清热祛瘀汤治疗药流产后出血

目的：评价清热祛瘀汤治疗药流产后出血疗效。方法：将停经≤49天的健康正常早孕妇女随机分3组，每组50例，组Ⅰ：药流产后即服诺氟沙星0.2g，3／日×4;组Ⅱ：西药同组1，在第1～3天服清热祛瘀汤;组Ⅲ：西药同组Ⅰ，第5天起不管孕囊是否排出加服清热祛瘀汤×5天。结果：组Ⅱ孕囊排出时间最短，直径较大，与其它二组相比，有显著差异（P＜0.05）;其恶心、呕吐发生率最低，具极显著差异（P＜0.01）。组Ⅲ流产后阴道出血量最少，出血持续时间最短，与组Ⅰ相比具极显著差异（P＜0.01）。结论：清热祛瘀汤对促进孕囊的排出，减少药流后出血等副反应是良好的。     

桂枝汤的药理学研究 五、加味、减味桂枝汤和桂枝汤的药理作用比较

比较了桂枝汤和桂枝去芍药汤、桂枝加桂汤、桂枝加芍药汤的实验药理作用差别,发现四方均能抑制流感病毒性肺炎、提高感染小鼠的网状内皮系统廓清能力,抑制皮肤迟发性超敏反应,作用均以桂枝汤最强,其次为桂枝加桂汤。桂枝汤、桂枝加桂和桂枝加芍药汤具有镇静作用,以桂枝加桂汤最强。桂枝加芍药汤、桂枝加桂汤和桂枝汤依次有镇痛作用。四方对正常肠蠕动功能无明显有规律的影响,但均能使亢进的肠蠕动抑制。实验结果与《伤寒论》对四方所述解表、调和营卫,治胸满、脉促,奔豚气和腹满时痛的主证大体吻合。     

桂枝汤的药理学研究——三、对小鼠非特异性屏障机能的影响

流感病毒所致小鼠病毒性肺炎,随着病程逐步加重,肺指数值上升,单核巨噬细胞系统的吞噬功能受抑,病鼠的心、肝、脾、肾、胸腺、肾上腺等重要器官也逐日减重。给病鼠以相当于人的临床剂量的桂枝汤能明显对抗上述改变,但桂枝汤对正常小鼠无明显影响这一结果提示RES功能可能与祖国医学的“营卫”有某些关联。     

炙甘草汤含药血清对兔心肌细胞瞬间外向钾电流的影响

目的 用血清药理学的方法研究炙甘草汤含药血清对兔心肌细胞瞬间外向钾电流（ho）的影响。方法 进行单个心室肌细胞的分离和膜片钳全细胞记录,将心室肌细胞分为对照组、空白血清组及5％、10%、20％、40%含药血清组,分别以普通细胞外液及加入上述不同浓度血清的细胞外液进行灌流,检测不同浓度含药血清对I10的影响。结果 含药血清可抑制I10,5％、10%、20%、40%含药血清分别将I10峰值（PA／PF）从（16．1±1．4）降至（13．9±1．5）、（11．8±1．9）、（8．3±1．5）、（8．2±1．2）,洗脱后其作用可消除。结论 炙甘草汤含药血清可抑制l。,且呈浓度依赖性作用增强,可能是炙甘草汤抗心律失常作用的机理。     

蒿芩清胆汤治疗系统性红斑狼疮活动期临床观察

目的观察蒿芩清胆汤治疗系统性红斑狼疮（SLE）活动期的疗效和安全性.方法选取SLE患者120例,随机分为两组,治疗组用蒿芩清胆汤和泼尼松,对照组用泼尼松和环磷酰胺,疗程3个月.观察治疗前后SLE活动指数（SLEDAI）及各项免疫指标,血尿常规、肝肾功能及其他不良反应发生情况.结果治疗组和对照组总有效率分别为81.67%（49/60例）、76.67%（46/60例）,两组比较差异无显著性.两组在改善SLEDAI、血沉（ESR）、C3、24h尿蛋白定量、抗dsDNA抗体方面均取得满意效果,治疗组未发现明显不良反应.结论蒿芩清胆汤治疗SLE活动期疗效显著,安全性好.     

Clinical study of Jiawei Huangqi Guizhi Wuwu Decoction in preventing and treating peripheral neuro-sensory toxicity caused by oxaliplatin

Objective: To evaluate the efficacy of Jiawei Huangqi Guizhi Wuwu Decoction (JHGWD) in treating neuro-sensory toxicity induced by oxaliplatin.Methods: A randomized controlled self-crossover trial was performed. Thirty-one patients were randomly divided into AB and BA groups. Patients in A cycle belonged to the treated group, who were treated with chemotherapy combined with oxaliplatin plus JHGWD. Patients in B cycle belonged to the control group and were treated with chemotherapy alone. The peripheral neuro-sensory toxicity was observed and analyzed.Results: The main neurotoxicity was cold-induced paresthesia after the use of oxaliplatin, which included hyperaesthesia, chill, anaesthesia in the extremities, electrified sensation, formication, foreign body sensation and pain that might be exacerbated by exposure to cold. Twenty patients (64.5%) suffered from neuro-sensory toxicity in the treated group and 27 cases (87. 1%) in the control group. Symptoms were more serious and lasted longer in the control group than those in the treated group (P<0.01).Conclusion: JHGWD could prevent and reduce the occurence and intensity of acute peripheral neuro-sensory toxicity caused by oxaliplatin.     

Clinical study on Ganbi decoction in treating antituberculotic agent-caused liver injury

Objective: To study the effect and mechanism of Ganbi decoction (GBD) in treating patients with antituberculotic agent caused liver injury (ATB-LI).Methods: One hundred and twenty-eight patients with ATB-LI were randomly assigned to the treated group (n = 66) and the control group (n = 62) with the envelop method. Meanwhile, 60 healthy persons were selected as the healthy control group. The treated group was treated by GBD one dose every day with the constituents modified depending on patients’ symptoms, and the control group was treated with glucuronolactone tablets and inosine injection. One week was taken as one treatment course. The changes of clinical syndromes, physical signs, T-lymphycyte sub-groups and serum level of nitric oxide (NO) were observed before and after treatment and the recovery time of liver function was recorded. The outcome was compared with that in the healthy control group.Results: In the treated group, 28 patients (42.4%) were cured, 30 (45.5%) improved and 8 (12.1%) ineffectively cured, the total effective rate being 87.9% (58/66). In the control group, 17 patients (27.4%) were cured, 24 (38.7%) improved, and 21 (33.9%) ineffectively cured, the total effective rate being 66. 1 % (41/62). The total effective rate in the treated group was significantly higher than that in the control group (P< 0. 05). Liver function was improved in both groups, recovery time in the treated group was 12.0 ±7.0 days, which was significantly shorter than that in the control group (16.0 ±8.0 days), showing significant difference between the two groups (P< 0.05). The levels of CD3, CD4 and CD8 were significantly higher and level of NO significantly lower in the two groups of patients than those in the healthy control group (P< 0.05), but these parameters were improved more significantly in the treated group after treatment, when compared with those before treatment or with those in the control group, all showing significant difference (P< 0.05).Conclusion: GBD could prevent ATB-LI, and its mechanism could be by way of reducing NO production induced by endotoxin of macrophage and stimulating the proliferation of T-lymphycyte to elevate immunity.     

降逆和胃汤治疗反流性食管炎45例临床观察

目的观察降逆和胃汤治疗反流性食管炎（reflux esophagitis,RE）的疗效。方法75例符合纳入标准的RE患者,随机分为两组。治疗组45例,口服降逆和胃汤,每天1剂;对照组30例,口服奥美拉唑20mg,每天1次;两组疗程均为8周。于治疗前后进行临床症状疗效、胃镜下RE分级和积分评价。结果应用降逆和胃汤和奥美拉唑治疗RE,均能明显改善患者的临床症状,治疗组痊愈率37．8％（17例）,总有效率为84．5％;对照组痊愈率为36．7％（11例）,总有效率为83.3％;两组治疗后各症状积分和总积分均明显低于治疗前（P〈0．01）。胃镜下,治疗后两组0级均明显增多,Ⅲ级均为0;治疗组治愈率为48．9％（22例）,总有效率为91．1％;对照组治愈率为46、7％（14例）,总有效率为93．3％;治疗后组内胃镜疗效比较,差异均有显著性（P〈0．01）。该结果显示,降逆和胃汤在改善RE患者的烧心、反酸和胸痛等临床症状、胃镜下食管黏膜炎症以及促进胃镜下食管炎的愈合等方面的疗效与奥美拉唑的疗效相近,但停药12周后复发情况比较却明显低于奥美拉唑（P〈0．05）,且未见不良反应发生。结论降逆和胃汤治疗RE具有较好的疗效。     

点燃癫痫模型基因的差异表达及草果知母汤对其影响

目的 筛选与点燃癫痫模型发病及单果知母汤发挥疗效相关联的基因。方法 使用mRNA昼N差异显示技术（DDRT-PCR）,筛选差异基N务带,并使用Northern印记杂交排除假阳性。结果 正常对照组、模型组、中药组存在110条差异条带,其中11务基因表达有明显差异的片段在正常对照组不存在,但出现在模型组,又在治疗组消失,说明这11条基因是与癫痫发病和治疗密切关联的基因。经NCBI美国国家基因库检索,这11条基因中的7条为同源基因,有4条基因片段为功能未知的新基因,其中3条新基因经Northern印记杂交排除了假阳性的可能,已经在GeneBank进行了注册,注册号分别CK325391、CK325392、CK325393、CK325394。结论 草果知母汤可能通过影响海马组织部分基因片段的表达而起到治疗癫痫模型的作用。     

加味黄连温胆汤治疗糖尿病无症状心肌缺血的临床观察

目的 观察加味黄连温胆汤治疗糖尿病无症状心肌缺血的临床疗效。方法 将65例患者随机分为两组,对照组（30例）服用单硝酸异山梨酯（欣康片）20mg,每日2次;治疗组（35例）加服加味黄连温胆汤。疗程均为1个月。观察两组治疗前后血糖、糖化血红蛋白、血脂、心肌酶谱、血液流变学、尿白蛋白、血常规、尿常规和肝肾功能,及24h动态心电图监测和心电图平板运动试验等指标。结果 临床总有效率治疗组（88．6％。31／35）和对照组（56．7％,17／30）比较差异有显著性（P〈0．05）。治疗组治疗后心肌缺血发作频率、发作累计时间、与活动有关发生率均明显低于对照组;血脂、血液流变学方面均较治疗前有明显改善（P〈0．05或P〈0．01）,红细胞聚集指数（RBCAI）、红细胞变形指数（RBCTI）与对照组比较差异有显著性（P〈0．05）。对照组仅全血黏度治疗后有改善（P〈0．05）,其余指标治疗前后比较差异无显著性。结论 加味黄连温胆汤具有改善心肌缺血和血液流变学、降低血脂作用。