Effect of Yishen Huayu Fang on kidney tissue E-cadherin expression in unilateral ureter ligation in rats

OBJECTIVE:To observe E-calcium sticky protein(E-cadherin) expression in kidney tissues in a rat model of unilateral ureter ligation and the effect of Yishen Huayu Fang(formula of tonifying the kidney and dissolving accumulated blood stasis) on the expression.METHODS:A total of 150 clean grade male rats were randomly divided into a control group,model group,low-dose Yishen Huayu Fang group(low-dose group),high-dose Yishen Huayu Fang group(high-dose group),and Lotensin group.A renal fibrosis model was established with unilateral ureteral obstruction(UUO).Pathological changes of rat renal tissue were observed with light microscopy on days 3,7,14,21,and 28 after UUO.Changes in kidney tissue E-cadherin expression were observed with immunohistochemistry.RESULTS:Three days after modeling,kidney edema appeared followed by gradual inflammatory cell infiltration,and part of the small tubules disappeared while the renal cortex thinned.Meanwhile,the E-cadherin expression level dropped,which was negatively correlated with the obstruction time.After intervention,E-cadherin expression was increased in all treatment groups(P<0.01 or P<0.05),while there were no significant differences between the high-dose and Lotensin groups.CONCLUSION:Yishen Huayu Fang delays the renal fibrosis process by promoting E-cadherin expression in renal tissues and reducing extracellular matrix deposition.     

葛根芩连汤临床应用及实验研究进展

葛根芩连汤具有解表清里之效,主治邪热下利。临床应用指征主要是:①身热下利、肛门灼热、大便不爽或臭秽难闻,甚或脓血便,小便色黄等肠道湿热者;②脘腹胀满、消谷善饥、头身困重、四肢倦怠、口黏、口渴、牙龈肿痛、口舌生疮等脾胃湿热者;③舌红苔黄腻,脉滑数或濡数者。现阶段虽然对葛根芩连汤的研究已不断深入,但仍有不足,比如目前已有大量动物实验研究证明葛根芩连汤可改变炎性因子水平,改善炎性反应,但相关临床研究较少,今后还需加强临床研究,为葛根芩连汤的临床应用提供更多客观依据。     

翁舌汤灌肠治疗大肠湿热型溃疡性结肠炎临床研究

目的:观察翁舌汤灌肠治疗大肠湿热型溃疡性结肠炎的疗效及其对患者血清炎症因子水平的影响.方法:将80例大肠湿热型溃疡性结肠炎患者按随机数字表法分为观察组和对照组各40例.观察组给予翁舌汤灌肠治疗,对照组给予美沙拉嗪栓肛门塞入治疗,两组均连续治疗8周.比较两组患者的临床疗效、肠黏膜征象积分和血清炎症因子水平.结果:治疗后,...     

Weekend catch-up sleep and depression: results from a nationally representative sample in Korea

BackgroundThere is limited information on the association between weekend catch-up sleep (CUS), which has beneficial effects on health, and depression. This study aimed to investigate the association between CUS and depression in adults.MethodsWe used the data of the Seventh Korea National Health and Nutrition Examination Survey, 2016. Depression was defined as Patient Health Questionnaire-9 score ≥10. We categorized CUS duration as ≤0, 0 < to 1, 1 < to 2, and >2 h.ResultsOf 5550 eligible participants, 3286 (54.9%), 1033 (19.5%), 723 (14.7%) and 508 (10.9%) had CUS duration ≤0, 0 < to 1, 1 < to 2, and >2 h, respectively; of these, the prevalence of depression was 7.0%, 4.2%, 2.9%, and 6.0%, respectively. Multivariable regression analyses including covariates revealed that individuals with CUS duration 1 < to 2 h had a significantly decreased risk of depression compared to individuals with CUS duration ≤0 h (odds ratio [OR] = 0.517, 95% CI = 0.309–0.865). Individuals with CUS duration 0 < to 1 h (OR = 0.731, 95% CI = 0.505–1.060) and >2 h (OR = 1.164, 95% CI = 0.718–1.886) showed no significantly different risk of depression.ConclusionsThe risk of depression in individuals with CUS duration 1 < to 2 h was lower than for those with CUS duration ≤0 h. This finding provides a better understanding on the association between CUS and depression; and can be a basis for better management of depression.     

泻黄散加减治疗心脾积热型小儿疱疹性咽峡炎临床研究

目的:比较泻黄散加减与利巴韦林治疗心脾积热型小儿疱疹性咽峡炎的临床疗效。方法:选取120例心脾积热型疱疹性咽峡炎患儿作为研究对象,按照随机数字表法分为研究组与对照组各60例。在常规给予物理降温、补液、抗感染等治疗的基础上,对照组给予利巴韦林每天10 mg/kg静脉滴注,研究组给予泻黄散加减口服。比较两组患儿治疗前后4个主症和10个次症的评分变化,以及两种治疗方法的总有效率。结果:治疗后,两组患儿4项主症及10项次症评分均有所下降(P<0.05),且研究组下降较对照组明显(P<0.05);研究组总有效率93.33%,对照组75.00%,两组比较差异有统计学意义(P<0.05)。结论:泻黄散加减治疗小儿疱疹性咽峡炎临床有效,且优于利巴韦林。     

中医药预防新型冠状病毒肺炎方法探讨

2019年12月于湖北省武汉市发现的新型冠状病毒肺炎,其潜伏期较长,传染性极强,缺乏针对性强的特效药,积极的预防至关重要。通过分析新型冠状病毒肺炎的中医发病特点,结合自贡地区气候环境以及体质因素等提出口服中药、佩戴香囊、中药熏蒸、中医运动等预防方法,取得一定的效果,可为临床提供参考。     

健脾栓配合西医治疗脾虚湿热型激素抵抗型溃疡性结肠炎临床观察

目的探讨健脾栓配合西医治疗脾虚湿热型激素抵抗型难治性溃疡性结肠炎的临床疗效。方法选取2016年5月—2019年1月收治的98例脾虚湿热型激素抵抗型难治性溃疡性结肠炎患者,根据治疗方案分组,各49例。对照组给予常规西医治疗,观察组在对照组基础上配合健脾栓治疗。对比2组临床疗效及不良反应发生率。结果观察组治疗总有效率(91.7%)高于对照组(71.3%),差异有统计学意义(P<0.05),不良反应发生率(12.2%)与对照组(10.2%)比较,差异无统计学意义(P>0.05)。结论健脾栓配合西医治疗脾虚湿热型激素抵抗型难治性溃疡性结肠炎可取得显著疗效,值得推广。     

常压密闭条件下小鼠的氧耗特征

运用自制的小鼠氧耗检测仪，检查在常压密闭条件下清醒小鼠的氧耗变化。结果表明：在这种条件下，累加时间－氧耗曲线呈对数型变，分钟氧耗曲线则表现出明显的时间应变化，开始的上升相和继这的下降相反映清醒动物的反射活动对氧耗的影响，最后的平缓下降段则可能反映上述调节活动失效动物所处的低氧耗状态。     

某钨矿1321例尘肺活存情况分析

本文用寿命表法对江西某钨矿1321例尘肺病人累积活存情况和病情变化作了统计分析。得出30年累积活存概率为31％,累积活存概率与观察时间呈负相关;病情稳定概率为29％,累积稳定概率与观察时间呈负相关。同时对该矿不同生产时期产生的尘肺累积活存概率和累积稳定概率作了分析。     

李克绍清透凉营法理论阐释与临床应用

介绍李克绍教授清透凉营法主治证候病机与临床应用。在温热病发病过程中,温热邪气极易损伤阴血津液,故温热病后期,或多或少总会发生阴液损伤,这是清透凉营法主治证候之病机。具体而言,阴虚郁热是病机之本,风热外感则是发病原因,阴虚与郁热在温热病发病过程中相互联系,具有一定的演化机制。清透凉营法遵循治热以寒、虚则补之的治则,恰合《内经》热淫于内之治法。李老临证善用青蒿、白薇、玄参,三者配伍具有清热透达、益阴凉血、解毒散结之力,扶正达邪、预护其阴之优势。