冬连胶囊对实验性糖尿病大鼠早期胰岛素抵抗的影响

Objective To investigate the effects of Donglian Capsule(the combination of Ophiopogonis Tuber Polysaccharide with Rhizoma Coptidis Alkaloids, OPRA for short, Component of Chinese medicine)on early insulin resistance in experimental diabetic rats. Methods The animal model of insulin resistance in 2 type diabetic was established by injecting low dose of STZ in 60 high fat-fed SD rats. After one week, the successful models were randomly divided into 4 groups: untreated, high and low OPRA-treated, mefformin-treated group, Meanwhile, a normal control group was designed. After four weeks, the differences of FBG, PG, INS and C-P were compared among the groups. Results The OPRA can significantly reduced the level of serum TC and FBG, increased the C-E ]Lightened the IRI(P<0.01). Conclusion The OPRA can reduce the level of serum TG and FBG, and decrease insulin resistance to protect the β-cell function.     

冬连胶囊对实验性糖尿病大鼠早期胰岛素抵抗的影响

Objective To investigate the effects of Donglian Capsule(the combination of Ophiopogonis Tuber Polysaccharide with Rhizoma Coptidis Alkaloids, OPRA for short, Component of Chinese medicine)on early insulin resistance in experimental diabetic rats. Methods The animal model of insulin resistance in 2 type diabetic was established by injecting low dose of STZ in 60 high fat-fed SD rats. After one week, the successful models were randomly divided into 4 groups: untreated, high and low OPRA-treated, mefformin-treated group, Meanwhile, a normal control group was designed. After four weeks, the differences of FBG, PG, INS and C-P were compared among the groups. Results The OPRA can significantly reduced the level of serum TC and FBG, increased the C-E ]Lightened the IRI(P<0.01). Conclusion The OPRA can reduce the level of serum TG and FBG, and decrease insulin resistance to protect the β-cell function.     

冬连三七组分调控AGEs/p38MAPK改善糖尿病动脉粥样硬化兔氧化应激的机理研究

目的研究冬连三七组分（Composition of Ophiopogon polysaccharide， Notoginseng total saponins and Rhizoma Coptidis alkaloids CONR）调控AGEs/p38MAPK信号转导通路改善糖尿病动脉粥样硬化（diabetic atherosclerosis，DA）兔氧化应激反应。方法设立空白组、模型组、辛伐他汀组、CONR高剂量组、CONR低剂量组、SB203580组；脉推注四氧嘧啶并且配合腹主动脉内膜球囊损伤术诱导雄性纯种新西兰大白兔的DA模型，实验组分别每日给予CONR450 mg/kg、CONR 150 mg/kg；辛伐他汀3 mg/kg灌胃10周，12 h重复腹腔注射SB203580 2 mg/kg 10周；正常组每日给予生理盐水20mL灌胃作为对照。结果实验各组对AGEs均有降低作用，对p-p38MAPK蛋白高表达均有抑制作用，与模型组比较差异有统计学意义。CONR高、低剂量组、辛伐他汀组对p-p38MAPK蛋白的抑制作用优于SB203580组（P<0.01），CONR高、CONR低剂量组、辛伐他汀组之间差异无统计学意义（P>0.05）。模型组大兔血清MDA高于空白组，有统计学差异（P<0.01）。给药后，CONR高剂量组、SB203580组及辛伐他汀组显著降低MDA（P<0.01）。模型组SOD活性显著降低（P<0.01），实验各组显著增强SOD活性（P<0.01）。结论冬连三七组分可能通过干预AGEs/p38MAPK信号转导通路改善DA兔的氧化应激反应。     

补肾延年丹对老年大鼠全血细胞DNA修复能力的影响

补肾延年丹对老年大鼠全血细胞非程序DNA合成（UDS）的实验结果表明：40秒UF诱导下大鼠全血细胞UDS各组间差异无显著意义（P＞0.05），80秒UV诱导下大鼠全血细胞UDS各组间差异有显著意义（P＝0.05），补肾延年丹大、中、小剂量组UDS均高于老年空白对照组，说明补肾延年丹能提高老年大鼠对UV损伤时DNA的修复能力。     

舒血宁片治疗冠心病的临床研究

４６例冠心病患者随机按２：１比例分为治疗组和对照组，分别给予舒血宁Ⅱ号片与Ⅰ号片。结果表明舒血宁Ⅱ和Ⅰ号片均可改善冠心病心绞痛症状，总有效率分别为６０．００％和８３．８７％，两者无显著差异；但对中、重度患者Ⅱ号片的总有效率为８３．３３％，Ⅰ号片仅为３３．３３％，两才比较差异显著；它们对心电图也有一定的改善作用，总有效率分别为６０．００％和７４．１９％，两者无显著差异；对血脂ＴＣ和ＴＧ两药都有一定的     

冬连胶囊对实验性糖尿病大鼠早期胰岛素抵抗的影响

Objective To investigate the effects of Donglian Capsule(the combination of Ophiopogonis Tuber Polysaccharide with Rhizoma Coptidis Alkaloids, OPRA for short, Component of Chinese medicine)on early insulin resistance in experimental diabetic rats. Methods The animal model of insulin resistance in 2 type diabetic was established by injecting low dose of STZ in 60 high fat-fed SD rats. After one week, the successful models were randomly divided into 4 groups: untreated, high and low OPRA-treated, mefformin-treated group, Meanwhile, a normal control group was designed. After four weeks, the differences of FBG, PG, INS and C-P were compared among the groups. Results The OPRA can significantly reduced the level of serum TC and FBG, increased the C-E ]Lightened the IRI(P<0.01). Conclusion The OPRA can reduce the level of serum TG and FBG, and decrease insulin resistance to protect the β-cell function.     

冬连胶囊对实验性糖尿病大鼠早期胰岛素抵抗的影响

Objective To investigate the effects of Donglian Capsule(the combination of Ophiopogonis Tuber Polysaccharide with Rhizoma Coptidis Alkaloids, OPRA for short, Component of Chinese medicine)on early insulin resistance in experimental diabetic rats. Methods The animal model of insulin resistance in 2 type diabetic was established by injecting low dose of STZ in 60 high fat-fed SD rats. After one week, the successful models were randomly divided into 4 groups: untreated, high and low OPRA-treated, mefformin-treated group, Meanwhile, a normal control group was designed. After four weeks, the differences of FBG, PG, INS and C-P were compared among the groups. Results The OPRA can significantly reduced the level of serum TC and FBG, increased the C-E ]Lightened the IRI(P<0.01). Conclusion The OPRA can reduce the level of serum TG and FBG, and decrease insulin resistance to protect the β-cell function.     

冬连胶囊对实验性糖尿病大鼠早期胰岛素抵抗的影响

Objective To investigate the effects of Donglian Capsule(the combination of Ophiopogonis Tuber Polysaccharide with Rhizoma Coptidis Alkaloids, OPRA for short, Component of Chinese medicine)on early insulin resistance in experimental diabetic rats. Methods The animal model of insulin resistance in 2 type diabetic was established by injecting low dose of STZ in 60 high fat-fed SD rats. After one week, the successful models were randomly divided into 4 groups: untreated, high and low OPRA-treated, mefformin-treated group, Meanwhile, a normal control group was designed. After four weeks, the differences of FBG, PG, INS and C-P were compared among the groups. Results The OPRA can significantly reduced the level of serum TC and FBG, increased the C-E ]Lightened the IRI(P<0.01). Conclusion The OPRA can reduce the level of serum TG and FBG, and decrease insulin resistance to protect the β-cell function.     

治瘫灵治疗老年中风恢复期及后遗症的临床研究

将315例老年中风恢复期及后遗症患者,随机分治疗组(Ⅰ组)和对照组(Ⅱ组),两组分别服用治瘫灵胶囊和维脑路通片剂,疗程8周。结果:Ⅰ组明显优于Ⅱ组,总有效率分别为83.49％和54.37％,差异显著(p<0.01)。Ⅰ组对神经功能缺损的改善优于Ⅱ组;对全血粘度、血浆比度粘度、血小板粘附、血栓弹力图、体外血栓长度等药后有显著改善(p<0.01),Ⅱ组无明显变化。48例服用治瘫灵患者治疗前后行颅CT检查,18例梗塞面积缩小,占37.50％。