普乐林治疗冠心病心绞痛的临床体会

1．1资料和方法：选择符合WTO关于冠心病心绞痛诊断标准，选择冠心病心绞痛100例，采用随机单盲对照法，分为普乐林注射液和香丹注射液组。每组病人各50例。普乐林组40例，女10例，年龄52—80岁。香丹组年龄及性别与治疗组无差别。普乐林组用烟台鲁银药业有限公司提供的普乐林注射液，每次400mg加5％葡萄糖或0．9％生理盐水静脉点滴，1／d，疗程10—20d。香丹组用江苏安格药业有限公司提供的香丹注射液，每支2ml(该药由丹参和降香的提取物制成     

ASSOCIATION OF PLASMA HOMOCYSTEINE LEVEL AND N^5,N^10—METHYLENETETRAHYDROFOLATE REDUCTASE GENE POLYMORPHISM WITH CEREBRAL INFARCTION

OBJECTIVE: To investigate the relationship of plasma homocysteine (Hcy) level to stroke and genetic factor to elevated plasma Hcy level. METHODS: The plasma Hcy level was measured by capillary electrophoresis-ultraviolet detection and the gene polymorphism of N5,N10-methylenetetrahydrofolate reductase (MTHFR) was studied with PCR-RFLP assay in 43 patients with cortical cerebral infarction and 42 healthy control. RESULTS: The plasma Hcy level of the patients (19.3 +/- 6.0 micromol/L) was markedly higher than that of the controls (13.7 +/- 5.4 micromol/L) (t = 4.16, P < 0.001). There are 3 genotypes, C/C, C/T and T/T, about base-variation of MTHFR gene at locus 677. The plasma Hcy level of the subjects with T/T genotype was higher than that of subjects with other genotypes. However, the frequencies of each genotype and allele were not significantly different between the patients and the controls. CONCLUSIONS: The elevated plasma Hcy level is a risk factor for atherothrombotic cerebral infarction, and is related to the C-->T mutation at locus 677 of MTHFR gene.     

美国G5振动排痰机在心外科术后病人护理中的应用

手工叩背是心外科术后病人呼吸系统护理的重要手段之一，然而在临床实施过程中由于手工叩背存在着一些限制条件，如：需患儿体位配合，节率无法控制，频率无准确标准。力量轻重不易控制，不持久，手法复杂费力。易使操作者疲劳，易引起患儿反感。术后还易引起刀口开裂等等。而先心病术后的患儿大多使用机械通气来降低肺血管阻力。促进心功能恢复不能翻身，即使手工叩背排痰都无法实现。这一方法在临床应用上受到阻碍。美国G5振动排痰机能有效促进排痰，基于此。笔者想通过临床验证来了解美国G5振动排痰机能否提高排痰效果，减轻患儿病痛。     

葡萄胎化疗的护理体会

良性葡萄胎系由于绒毛上皮细胞增生，问质水肿、变性所致，可在生育年龄任何时期发生。我院从1998年至2004年共收治葡萄胎65例，均采用先清宫后用5-氟脲嘧啶静脉化疗，取得满意效果。     

子宫全切术与子宫次全切除术对妇女性生活满意度影响比较

目的：比较子宫全切术、子宫次全切除术两种手术方式对患者性生活满意度及性激素水平的影响。方法：观察73例全子宫切除术患者，52例次全子宫全切除术患者，采用评分法比较两种术式对性生活的影响及观察促卵泡刺激素（FSH）、黄体生成素（LH）、雌二醇（E2）水平的改变。结果：术后3，6个月性生活满意度评分次全子宫全切除术组明显高于全子宫切除术组，差异有显著性（P＜0．01），术后9，12个月两组比较评分差异无显著性（P＞0．05），术后1年两组与术前自身比较，评分差异无显著性（P＞0．05）。两组手术前后性激素水平的改变，差异无显著性（P＞0．05）。结论：两种手术方式对妇女性行为及性激素影响均不明显，术前、术后早期对患者进行必要的心理辅导，对保护患者的性功能有一定的帮助。     

海口市二次供水微生物污染调查与控制研究

目的：为了保障二次供水卫生安全，方法：采集水样进行七项微生物指标检测，参与二次供水卫生管理法规的制订，并设立专门的饮水卫生监督机构，实行定点定时检测，成立专业清理肖毒公司，推行放水→清除污泥→高压冲洗→抽干→高压冲洗→抽干－二氧化氯消毒30分钟→进水→检测合格→供水的水池清洗消毒操作程序。结果：实施干预措施前水质微生物指标合格率为78％，致病菌检出率为7％，实施干预措施后，二次供水卫生状况大为改观，定点监测微生物指标合格率达100％，结论：通过对海口市二次供水微生物污染调查并采取相应的控制措施，可以保障二次供水的卫生安全。     

一例宫颈癌患者的辅助化疗

西某某，女，47岁，因“同房后不规则阴道出血1^＋年，分泌物增多4月”于2004年5月14日入我院。患者平素月经规则，周期28～30天，经期5～6天，末次月经为2004年4月9日。患者于1^＋年前无明显诱因出现同房后阴道出血，鲜红色，量少，可自止，月经周期及经期无明显改变，未予诊治。4个月前出现阴道分泌物增多，黄绿色，有臭味，每日需用卫生巾两片。     

女患者导尿时预防尿管误入阴道的方法

术前留置尿管对手术患者至关重要[1],是观察术中血容量和指导补液的一项重要依据.女患者由于尿道短而直,插管比较容易.但在临床护理操作中有时会造成尿管误入阴道,对未婚女患者造成身体和心理上的巨大伤害.鉴此,我们于2006年6～10月摸索出一种新的导尿方法,应用于43例女患者,一次置管成功率100%,无1例误入阴道,报告如下.     

组织特异性胞嘧啶脱氨酶和5-氟胞嘧啶热化疗对裸鼠结肠癌肝脏转移的影响

Objective To investigate the effects of tissue specific cytosine deaminase/5-fluorocytosine (CD/5-FC) thermotherapy on hepatic metastasis of colonic carcinoma in nude mice. Methods Forty-five nude mice were randomly divided into control group, 5-FC group and 5-FC thermotherapy group according to the random number table (15 mice in each group). Mice models of hepatic metastasis of colonic carcinoma were established by portal vein injection of LoVo/CEACD cells. The hepatic metastasis rate and number of metastatic nodules of the 3 groups were compared by ehi-square test and one-way ANOVA. The pathological changes in tumor tissues and apoptotic index of tumor cells were observed. The expression of the CD gene in tumor tissues was detected by fluorescent quantitative RT-PCR and Western blot. Results The number of metastatic nodules and liver metas-tasis rate were 4.6±1.3 and 100.0% in control group, 2.2±1.0 and 60.0% in 5-FC group, 0.5±0.8 and 13.3% in 5-FC thermotherapy group, with statistical difference among the 3 groups (F=25.898, χ2=5.208, 19.548, 5.168, P<0.05). The mean apoptotic indexes of tumor cells of the 3 groups were 4.6%, 9.9% and 17.4%, respectively. Vacuolar degeneration, cell necrosis, cytolysis and apoptotic bodies were mostly observed in the 5-FC thermotherapy group. The expression of CD gene in tumor tissue was detected in all the groups. Conclusion Tissue specific CD/5-FC thermotherapy has inhibitory effects on the hepatic metastasis of LoVo cells transfected with CD gene.     

ADR风向标

西布曲明关键词:禁忌证和心血管不良反应近日,加拿大卫生部就西布曲明禁忌证和心血管不良反应问题再次提出警示。