Long-term hypoxia induces changes in neuropeptide-Y-like immunoreactivity (NPY-LI) and/or in the content of serotonin (5-HT)
and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) at the central level. To determine whether these alterations depend
on the integrity of carotid body (CB) chemoreceptors, intact rats or those whose carotid sinus nerve was transected (CSNT)
were exposed to hypoxia (10% O2) or to normoxia for 14 days. Thereafter, NPY-LI, 5-HT and 5-HIAA levels in discrete brain regions were determined. The increase
in NPY-LI in the ventrolateral medulla oblongata (VLM) of intact hypoxic rats was mostly abolished after CSNT and therefore
is mainly mediated by CB chemoreceptors. In contrast, other hypoxia-induced changes were similar or even enhanced in CSNT
as compared to intact rats and therefore do not depend on the integrity of CB chemoreceptors. This was the case for the increase
of NPY-LI in the striatum and the caudal dorsomedian medulla oblongata (DMM), as well as for all the changes in 5-HT and 5-HIAA
in the DMM, the VLM, the raphe nuclei, the striatum and the frontal cortex. We propose that long-term hypoxia alters brain
NPY-LI and indolamine content through the stimulation of CB chemoreceptors or ancillary chemoreceptors, as well as through
local biochemical or morphological mechanisms.
Received: 5 May 1998 / Received after revision: 27 July 1998 / Accepted: 3 September 1998 相似文献
Background: Investigation of haplotype/allele frequency data of Y-STR loci in ethnically diverse populations is essential for forensic reference database construction and genetic application. However, the population genetic characteristics of the Chinese Miao minority from Guizhou Province remain uncharacterised.
Aim: To assess forensic characteristics for 23 Y-Chromosomal STR loci in Guizhou Miao and explore population genetic relationships with geographically neighbouring populations.
Subjects and methods: Twenty-three Y-Chromosomal STRs were genotyped using the Powerplex® Y23 system in 103 unrelated Chinese Miao males from Guizhou Province, southwest China. Haplotypes and forensic parameters were obtained. Population relationships of Guizhou Miao with others were revealed using AMOVA and an MDS plot.
Results: A total of 96 haplotypes were identified with overall haplotype diversity (HD) and discrimination capacity (DC) of 0.9985 and 0.9320, respectively. Genetic differentiation was observed with most of the comparison populations, prominently for Guizhou Shui.
Conclusion: The 23 Y-STR loci were highly polymorphic and discriminating in the Guizhou Miao population and could be used for forensic practice and population genetic studies. Population relationship analysis revealed Guizhou Miao had a close genetic relationship with geographically close Guizhou Gelao, as well as Han majorities derived from different regions. 相似文献
We are currently facing an obesity pandemic, with worldwide obesity rates having tripled since 1975. Obesity is one of the main risk factors for the development of non-communicable diseases, which are now the leading cause of death worldwide. This calls for urgent action towards understanding the underlying mechanisms behind the development of obesity as well as developing more effective treatments and interventions. Appetite is carefully regulated in humans via the interaction between the central nervous system and peripheral hormones. This involves a delicate balance in external stimuli, circulating satiating and appetite stimulating hormones, and correct functioning of neuronal signals. Any changes in this equilibrium can lead to an imbalance in energy intake versus expenditure, which often leads to overeating, and potentially weight gain resulting in overweight or obesity. Several lines of research have shown imbalances in gut hormones are found in those who are overweight or obese, which may be contributing to their condition. Therefore, this review examines the evidence for targeting gut hormones in the treatment of obesity by discussing how their dysregulation influences food intake, the potential possibility of altering the circulating levels of these hormones for treating obesity, as well as the role of short chain fatty acids and protein as novel treatments. 相似文献
目的:研究左旋精氨酸、牛磺酸、卡托普利单用及合用对自发性高血压大鼠的血压以及血神经肽Y、血脂水平的影响。方法:①用MRB-ⅢA型血压记录仪(上海第二医科大学高血压研究所),在大鼠清醒状态下,测鼠尾的尾动脉收缩压。②用酶法测定血清胆固醇(TC)、甘油三酯(TG)。③用^125I标记法和放射免疫法测血浆神经肽Y。结果:①经过四周药物治疗,左旋精氨酸且(L-arg)、牛磺酸组(Tau)血压均无变化(P>0.05)。卡托普利组(Cap )、三药合用组(L-arg Tau Cap)血压均下降(P<0.0005),L-arg Tau Cap组,血压下降比卡托普利组明显(P<0.01)。②经过四周药物治疗,牛磺酸组TC降低,TG无变化。L-arg Tau Cap组TC和TG均降低,左旋精氨酸组、卡托普利组TC和TG均无变化(P>0.05)。③经过四周药物治疗,左旋精氨酸组、牛磺酸组NPY无变化(P>0.05)。卡托普利组、L-arg Tau Cap 组NPY下降。用药前后,四组SHR大鼠血压高低与血浆神经肽Y的浓度均呈正相关(P<0.05)。结论:①四组大鼠治疗后,左旋精氨酸、牛磺酸组血压换变化;卡托普利组和合用组均出现血压降低,合用组降压效果经弹卡托普利明显。②牛磺酸治疗组血清胆固醇降低;三种药物合用组血清胆固醇和甘油三酯的降低。左旋精氨酸组、卡托普利组血脂无变化。③自发 性高血压大鼠的血压变化与血浆神经肽Y浓度的变化呈正相关,神经肽Y可能参与了高血压的发生发展。 相似文献