首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   1篇
  完全免费   3篇
  综合类   4篇
  2014年   1篇
  2012年   2篇
  1990年   1篇
排序方式: 共有4条查询结果,搜索用时 15 毫秒
1
1.
在硅胶G板上,以正丁醉-26%氨水-无水乙醇(30:3:1)为展开剂,用薄层扫描法分离测定了中国姜黄属植物毛郁金Curcuma aromatica Salisb.,温郁金C. wenyujin Y. H. Chen et C.Ling(or C. aromatica cv. Wenyujin),莪术C. aeruginosa Roxb.,黄莪术C. zedoaria (Christm.)Rosc.,桂莪术C. kwangsiensis S. G. Lee et C. F. Liang,川郁金C. chuanyujin C. K. Hsich et H.Zhang,姜黄C. longa L.根茎中姜黄素(curcumin),去甲氧基姜黄素(demethoxycurcumin),双去甲氧基姜黄素(bisdemethoxycurcumin)和总姜黄素(curcuminoids)的含量,回收率97.07%~102.0%(n=6),变异系数为3.1%~5.0%。  相似文献
2.
目的 研究姜黄色素聚电解质纳米粒(CUR-PENPs)经大鼠尾静脉注射后的体内药代动力学。方法 通过静电吸附法制备CUR-PENPs并对其表征;以姜黄色素(CUR)溶液为对照,研究大鼠尾静脉注射CUR-PENPs的体内药动学。结果 透射电镜观察CUR-PENPs呈较规则类球体,平均粒径为(243.0±1.1)nm,Zeta电位为(-28.13±1.41)mV,载药量为5.5%。大鼠尾静脉注射CUR-PENPs的血药浓度-时间曲线下面积(AUC)为CUR溶液3.3倍,血浆清除率(CL)降为CUR溶液的27.8%。结论 CUR-PENPs能相对延长CUR体内滞留时间,提高药物AUC。  相似文献
3.
Objective To investigate and compare the action of curcuminoids on the causal pathogens of Candida albicans growth. Methods The effects of curcumin (CUR) and demethoxycurcumin (DMC) on C. albicans growth were first investigated and compared by microcalorimetry coupled with multiple analytical methods. The quantitative thermo-kinetic parameters obtained from these curves were analyzed to show difference of the actions. Results By analyzing the main parameters screened from principal component analysis together with 50% inhibiting concentration values, it was demonstrated that both CUR and DMC showed good antifungal activities and CUR was stronger. It was further concluded from structure-activity relationship that the existence of methoxy group might enhance lipophilicity of the mother nucleus, which made it easier for the molecular to enter into the cell membrane of fungi to inhibit its growth. Conclusion This study provides a new method for screening new antifungal agents with high efficacy and low toxicity. Meanwhile, it contributes to the application of curcuminoids as food additive, colorant, and drug. Microcalorimetry is real-time, online, and dynamic, and it could be used to characterize the subtle difference among the effects of synthetic and natural products on the vital process of fungi.  相似文献
4.
目的 建立从姜黄中制备姜黄素、去甲氧基姜黄素和二去甲氧基姜黄素对照品的方法,并对姜黄素进行细胞毒性初步研究。方法 通过硅胶柱色谱对姜黄丙酮提取物进行分离纯化,IR、MS、1H-NMR波谱学方法对化合物进行结构鉴定,通过TLC和HPLC对其进行纯度检测;倒置显微镜观察姜黄素对高侵袭性人乳腺癌MCF-7细胞、低侵袭性人乳腺癌MDA-MB-231细胞和人肝癌HepG2细胞的毒性。结果 从姜黄中分离、纯化出姜黄素、去甲氧基姜黄素和二去甲氧基姜黄素对照品,质量分数均>98%。10、100 ng/mL的姜黄素能明显抑制MCF-7、MDA-MB-231和HepG2细胞的生长,对HepG2细胞杀伤力较大。结论 该法制备出的姜黄素、去甲氧基姜黄素和二去甲氧基姜黄素对照品符合中药化学对照品的相关要求,可作为姜黄药材及其制剂质量控制以及中药药效物质基础研究用的化学对照品;一定质量浓度的姜黄素能明显抑制人乳腺癌细胞和人肝癌细胞生长。  相似文献
1
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号