他扎罗汀乳膏短时接触疗法治疗寻常痤疮的临床研究

目的 评价0.1%他扎罗汀乳膏短时接触疗法治疗寻常痤疮时能否有效减轻局部不良反应,以及对临床疗效和症状反复的影响.方法 多中心、随机对照方法,将纳入观察的187例寻常痤疮病例分为短时接触疗法8周组,短时接触疗法12周组和常规治疗组.按Doshi痤疮综合分级系统(GAGS)计分评价,观察在治疗开始前(基线期)、完成时以及完成后的第2、4、8周内症状变化情况,评估局部不良反应和疗效,以及对病情反复的影响.结果 短时接触疗法8周组、12周组和常规治疗组局部不良反应率分别为11.48%、12.90%和38.33%,三组比较,差异有统计学意义(X2=13.31,P<0.01).短时接触疗法12周组总有效率(80.65%)较8周组(63.93%)高(X2=3.84,P<0.05).三组总有效率比较,差异无统计学意义(X2=1.98,P>0.05).短时接触疗法12周组能明显降低病情反复,三组间2,4、8周各随访段病情反复率比较,差异均有统计学意义(X2=3.29,3.78和5.85,P<0.05或P<0.01).结论 0.1%他扎罗汀乳膏短时接触疗法治疗寻常痤疮能有效减轻局部不良反应,且不降低疗效;而延长短时接触疗法疗程能减少症状反复,提高疗效.     

Milk consumption: aggravating factor of acne and promoter of chronic diseases of Western societies

Consumption of cow's milk and cow's milk protein result in changes of the hormonal axis of insulin, growth hormone and insulin‐like growth factor‐1(IGF‐1) in humans. Milk consumption raises IGF‐1 serum levels in the perinatal period, adolescence and adulthood. During puberty with the physiological onset of increased secretion of growth hormone, IGF‐1 serum levels increase and are further enhanced by milk consumption. IGF‐1 is a potent mitogen; after binding to its receptor in various tissues, it induces cell proliferation and inhibits apoptosis. Keratinocytes and sebocytes, as well as the androgen‐synthesizing adrenals and gonads, are stimulated by IGF‐1. The epidemic incidence of adolescent acne in Western milk‐consuming societies can be explained by the increased insulin‐ and IGF‐1‐stimulation of sebaceous glands mediated by milk consumption. Acne can be regarded as a model for chronic Western diseases with pathologically increased IGF‐1‐stimulation. Many other organs, such as the thymus, bones, all glands, and vascular smooth muscle cells as well as neurons are subject to this abnormally increased hormonal stimulation. The milk‐induced change of the IGF‐1‐axis most likely contributes to the development of fetal macrosomia, induction of atopy, accelerated linear growth, atherosclerosis, carcinogenesis and neurodegenerative diseases. Observations of molecular biology are supported by epidemiologic data and unmask milk consumption as a promoter of chronic diseases of Western societies.     

民族医药发展论坛召开

近日，以“传承保护、创新发展”为主题的民族医药发展论坛召开，与会专家一致强调，发展民族医药应遵循自身规律。本次论坛设立“中医、民族医发展战略研究”、“中医及针灸的文化传承与保护”、“民族医药现代研究”为主题的三个分论坛进行学术交流。代表们围绕挖掘和整理各少数民族有效方药，抢救和保护民族医药中濒临失传的特色诊疗技术以及传统民族医药的现代化研究等问题展开讨论。     

Taste and olfactory disturbances after treatment for acne with isotretinoin,a 13-cis-isomer of retinoic acid

Summary We report an olfactory disturbance after acne treatment with isotretinoin. A disturbance in taste was also reported by the patient. Examination of the nose showed no pathological findings. A CT scan was done to exclude a tumor or a lesion at the lamina cribrosa. Taste and smell examinations were performed and verified the lost qualities.     

Glycolic acid peeling in the treatment of acne

BACKGROUND: Glycolic acid chemical peels have been widely accepted as a useful modality in many cutaneous conditions characterized by abnormalities of keratinization. OBJECTIVE: The aim of this study is to evaluate the use of glycolic peels in the main clinical forms of acne. METHODS: Between January 1995 and December 1996, 80 women, aged 13-40 years, were visited for acne and selected for the study at the Cagliari University Dermatology Department (Italy). The type and severity of acne in each patient was assessed following the Leeds technique. The chemical peels were performed with a 70% glycolic acid solution, for times that varied in a range between 2 and 8 minutes. The number and frequency of the applications depended on the intensity of the clinical response. RESULTS: The main clinical forms were comedonic acne in 32 cases, papulo-pustular acne in 40 cases and nodule-cystic acne in the remaining eight cases. The most rapid improvement was observed in comedonic acne. In the papulo-pustular forms an average of six applications was necessary. Although nodular-cystic forms required eight to ten applications, a significant improvement of the coexisting post-acne superficial scarring was noted. The procedure was well tolerated and patient compliance was excellent. CONCLUSION: Glycolic acid chemical peels are an effective treatment for all types of acne, inducing rapid improvement and restoration to normal looking skin.     

中西医结合治疗痊疮重组优化方案

痤疮是一种青春期常见的毛囊皮脂腺的慢性炎症性疾病。表现为粉刺、丘疹、脓疱、结节和瘢痕，好发于面背胸等富含皮脂腺的部位。据调查，我国44．5％的青少年患有痤疮。近65％的（16～17）岁学生既往患过痤疮。有关发病年龄也已从青年型转向非青年型（老中青均可发生）。痤疮的发病率逐年上升，且范围不断扩大，其发病率都明显增加。目前对于痤疮的认识，中医、西医都已越来越清楚，但治疗方法两者都存在局限性，西医激素的使用一直经久不衰。但众所周之，长期使用激素副作用较大，患者接受度较低。而中医对于炎性，重度痤疮的治疗控制不具有优势。在临床工作中根据痤疮的不同程度，灵活选用系统治疗与局部治疗的药物来配合，结合中医与西医各自学科特点重组设计治疗痤疮的优化方案。     

天津市大学生痤疮发病因素相关性调查与分析

目的了解天津市大学生寻常痤疮的流行现况并作相关危险因素分析。方法2008年9月至11月对天津市13所高校2006级至2008级在校大学生痤疮发病情况进行现况调查。结果总回收问卷1 709例中现患寻常痤疮830例,现患率为48.57%。其中男性610人（35.69%）,男性现患率42.46%。女性1 099人（64.31%）,女性现患率51.96%。两性间现患率的差异有统计学意义（x~2=14.2,P〈0.01）。多因素logistic回归分析结果显示：痛经、月经时间不正常、睡眠不足、喜食油炸或肥腻食品以及遗传因素为危险因素。结论痤疮是天津市大学生中常见病、多发病。女生现患率较男性高。寻常痤疮是多因素疾病。     

维胺酯治疗痤疮类皮肤病的临床观察

<正> 维甲酸类(retinoids)在皮肤科临床上的应用,即在痤疮、银屑病、各种角化异常性皮肤病以及某些癌前或癌性疾病的治疗上,均取得了令人鼓舞的治疗效果。口服维甲酸类药物在皮肤科的应用,已有较详细的介绍。本文就国产维甲酸类衍生物维甲酯在痤疮类皮肤病中的疗效及其毒副作用作以下介绍。维胺酯的化学名称为N-(4-氧碳基苯基)维生素甲酰胺N-(ethoxycarbephenyl)-retinamide。分子式C_(29)H_(37)NO_3其化学结构式如下。     

HPLC-PDA检测祛痘除螨类化妆品中非法添加盐酸米诺环素方法的建立

目的建立用高效液相色谱-二极管阵列检测法（HPLC-PDA）检测祛痘除螨类化妆品中非法添加的盐酸米诺环素,以打击化妆品中非法添加禁限物质的不法行为。方法采用Waters Symmetry C18（5μm,4.6 mm×250 mm）色谱柱;以醋酸铵缓冲盐溶液（取醋酸铵15 g、氯化钾10 g与乙二胺四乙酸二钠5 g,加水溶解并稀释成1 000 ml）-乙腈（70∶30）为流动相等度洗脱;流速为1.0 ml/min;柱温为25℃;检测波长280 nm;用PDA检测,以保留时间和紫外光谱图定性,峰面积定量。结果盐酸米诺环素在1~100μg/ml范围内与峰面积呈良好的线性关系,相关系数为1.000 0,检出限为0.1μg/ml,方法的回收率为88.5%~98.5%,RSD为1.0%~1.5%（n=6）。结论该方法特异性强,灵敏度高,准确可靠,适用于不同基质样品中盐酸米诺环素的检测。     

口服米诺环素联合外用Derma光治疗重度寻常型痤疮临床观察

目的：探讨口服米诺环素联合外用Derma光治疗重度寻常型痤疮的临床疗效,为临床治疗提供理论依据。方法：选择符合标准的患者80例,采用随机数字的方法分为观察组和对照组各40例,对照组应用口服米诺环素,观察组应用口服米诺环素联合外用Derma光治疗,治疗8周后比较临床疗效。结果：治疗8周后观察组患者总有效率为97.50%,明显高于对照组的80.00%,差异有统计学意义（P〈0.05）。治疗前两组患者GAGS评分相似,差异无统计学意义（P〉0.05）;治疗后,两组患者GAGS评分较治疗前均下降,差异有统计学意义（P〈0.05）,但是观察组患者下降幅度更大（P〈0.05）。治疗期间观察组2例患者经红蓝光照射后面部皮肤出现轻度潮红、瘙痒和脱屑,对症处理1周后症状缓解。对照组未见不良反应。患者均随访3个月,观察组患者复发2例（5.00%）,对照组复发8例（20.00%）,差异有统计学意义（P〈0.05）。结论：口服米诺环素联合外用Derma光治疗重度寻常型痤疮的临床疗效确切,安全可靠,复发率低,值得临床推广使用。