窄谱蓝光联合1%克林霉素磷酸酯凝胶治疗寻常痤疮疗效观察

目的观察窄谱蓝光联合外用克林霉素磷酸酯凝胶治疗寻常痤疮的疗效。方法 110例痤疮患者随机分为两组,治疗组58例,采用窄谱蓝光照射联合外用1%克林霉素磷酸酯凝胶治疗;对照组52例,外用1%克林霉素磷酸酯凝胶治疗。结果治疗组和对照组有效率分别为75.9%和25.0%,治疗组疗效和有效率高于对照组(P<0.01)。结论窄谱蓝光照射联合外用1%克林霉素磷酸酯凝胶治疗痤疮疗效优于单用克林霉素磷酸酯凝胶。     

Successful treatment of acne keloidalis nuchae with erbium:YAG laser: a comparative study

Background: Acne keloidalis nuchae (AKN) is a chronic inflammatory disease involving hair follicles of the neck. It is a form of keloidal scarring alopecia that is often refractory to medical or surgical management.

Objective: To evaluate the efficacy of Er:YAG laser in the treatment of AKN as compared to long pulsed Nd:YAG laser. Patients and

Methods: This study was conducted on 30 male patients with AKN. Their ages ranged from 19 to 47 years with a mean age of 36.87 ± 7.8 years. Patients were divided randomly into two groups of 15 patients, each receiving six sessions of either Er:YAG or long-pulsed Nd:YAG laser therapy.

Results: A statistically significant decrease in the number of papules was detected at the end of therapy in both groups, with a mean of 91.8% improvement in the Er:YAG group versus 88% in the Nd:YAG group. A significant decrease in plaques count was detected only in the Er: YAG group while a significant decrease in plaques size and consistency was recorded in both groups.

Conclusion: The Er: YAG laser proved to be a potentially effective and safe modality both in the early and late AKN lesions.     

Clinical and usability study to determine the safety and efficacy of the Silk'n Blue Device for the treatment of mild to moderate inflammatory acne vulgaris

Abstract

Introduction: Home devices for acne vulgaris have emerged as a way to utilize our current light based technology for the care of our patients suffering from acne vulgaris. Materials and methods: Patient received eight treatments with the Silk'n Blue device over a 4-week period. Follow-up visits were at 1 month and 3 months. Results: Seventeen subjects were entered into this institutional review board (IRB) approved clinical research project. There was a statistically significant decrease in mean acne counts from baseline through the follow-up visits, p = 0.002. Percent reduction was also statistically significant, p = 0.041. The study also showed that 36.4% of the patients had complete clearance with the study device. 100% of the patients showed full comprehension with the label for the device. There were no adverse events. Photos were captured. Discussion: The Silk'n Blue device has an array of 24 LEDs emitting a spectrum of light in the blue-violet range of light (405–460 nm). Subjects enrolled in this clinical trial clearly were able to understand the labeling for the device. Conclusions: The Silk'n Blue device is a safe efficacious at home device for the treatment of mild to moderate inflammatory acne vulgaris.     

表皮葡萄球菌共生性稳态与皮肤疾病

【摘要】 表皮葡萄球菌对人体兼具保护和致病双重作用：一方面抑制病原菌和炎症、辅助皮肤固有免疫系统,维持皮肤微环境平衡;另一方面具有致病潜能。表皮葡萄球菌具体作用不仅取决于自身,也与宿主免疫系统、其他微生物以及环境的互相作用有关。这种互相作用的平衡即为表皮葡萄球菌共生性稳态,当稳态被打破后就可能发生多种皮肤疾病,如寻常痤疮、特应性皮炎、玫瑰痤疮以及黑素瘤。影响表皮葡萄球菌共生性稳态的因素包括温度、氧含量和营养等环境条件、抗生素以及其他微生物的数量、微生态多样性等。本文对近年来表皮葡萄球菌共生性稳态的研究进行综述。     

复方金银花治疗轻中度寻常痤疮的临床效果

目的 探讨在轻中度寻常痤疮的治疗中运用复方金银花的效果。方法 选取我院2021年1月-2022年6月收治的70例轻中度痤疮患者作为研究对象,采用随机数字表法分为对照组和观察组,各35例。对照组采取常规治疗,观察组采取复方金银花治疗,比较两组临床疗效、免疫功能指标变化、炎症因子水平变化、皮损程度积分、不良反应发生情况以及治疗满意度。结果 观察组治疗总有效率为97.14%,高于对照组的71.43%,差异有统计学意义（P＜0.05）;两组治疗后免疫功能各项指标高于治疗前,且观察组高于对照组,差异有统计学意义（P＜0.05）;两组治疗后CRP、白介素-6、白细胞计数以及降钙素原水平均低于治疗前,且观察组低于对照组,差异有统计学意义（P＜0.05）;两组治疗后皮损程度评分均低于治疗前,且观察组低于对照组,差异有统计学意义（P＜0.05）;观察组不良反应总发生率为2.06%,低于对照组的22.86%,差异有统计学意义（P＜0.05）;观察组总满意度为97.14%,高于对照组的68.57%,差异有统计学意义（P＜0.05）。结论 在轻中度寻常痤疮的治疗中运用复方金银花可有效提升临床疗效,增强患者免疫功能,降低炎性水平,减轻皮损程度,且不良反应少,可提高患者治疗满意度。