Drug delivery into the skin by degradable particles

Recently, it was demonstrated that particles could be utilized as carrier systems for drugs into the hair follicles. In the present study, a two-component drug delivery system is presented consisting of degradable particles loaded with fluorescein isothiocyanate and a separate protease formulation for degradation. The particles were applied alone, 30 min previous to the protease application and simultaneously with the protease onto porcine skin. Subsequently, biopsies were removed, and the penetration depths of the particles were analyzed using laser scanning microscopy.The obtained results demonstrate that the particles alone achieved a penetration depth of around 900 μm. Similar results were obtained for the successive application of particles and protease, whereas a release of the fluorescent dye was only observed in the upper 250 μm corresponding to the penetration depth of the protease. In the case of the simultaneous application, the particles were partly dissolved before application, leading to a reduced particle size and diminished penetration depth.The results revealed that degradable particles are a promising tool for drug delivery into the skin.     

2015名中学生痤疮流行病学调查

目的调查本地区中学生痤疮患病情况，为今后的临床研究提供资料。方法用分层整群抽样调查方法对本地区8所学校的2015名中学生进行关于痤疮的流行病学问卷调查。结果77．07％的中学生有座疮病史，现患率为54．99％，初次发病平均年龄（13．36±1．38）岁。结论中学生座疮患病率较高，但他们对痤疮的有关知识了解不足，因而有必要在学校或社区开展有关痤疮知识的健康教育。     

Clinical and usability study to determine the safety and efficacy of the Silk'n Blue Device for the treatment of mild to moderate inflammatory acne vulgaris

Abstract

Introduction: Home devices for acne vulgaris have emerged as a way to utilize our current light based technology for the care of our patients suffering from acne vulgaris. Materials and methods: Patient received eight treatments with the Silk'n Blue device over a 4-week period. Follow-up visits were at 1 month and 3 months. Results: Seventeen subjects were entered into this institutional review board (IRB) approved clinical research project. There was a statistically significant decrease in mean acne counts from baseline through the follow-up visits, p = 0.002. Percent reduction was also statistically significant, p = 0.041. The study also showed that 36.4% of the patients had complete clearance with the study device. 100% of the patients showed full comprehension with the label for the device. There were no adverse events. Photos were captured. Discussion: The Silk'n Blue device has an array of 24 LEDs emitting a spectrum of light in the blue-violet range of light (405–460 nm). Subjects enrolled in this clinical trial clearly were able to understand the labeling for the device. Conclusions: The Silk'n Blue device is a safe efficacious at home device for the treatment of mild to moderate inflammatory acne vulgaris.     

反常性痤疮17例临床分析

【摘要】 目的 探讨反常性痤疮患者的临床特点以及治疗方案。 方法 对门诊诊治的17例反常性痤疮患者的一般情况、临床特点、治疗方案进行回顾性分析。 结果 17例患者均为男性,发病年龄20岁左右,病程2 ~ 50年,主要临床表现为颈部、腋窝、腹股沟、会阴、臀部出现疼痛性炎性丘疹、结节、脓肿,伴瘘管窦道形成,反复发作。10例患者有家族史,7例为散发病例。治疗方法主要是口服维A酸类药物联合抗生素治疗,较严重的患者采用外科手术治疗。 结论 反常性痤疮患者以顶泌汗腺部位出现脓肿、窦道、瘢痕为主要临床表现,治疗应根据皮损的严重程度选择不同的治疗方案。     

复方甘草酸苷片联合多西环素胶囊、0.025%维A酸乳膏治疗中重度痤疮的临床观察

我们于2012年10月至2013年10月,运用复方甘草酸苷片联合多西环素胶囊、0.025%维A酸乳膏治疗中重度痤疮,取得满意疗效……     

痤疮的发病机制及其治疗

重度痤疮以显著的炎症反应、反复发作及易留下永久性瘢痕为特点,仍是当今痤疮治疗的一个难题.重度痤疮的发病有一定的人群倾向性,它与个体的炎症及免疫反应、遗传因素、性激素水平、氧化应激反应及血清生化等相关,治疗主要为药物治疗及物理治疗,其中对痤疮瘢痕的治疗也是重度痤疮治疗中很重要的一部分.研究重度痤疮的发病机制可在一定程度上预防痤疮发展为重度痤疮,并且指导临床治疗.

Abstract：

Severe acne is characterized by evident inflammatory reaction, recrudescence and inclination to leave permanent scars.Its treatment is still a troublesome problem over the world.The development of severe acne has a certain tendency in populations, and is related to the inflammatory and immune responses, genetic factors, sexual hormone levels, oxidative stress and serum biochemistry in individuals.Severe acne is mainly managed by medication and physical therapy.The treatment of acne scar is an important part of severe acne management.So, to study the pathogenesis of severe acne may benefit the prevention and control of it.     

光动力疗法治疗寻常痤疮的研究进展

寻常痤疮是临床上最常见的皮肤病之一,是一种由多因素综合作用引起的,累及毛囊皮脂腺的慢性炎症性皮肤病,其发病率呈逐年上升的趋势,并且影响患者的生活质量.传统的治疗方法为局部或系统治疗,具有潜在的毒副作用,加之细菌对抗生素耐药性的不断增加.近年来,光动力疗法已广泛应用于痤疮的治疗中,并成为治疗痤疮的有效方法,尤其是针对炎症性痤疮,其疗效优于单独光照治疗.光动力疗法的光源主要有二极管激光、强脉冲光、蓝光、红光.研究结果显示,该疗法安全、有效,不良反应较小.     

光动力疗法治疗寻常型痤疮的研究进展

光动力疗法通过干预痤疮发生的病理生理过程发挥治疗作用,为获得临床疗效必须选择理想的光敏剂、光源以及合适的波长和照射能量。笔者从痤疮的发病机制出发,探讨近年来光动力方法治疗痤疮的各种治疗参数选择和治疗效果的研究进展。     

痤疮涂膜剂联合阿达帕林治疗女性青春期后痤疮临床研究

目的探讨痤疮涂膜剂联合阿达帕林治疗女性青春期后痤疮临床疗效及安全性,寻求有效的治疗方案。方法选择104例女性青春期后痤疮患者,随机开放分为验证组及对照组,验证组每天中午皮损处外用痤疮涂膜剂,同时每晚睡前患处涂沫0．1％阿达帕林凝胶一次;对照组仅单纯每晚外用阿达帕林凝胶患处一次。治疗8周,评定疗效,观察随访。结果验证组治愈率36．5％,有效率达96．2％;对照组治愈率15．4％,有效率82．7％。两组治愈率、有效率比较经χ^2检验P〈0．05,均有统计学差异。结论痤疮涂膜剂联合阿达帕林治疗女性青春期后痤疮疗效显著,且不良反应轻微,方法安全简便,患者易接受,值得临床推广应用。     

痤疮患者血清白介素4和干扰素γ水平与瘢痕形成相关性研究

目的通过检测中度痤疮患者血清白介素（IL）4和干扰素（IFN）γ水平,探讨痤疮患者瘢痕形成的免疫应答机制。方法采集中度痤疮瘢痕形成患者（瘢痕组）的血清,用双抗体夹心酶联免疫吸附试验（ELISA）方法检测受试者血清IL-4和IFN-γ水平,并以中度无瘢痕（无瘢痕组）、轻度痤疮以及健康人作为对照组。分析中度痤疮患者血清IL-4和IFN-γ水平以及IL-4/IFN-γ的比值与瘢痕形成的相关性。结果瘢痕组血清IL-4水平上升,与后三组比较差异有统计学意义（P值分别为0.00,0.002,0.017）;而瘢痕组IFN-γ水平下降,与后三组比较差异有统计学意义（P值分别为0.005,0.007,0.046）。瘢痕组IL-4/IFN-γ的比值高于其他三组,经比较差异有统计学意义值均（P〈0.001）。结论痤疮瘢痕形成患者机体存在免疫应答异答,体液免疫优势应答与瘢痕形成密切相关。