如东县农村集镇餐具消毒卫生管理

近几年来随着改革开放的不断深入,食品饮食业也随之迅速发展起来,特别在农村集镇的发展更为突出,个体饮食和食品摊贩似雨后春笋迅猛发展,活跃了农村市场经济,使一些人致富起来,但是也相应地带来了食品卫生管理工作的问题,食     

一起食物中毒行政诉讼案的反思

一起食物中毒行政诉讼案的反思如东县卫生防疫站徐治１９９１年５月１７日，如东县发生了一起７２人烧鸡或盐水鸡中毒的严重事件，肇事者个体户刘某，不服县卫生防疫站的处罚，先后上诉县市法院，经两次审理两次判决，结果以维持原行政处罚结案。此案虽已了结，但仍给我们...     

安全使用农药与健康教育

本文介绍了在安全使用农药工作中，实施健康教育干预，取得的显著成效。并对安全使用农药中健康教育的问题提出了建议。     

脑源性神经营养因子Val66Met功能基因多态性与环境因素对抗抑郁剂临床疗效的影响

Objective To explore the effect of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism,environmental factor and their interactions on antidepressant treatment.Methods 340 patients of major depressive disorder (MDD) who met the diagnosis criteria of MDD ( DSM-Ⅳ Axis Ⅰ) were recruited.280 patients of them were finished 12 weeks antidepressant treatment.The severity of depression was measured with the Hamilton Depression Rating Scale (HDRS) before and after 12 weeks antidepressant treatment.Childhood Trauma Questionnaire,28-item Short Form (CTQ-SF) and Life Events Scale (LES) were used to evaluate childhood adverse and life stress before onset.Genotyping of BDNF Val66Met polymorphism was detected by Illumina GoldenGate assays.Results Male patients proportion were significantly higher in non-remitters than remitters (P =0.008 ).After adjusting by gender, the frequencies of genotype and allele for the BDNF Val66Met polymorphism were no significant difference between remitters (AA: AG: GG = 28: 79: 40, A:G = 135:159 ) and non-remitters (AA: AG: GG = 29:81:23 ,A: G = 139:127 ) (P ＞0.05 ).There was no significant difference of CTQ scores and LES scores between the two groups (P＞0.05 ).The regression analysis showed that social intercourse problem and age were the risk factor for the severity of depression.The gender, HDRS baseline scores and mental disorder family history were associated with the efficacy of 12 weeks antidepressant.However,there was no significantly relationship between the interaction of BDNF Val66Met polymorphism and environment with the antidepressant treatment.Conclusion The older men with the mental disorder family history, severe depression symptom would be less-response to antidepressant treatment.However, BDNF Val66Met polymorphism, childhood trauma, life events stress and the interaction of BDNF Val66Met polymorphism and environment have no significantly effect on the 12 weeks antidepressant treatment.     

抗感染药物用药信息分析

目的：调查抗感染药物的使用趋势,供生产,销售,使用等部门参考。方法：对1994－1999年购人和抗感染药物,包括5a的购药品种和金额的趋势以及购入金额前20位药品进行分析。结果：抗感染药物占药品总金额的百分比以每年5．10％的幅度降低,头孢菌素类,青霉素类,大环内酯类,氨基糖苷类和喹诺酮类依次位于前5位。抗感染药物前20位的品种中,头孢菌素类约50％,头孢拉定高居首位。结论：头孢菌素类抗生素在抗感染药物中占主导地位。     

脑源性神经营养因子Val66Met功能基因多态性与环境因素对抗抑郁剂临床疗效的影响

Objective To explore the effect of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism,environmental factor and their interactions on antidepressant treatment.Methods 340 patients of major depressive disorder (MDD) who met the diagnosis criteria of MDD ( DSM-Ⅳ Axis Ⅰ) were recruited.280 patients of them were finished 12 weeks antidepressant treatment.The severity of depression was measured with the Hamilton Depression Rating Scale (HDRS) before and after 12 weeks antidepressant treatment.Childhood Trauma Questionnaire,28-item Short Form (CTQ-SF) and Life Events Scale (LES) were used to evaluate childhood adverse and life stress before onset.Genotyping of BDNF Val66Met polymorphism was detected by Illumina GoldenGate assays.Results Male patients proportion were significantly higher in non-remitters than remitters (P =0.008 ).After adjusting by gender, the frequencies of genotype and allele for the BDNF Val66Met polymorphism were no significant difference between remitters (AA: AG: GG = 28: 79: 40, A:G = 135:159 ) and non-remitters (AA: AG: GG = 29:81:23 ,A: G = 139:127 ) (P ＞0.05 ).There was no significant difference of CTQ scores and LES scores between the two groups (P＞0.05 ).The regression analysis showed that social intercourse problem and age were the risk factor for the severity of depression.The gender, HDRS baseline scores and mental disorder family history were associated with the efficacy of 12 weeks antidepressant.However,there was no significantly relationship between the interaction of BDNF Val66Met polymorphism and environment with the antidepressant treatment.Conclusion The older men with the mental disorder family history, severe depression symptom would be less-response to antidepressant treatment.However, BDNF Val66Met polymorphism, childhood trauma, life events stress and the interaction of BDNF Val66Met polymorphism and environment have no significantly effect on the 12 weeks antidepressant treatment.     

我院1994年～1999年用药分析

目的 :客观评估用药情况 ,为合理调控用药结构提供依据。方法 :本文对我院1994年～1999年用药数据 ,从药品金额、药理分类、用药金额排名、抗微生物药品等几方面进行统计分析。结果与结论 :药品金额年增长率为18 46 % ,处方金额年增长率14 56 % ,抗微生物药品金额比重年平均降低5 67 % ,前15位的药品金额百分比逐年下降10 64 %     

冠心病合并抑郁障碍的机制

冠心病在我国的发病率逐年增加,抑郁性障碍也是非常普遍的疾病,包括轻中度抑郁、反应性抑郁症、老年抑郁症等.发生心血管事件的病人更易出现抑郁症状,而抑郁性障碍也是病人将来发生或再发生心血管事件的独立危险因素[1].冠心病合并抑郁性障碍的情况已逐渐受到大家的重视,但具体的机制还不完全清楚.为了进一步明确冠心病合并抑郁性障碍的机制,现将相关研究进行综述.     

长期应激对大鼠行为和部分内分泌免疫指标的影响

目的 研究长期温和不可预知的应激对大鼠行为和血浆促肾上腺皮质激素(ACTH)、皮质醇(CORT)、肿瘤坏死因子(TNF)、白介素-1β(IL-1β)和白介素-2(IL-2)的影响.方法 用敞箱实验、糖水消耗实验和Morris水迷宫实验观察行为学变化,用放射免疫法观察血浆ACTH、CORT、TNF、IL-1β和IL-2的变化.结果 在敞箱实验中,应激组水平得分在第4,5,6,7周[分别为(23.5±29.0)分,(16.7±17.4)分,(11.7±12.7)分,(20.8±17.1)分]低于对照组[分别为(51.2±32.1)分,(57.4±51.4)分,(65.7±46.3)分,(60.4±40.9)分],差异具有显著性(P＜0.05),垂直得分在第6、7周[分别为(3.7±4.6)分,(5.3±4.8)分]低于对照组[分别为(18.8±17.9)分,(16.5±13.4)分],差异具有显著性(P＜0.05),清洁时间在第7周[(55.2±45.6)s]高于对照组[(18.3±22.4)s],差异具有显著性(P＜0.05),应激组的中央格停留时间和粪便颗数与对照组差异无显著性;糖水消耗实验中,2组间差异无显著性;在Morris水迷宫实验中,2组间差异无显著性;应激组血清ACTH、TNF、IL-1β、IL-2与对照组差异无显著性,应激组血清CORT[(1.92±1.07)ng·ml-1]比对照组[(3.73±2.21)ng·ml-1]低,差异具有显著性(P＜0.05).结论 经过长期温和不可预知的应激后,大鼠在敞箱中的行为表现会降低,但随着时间的推移,行为能力增强;大鼠在糖水消耗和Morris水迷宫实验中,均没有改变;大鼠的血清CORT出现了降低,血清ACTH、TNF、IL-1β和IL-2均没有变化.     

ABCBl基因rsl045642位点多态性与文拉法辛疗效的关联研究

目的：探讨ABCB1基因rs1045642位点多态性对抗抑郁剂文拉法辛疗效的影响。方法：纳入统计的89例抑郁症患者服用抗抑郁剂文拉法辛75～150 mg并随访6周,其中88例随访8周。使用汉密尔顿抑郁17项量表（ HAMD-17）评定抑郁症状的严重程度和治疗效果。采用基因芯片检测ABCB1基因的单核苷酸多态性（ SNPs） rs1045642,并通过Unphased3.0.13软件分析rs1045642位点与文拉法辛疗效的关联性。结果：（1）6周有效组和无效组间在性别、年龄、教育程度、家族史、发病次数及HAMD-17项基线分数之间差异无统计学意义（均P＞0.05）。（2）8周痊愈组和未痊愈组间性别、年龄、教育程度、家族史、发病次数及HAMD-17项基线评分之间差异无统计学意义（均 P ＞0.05）。（3）单个位点的关联分析发现, ABCB1基因rs1045642位点的基因型和等位基因分布频率在有效组、无效组间和痊愈组、非痊愈组间差异无统计学意义（均P＞0.05）。结论：ABCB1基因rs1045642位点多态性与抗抑郁剂文拉法辛疗效无显著相关,尚需在更加同质、更大样本中进一步验证。