胃癌10和11组淋巴结转移及其清扫

目的：研究胃癌脾门淋巴结(No．10)和脾动脉周围淋巴结(No．11)转移规律，进一步探讨No．10和11清扫的必要性和方法。方法：1991年-2000年132例行全胃切除，D2以上淋巴结清扫的胃癌患者，回顾性研究临床病理资料，包括性别、年龄、肿瘤部位、大小、浸润深度、病理类型、其他淋巴结转移等对No．10和11转移的影响，比较全胃切除和全胃联合脏器切除的并发症发生率。结果：胃癌具有较高的No．10或11淋巴结转移率(18．9％)，Logistic回归分析表明，胃癌部位、病理类型、浸润深度和大小弯淋巴结转移五项临床病理指标影响No．10和U转移率。联合脏器切除的并发症发生率(32％)明显高于单纯全胃切除(11．2％)，联合肢体尾切除增加肠下脓肿发生率，而脾切除并不增加全胃切除的危险性。结论：No．10和11在胃癌有较高的转移率和特定的转移规律，预防性和治疗性的清扫实属必要，联合左侧肢体尾加脾切除增加手术危险性，应严格掌握的适应证。而保留胰腺，切除脾血管和脾清扫No．10．和ll淋巴结合理可靠。     

The role of primary total hip replacement for the treatment of the displaced femoral neck fractures

Summary The management of displaced intracapsular fractures of the hip is still controversial because of the high incidence of complications after internal fixation or hemiarthroplasty. To avoid some of these complications we have used primary total hip replacement for independently mobile patients over 65 years of age.Of 49 patients who were interviewed an average of 4.6 years after total hip replacement, 81.6% had excellent or good results as assessed by the Harris Hip Score. At that time two hips had been revised and another converted to Girdlestone due to deep infection. The survival of the prostheses was at 5 years 91.3%.It is concluded that total hip replacement is an established method of management for a selected group of patients with this injury, but further prospective studies are needed in order to define the groups of patients that benefit the most.     

Body composition in the elderly: Total body water and anthropometry

Body composition measured with isotopic dilution was compared with anthropometric measurements. The study was carried out in 47 subjects from both sexes, 65 to 92 years old. Total body water (TBW), anthropometric measurements, and dynamometry were assessed. TBW was significatively higher in men than women and decreased with age. Dynamometry and fatfree mass were well correlated (r=0.73 in males and r=0.58 in females) and significantly different between sexes. A negative correlation was found for dynamometry with age, being significant for women. Linear regression equations to predict TBW from anthropometric measurements in males and females were obtained: Males: TBW(I)=19.349+0.617 weight(kg) — 0.931 mid-arm circumference(cm)+0.122 dynamometry (kg) Females: TBW(l)=−5.531+0.343 weight(kg)-0.213 triceps skinfold (mm)+ 0.148 dynamometry(kg) + 3.424 wrist diameter (cm). This simple model is proposed for use in epidemiological and field studies where other more sophisticated methods can not be applied.     

深静脉高营养（TPN）预防食管癌切除术后吻合口瘘的临床研究

本研究收集食管癌行食管癌切除胃代食管术病例２６５例，分为未用深静脉高营养组（ＮＴＰＮ）和深静脉高营养组（ＴＰＮ）。分别对各组临床资料进行比较分析，结果显示：ＴＰＮ组葡萄糖供给量（８．３７±２．１２ｇ／ｋｇ／２４小时）显著高于ＮＴＰＮ组（２．７７±０．７１ｇ／ｋｇ／２４小时）（Ｐ＜０．０１），（０．３０±０．１４ｇ／ｋｇ／小时）Ｐ＜０．０５。吻合口瘘发生率ＴＰＮ组（２．１％）则显著低于ＮＴＰＮ组（１５．２％）Ｐ＜０．００１。结果提示ＴＰＮ组可明显降低吻合口瘘发生率。作者于ＴＰＮ促进吻合的愈合，预防吻合口瘘发生的有关机理进行了讨论。     

全肠外营养对老年晚期消化系统恶性肿瘤病人生存期的影响

目的:评估全肠外营养(TPN)对老年晚期消化系统恶性肿瘤病人生存期的影响。方法:回顾性分析121例老年晚期消化系统恶性肿瘤病人TPN治疗后的生存期。结果:TPN治疗后,患者生存期不同程度延长,为9～126天,平均68.1天,多数在两月左右。结论:TPN可延长老年晚期消化系统恶性肿瘤病人的生存期。     

麝香保心分散片的制备和人参总皂苷的体外溶出度研究

目的　制备麝香保心分散片 ,考察人参总皂苷的体外溶出度。方法　以PVPP为崩解剂、MCC为填充剂、CMC Ca为溶胀性辅料、1%HPMC水溶液为粘合剂 ,制备麝香保心分散片 ;采用比色法以人参总皂苷为测定指标 ,考察其体外溶出度。结果与结论　按最佳工艺制备的麝香保心分散片在 (2 0± 1)℃水中于 15s内可完全崩解且分散均匀 ,其指标性成分人参总皂苷的溶出速率明显高于麝香保心丸     

Intakes and major dietary sources of cholesterol and phytosterols in the British diet

Cholesterol intakes in Britain have been re-estimated by analysing Total Diet samples taken in 1991 and from 1993 National Food Survey records. The Total Diet samples contained only 284 mg/day compared with 319 mg/day in 1987 and 337 mg/day in 1981, while the National Food Survey showed intakes had fallen to 238 mg/day from 259 mg/day in 1990 and 405 mg/day in 1970-75. More details of the intakes by adults in 1986/87 are given, and compared with the results from the other methods. Daily intakes of eight phytosterols were also estimated, the main ones being β-sitosterol, campesterol, stigmasterol and 57-stigmastenol whose intakes were 104, 49, 10 and 4 mg/day, respectively, in 1991. These intakes had increased since 1981, reflecting the rising consumption of vegetable oils.     

珊瑚型人工髋关节置换术的临床随访及松动原因的分析

自１９８３年至今应用珊瑚型人工髋关节置换术共５４例６０髋。其中人工全髋关节置换术３４例４０髋，人工股骨头置换术２０例２０髋。在５４例６０髋珊瑚型人工髋关节置换术中，有３７髋随访６个月～１３年，平均随访时间约７年，疗效满意率为８５．１％，其中假体松动４例占１４．８％，髋臼松动２例７．４％。假体松动原因是假体与股骨负重界面之间没有达到稳定接触，假体与髓腔形状不相匹配，修整髓腔松质骨时，髓腔扩大器应比假体小一号，避免假体与界面存留缝隙。对于髋臼发育不良的患者应避免髋关节旋转中心向外侧移位，应向内上方加深髋臼以减少水平移位距离，其次髋臼植骨加盖勿在负重区。     

全腔静脉肺动脉连接手术前后血浆心钠素含量变化及其临床意义

目的　探讨全腔静脉肺动脉连接手术 (TCPC)前后心钠素 (ANP)的变化情况及其临床意义。方法　观察组为 18例全腔静脉肺动脉连接术患者 ;对照组选择 18例房间隔缺损、室间隔缺损心内修复术患者 ,两组分别于术前、术后第 1天、第 5天、第 4周和术后 6个月测量其心钠素含量。结果　观察组ANP含量术后第 1天显著下降 (t=2 6 2 3,P <0 0 1) ,此后直至出院前均显著高于对照组 ,术后 6个月时两组间无差别。观察组 7例术后出现胸腔积液并发症 ,其早期心钠素含量显著低于未发生该并发症的 11例患者 (P <0 0 5 )。结论　TCPC术后 ,因完全旷置右心 ,右房压显著下降 ,早期心钠素分泌量不足 ,这可能会导致机体水盐代谢失衡 ,与术后早期胸腔积液并发症密切相关。