随访8周。使用汉密尔顿抑郁17项量表( HAMD-17)评定抑郁症状的严重程度和治疗效果。采用基因芯片检测ABCB1基因的单核苷酸多态性( SNPs) rs1045642,并通过Unphased3.0.13软件分析rs1045642位点与文拉法辛疗效的关联性。结果:(1)6周有效组和无效组间在性别、年龄、教育程度、家族史、发病次数及HAMD-17项基线分数之间差异无统计学意义(均P>0.05)。(2)8周痊愈组和未痊愈组间性别、年龄、教育程度、家族史、发病次数及HAMD-17项基线评分之间差异无统计学意义(均 P >0.05)。(3)单个位点的关联分析发现, ABCB1基因rs1045642位点的基因型和等位基因分布频率在有效组、无效组间和痊愈组、非痊愈组间差异无统计学意义(均P>0.05)。结论:ABCB1基因rs1045642位点多态性与抗抑郁剂文拉法辛疗效无显著相关,尚需在更加同质、更大样本中进一步验证。 相似文献
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复方血栓通胶囊治疗视网膜静脉阻塞69例 总被引:3,自引:1,他引:2
目的观察补气、清热凉血、化瘀止血、活血祛瘀的药物合用治疗视网膜静脉阻塞的疗效。方法69例患者均服用中成药复方血栓通胶囊,药物组成黄芪、三七、丹参、玄参。结果总有效率为93%。提示该药对本病具有改善视野及视网膜血液循环促进局部炎症、出血、渗出物的消散和吸收。 相似文献
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龙胆泻肝丸在眼科中的应用 总被引:1,自引:1,他引:0
笔者临床上将龙胆泻肝丸用于肝胆实火所致的多种眼病,疗效显著,现举4例如下。 相似文献