对称性肢端角化病合并血管炎一例

患者男,20岁.因肢端角化性斑片,双小腿红斑结节反复5年,于2008年7月31日来我院就诊.患者于5年前无明显诱因双足背出现褐色角化性斑片,有明显季节性,夏季较重,冬季自然缓解或消退,浸水后变白,无明显自觉症状,皮损进行性加重,逐渐累及趾背、踝部、双手背、指背、腕部屈侧、肘膝关节伸侧.     

淋球菌多抗原序列分型方法研究进展

淋球菌分型研究包括表型分型和基因分型研究.淋球菌多抗原序列分型方法是一种基于测序的、应用前景广阔的基因分型方法,其检测标本不仅可以是茵培养物,还可以直接用于拭子标本的分型研究.PCR分别扩增两个编码淋球菌外膜蛋白基因(por和tbpB)的高变区,PCR扩增产物测序后与淋球菌多抗原序列分型方法网站比对以获取菌株的基因型.淋球菌多抗原序列分型方法具有操作简单、结果客观、国内外实验室间结果可比性等优势,该方法已经在预测淋球菌耐药性、分析性网络、鉴定特殊菌株爆发和流行等方面广泛应用.     

246名女性皮肤老化特征及相关因素的调查分析

目的 探讨女性面部皱纹的发生情况及相关影响因素.方法 采用问卷表调查的方法,将研究对象根据工种及日均日晒时间分为室内组和室外组,使用图像分析仪SIA0612标准化拍照,结合Visioscan VC98定量测量皱纹的结果,将研究对象面部皱纹分0～9级分析.利用SPSS 17.0分析防晒情况、护肤美容、皱纹发生时间、发生部位等并对皱纹产生可能相关因素进行室内外组对比分析.结果 246名19～71岁女性,回顾各不同年龄阶段使用防晒措施的比例是:6～11岁年龄段为11%;12～18岁为13.5%;19～29岁为38.5%;30～39岁为39.2%;40～59岁为44%;60～75岁为0.在近5年阶段的为最多达44.1%.出现皱纹与色素斑时间及情况比较:目前无皱纹的占5.7%,目前无色素斑的占21.7%.发现皱纹时间以30～35岁为最多,发现色素斑时间以25～30岁为最多.室内组人群面部皱纹发生的顺序由多到少依次是眶下、外眦、鼻唇沟区域、眉间;室外组皱纹最多出现的依次顺序依次是:外眦、眶下、眉间、鼻唇沟.室内人群皱纹最常发生于鱼尾纹,至少在45岁达100%.而室外人群的皱纹发生普遍早,鱼尾纹至少在30岁就达100%.结论 皱纹和色素斑均为中国女性皮肤老化的主要表现.色素斑出现时间略早于皱纹.女性皮肤光老化的主要表现依次为肤色灰黄、皮肤干燥、粗糙、皮革样外观、显著的红血丝和(或)严重的色素斑、脆性增加等.室内组女性皱纹出现次序和时间都有别于室外组.

Abstract：

Objective To estimate the prevalence and associated factors of facial wrinkling in females.Methods Questionnaires were designed and delivered to collect related data on volunteers. The subjects were divided into outdoor and indoor groups. Wrinkles were classified into 9 grades based on photos taken by SIA0612 image analyzer and quantification analysis via Visioscan VC 98. SPSS 17.0 software was used to assess the associated factors of wrinkling, including sun-protective measures, skin care and cosmetology, onset age and location of wrinkles in these subjects. Results A total of 246 patients aged 19 - 71 years were recruited in this study. Sun-protective measures were applied in 13.5% of the subjects between 12 and 18 years of age,38.5% of those between 19 and 29 years of age, 39.2% of those between 30 and 39 years of age, 44% of those between 40 and 59 years of age, and in none of those between 60 and 75 years of age, 44.1% of all the subjects in the latest 5 years. Wrinkles were absent in 5.7% of the subjects, and pigmentation macules absent in 21.7%. The first development of wrinkles was mainly observed in subjects aged 30 to 35 years, and that of pigmentation macules in those aged 25 to 30 years. The most common locations of facial wrinkles, in order of decreasing frequency, were infraorbital area, lateral angle of eye, nasolabial fold, glabella in the indoor group,lateral angle of eye, infraorbital area, glabella and nasolabial fold in the outdoor group. Fishtail lines seemed to be the commonest wrinkles with an earliest onset among these wrinkles, and showed a prevalence of 100% in subjects aged 45 years or older in the indoor group, and in those aged 30 years or older in the outdoor group.Conclusions Wrinkles and pigmentation macules are dominate manifestations of skin aging in Chinese females. The onset of pigmentation macules is earlier than that of wrinkles. The main manifestations of skin aging in Chinese females, in order of decreasing frequency, are yellow-grey skin, skin dryness, roughness,leather-like appearance, teleangiectasia, and (or) severe pigmentation macules, increase in skin fragility, etc.The order and age of wrinkle appearance are different between indoor and outdoor females.     

大疱性手足口病一例

<正>临床资料患儿,男,10个月。因发热皮疹4天于2014年6月26日来我院就诊。4天前患儿无明显诱因出现发热,体温最高39℃,服用对乙酰氨基酚滴剂后体温能降至正常。4天前患儿口腔出现红斑水疱,皮疹渐蔓延至手足心、臀部、四肢、躯干。患儿发病以来进食尚可,无恶心呕吐,无咳嗽咳痰,无腹痛腹泻,无易惊,无肢体抖动,无惊厥抽搐等。2014年6月24日外院血常规:WBC 19.5×109/L,淋巴细胞5.9×109/L,单核细胞1.6×109/L,粒细胞12×109/L,CRP14mg/L。在外院给予头孢类抗生素输液治疗2天,外用     

淋病奈瑟球菌对头孢曲松耐药性及耐药机制研究进展

头孢曲松作为淋病一线治疗药物之一,目前仍比较敏感,国内外尚未报道临床治疗失败病例,体外药敏试验也只发现少数散发头孢曲松耐药株。但是,淋病奈瑟球菌（淋球菌）对头孢曲松敏感性下降的趋势已很明显,而且中国少数地区淋球菌头孢曲松耐药株检出率>5%,故应密切监测淋球菌对头孢曲松的敏感性变化。目前淋球菌对头孢曲松的耐药机制尚不明确,penA和mtrR等基因突变在耐药中的作用成为关注热点。     

幼年黄色肉芽肿l例

临床资料患者,女,9岁。因右大腿增生物1年就诊。患者1年前发现右大腿内侧一约米粒大淡黄红色丘疹,皮损缓慢增大,无明显自觉症状。发病以来无视力改变及其它异常。否认家族中有类似病史及神经纤维瘤病史。查体：系统检查未见明显异常。皮肤科检查：右大腿内侧可见一约0.5 cm×1 cm×1 cm大黄红色半球状丘疹,表面干燥伴细小裂隙,触之较硬（图1）。实验室检查：血、尿、粪常规、肝肾功能、血糖、血脂未见明显异常。     

淋病奈瑟球菌对头孢曲松耐药性及耐药机制研究进展

头孢曲松作为淋病一线治疗药物之一,目前仍比较敏感,国内外尚未报道临床治疗失败病例,体外药敏试验也只发现少数散发头孢曲松耐药株。但是,淋病奈瑟球菌（淋球菌）对头孢曲松敏感性下降的趋势已很明显,而且中国少数地区淋球菌头孢曲松耐药株检出率〉5％,故应密切监测淋球菌对头孢曲松的敏感性变化。目前淋球菌对头孢曲松的耐药机制尚不明确,pertA和mtrR等基因突变在耐药中的作用成为关注热点。     

泌尿生殖道支原体感染的流行病学现状

泌尿生殖道支原体感染是引起非淋菌性尿道炎、宫颈炎、盆腔炎、不孕不育等疾病的重要病因之一.研究表明,性工作者、有泌尿生殖道症状者、合并免疫相关性疾病者等人群中支原体检出率较高.泌尿生殖道支原体感染之后致病是否与病原体的类别及亚型、患者的性别及年龄、性行为方式以及是否合并其他性传播疾病等因素有关.