全文获取类型
收费全文 | 2957篇 |
免费 | 312篇 |
国内免费 | 37篇 |
专业分类
耳鼻咽喉 | 37篇 |
儿科学 | 104篇 |
妇产科学 | 85篇 |
基础医学 | 337篇 |
口腔科学 | 51篇 |
临床医学 | 321篇 |
内科学 | 702篇 |
皮肤病学 | 23篇 |
神经病学 | 494篇 |
特种医学 | 41篇 |
外科学 | 183篇 |
综合类 | 208篇 |
预防医学 | 281篇 |
眼科学 | 54篇 |
药学 | 235篇 |
6篇 | |
中国医学 | 56篇 |
肿瘤学 | 88篇 |
出版年
2024年 | 8篇 |
2023年 | 92篇 |
2022年 | 82篇 |
2021年 | 170篇 |
2020年 | 188篇 |
2019年 | 119篇 |
2018年 | 125篇 |
2017年 | 141篇 |
2016年 | 122篇 |
2015年 | 99篇 |
2014年 | 206篇 |
2013年 | 210篇 |
2012年 | 110篇 |
2011年 | 134篇 |
2010年 | 135篇 |
2009年 | 123篇 |
2008年 | 137篇 |
2007年 | 109篇 |
2006年 | 124篇 |
2005年 | 91篇 |
2004年 | 74篇 |
2003年 | 66篇 |
2002年 | 74篇 |
2001年 | 51篇 |
2000年 | 41篇 |
1999年 | 49篇 |
1998年 | 31篇 |
1997年 | 29篇 |
1996年 | 30篇 |
1995年 | 22篇 |
1994年 | 22篇 |
1993年 | 20篇 |
1992年 | 33篇 |
1991年 | 21篇 |
1990年 | 17篇 |
1989年 | 18篇 |
1988年 | 16篇 |
1987年 | 14篇 |
1986年 | 14篇 |
1985年 | 27篇 |
1984年 | 26篇 |
1983年 | 10篇 |
1982年 | 16篇 |
1981年 | 13篇 |
1980年 | 12篇 |
1979年 | 7篇 |
1978年 | 4篇 |
1977年 | 5篇 |
1975年 | 5篇 |
1974年 | 5篇 |
排序方式: 共有3306条查询结果,搜索用时 15 毫秒
11.
《Sleep medicine》2020
BackgroundTo date, no previous studies have evaluated the relationship between sleep duration and quality of life (QOL) or depression in the general population after controlling for daytime sleepiness and sleep disturbances.MethodsA web-based cross-sectional survey was conducted with 8698 subjects aged 20–69 years. We examined the relationships between weekday sleep duration and daytime sleepiness, sleep disturbance, QOL and depression, using the Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index (without the item for sleep duration), 8-item Short Form and Center for Epidemiological Studies Depression Scale (CES-D).ResultsDaytime sleepiness tended to increase in proportion to shorter weekday sleep durations. Sleep disturbances, physical and mental QOL, and CES-D scores were worse in both the shorter and longer sleep groups compared with the group with 7–8 h of sleep. Hierarchical logistic regression analyses revealed that short sleep duration but not long sleep duration was significantly associated with reduction of both physical and mental QOL, even after controlling for the presence of daytime sleepiness and sleep disturbance. Both short and long sleep duration were independently and significantly correlated with depression after controlling for daytime sleepiness; however, there was no statistically significant association after adjusting for the effects of sleep disturbance.ConclusionsThe results suggested adverse effects of short sleep but not long sleep on both physical and mental QOL. In addition, the negative impact of specific types of sleep disturbance on depression may be greater than the impact of shortening of sleep duration. 相似文献
12.
13.
《Sleep medicine》2021
ObjectiveThis study aimed to evaluate the relationship between sleep duration trajectories from adolescence to early adulthood and working memory, schooling and income at 22 years in the Pelotas 1993 Birth Cohort.MethodsSleep duration was self-reported at ages 11, 18 and 22. Sleep trajectories were identified using finite mixture models. Schooling was recorded as the number of completed years of education. Working memory was evaluated using The Digit Span test and income was recorded for who reported have a job and received a payment for this in the previous month. All analyses were stratified by sex.ResultsWe used crude and adjusted (for demographic, health and behavior characteristics measured at perinatal and 11-years) linear or quantile regression analyses. A total of 2915 individuals were included. Three trajectories for males were used: “increase and maintenance” (3.4%), “fast reduction and maintenance” (45.0%) and “constant reduction” (51.6%). For females, we used the trajectories: “increase and decrease” (2.4%), “fast reduction and maintenance” (25.6%) and “constant reduction” (72.0%). Males from “increase and maintenance” and females from “increase and decrease” trajectories scored, on average, 1.6 and 1.8 points lower, respectively, in working memory test. They presented a median of 1.4 and 2.6 fewer schooling years, respectively, compared to individuals from the “fast reduction and maintenance” trajectory. Regarding income, no significant association was observed.ConclusionSleep duration during adolescence could affect cognitive and educational outcomes in early adulthood. Individuals who presented the expected sleep trajectory (decrease of sleep duration across adolescence) presented better outcomes. 相似文献
14.
15.
《Gait & posture》2019
BackgroundThe aim of this study was to evaluate whether there are any significant differences in muscle activity between individuals living with type II diabetes mellitus (T2DM) and individuals living with T2DM and peripheral arterial disease (PAD), during gait at a self-selected speed. The influence of different stages of PAD on muscle activity during gait was also assessed with the use of surface electromyography (EMG).Research questionDoes PAD affect lower limb muscle activity during gait in the presence of T2DM?MethodsThis quantitative study involves a prospective, comparative, non-experimental subject design. Ninety participants were divided into three groups namely Group A (thirty participants living with T2DM), Group B(i) (thirty participants living with T2DM and mild PAD) and Group B(ii) (thirty participants living with T2DM and severe PAD). Surface electrode sensors were placed according to SENIAM guidelines, on six main lower limb muscles on both limbs. Muscle activity was recorded using a wireless system, where participants were instructed to walk at a self-selected speed on a 10-m walkway. Average Burst RMS was performed and the amplitude (mV) and the duration of muscle activation (s) was analysed.ResultsThere was a significant increase in muscle amplitude and duration of activation in the presence of lower limb ischaemia during gait. The largest significant difference (p = <0.05) in EMG amplitude and duration of activation when looking at the twelve muscles in general was found between participants living with T2DM and participants living with T2DM and severe PAD.SignificanceThe increase in muscle activity indicates that there are musculoskeletal and biomechanical changes in the lower limb musculature with increasing severity of PAD. Higher muscle exertion demands are required during gait which may result in earlier fatigue. EMG tests would be beneficial for detecting muscle dysfunction objectively and non-invasively in T2DM and PAD. 相似文献
16.
《Sleep medicine》2020
ObjectivesPrior evidence suggests that sleep duration and sleep difficulties may be associated with cognitive function in old age, but little is known about the sleep–cognition association in late mid-life. Our aim was to examine the associations of accelerometer-based sleep duration as well as subjective sleep difficulties with different domains of cognitive function among aging workers.MethodsThe study population consisted of 289 participants (mean age 62.4 years, SD 1.02; 83% women) from the Finnish Retirement and Aging Study (FIREA). Sleep difficulties were measured using Jenkins Sleep Problem Scale (difficulties falling asleep, difficulties maintaining sleep, waking up too early in the morning, and nonrestorative sleep). Sleep duration was measured with wrist-worn accelerometer and self-report, and participants were divided into short (<7 h/night), mid-range (7–9 h/night) and long (≥9 h/night) sleepers. Participants underwent extensive cognitive testing covering three domains: (1) memory, (2) executive function, and (3) attention and information processing.ResultsGreater difficulties in waking up too early in the morning were associated with poorer executive function measured with Spatial Working Memory (SWM) test (p = 0.005). Additionally, nonrestorative sleep was associated with poorer executive function measured with Trail Making Test, B–A, (p = 0.036) and borderline significantly with lower SWM (p = 0.056). Compared to mid-range sleepers, long sleepers tended to have poorer cognitive function (all memory function tests and SWM), but the associations were not statistically significant due to small number of long sleepers.ConclusionsSubjective sleep difficulties may be linked to poorer executive function in a relatively healthy population of older workers in their 60 s. Thus, promoting good sleep quality may translate into better cognitive health in late mid-life. 相似文献
17.
18.
19.
ObjectivesTo explore the relationships among potentially modifiable factors related to childbirth and effective breastfeeding initiation at approximately 36 hours after birth and duration and exclusivity at hospital discharge, 2 weeks, 2 months, and 6 months after birth in primiparous women and to explore whether modifiable and nonmodifiable secondary factors and covariates influenced the relationships among factors related to childbirth and these breastfeeding outcomes.DesignA prospective, longitudinal, cohort study.SettingThe postpartum units of two general hospitals in eastern Canada.ParticipantsNinety-seven mother–infant dyads.MethodsWe recorded demographic, childbirth, obstetric history, and breastfeeding data through chart review. A breastfeeding observation was completed at approximately 36 hours after birth by unit nurses. Participants maintained breastfeeding logs in hospital and for 6 months after birth and completed three self-report questionnaires before discharge. We analyzed outcomes using backward stepwise linear and logistic regression.ResultsOne childbirth factor, labor induced with oxytocin, was negatively associated with effective initiation of breastfeeding, and none was related to breastfeeding duration and exclusivity at any time point. Maternal weight; professional support; and newborn’s gestational age at birth, 5-minute Apgar score, weight loss, LATCH score, and active feeds (newborn actively suckled at the breast) were significantly associated with breastfeeding outcomes.ConclusionInduction of labor with oxytocin should be used judiciously; when used, nurses must be hypervigilant to assess the mother–infant dyad for breastfeeding issues and to intervene to prevent or remediate them. 相似文献
20.